We have developed a closed-loop, high-throughput system that applies electrical stimulation and optical recording to facilitate the rapid characterization of extracellular, stimulus-evoked neuronal activity. In our system, a microelectrode array deli...
In mice, zygotic genome activation (ZGA) occurs in two steps: minor ZGA at the one–cell stage and major ZGA at the two–cell stage. Regarding the regulation of gene transcription, minor ZGA is known to have unique features, including a tra...
Dihydroorotase (DHOase) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate to dihydroorotate, a key step in de novo pyrimidine biosynthesis. A flexible active site loop in DHOase undergoes conformational switching between loop-in and loo...
Active Distribution Networks are Multi-Input Multi-Output (MIMO) systems with coupled dynamics, which cause interactions among the control loops of Distributed Energy Resources (DERs). This undesired effect leads to performance degradation of voltage...
To investigate the security issues of loop-closing operations in medium–low-voltage distribution networks under the influence of stochastic fluctuations from distributed generators (DGs) and loads, probabilistic power flow is introduced for ana...
Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. The hydrogen bonding network in their active site plays an important conformational role and supports the ph...
Hydrogen can be induced in various ways into reduced-activation ferritic/martensitic (RAFM) steels when they are used as structural materials for advanced nuclear systems. However, because of the fast diffusion of hydrogen in metals, the effect of hy...
There has been a considerable importance for the islanding detection due to the growing integration of distributed generations (DGs) in the modern power grids. This paper proposes a novel active islanding detection scheme for synchronous DGs, conside...
This paper describes active battery balancing based on a bidirectional buck converter, a flyback converter, and battery cells by using the proposed chain-loop comparison strategy. The role of the bidirectional buck converter is to charge/discharge th...
In this study, a noncontact fabric loop sensor based on magnetic-field-induced conductivity, which can simultaneously detect cardiac activity and respiration signals, was developed and the effects of the sensor’s shape and measurement position...
Allantoinase (ALLase; EC 3.5.2.5) possesses a binuclear metal center in which two metal ions are bridged by a posttranslationally carbamylated lysine. ALLase acts as a key enzyme for the biogenesis and degradation of ureides by catalyzing the convers...
The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves int...
In the permanent magnet direct-drive wind power grid-connected system, in order to solve the coupling problem between
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol. It is believed that the permea...
This paper presents a shunt active power filter connected to the grid via an LCL coupling circuit with implemented closed-loop control. The proposed control system allows selective harmonic currents compensation up to the 50th harmonic with the utili...
The application of a distribution static synchronous compensator (D-STATCOM) is the best technical means to solve the problem of reactive power compensation and harmonics. The D-STATCOM system has the characteristics of variable parameters, strong co...
Distributed Energies Resources (DERs) can be controlled for supporting the voltage regulation at nodes of an Active Distribution Network (ADN) where they are connected. However, since the ADN is a Multi-Input Multi-Output (MIMO) system with coupled d...
Voltage constraints usually place restrictions on how distributed generation (DG) can be connected to weak distribution networks. As DG capacity increases, active voltage control techniques are needed. Active approaches can greatly lower connection c...
To address the prevalent issues of oscillation and overshoot in high-voltage circuit breaker motor direct-drive mechanisms under classical PI control, this paper proposes an optimized PI speed loop with active damping characteristics. By first establ...
This paper offers a comprehensive methodology for the synthesis and analysis of active filters, including low-pass, high-pass, and band-pass configurations, utilizing operational amplifiers and multi-loop negative feedback systems. The approach invol...
The task of tracking cooperative satellites equipped with laser retroreflectors, by means of Satellite Laser Ranging (SLR), is an issue well described in the literature. The follow-up movement of the ground-based transceiver telescope behind an orbit...
Hardware-in-the-loop (HIL) simulation is an essential tool for rapid and cost-effective development and validation of power-electronic systems. The primary objective of this work is to validate and fine-tune a PLECS-based HIL model of a single dual a...
Wnt5a signaling has been implicated in the progression of cancer by regulating multiple cellular processes, largely migration and invasion, epithelial-mesenchymal transition (EMT), and metastasis. Since Wnt5a signaling has also been involved in infla...
We have recently demonstrated that mesoglycan, a fibrinolytic compound, may be a promising pro-healing drug for skin wound repair. We showed that mesoglycan induces migration, invasion, early differentiation, and translocation to the membrane of kera...
Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is dir...
Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) in both germline and sporadic neuroblastoma. Here, we have investigated the Y1278S mutation, observed in four patient cases, and its potentia...
For nearly three decades, R loops have been closely linked with class switch recombination (CSR), the process that generates antibody isotypes and that occurs via a complex cascade initiated by transcription-coupled mutagenesis in switch recombinatio...
