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56 Results Found

  • Article
  • Open Access
585 Views
10 Pages

Impact of the Different Corneal Storage Flasks on Endothelial Cell Loss During Cultivation—A Retrospective Analysis

  • Tarek Safi,
  • Carolin Marion Kolb-Wetterau,
  • Stephanie D. Grabitz,
  • Francesco Buonfiglio,
  • Melissa Apel and
  • Joanna Wasielica-Poslednik

11 October 2025

Objectives: To evaluate the impact of different corneal storage containers—with and without corneal holders—on endothelial cell density (ECD) and endothelial cell loss (ECL) during organ culture, following a temporary shortage of Böh...

  • Article
  • Open Access
1 Citations
1,312 Views
10 Pages

Hemi-Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (Hemi-UT-DSAEK) Using Pediatric Donor Corneas: A Case Series

  • Pia Leon,
  • Lorena Francescutti,
  • Pietro Gentile,
  • Federica Birattari,
  • Diego Ponzin,
  • Davide Camposampiero,
  • Antonella Franch and
  • Mohit Parekh

22 August 2023

Objective: We sought to evaluate the clinical outcomes of hemi-UT-DSAEK grafts from the pediatric donor corneas of patients affected by Fuchs Endothelial Corneal Dystrophy (FECD). Methods: A prospective, interventional case series was conducted at th...

  • Article
  • Open Access
1 Citations
817 Views
25 Pages

1 September 2025

The article explores how the design of informational and promotional messages from financial institutions influences their reception by young people. The study combined eye tracking, individual in-depth interviews (IDIs), and text mining analysis to...

  • Article
  • Open Access
3 Citations
2,204 Views
14 Pages

Transcriptional Profiling Provides New Insights into Organ Culture-Induced Changes in Human Donor Corneas

  • Julian Wolf,
  • Paola Kammrath Betancor,
  • Philip Maier,
  • Sonja Ute Heinzelmann,
  • Jana Jiang,
  • Clemens Lange,
  • Thomas Reinhard,
  • Günther Schlunck and
  • Thabo Lapp

22 November 2022

Corneal transplantation is one of the most common forms of tissue transplantation worldwide. Donor corneal tissue used in transplantation is provided by eye banks, which store the tissue in culture medium after procurement. To date, the effects of ce...

  • Article
  • Open Access
3,243 Views
9 Pages

RT-PCR Testing of Organ Culture Medium for Corneal Storage Fails to Detect SARS-CoV-2 Infection Due to Lack of Viral Replication

  • Lisa Müller,
  • Philipp Niklas Ostermann,
  • Heiner Schaal,
  • Sabine Salla,
  • Jörg Timm,
  • Gerd Geerling and
  • Johannes Menzel-Severing

22 January 2022

Concerns of possible transmission of SARS-CoV-2 from donors to patients by corneal transplantation have caused a decline in corneal transplantations. Graft culture media are routinely tested for infectious risks, but it is unclear whether this consti...

  • Article
  • Open Access
2 Citations
2,666 Views
11 Pages

Specular Microscopy of Human Corneas Stored in an Active Storage Machine

  • Thibaud Garcin,
  • Emmanuel Crouzet,
  • Chantal Perrache,
  • Thierry Lepine,
  • Philippe Gain and
  • Gilles Thuret

26 May 2022

Purpose: Unlike corneas stored in cold storage (CS) which remain transparent and thin, corneas stored in organoculture (OC) cannot be assessed by specular microscopy (SM), because edema and posterior folds occur during storage and prevent from specul...

  • Article
  • Open Access
2 Citations
2,066 Views
10 Pages

Challenges of DMEK Technique with Young Corneal Donors’ Grafts: Surgical Keys for Success—A Pilot Study

  • Mayte Ariño-Gutierrez,
  • Mercedes Molero-Senosiain,
  • Barbara Burgos-Blasco,
  • Beatriz Vidal-Villegas,
  • Pedro Arriola-Villalobos,
  • Jose Antonio Gegundez-Fernandez,
  • Gregory Moloney and
  • Luis Daniel Holguín

30 September 2023

Purpose: To report on the surgical maneuvers recommended for a successful unfolding of very young donors in order to accomplish an uneventful Descemet Membrane Endothelial Keratoplasty (DMEK) surgery. Methods: Five patients (three females and two mal...

