Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding c...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells without toxicity to normal cells. TRAIL binds to death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) expressed on cancer cell surface and activates apopt...
27 August 2020
Background: The current study sought to understand whether trail users reported better wellness and health status compared to the non-users, and to recognize the associated factors. Methods: Eight trails from different locations and settings within I...
Melanoma of the skin has become a prime example for demonstrating the success of targeted cancer therapy. Nevertheless, high mortality has remained, mainly related to tumor heterogeneity and inducible therapy resistance. But the development of new th...
The death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has long been recognized for its potential as a cancer therapeutic due to its low toxicity against normal cells. However...
Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surg...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that selectively induces apoptosis in tumor cells without harming normal cells, making it an attractive agent for cancer therapy. TRAIL induces a...
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows a promising therapeutic potential in cancer treatment as it exclusively causes apoptosis in a broad spectrum of cancer cells through triggering the extrinsic apoptosis pa...
National Trail is an integral component of the system of natural reserves. China’s study on the creation of National Trail is scattered and lacks theory and policy at present. Here, the theoretical framework, technical procedure, and constructi...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF protein superfamily, represents a multifaceted cytokine with unique biological features including both proapoptotic and pro-survival effects in different cell...
The LiDAR sensor embedded in recent iPhone Pro devices offers new opportunities for rapid, low-cost, and spatially detailed assessment of outdoor recreational infrastructure. Framed within mobile sensing and IoT-based environmental monitoring, this p...
Despite advances in clinical management, osteosarcoma and Ewing sarcoma, the two most frequent malignant primary bone tumors at pediatric age, still have a poor prognosis for high-risk patients (i.e., relapsed or metastatic disease). Triggering a TRA...
19 August 2021
Physical activity (PA), associated with all-cause mortality, morbidity, and healthcare costs, improves vitamin D absorption, immune response, and stress when completed outdoors. Rural communities, which experience PA inequities, rely on trails to mee...
The TNF-superfamily member TRAIL is known to mediate selective apoptosis in tumor cells suggesting this protein as a potential antitumor drug target. However, initial successful pr-clinical results could not be translated into the clinic. Reasons for...
Landslide trails are important elements of landslide inventory maps, providing valuable information for landslide risk and hazard assessment. Compared with traditional manual mapping, skeletonization methods offer a more cost-efficient way to map lan...
Triple-negative breast cancer (TNBC) is an aggressive disease with poor prognosis and limited therapeutic options. Recent advances in the immunotherapy field have enabled the development of new treatment strategies, among which the use of bispecific...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand (Apo2L), is a member of the TNF cytokine superfamily. TRAIL has been widely studied as a novel strategy for tumor elimination, as cancer cells overexpre...
This study examines the planning challenges and opportunities in conserving national trails, focusing on the Israel National Trail. National trails offer crucial benefits, including health promotion, social connectivity, cultural education, ecologica...
The geological aspects of tourism are much more extensive than just places to be viewed and/or experienced. The terrain traveled is also a geological phenomenon and an attraction in itself. For a hiker or a rider the type of trail is important. Featu...
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand- receptor (TRAIL-R) family has emerged as a key mediator of cell fate and survival. Ligation of TRAIL ligand to TRAIL-R1 or TRAIL-R2 initiates the extrinsic apoptotic pathway character...
Rapidly developing resistance against different therapeutics is a major stumbling block in the standardization of therapy. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated signaling has emerged as one of the most highly...
Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL)-based therapeutics potently induce apoptosis in can...
Trail running (TR) is performed in a natural environment, including various ranges of slopes where maximal oxygen consumption is a major contributor to performance. The aim of this study is to investigate the validity of tests performed in uphill con...
Rail-trail corridors in the agricultural Midwest exhibit layered ecological conditions influenced by the material legacy of railroad infrastructure and contemporary land use pressures. This study uses a mixed-methods approach integrating GIS analysis...
A treetop trail is an elevated linear green open space that plays a key role in forming a scientifically rational urban space and meeting the growing leisure needs of the people. Taking the Mountains-to-Sea Trail in Xiamen, China as a case, and throu...
Accurate information on trail difficulty is essential for ensuring safety and enhancing the effectiveness of forest-based health and recreational activities. This study examined the physiological responses of middle-aged adults to varying trail diffi...
Conservationists are calling for bold strategies to connect wildlands and halt extinctions. A growing number of scientists recommend that 50% of all land must be held in a protected area network to maintain biodiversity. We assessed lands adjacent to...
Isoflavones are a class of bioactive polyphenols with cancer chemopreventive properties. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a naturally occurring antitumor agent that selectively induces programmed death (apoptosis) in...