This paper presents a perception-aware path planner for active SLAM in dynamic environments using micro-aerial vehicles (MAV). The “Next-Best-View” planner (NBVP planner) is combined with an active loop closing, which is called the Active...
This paper deals with the robust control method for permanent magnet synchronous motor (PMSM) speed-regulation system based on active disturbance compensation. Different from the classical PMSM disturbance compensation scheme, a novel disturbance fee...
The conformational state of the activation loop (A-loop) is pivotal for the activity of most protein kinases. Hence, the characterization of the conformational dynamics of the A-loop is important to increase our understanding of the molecular process...
Transcription–replication conflicts (TRCs) often occur in cells and cause DNA replication fork stalling. In this study, we investigated the interplay of RNA polymerase (RNAP), DNA polymerase, and RNase H1 (RH1) during head-on TRC in vitro with...
R3C ligase ribozyme catalyzes the nucleophilic attack by a 3′-hydroxyl on a 5′-α-phosphorus of triphosphates to form a 3′-5′-phosphodiester bond. In the present study, although the truncation of R3C ribozyme was accompanied by a large reduction in li...
Human vitamin K epoxide reductase (hVKORC1) enzymatic activity requires an initial activation by a specific redox protein, a less studied step in the hVKORC1 vital cycle. Significant steric conditions must be met by enzymes, being that to adapt their...
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored....
The mechanism of transcription proceeds through the formation of R-loop structures containing a DNA–RNA heteroduplex and a single-stranded DNA segment that should be placed inside the elongation complex; therefore, these nucleic acid segments a...
To enhance the speed regulation accuracy and robustness of permanent magnet synchronous motor (PMSM) drives under complex operating conditions, this paper proposes a dual-loop active disturbance rejection control strategy optimized by an opposition-b...
Active power filters (APFs) are dynamic power electronic devices that suppress harmonics and reactive power. To simplify the detection and extraction of traditional APF harmonics and reactive current, this paper proposes a direct source current contr...
This paper presents a passivity-based control (PBC) approach integrated with filtering for a supercapacitor (SC) in a semi-active hybrid energy storage system. The PBC is designed as a current controller using the reference provided by the filter to...
A comparative analysis of crystal structure, Raman spectra, and dielectric hysteresis loops was carried out for organic ferroelectric crystals of 2-methylbenzimidazole (MBI) grown from ethanol (MBIet), acetone (MBIac), deuterated acetone (MBId-ac), o...
This paper proposed a 5.42~6.28 GHz type-II phase locked loop (PLL) for the sake of both loop filter switching capability and extensive programmability. An on-chip loop filter is used in conjunction with off-chip one to form a switching filter pair f...
This paper presents the development of a hardware-in-the-loop ground testbed featuring active gravity compensation via software-in-the-loop integration, specially designed to support research in autonomous robotic removal of space debris. The testbed...
In order to improve the dynamic response speed and the steady-state performance of the DC side bus voltage of the wind power grid-connected inverter, a mathematical model of a typical three-phase voltage type PWM (Pulse Width Modulation, PWM) grid-co...
A circular economy is defined as a socially responsible, policy-driven model of business or enterprise operations that contributes to more sustainable society for both current and future generations. Although the implementation of circularity princip...
The control of wastewater treatment plants (WWTPs) is an ecologically, economically, and socially important objective. In the case of plants using activated sludge (ASP) processes, their control presents a significant challenge due to the complexity...
This paper presents a design synthesis method for robust controllers of active vehicle suspensions (AVSs). Various control techniques have been applied to the design of AVSs for enhancing ride comfort and handling performance of ground vehicles. Howe...
A new controller based on a fractional-order synergetic controller (FOSC) is proposed for a three-level T-type inverter using a shunt active power filter (SAPF). The SAPF is designed to compensate for the reactive power and eliminate the current harm...
In this paper, a fractional-order extension of a negative position feedback (NPF) controller for active damping is proposed. The design of the controller is motivated by the frequency-domain loop shaping analysis, and the controller dynamics are defi...
Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-fold superfamily which act on a broad range of β-lactam antibiotics. A previous study on BLEG-1 (formerly called Bleg1_2437), a hypothetical protein from Bacillu...
Superheated steam temperature (SST) is a significant index for a coal-fired power plant. Its control is becoming more and more challenging for the reason that the control requirements are stricter and the load command changes extensively and frequent...
Methane activation chemistry, despite being widely reported in literature, remains to date a subject of debate. The challenges in this reaction are not limited to methane activation but extend to stabilization of the intermediate species. The low C-H...
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