  • Article
  • Open Access
3 Citations
2,259 Views
11 Pages

Effect of Low-Temperature Preservation in Optisol-GS on Preloaded, Endothelium-Out DMEK Grafts

  • Alessandro Ruzza,
  • Stefano Ferrari,
  • Matteo Airaldi,
  • Vito Romano and
  • Diego Ponzin

28 January 2023

The aim of the study was to assess different temperature ranges for the preservation of pre-loaded Descemet Membrane Endothelial Keratoplasty (DMEK) grafts in the DMEK RAPID Mini device. Methods: Three groups of 15 DMEK grafts (five per group) were p...

  • Article
  • Open Access
21 Citations
6,301 Views
19 Pages

A Novel Approach of Harvesting Viable Single Cells from Donor Corneal Endothelium for Cell-Injection Therapy

  • Hon Shing Ong,
  • Gary Peh,
  • Dawn Jin Hui Neo,
  • Heng-Pei Ang,
  • Khadijah Adnan,
  • Chan Lwin Nyein,
  • Fernando Morales-Wong,
  • Maninder Bhogal,
  • Viridiana Kocaba and
  • Jodhbir S. Mehta

9 June 2020

Donor corneas with low endothelial cell densities (ECD) are deemed unsuitable for corneal endothelial transplantation. This study evaluated a two-step incubation and dissociation harvesting approach to isolate single corneal endothelial cells (CECs)...

  • Article
  • Open Access
2 Citations
1,857 Views
16 Pages

A Pilot Case Series on the Use of a Large Mushroom-Shaped Corneal Graft for the Surgical Management of Post-Penetrating Keratoplasty Ectasia and Endothelial Failure

  • Antonio Moramarco,
  • Luigi Fontana,
  • Natalie di Geronimo,
  • Giulio Rapezzi,
  • Giacomo Savini,
  • Pietro Viola,
  • Maurizio Mete and
  • Vito Romano

8 January 2025

Objective: The aim of this study was to evaluate the effect of a surgical technique for managing post-penetrating keratoplasty (PK) ectasia complicated by late endothelial failure (LEF). Methods: A single-center pilot case series was conducted regard...

  • Article
  • Open Access
2 Citations
4,331 Views
14 Pages

The United States and China Financial Communication and the Notion of Risk

  • Changjun Zheng,
  • Konan Richard Kouadio and
  • Bienmali Kombate

The close relationship between governments and their central banks generates risks for both partners. This paper presents an original qualitative empirical approach based on textual analysis of the United States of America, China, and their Central B...

  • Article
  • Open Access
1 Citations
2,686 Views
9 Pages

A Morphometric Study of the Pars Plana of the Ciliary Body in Human Cadaver Eyes

  • Jaime Guedes,
  • Bruno F. Fernandes,
  • Denisse J. Mora-Paez,
  • Rodrigo Brazuna,
  • Alexandre Batista da Costa Neto,
  • Dillan Cunha Amaral,
  • Adriano Cypriano Faneli,
  • Ricardo Danilo Chagas Oliveira,
  • Adroaldo de Alencar Costa Filho and
  • Adalmir Morterá Dantas

This study aimed to determine the pars plana length in postmortem human eyes using advanced morphometric techniques and correlate demographics to ocular metrics such as age, sex, ethnicity, and axial length. Between February and July 2005, we conduct...

  • Article
  • Open Access
703 Views
14 Pages

Eyeing ID: Access to Identification as a Barrier to Banking and Other Social Determinants of Health

  • Katie Bonner,
  • Natalia Fana,
  • Sarah Lunney,
  • Sarah Campbell,
  • Deanna Merriam,
  • Cristian Estrella Almonte and
  • Sarah Gander

Personal identification (ID) is a prerequisite to many financial and social services; however, many vulnerable residents do not have ID and lack the resources to acquire it. To assess the impact of ID inaccessibility in a local context, a study was c...

  • Article
  • Open Access
3 Citations
1,981 Views
10 Pages

22 October 2022

Grafts used for corneal donation should be sterile to avoid transplantation failure and secondary infection. However, there are no clear and globally accepted specifications from eye banks on microbial sampling sites. The objective of this study was...

