We have developed a closed-loop, high-throughput system that applies electrical stimulation and optical recording to facilitate the rapid characterization of extracellular, stimulus-evoked neuronal activity. In our system, a microelectrode array deli...
In mice, zygotic genome activation (ZGA) occurs in two steps: minor ZGA at the one–cell stage and major ZGA at the two–cell stage. Regarding the regulation of gene transcription, minor ZGA is known to have unique features, including a tra...
Hypertension is increasingly recognized as involving chronic inflammation beyond its hemodynamic origins. This review proposes the Mechano-Immune-Vascular Activation Loop as an integrative conceptual framework—a positive feedback circuit in whi...
Dihydroorotase (DHOase) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate to dihydroorotate, a key step in de novo pyrimidine biosynthesis. A flexible active site loop in DHOase undergoes conformational switching between loop-in and loo...
Active Distribution Networks are Multi-Input Multi-Output (MIMO) systems with coupled dynamics, which cause interactions among the control loops of Distributed Energy Resources (DERs). This undesired effect leads to performance degradation of voltage...
To investigate the security issues of loop-closing operations in medium–low-voltage distribution networks under the influence of stochastic fluctuations from distributed generators (DGs) and loads, probabilistic power flow is introduced for ana...
Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. The hydrogen bonding network in their active site plays an important conformational role and supports the ph...
Hydrogen can be induced in various ways into reduced-activation ferritic/martensitic (RAFM) steels when they are used as structural materials for advanced nuclear systems. However, because of the fast diffusion of hydrogen in metals, the effect of hy...
There has been a considerable importance for the islanding detection due to the growing integration of distributed generations (DGs) in the modern power grids. This paper proposes a novel active islanding detection scheme for synchronous DGs, conside...
This paper describes active battery balancing based on a bidirectional buck converter, a flyback converter, and battery cells by using the proposed chain-loop comparison strategy. The role of the bidirectional buck converter is to charge/discharge th...
In this study, a noncontact fabric loop sensor based on magnetic-field-induced conductivity, which can simultaneously detect cardiac activity and respiration signals, was developed and the effects of the sensor’s shape and measurement position...
Allantoinase (ALLase; EC 3.5.2.5) possesses a binuclear metal center in which two metal ions are bridged by a posttranslationally carbamylated lysine. ALLase acts as a key enzyme for the biogenesis and degradation of ureides by catalyzing the convers...
Active magnetic bearings (AMBs) require accurate dynamic models for controller design and performance analysis, but their inherent open-loop instability makes modeling difficult under practical operating conditions. This study presents a closed-loop...
The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves int...
In the permanent magnet direct-drive wind power grid-connected system, in order to solve the coupling problem between
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol. It is believed that the permea...
This paper presents a shunt active power filter connected to the grid via an LCL coupling circuit with implemented closed-loop control. The proposed control system allows selective harmonic currents compensation up to the 50th harmonic with the utili...
Distributed Energies Resources (DERs) can be controlled for supporting the voltage regulation at nodes of an Active Distribution Network (ADN) where they are connected. However, since the ADN is a Multi-Input Multi-Output (MIMO) system with coupled d...
Voltage constraints usually place restrictions on how distributed generation (DG) can be connected to weak distribution networks. As DG capacity increases, active voltage control techniques are needed. Active approaches can greatly lower connection c...
The application of a distribution static synchronous compensator (D-STATCOM) is the best technical means to solve the problem of reactive power compensation and harmonics. The D-STATCOM system has the characteristics of variable parameters, strong co...
To address the prevalent issues of oscillation and overshoot in high-voltage circuit breaker motor direct-drive mechanisms under classical PI control, this paper proposes an optimized PI speed loop with active damping characteristics. By first establ...
This paper offers a comprehensive methodology for the synthesis and analysis of active filters, including low-pass, high-pass, and band-pass configurations, utilizing operational amplifiers and multi-loop negative feedback systems. The approach invol...
The task of tracking cooperative satellites equipped with laser retroreflectors, by means of Satellite Laser Ranging (SLR), is an issue well described in the literature. The follow-up movement of the ground-based transceiver telescope behind an orbit...
Nonlinear and asymmetrical loads in microgrids cause severe current distortion and phase unbalance, presenting critical challenges for grid-connected energy storage inverters. Conventional dq-frame Linear Active Disturbance Rejection Control (LADRC)...
Hardware-in-the-loop (HIL) simulation is an essential tool for rapid and cost-effective development and validation of power-electronic systems. The primary objective of this work is to validate and fine-tune a PLECS-based HIL model of a single dual a...
Embodied intelligence offers a system-level paradigm for improving the adaptability of robotic harvesting in complex horticultural environments by coupling perception, decision-making, and physical interaction. This review systematically analyzes rec...
