Under the massive pedestrian flow, pedestrians arching phenomenon forms easily at bottleneck in subway hubs, which might stampede and crush. To explore pedestrian arching mechanism at bottleneck in subway transit hub, this paper conducts a series of...
Splicing is a tightly orchestrated process by which the brain produces protein diversity over time and space. While this process specializes and diversifies neurons, its deregulation may be responsible for their selective degeneration. In amyotrophic...
Colorectal cancer is one of the leading causes of cancer-associated mortality across the worldwide. One of the major challenges in colorectal cancer is the understanding of the regulatory mechanisms of biological molecules. In this study, we aimed to...
Ports and their affiliated shipping routes are fundamental to the maritime logistics system, crucial for global trade. However, they face risks from natural disasters and human-induced crises. Enhancing port resilience, the ability to quickly recover...
This study presents the interaction with the human host metabolism of SARS-CoV-2 ORF7b protein (43 aa), using a protein–protein interaction network analysis. After pruning, we selected from BioGRID the 51 most significant proteins among 2753 pr...
Background: Kazakhstan’s transport system plays a key role in Eurasian logistics due to its position along the Middle Corridor. However, multimodal freight transport remains under-optimized due to infrastructure bottlenecks, uneven cargo flows,...
This study aims to develop an integrated wireless monitoring system named MANTiS-32, which leverages an open-source platform to enable autonomous modular operation, high-speed large-volume data transmission via Wi-Fi, and the integration of multiple...
Among the micro-logistic transport systems, railway stations should be highlighted, such as one of the most important transport infrastructure elements. The efficiency of the transport industry as a whole depends on the quality of their operation. Su...
Composite rotors, attributing to their leveraging characteristics of the light weight, high strength, high rigidity, corrosion resistance, and low noise, can significantly reduce the moment of inertia and enhance equipment operational efficiency. Usi...
Background/Objectives: Cutaneous melanoma is one of the aggressive forms of skin cancer originating from melanocytes. The high incidence of melanoma metastasis continues to rise, partly due to the complex nature of the molecular mechanisms driving it...
The effect of breed on milk components—fat, protein, lactose, and water—has been observed to be significant. As fat is one of the major price-determining factors for milk, exploring the variations in fat QTLs across breeds would shed ligh...
The transcriptional regulatory network (TRN) is the central pivot of a prokaryotic organism to receive, process and respond to internal and external environmental information. However, little is known about its spatial organization so far. In recent...
The UK is home to several major air commercial and transport hubs. As a result, there is a high demand for Maintenance, Repair, and Overhaul (MRO) services to ensure that fleets of aircraft are in airworthy conditions. MRO services currently involve...
Slow steaming, i.e., the possibility to ship vessels at a significantly slower speed than their nominal one, has been widely studied and implemented to improve the sustainability of long-haul supply chains. However, to create an efficient symbiosis w...
Non-obstructive azoospermia is a severe infertility factor. Currently, the etiology of this condition remains elusive with several possible molecular pathway disruptions identified in the post-meiotic spermatozoa. In the presented study, in order to...
Singapore has established six Integrated Construction and Prefabrication Hubs with the goal of meeting ambitious productivity targets and building a resilient precast supply chain by 2024. These factories are equipped with high levels of mechanizatio...
Blockchain sharding is a promising approach to improving system scalability. However, traditional designs rely on lock-based cross-shard commit protocols, which introduce significant performance bottlenecks due to repeated on-chain communication and...
There is still a lack of effective therapies for Alzheimer’s disease (AD), the leading cause of dementia and cognitive decline. Identifying reliable biomarkers and therapeutic targets is crucial for advancing AD research. In this study, we deve...
In this paper, newly discovered mechanisms of atresia and cell death processes in bovine ovarian follicles are investigated. For this purpose the mRNA expression of receptor interacting protein kinases 1 and 3 (RIPK1 and RIPK3) of the granulosa and t...
The severity of natural disasters is increasing every year, having an impact on many people’s lives. During the response phase of disasters, airports are important hubs where relief aid arrives while people need to be evacuated to safety. Howev...
(1) Background: As global urbanization accelerates, effective mobility in metropolitan areas becomes crucial. City transportation systems, often congested, have diverse transit modes and numerous access points. Our study focuses on the transportation...
Vertical mobility, as a commercial service, has been considered for scheduled volume and long-distance mobility services. To overcome its limits and increase its potential coverage, flexibility, and adaptability, centralized mobility hubs, similar to...
Complex water networks face prominent contradictions among flood control, water supply, and ecological protection, and traditional scheduling models struggle to address multi-dimensional water security challenges. To solve this problem, this study pr...
