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26 Results Found

  • Article
  • Open Access
15 Citations
6,038 Views
14 Pages

19 April 2021

In this paper, we use an SIRD model to analyze the evolution of the COVID-19 pandemic in Spain, caused by a new virus called SARS-CoV-2 from the coronavirus family. This model is governed by a nonlinear system of differential equations that allows us...

  • Article
  • Open Access
23 Citations
3,564 Views
11 Pages

Stability Analysis and Existence of Solutions for a Modified SIRD Model of COVID-19 with Fractional Derivatives

  • Bilal Basti,
  • Nacereddine Hammami,
  • Imadeddine Berrabah,
  • Farid Nouioua and ,
  • Rabah Djemiat and
  • Noureddine Benhamidouche
  • + 1 author+ 0 author

4 August 2021

This paper discusses and provides some analytical studies for a modified fractional-order SIRD mathematical model of the COVID-19 epidemic in the sense of the Caputo–Katugampola fractional derivative that allows treating of the biological models of i...

(This article belongs to the Special Issue New Trends in Fractional Calculus and Applications in Engineering and Infectious Diseases)
  • Article
  • Open Access
20 Citations
4,457 Views
20 Pages

Modeling Provincial Covid-19 Epidemic Data Using an Adjusted Time-Dependent SIRD Model

  • Luisa Ferrari,
  • Giuseppe Gerardi,
  • Giancarlo Manzi,
  • Alessandra Micheletti and ,
  • Federica Nicolussi,
  • Elia Biganzoli and
  • Silvia Salini
  • + 2 authors+ 0 author

In this paper, we develop a forecasting model for the spread of COVID-19 infection at a provincial (i.e., EU NUTS-3) level in Italy by using official data from the Italian Ministry of Health integrated with data extracted from daily official press co...

(This article belongs to the Collection COVID-19 Research)
  • Article
  • Open Access
12 Citations
7,038 Views
15 Pages

16 October 2021

In this study, we developed a compartmental SIRD model to analyze and forecast the transmission dynamics of the COVID-19 pandemic in Bangladesh during the third wave caused by the Indian delta variant. With the help of the nonlinear system of differe...

(This article belongs to the Topic Burden of COVID-19 in Different Countries)
  • Article
  • Open Access
1 Citations
3,708 Views
13 Pages

20 April 2021

We selected the COVID-19 outbreak in the state of Oregon, USA as a system for developing a general geographically nuanced epidemiological forecasting model that balances simplicity, realism, and accessibility. Using the life history simulator HexSim,...

(This article belongs to the Section Landscape Ecology)
  • Article
  • Open Access
1 Citations
2,317 Views
24 Pages

Non-Parametric Model-Based Estimation of the Effective Reproduction Number for SARS-CoV-2

  • Jacques Hermes,
  • Marcus Rosenblatt,
  • Christian Tönsing and
  • Jens Timmer

22 November 2023

Describing viral outbreaks, such as the COVID-19 pandemic, often involves employing compartmental models composed of ordinary differential equation (ODE) systems. Estimating the parameter values for these ODE models is crucial and relies on accessibl...

  • Article
  • Open Access
13 Citations
3,624 Views
14 Pages

A Time-Delayed Deterministic Model for the Spread of COVID-19 with Calibration on a Real Dataset

  • Giovanni Nastasi,
  • Carla Perrone,
  • Salvatore Taffara and
  • Giorgia Vitanza

20 February 2022

During the evolution of the COVID-19 pandemic, each country has adopted different control measures to contrast the epidemic’s diffusion. Restrictions to mobility, public transport, and social life in general have been actuated to contain the sp...

  • Article
  • Open Access
4 Citations
2,149 Views
15 Pages

In this work, we investigate the extended numerical discretization technique for the solution of fractional Bernoulli equations and SIRD epidemic models under the Caputo fractional, which is accurate and versatile. We have demonstrated the method&rsq...

(This article belongs to the Special Issue Advanced Numerical Methods for Fractional Functional Models)
  • Article
  • Open Access
  • Best Paper Award
12 Citations
7,489 Views
45 Pages

22 March 2024

The susceptible–infected–recovered–vaccinated–deceased (SIRVD) epidemic compartment model extends the SIR model to include the effects of vaccination campaigns and time-dependent fatality rates on epidemic outbreaks. It encomp...

