59 Results Found

The problem of bamboo’s strength depends on the length used. From past experiments, it was found that the physical properties of bamboo have thickness at the bottom and a tapered end, resulting in the strength of the bamboo in each part being d...

High dam discharge can lead to total dissolved gas (TDG) supersaturation in the downstream river, and fish in the TDG-supersaturated flow can suffer from bubble disease and even die. Consequently, it is of great value to study the transport and dissi...

Total dissolved gas (TDG) supersaturation, which can be caused by flood discharge, results in gas bubble disease (GBD) in fish and threatens their survival downstream of dams. TDG supersaturation has become a serious environmental problem in the Yang...

A simple and reliable ultra-high-performance liquid chromatographic (UHPLC) method was developed and validated for determination of tetrahydrocurcumin diglutaric acid (TDG) and applied for evaluation of its bioaccessibility. The analytical method was...

Total dissolved gas (TDG) is suggested to be one possible explanation for the extensive mortality of endemic fish suffered from gas bubble disease (GBD). We investigated the effects of water depth on adult Schitzothorax prenanti susceptibility to GBD...

Porcine circovirus type 2 (PCV2) is one of the major threats to pig farms worldwide. Although PCV2 has been identified to promote IL-10 production, the detailed regulatory roles of PCV2 Rep for IL-10 production remain unclear. Herein, we first found...

Stepwise oxidation of the epigenetic mark 5-methylcytosine and base excision repair (BER) of the resulting 5-formylcytosine (5-fC) and 5-carboxycytosine (5-caC) may provide a mechanism for reactivation of epigenetically silenced genes; however, the f...

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which ca...

Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are cu...

Objective: The aim of this study was to analyze the effects of different particle sizes of Tetrastigma hemsleyanum Diels et Gilg (TDG) powders on physical properties, dissolution, in vitro antioxidant activity, and in vivo hepatoprotective properties...

In circumstances where total dissolved gas (TDG) levels are variable, the peak TDG and duration are expected to be the dominant drivers of fish survival. Focusing on the peak TDG and duration in natural rivers, a laboratory experiment and field exper...

To assess the effect of TDG on the survival of different sizes of pelagic fish, bighead carp (Hypophthalmichthys nobilis) were subjected to TDG supersaturated water at levels of 125, 130, 135, and 140%. The results showed that apparent abnormal behav...

When water is spilled over dams, atmospheric gases can become entrained, resulting in supersaturated water. Total dissolved gas (TDG) > 110% saturation can cause gas bubble trauma (GBT) in fish. The negative effects of GBT include increased buoyan...

Collisional debris around interacting and post-interacting galaxies often display condensations of gas and young stars that can potentially form gravitationally bound objects: Tidal Dwarf Galaxies (TDGs). We summarise recent results on TDGs, which ar...

Two endemic fish in the upper Yangtze River, the Rock Carp (Procypris rabaudi) and Prenant’s Schizothoracin (Schizothorax prenanti), were used as research objects in this study to assess the effects of total dissolved gas (TDG) supersaturation...

The recent construction and operation of high dams have greatly changed the natural flood process. To meet the ecological demands and flood control requirements of rivers, dams discharge flow through the flood discharge facility, always accompanied b...

DNA methylation is an essential covalent modification that is required for growth and development. Once considered to be a relatively stable epigenetic mark, many studies have established that DNA methylation is dynamic. The 5-methylcytosine (5-mC) m...

Previously, galectin-1 (GAL1) was found to be up-regulated in obesity-prone subjects, suggesting that use of a GAL1 inhibitor could be a novel therapeutic approach for treatment of obesity. We evaluated thiodigalactoside (TDG) as a potent inhibitor o...

Detailed investigation of ligand–protein interactions is essential for better understanding of biological processes at the molecular level. Among these binding interactions, the recognition of glycans by lectins is of particular importance in s...

In children, motor competence (MC) and the amount of physical activity are tightly interconnected. In adults with Down syndrome (DS), MC has been poorly addressed, resulting in a limited understanding of the possibility to improve MC over time. Here,...

Human Galectin-3 (hGal-3) is a protein that selectively binds to β-galactosides and holds diverse roles in both normal and pathological circumstances. Therefore, targeting hGal-3 has become a vibrant area of research in the pharmaceutical chemis...

As sensor nodes communicate via wireless channels, information security is essential for wireless sensor networks. Efficient protection mechanisms to ensure data security among nodes are critical. This study developed the bi-directed grouping (top-do...

Solving the Euler equations often requires expensive computations of complex, high-order time derivatives. Although Taylor Discontinuous Galerkin (TDG) schemes are renowned for their accuracy and stability, directly evaluating third-order tensor deri...

Thymine DNA Glycosylase (TDG) is an enzyme of the base excision repair mechanism and removes damaged or mispaired bases from DNA via hydrolysis of the glycosidic bond. Specificity is of high importance for such a glycosylase, so as to avoid the damag...