Early diagnosis of Diabetic Retinopathy (DR) is critical for preventing irreversible vision loss, but precise lesion annotation by ophthalmologists is the dominant cost in building any clinical-grade DR detection model. The structural problem in real...
Wnt5a signaling has been implicated in the progression of cancer by regulating multiple cellular processes, largely migration and invasion, epithelial-mesenchymal transition (EMT), and metastasis. Since Wnt5a signaling has also been involved in infla...
We have recently demonstrated that mesoglycan, a fibrinolytic compound, may be a promising pro-healing drug for skin wound repair. We showed that mesoglycan induces migration, invasion, early differentiation, and translocation to the membrane of kera...
Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is dir...
Numerous mutations have been observed in the Anaplastic Lymphoma Kinase (ALK) receptor tyrosine kinase (RTK) in both germline and sporadic neuroblastoma. Here, we have investigated the Y1278S mutation, observed in four patient cases, and its potentia...
For nearly three decades, R loops have been closely linked with class switch recombination (CSR), the process that generates antibody isotypes and that occurs via a complex cascade initiated by transcription-coupled mutagenesis in switch recombinatio...
This paper presents a perception-aware path planner for active SLAM in dynamic environments using micro-aerial vehicles (MAV). The “Next-Best-View” planner (NBVP planner) is combined with an active loop closing, which is called the Active...
This paper deals with the robust control method for permanent magnet synchronous motor (PMSM) speed-regulation system based on active disturbance compensation. Different from the classical PMSM disturbance compensation scheme, a novel disturbance fee...
The conformational state of the activation loop (A-loop) is pivotal for the activity of most protein kinases. Hence, the characterization of the conformational dynamics of the A-loop is important to increase our understanding of the molecular process...
Transcription–replication conflicts (TRCs) often occur in cells and cause DNA replication fork stalling. In this study, we investigated the interplay of RNA polymerase (RNAP), DNA polymerase, and RNase H1 (RH1) during head-on TRC in vitro with...
R3C ligase ribozyme catalyzes the nucleophilic attack by a 3′-hydroxyl on a 5′-α-phosphorus of triphosphates to form a 3′-5′-phosphodiester bond. In the present study, although the truncation of R3C ribozyme was accompanied by a large reduction in li...
Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored....
Human vitamin K epoxide reductase (hVKORC1) enzymatic activity requires an initial activation by a specific redox protein, a less studied step in the hVKORC1 vital cycle. Significant steric conditions must be met by enzymes, being that to adapt their...
Terahertz metasurfaces capable of dynamic modulation face a fundamental trade-off: high-quality-factor resonances require structural symmetry, but active tuning typically relies on symmetry-breaking that inevitably introduces radiative losses. This s...
The mechanism of transcription proceeds through the formation of R-loop structures containing a DNA–RNA heteroduplex and a single-stranded DNA segment that should be placed inside the elongation complex; therefore, these nucleic acid segments a...
To enhance the speed regulation accuracy and robustness of permanent magnet synchronous motor (PMSM) drives under complex operating conditions, this paper proposes a dual-loop active disturbance rejection control strategy optimized by an opposition-b...
Active power filters (APFs) are dynamic power electronic devices that suppress harmonics and reactive power. To simplify the detection and extraction of traditional APF harmonics and reactive current, this paper proposes a direct source current contr...
This paper presents a passivity-based control (PBC) approach integrated with filtering for a supercapacitor (SC) in a semi-active hybrid energy storage system. The PBC is designed as a current controller using the reference provided by the filter to...
This paper addresses the vibration response produced at the supporting foundation by multiple low-frequency tonal components transmitted through magnetic bearing supports. A composite active magnetic bearing (AMB) control method is proposed in which...
The integration of catalytic methane decomposition (CMD) with CO2 gasification (Reverse Boudouard Reaction) offers a promising chemical looping route for carbon-negative hydrogen and syngas production. This work systematically investigates the gasifi...
A comparative analysis of crystal structure, Raman spectra, and dielectric hysteresis loops was carried out for organic ferroelectric crystals of 2-methylbenzimidazole (MBI) grown from ethanol (MBIet), acetone (MBIac), deuterated acetone (MBId-ac), o...
This paper proposed a 5.42~6.28 GHz type-II phase locked loop (PLL) for the sake of both loop filter switching capability and extensive programmability. An on-chip loop filter is used in conjunction with off-chip one to form a switching filter pair f...
This paper presents the development of a hardware-in-the-loop ground testbed featuring active gravity compensation via software-in-the-loop integration, specially designed to support research in autonomous robotic removal of space debris. The testbed...
Sub-synchronous oscillation problems may be induced when direct-drive wind turbines are connected to a weak AC power grid, and then it is necessary to analyze the mechanism of sub-synchronous oscillation and study effective suppression methods. In th...
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