Creating simplified visualizations of large 3D trail sets with limited occlusion and preservation of the main structures in the data is challenging. We address this challenge for the specific context of 3D fiber trails created by DTI tractography. Fo...
Ants deposit trail pheromones that guide nestmates to food sources. We tested the hypotheses that ant community members (Western carpenter ants, Camponotus modoc; black garden ants, Lasius niger; European fire ants, Myrmica rubra) (1) sense, and foll...
This paper presents a vision sensor-based solution to the challenging problem of detecting and following trails in highly unstructured natural environments like forests, rural areas and mountains, using a combination of a deep neural network and dyna...
Urban trails, as vital urban spaces that integrate historical context with contemporary life, play a central role in the rise of deep tourism and the “City Walk” phenomenon. Their spatial legibility positions them as distinctive narrative...
8 December 2021
Background: The extent to which mountain biking impacts upon the environment is largely determined by rider behaviours. The purpose of this study was to gain a better understanding of how mountain bikers interact with the natural environment and expl...
Cancer is a therapeutically challenging and genomically complicated disease. Pioneering studies have uncovered multifaceted aspects of cancer, ranging from intra- and inter-tumor heterogeneity, drug resistance, and genetic/epigenetic mutations. Loss...
Modern humans, and other hominins before them, have walked across the landscapes of most continents for many millennia. They shared these landscapes with other large animals, especially mammalian herbivores and their predators, whose footsteps define...
The island-nation of Dominica, 790 km2 in area, is located approximately 1126.5 km Southeast of Florida, USA. In the mid-1990s, Dominica embarked on developing the 183.5 km Waitukubuli National Trail (WNT), the first and only national trail model in...
Colorectal cancer (CRC) remains a major clinical challenge due to resistance to conventional cell death-inducing therapies. TRAIL selectively induces apoptosis in cancer cells via death receptors, but its effectiveness in preclinical models is limite...
Numerous biologic approaches are being investigated as anti-cancer therapies in an attempt to induce tumor regression while circumventing the toxic side effects associated with standard chemo- or radiotherapies. Among these, tumor necrosis factor–rel...
Greenways provide multiple benefits for trail users’ individual experiences based on users’ background environment and their perceptions of characteristics such as the trail width, vegetation, water, and facilities. Although greenway trai...
Audit logs are a critical component in today’s enterprise business systems as they provide several benefits such as records transparency and integrity and security of sensitive information by creating a layer of evidential support. However, cur...
TRAIL, a member of TNF superfamily, is a potent inducer of neuronal death. Neurotoxic effects of TRAIL appear mediated by its death receptor TRAIL-R2/DR5. To assess the role of TRAIL/TRAIL-R2 pathway in AD-related neurodegeneration, we studied the im...
Death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) and their corresponding death receptors (e.g., DR5) not only initiate apoptosis through activation of the extrinsic apoptotic pathway but also exert non-ap...
TNF-related apoptosis-inducing ligand (TRAIL) was originally discovered, almost 20 years ago, for its ability to kill cancer cells. More recent evidence has described pleiotropic functions, particularly in the cardiovascular system. There is potentia...
Walking tourism is increasingly supported by a wide range of digital technologies that are crucial for mitigating environmental impacts and promoting sustainable territorial development, yet their adoption remains fragmented and rarely interpreted wi...
Despite intensive scientific efforts, the therapy of peritonitis is presently limited to symptomatic measures, including infectious source control and broad-spectrum antibiotics. Promising therapeutic approaches to reduce morbidity and mortality are...
Unique observation of a long-lasting meteor trail of about half an hour duration is described. The trail resulted from a burning meteor from the Leonid storm flux in the middle latitudes over eastern Siberia. We describe three-dimensional morphologic...
Leisure time and its quality use is becoming increasingly important in society. We can spend it primarily on physical activity, which offer many options, as it provides an entertainment and has a complex effect on our physical and mental health. Walk...
Poor air quality represents a significant health risk for individuals engaging in recreation activities outdoors in urban parks and trails. This study investigated temporal variability in particulate matter (PM) exposure along an urban waterfront tra...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a pro-apoptotic protein showing broad biological functions. Data from animal studies indicate that TRAIL may possibly contribute to the pathophysiology of cardiomyopathy, atherosclero...
Cancer resistance to treatments is a challenge that researchers constantly seek to overcome. For instance, TNF-related apoptosis-inducing ligand (TRAIL) is a potential good prospect as an anti-cancer therapy, as it attacks tumor cells but not normal...
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