  • Article
  • Open Access
10 Citations
10,471 Views
24 Pages

26 December 2022

Mobile banking is nowadays a standard service provided by banks worldwide because it adds convenience for people. There is no more rushing to a bank or waiting in lines for a simple transaction that can be conducted from anywhere and at any time in t...

  • Article
  • Open Access
7 Citations
3,187 Views
11 Pages

Metagenomic Shotgun Sequencing Analysis of Canalicular Concretions in Lacrimal Canaliculitis Cases

  • Yukinobu Okajima,
  • Takashi Suzuki,
  • Chika Miyazaki,
  • Satoshi Goto,
  • Sho Ishikawa,
  • Yuka Suzuki,
  • Kotaro Aoki,
  • Yoshikazu Ishii,
  • Kazuhiro Tateda and
  • Yuichi Hori

Lacrimal canaliculitis is a rare infection of the lacrimal canaliculi with canalicular concretions formed by aggregation of organisms. Metagenomic shotgun sequencing analysis using next-generation sequencing has been used to detect pathogens directly...

  • Article
  • Open Access
19 Citations
12,093 Views
34 Pages

Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience

  • Roger A. Astley,
  • Md Huzzatul Mursalin,
  • Phillip S. Coburn,
  • Erin T. Livingston,
  • James W. Nightengale,
  • Eddy Bagaruka,
  • Jonathan J. Hunt and
  • Michelle C. Callegan

Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which ba...

  • New Book Received
  • Open Access
6,164 Views
2 Pages

23 October 2009

Symmetry is as simple or as complicated as we are ready to absorb it in everything around us. From flowers to bridges, buildings, coke machines, and snowflakes; from molecules to walnuts, fences, pine cones, and sunflowers; from music to children's d...

  • Article
  • Open Access
14 Citations
4,728 Views
28 Pages

Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders

  • Nune Darbinian,
  • Armine Darbinyan,
  • John Sinard,
  • Gabriel Tatevosian,
  • Nana Merabova,
  • Faith D’Amico,
  • Tarek Khader,
  • Ahsun Bajwa,
  • Diana Martirosyan and
  • Michael E. Selzer
  • + 6 authors

21 December 2022

Prenatal alcohol exposure can cause developmental abnormalities (fetal alcohol spectrum disorders; FASD), including small eyes, face and brain, and neurobehavioral deficits. These cannot be detected early in pregnancy with available imaging technique...

  • Case Report
  • Open Access
13 Citations
6,641 Views
6 Pages

First Molecular Confirmation of Equine Ocular Setaria digitata in China

  • Feng Yu,
  • Bo Liu,
  • Shulei Chen,
  • Ziwen Yi,
  • Xianyong Liu,
  • Yiping Zhu and
  • Jing Li

28 March 2021

A 5-year-old Mongolian mare (Equus caballus Linnaeus, 1758) was observed to have corneal opacity and excessive ocular discharge. An ophthalmic examination revealed a moving thread-like cylindrical worm in the anterior chamber of the right eye. The pa...

  • Article
  • Open Access
8 Citations
2,680 Views
11 Pages

How to Predict the Suitability for Corneal Donorship?

  • Franziska Schön,
  • Adrian Gericke,
  • Julia Bing Bu,
  • Melissa Apel,
  • Alicia Poplawski,
  • Alexander K. Schuster,
  • Norbert Pfeiffer and
  • Joanna Wasielica-Poslednik

31 July 2021

Background: In Germany, more than one-third of donor corneas harvested are not suitable for transplantation. We evaluated the factors associated with the usability of donor corneas. Method: Data from 2032 consecutive donor corneas harvested at the Rh...

  • Article
  • Open Access
13 Citations
2,997 Views
14 Pages

7 July 2022

Background: Diabetic retinopathy (DR) is a complication associated with uncontrolled DM. It is a leading preventable cause of visual impairment in the world and a cause of blindness in those under 75 years old in developing countries. We aimed to exp...

  • Article
  • Open Access
8 Citations
3,992 Views
16 Pages

26 March 2024

Common age-related eye disorders include glaucoma, cataract, and age-related macular degeneration (AMD); however, little is known about their relationship with age. This study investigated the potential causal relationship between glaucoma and AMD wi...