Complex pedestrian or passenger crowd movements, such as intersecting movements, can create a bottleneck resulting in delays during emergency escape from public infrastructure such as major public transport hubs. Limited studies have examined the eff...
Marine (blue) biotechnology is an emerging field enabling the valorization of new products and processes with massive potential for innovation and economic growth. In the Mediterranean region, this innovation potential is not exploited as well as in...
Unmanned Aerial Vehicle Remote Sensing (UAV-RS) has emerged as a transformative technology in high-resolution Earth observation, with widespread applications in precision agriculture, ecological monitoring, and disaster response. However, a systemati...
Lung cancer is one of the most invasive cancers affecting over a million of the population. Non-small cell lung cancer (NSCLC) constitutes up to 85% of all lung cancer cases, and therefore, it is essential to identify predictive biomarkers of NSCLC f...
Drought is one of the most serious abiotic stressors in the environment, restricting agricultural production by reducing plant growth, development, and productivity. To investigate such a complex and multifaceted stressor and its effects on plants, a...
With the gradual adoption of smart hardware such as the Internet of Things (IoT) in warehousing and logistics, the efficiency bottlenecks and resource wastage inherent in traditional storage management models are now poised for breakthrough through d...
Specialized terminals in coastal ports play an increasingly important role in maritime transport. To enhance the resilience of specialized terminals, it is vital to increase their ability to maintain a certain level of function under various emergenc...
Bufferbloat is one of the leading causes of high data transmission latency and jitter on the Internet, which severely impacts the performance of low-latency interactive applications such as online streaming, cloud-based gaming/applications, Internet...
Bayesian approaches to decision trees (DTs) using Markov Chain Monte Carlo (MCMC) samplers have recently demonstrated state-of-the-art accuracy performance when it comes to training DTs to solve classification problems. Despite the competitive classi...
Increased expression of GNAi2, which encodes the α-subunit of G-protein i2, has been correlated with the late-stage progression of ovarian cancer. GNAi2, also referred to as the proto-oncogene gip2, transduces signals from lysophosphatidic acid (LPA)...
In recent decades, technological developments in archaeological geophysics have led to growing data volumes, so that an important bottleneck is now at the stage of data interpretation. The manual delineation and classification of anomalies are time-c...
The accurate identification of rice growth stages is critical for precision agriculture, crop management, and yield estimation. Remote sensing technologies, particularly multimodal approaches that integrate high spatial and hyperspectral resolution i...
Within the context of Industry 4.0, industrial systems are increasingly integrating digital tools such as discrete-event simulation (DES) and digital twins to enhance operational performance and facilitate data-driven decision-making. This research f...
Background: Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), are genetically complex and often linked to structural genomic variations such as copy number variants (CNVs). Current diagnostic strategies face challenges in...
Dar es Salaam Port, a crucial logistical hub in East Africa, faces significant challenges related to cargo handling efficiency, road congestion, and capacity constraints. The port’s performance is pivotal for regional trade, necessitating a com...
With the growth of trusted computing demand for big data analysis, cloud computing platforms are reshaping trusted data infrastructure by integrating Blockchain as a Service (BaaS), which uses elastic resource scheduling and heterogeneous hardware ac...
Sea buckthorn is a vital woody oil species valued for its role in soil conservation and its bioactive seed oil, which is rich in unsaturated fatty acids and other compounds. However, low seed oil content and small seed size are the main bottlenecks r...
The smart cities paradigm has gained significant attention as a tool to address the multifaceted challenges posed by contemporary urban mobility systems. While cities are eager to integrate cutting-edge technologies to evolve into digital and intelli...
KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allost...
Against the backdrop of global population growth and intensified resource competition, the sustainable development of the water-energy-food system (WEF) is facing challenges. Wetlands, as key ecological hubs, play a crucial role in regulating water c...
Malignancy of cancer has been linked to distinct subsets of stem-like cells, the so-called cancer stem cells (CSCs), which persist during treatment and seem to lead to drug-resistant recurrence. Metastatic spread of cancer cells is one of the hallmar...
Recording large amounts of users’ sessions performed through 3D applications may provide crucial insights into interaction patterns. Such data can be captured from interactive experiences in public exhibits, remote motion tracking equipment, im...
With the rapid development of high-speed railway (HSR) transportation in China, its impact on regional spatial patterns and shaping has become increasingly significant. This study took seven urban agglomerations in the Yellow River Basin as the resea...
Background: Against the backdrop of the large-scale and intensive development of the livestock industry, enhancing the reproductive efficiency of cattle has become a crucial factor in industrial development. Holstein cows, as the most predominant dai...