With the increasing growth of IoT applications in various sectors (e.g., manufacturing, healthcare, etc.), we are witnessing a rising demand of IoT middleware platform that host such IoT applications. Hence, there arises a need for new methods to ass...

Sustainable transformations towards the production of valuable chemicals constantly attract interest, both in terms of academic and applied research. C–H activation has long been scrutinized in this regard, given that it offers a straightforward path...

The transportation of dangerous goods (TDG) is a critical component of economic systems, especially in regions such as the Western Balkans (WB), where infrastructure and regulatory frameworks face significant challenges. This study assesses the curre...

Senna tora is one of the homologous crops used as a medicinal food containing an abundance of anthraquinones. Type III polyketide synthases (PKSs) are key enzymes that catalyze polyketide formation; in particular, the chalcone synthase-like (CHS-L) g...

Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing the effectiveness of therapeutic and diagnostic approaches in cancer treatment. Our study presents a promising strategy for apply...

The Normalized Difference Vegetation Index (NDVI) is a crucial remote-sensing metric for assessing land surface vegetation greenness, essential for various studies encompassing phenology, ecology, hydrology, etc. However, effective applications of ND...

The rapid expansion of the salmon industry has generated increasing amounts of waste sludge with negative environmental impacts. Sustainable alternatives, such as using stabilized sludge in agriculture, are needed to mitigate these effects. At the sa...

The neurosteroid allopregnanolone (AL) has many beneficial functions in the brain. This study tested the hypothesis that AL administered for three days into the third brain ventricle would affect the enzymatic activity of the DNA base excision repair...

Biodegradable poly(butylene succinate) (PBS)-based random copolymers containing thioether linkages (P(BSxTDGSy)) of various compositions have been investigated and characterized from the gas barrier, thermal, and mechanical point of view, after food...

This paper proposes an optimization procedure to achieve the best configuration of multiple degrees of freedom Tuned Mass Dampers (TMDs) to mitigate the pointing error of Very-Long-Baseline Interferometry (VLBI) Earth-based radio antennae operating u...

Hazelnut (Corylus avellana L.) is of great agroeconomic importance, prized for its nutritional value and antioxidant properties. Its yield and quality may differ due to factors such as season (S), locality (L) and cultivar (C). Our objective was to d...

Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the p...

Digital gradient sensing (DGS) is a non-contact and full-field optical measurement technique, which assesses mechanical behaviors of transparent materials or specular structures by measuring angular deflections of light rays. However, owing to the po...

This paper proposes a design procedure to determine the optimal configuration of multi-degrees of freedom (MDOF) multiple tuned mass dampers (MTMD) to mitigate the global dynamic aeroelastic response of aerospace structures. The computation of the ae...

In low- and middle-income countries (LMICs), where healthcare resources may be limited, the elderly are especially vulnerable to the adverse effects of cardiovascular diseases (CVDs). The aging population in these regions presents unique challenges,...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. While its etiology remains unclear, both genetic and environmental factors, including oxidative stress, have...

This study investigated the influence of long-chain n-3 polyunsaturated fatty acids (PUFAs) on the activity of antioxidant defence systems and DNA repair enzymes in the liver of newborn piglets born to gilts that were supplemented with fish oil or al...

In the search for alternatives to reduce the consumption of electric energy, the possibility of using natural light for lighting through TDD (tubular daylight devices) or TDGS (tubular daylight guidance systems) appears. These natural luminaires are...

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin deficiency and loss of pancreatic islet β-cells. The objective of this study is to identify de novo mutations in 13 trios from singleton families that contr...

For assessment of the insulation performance of high-voltage (HV) equipment installed in extra-high-voltage (EHV) systems, switching impulse voltage tests are performed in an HV testing laboratory. The waveform parameters of the switching impulse vol...

Considering the rising prevalence of smartphone usage among adolescents with intellectual disabilities and their frequent motor challenges, understanding its impact on their physical well-being is important. This study aims to investigate the impact...

In this study, cobalt neurotoxicity was investigated in human astrocytoma and neuroblastoma (SH-SY5Y) cells using proliferation assays coupled with LC–MS-based metabolomics and transcriptomics techniques. Cells were treated with a range of coba...

KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS mutations confer the constitutive activation of this oncogene, stimulating...

TET2 is a dioxygenase dependent on Fe2+ and α-ketoglutarate which oxidizes 5-methylcytosine (5meC) to 5-hydroxymethylcytosine (5hmeC). TET proteins successively oxidize 5mC to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carbox...

Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a plethora of pathological conditions including cardiovascular, neurological, immunological, gastrointestinal and renal diseases, as well as in cancer, diabetes a...

Base excision repair (BER) is an important mechanism for maintaining genomic integrity and preventing DNA damage and mutations induced by oxidative stress. This study aimed to examine the relationship between oxidative stress and BER activity in newb...