  • Communication
  • Open Access
1 Citations
1,649 Views
9 Pages

The Endogenous Expression of BMI1 in Adult Human Eyes

  • Zhongyang Lu,
  • Maria G. Morales,
  • Shufeng Liu and
  • Hema L. Ramkumar

9 October 2024

BMI1, also known as B lymphoma Mo-MLV insertion region 1, is a protein in the Polycomb group that is implicated in various cellular processes, including stem cell self-renewal and the regulation of cellular senescence. BMI1 plays a role in the regula...

  • Article
  • Open Access
10 Citations
3,110 Views
29 Pages

In recent years, limited works on EOG (electrooculography)-based biometric authentication systems have been carried out with eye movements or eye blinking activities in the current literature. EOGs have permanent and unique traits that can separate o...

  • Review
  • Open Access
22 Citations
10,970 Views
13 Pages

ABCC6 and Pseudoxanthoma Elasticum: The Face of a Rare Disease from Genetics to Advocacy

  • Karobi Moitra,
  • Sonia Garcia,
  • Michelle Jaldin,
  • Clementine Etoundi,
  • Donna Cooper,
  • Anna Roland,
  • Patrice Dixon,
  • Sandra Reyes,
  • Sevilay Turan and
  • Michael Dean
  • + 1 author

Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder characterized by the mineralization of connective tissues in the body. Primary manifestation of PXE occurs in the tissues of the skin, eyes, and cardiovascular system. PXE is primarily...

  • Feature Paper
  • Article
  • Open Access
9 Citations
5,317 Views
11 Pages

Several RNA viruses, including SARS-CoV-2, can infect or use the eye as an entry portal to cause ocular or systemic diseases. Povidone-Iodine (PVP-I) is routinely used during ocular surgeries and eye banking as a cost-effective disinfectant due...

  • Article
  • Open Access
79 Citations
9,564 Views
15 Pages

Developing a Motor Imagery-Based Real-Time Asynchronous Hybrid BCI Controller for a Lower-Limb Exoskeleton

  • Junhyuk Choi,
  • Keun Tae Kim,
  • Ji Hyeok Jeong,
  • Laehyun Kim,
  • Song Joo Lee and
  • Hyungmin Kim

19 December 2020

This study aimed to develop an intuitive gait-related motor imagery (MI)-based hybrid brain-computer interface (BCI) controller for a lower-limb exoskeleton and investigate the feasibility of the controller under a practical scenario including stand-...

  • Article
  • Open Access
1 Citations
1,681 Views
15 Pages

Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery: An Experimental Study

  • Rohit Shetty,
  • Pooja Khamar,
  • Ramaraj Kannan,
  • Puja Thacker,
  • Nimisha Rajiv Kumar,
  • Arkasubhra Ghosh and
  • Vrushali Deshpande

6 February 2025

Purpose: refractive surgery, such as LASIK and SMILE, induces a wound healing response that leads to significant corneal stromal remodeling. We have shown that the protein profile in the stroma changes dramatically immediately post-surgery. However,...

  • Article
  • Open Access
10 Citations
3,941 Views
18 Pages

Gaidropsarus gallaeciae (Gadiformes: Gaidropsaridae), a New Northeast Atlantic Rockling Fish, with Commentary on the Taxonomy of the Genus

  • Rafael Bañón,
  • Francisco Baldó,
  • Alberto Serrano,
  • David Barros-García and
  • Alejandro de Carlos

3 June 2022

A new species of rockling fish genus Gaidropsarus is described based on six specimens collected in Galicia and Porcupine Banks, in Atlantic European waters. An analysis of morphological characters has confirmed the specific status of specimens of a p...

  • Communication
  • Open Access
573 Views
8 Pages

27 November 2025

This study reports the first records of Sphyraena arabiansis in the Korean waters. The two specimens were collected from the coastal waters of Yeosu (1164 mm TL) and Jeju Island (1187 mm TL), Korea, on 31 July and 24 October 2025, respectively. This...

  • Review
  • Open Access
16 Citations
4,809 Views
25 Pages

Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy

  • Juliette Varin,
  • Clément Morival,
  • Noémien Maillard,
  • Oumeya Adjali and
  • Therese Cronin

26 November 2021

Gene therapy (GT) for ocular disorders has advanced the most among adeno-associated virus (AAV)-mediated therapies, with one product already approved in the market. The bank of retinal gene mutations carefully compiled over 30 years, the small retina...

  • Article
  • Open Access
38 Citations
12,092 Views
31 Pages

A Comparative Eye Tracking Study of Usability—Towards Sustainable Web Design

  • Mihai Țichindelean,
  • Monica Teodora Țichindelean,
  • Iuliana Cetină and
  • Gheorghe Orzan

18 September 2021

Websites are one of the most frequently used communication environments, and creating sustainable web designs should be an objective for all companies. Ensuring high usability is proving to be one of the main contributors to sustainable web design, r...

  • Article
  • Open Access
2,133 Views
14 Pages

Phylodynamic and Epistatic Analysis of Coxsackievirus A24 and Its Variant

  • Chia-Chi Cheng,
  • Pei-Huan Chu,
  • Hui-Wen Huang,
  • Guan-Ming Ke,
  • Liang-Yin Ke and
  • Pei-Yu Chu

8 August 2024

Coxsackievirus A24 (CV-A24) is a human enterovirus that causes acute flaccid paralysis. However, a Coxsackievirus A24 variant (CV-A24v) is the most common cause of eye infections. The causes of these variable pathogenicity and tissue tropism remain u...

  • Article
  • Open Access
4 Citations
2,055 Views
12 Pages

Factors Affecting the Density of Corneal Endothelial Cells Cultured from Donor Corneas

  • Marina Bertolin,
  • Alessandro Ruzza,
  • Vanessa Barbaro,
  • Elisa Zanetti,
  • Diego Ponzin and
  • Stefano Ferrari

5 November 2024

We investigated which specific correlation exists between the endothelial cell density (ECD) of corneal endothelial cell (CEC) cultures and the features of the donor corneas from which they originate. CEC cultures were prepared from one donor cornea...

  • Article
  • Open Access
1,153 Views
20 Pages

SOUTY: A Voice Identity-Preserving Mobile Application for Arabic-Speaking Amyotrophic Lateral Sclerosis Patients Using Eye-Tracking and Speech Synthesis

  • Hessah A. Alsalamah,
  • Leena Alhabrdi,
  • May Alsebayel,
  • Aljawhara Almisned,
  • Deema Alhadlaq,
  • Loody S. Albadrani,
  • Seetah M. Alsalamah and
  • Shada AlSalamah

14 August 2025

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder that progressively impairs motor and communication abilities. Globally, the prevalence of ALS was estimated at approximately 222,800 cases in 2015 and is projected to increase by nea...

  • Article
  • Open Access
1 Citations
2,441 Views
26 Pages

An Ecomorphological Description of Amblyraja radiata (Rajiformes: Rajidae) in Waters of Eastern Canada

  • David W. Kulka,
  • Carolyn M. Miri,
  • Sheila Atchison and
  • Mark R. Simpson

26 September 2024

We examine the distribution, habitat association, morphometrics, meristics, and reproductive attributes of Amblyraja radiata over much of its Canadian range, Grand Banks to Arctic waters. It is distributed widely on the shelf and upper slope between...

  • Article
  • Open Access
2,322 Views
20 Pages

15 September 2025

Medical image segmentation faces significant challenges due to domain shift between different clinical centers and data privacy restrictions. Current source-free domain adaptation methods for medical images suffer from three critical limitations, inc...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,900 Views
8 Pages

10 October 2024

Background: Techniques for the preparation of grafts for Descemet membrane endothelial keratoplasty (DMEK) can be classified into those that involve the manual dissection of the Descemet membrane (DM) and those that use an injection of a liquid or a...

  • Article
  • Open Access
140 Citations
10,304 Views
18 Pages

HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration

  • Sunao Sugita,
  • Michiko Mandai,
  • Yasuhiko Hirami,
  • Seiji Takagi,
  • Tadao Maeda,
  • Masashi Fujihara,
  • Mitsuhiro Matsuzaki,
  • Midori Yamamoto,
  • Kyoko Iseki and
  • Masayo Takahashi
  • + 23 authors

13 July 2020

Immune attacks are key issues for cell transplantation. To assess the safety and the immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an iPS ban...

  • Abstract
  • Open Access
1,660 Views
2 Pages

Detection of Stephanofilaria (Nematoda: Filariidae) in Buffalo Fly Lesions

  • Muhammad Noman Naseem,
  • Ala Tabor,
  • Ali Raza,
  • Constantin Constantinoiu,
  • Jess Morgan and
  • Peter James

Haematobia irritans exigua, commonly known as buffalo fly (BF), causes economic losses of about AUD $100 million per annum to the Australian cattle industry in terms of decreased production and costs of control. Lesions associated with BF infestatio...

  • Article
  • Open Access
688 Views
17 Pages

Comparative Evaluation of Temperature, Bottle Type, and Amphotericin B on Fungal Detection in Corneal Preservation Media Using the BACT/ALERT System®

  • Aleix Fernández,
  • Margarita Blanco,
  • Cristina Garcia,
  • Mariama Jallow,
  • Sara Monge,
  • Mar López,
  • Marina Hortolà,
  • Elba Agustí,
  • Anna Vilarrodona and
  • Gloria Soria

Fungal contamination of donor corneas, although rare, constitutes a serious infection risk to recipients. Therefore, microbiological quality control with methods optimized for fungal detection is crucial in eye banks to detect and discard contaminate...

  • Article
  • Open Access
52 Citations
4,762 Views
23 Pages

9 October 2020

The categorization of sleep stages helps to diagnose different sleep-related ailments. In this paper, an entropy-based information–theoretic approach is introduced for the automated categorization of sleep stages using multi-channel electroence...

  • Article
  • Open Access
2 Citations
2,299 Views
20 Pages

Suppressing Pro-Apoptotic Proteins by siRNA in Corneal Endothelial Cells Protects against Cell Death

  • Susanne Staehlke,
  • Siddharth Mahajan,
  • Daniel Thieme,
  • Peter Trosan and
  • Thomas A. Fuchsluger

Corneal endothelial cells (CE) are critical for the cornea’s transparency. For severe corneal damage, corneal tissue transplantation is the most promising option for restoring vision. However, CE apoptotic cell death occurs during the storage o...

  • Article
  • Open Access
3 Citations
2,231 Views
12 Pages

Scuticociliates are recognized as the causative agents of mass mortalities in certain cultured marine fishes, resulting in enormous economic losses. This study aimed to investigate a fatal infection caused by scuticociliates in farmed large yellow cr...

  • Article
  • Open Access
2,002 Views
13 Pages

Expression of Hormones’ Receptors in Human Corneal Endothelium from Fuchs’ Dystrophy: A Possible Gender’ Association

  • Maria De Piano,
  • Irene Abicca,
  • Valentin Dinu,
  • Anna Maria Roszkowska,
  • Alessandra Micera and
  • Domenico Schiano-Lomoriello

27 June 2024

Background: Age and sex are the most significant risk of factors for advanced Fuchs dystrophy. Nevertheless, few data are available on the hormone’s receptor pattern expressed in adult and advanced fuchs endothelial corneal dystrophy (FECD). We...

  • Review
  • Open Access
62 Citations
6,791 Views
22 Pages

Green Composites Based on Animal Fiber and Their Applications for a Sustainable Future

  • Guravtar Singh Mann,
  • Naved Azum,
  • Anish Khan,
  • Malik Abdul Rub,
  • Md Imtaiyaz Hassan,
  • Kisa Fatima and
  • Abdullah M. Asiri

24 January 2023

Global climate change is already affecting the environment, as glaciers are receding, ice on rivers and lakes is melting, plant and animal range`s have altering, and trees are blooming early. Therefore, focus has shifted towards sustainable materials...

  • Article
  • Open Access
55 Citations
6,111 Views
31 Pages

Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach

  • Luciane B. Silva,
  • Elenilze F. B. Ferreira,
  • Maryam,
  • José M. Espejo-Román,
  • Glauber V. Costa,
  • Josiane V. Cruz,
  • Njogu M. Kimani,
  • Josivan S. Costa,
  • José A. H. M. Bittencourt and
  • Cleydson B. R. Santos
  • + 2 authors

19 January 2023

Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the hAChE B si...

  • Review
  • Open Access
6 Citations
2,010 Views
23 Pages

4 April 2025

Human space exploration presents an unparalleled opportunity to study life in extreme environments—but it also exposes astronauts to physiological stressors that jeopardize key systems like vision. Corneal health, essential for maintaining prec...

  • Article
  • Open Access
48 Citations
7,810 Views
20 Pages

A sleep disorder is a medical condition that affects an individual’s regular sleeping pattern and routine, hence negatively affecting the individual’s health. The traditional procedures of identifying sleep disorders by clinicians involve questionnai...

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