(This article belongs to the Special Issue Advances in Dynamical Systems, Differential Equations, and Their Applications)
  • Article
  • Open Access
11 Citations
3,389 Views
17 Pages

This study utilizes modeling and simulation to analyze coronavirus (COVID-19) infection trends depending on government policies. Two modeling requirements are considered for infection simulation: (1) the implementation of social distancing policies a...

  • Article
  • Open Access
32 Citations
9,306 Views
25 Pages

Towards Providing Effective Data-Driven Responses to Predict the Covid-19 in São Paulo and Brazil

  • Fabio Amaral,
  • Wallace Casaca,
  • Cassio M. Oishi and
  • José A. Cuminato

13 January 2021

São Paulo is the most populous state in Brazil, home to around 22% of the country’s population. The total number of Covid-19-infected people in São Paulo has reached more than 1 million, while its total death toll stands at 25% of...

(This article belongs to the Section Intelligent Sensors)
  • Article
  • Open Access
21 Citations
2,646 Views
21 Pages

On Fuzzy and Crisp Solutions of a Novel Fractional Pandemic Model

  • Kalpana Umapathy,
  • Balaganesan Palanivelu,
  • Víctor Leiva,
  • Prasantha Bharathi Dhandapani and
  • Cecilia Castro

Understanding disease dynamics is crucial for accurately predicting and effectively managing epidemic outbreaks. Mathematical modeling serves as an essential tool in such understanding. This study introduces an advanced susceptible, infected, recover...

(This article belongs to the Special Issue Fractal and Fractional Statistics for Artificial Intelligence, Data Science, and Quantum Computing)
  • Article
  • Open Access
456 Views
11 Pages

Retrospective Analysis of an SIR Model Approach to Evaluate Vaccination Strategies in Early Pandemic Prevention

  • Alessandra Cartocci,
  • Davide Amodeo,
  • Valentina Lucarelli,
  • Gabriele Messina and ,
  • Gabriele Cevenini and
  • Paolo Barbini
  • + 1 author+ 0 author

9 May 2026

During the 2020–2021 period, increasingly complex models have been developed to understand the impact of containment measures, to predict pandemic trends, and then to optimally allocate the few vaccines available. The objective of this study is...

(This article belongs to the Special Issue Data Statistics for Epidemiological Research—2nd Edition)
  • Article
  • Open Access
4 Citations
4,155 Views
15 Pages

Accurate forecasting of the coronavirus disease 2019 (COVID-19) spread is indispensable for effective public health planning and the allocation of healthcare resources at all levels of governance, both nationally and globally. Conventional prediction...

  • Article
  • Open Access
1 Citations
1,499 Views
15 Pages

Appraisal of Clinical Explanatory Variables in Subtyping of Type 2 Diabetes Using Machine Learning Models

  • Amar H. Khamis,
  • Fatima Abdul,
  • Stafny Dsouza,
  • Fatima Sulaiman and ,
  • Costerwell Khyreim,
  • Mohammed E. Siddig and
  • Riad Bayoumi
  • + 2 authors+ 0 author

17 September 2025

Background: Clustering type 2 diabetes (T2D) remains a challenge due to its clinical heterogeneity and multifactorial nature. We aimed to evaluate the validity and robustness of the clinical variables in defining T2D subtypes using a discovery-to-pre...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
110 Citations
10,306 Views
12 Pages

Factors Associated with Risk of Diabetic Complications in Novel Cluster-Based Diabetes Subgroups: A Japanese Retrospective Cohort Study

  • Hayato Tanabe,
  • Haruka Saito,
  • Akihiro Kudo,
  • Noritaka Machii and ,
  • Hiroyuki Hirai,
  • Gulinu Maimaituxun,
  • Kenichi Tanaka,
  • Hiroaki Masuzaki,
  • Tsuyoshi Watanabe and
  • Michio Shimabukuro
  • + 7 authors+ 2 authors

Diabetes is a complex and heterogeneous disease, making the prediction of the risks of diabetic complications challenging. Novel adult-onset diabetes subgroups have been studied using cluster analysis, but its application in East Asians remains uncle...

(This article belongs to the Special Issue Pathophysiology and Complications of Type 2 Diabetes Mellitus)
  • Article
  • Open Access
8 Citations
3,701 Views
23 Pages

The Multi-Compartment SI(RD) Model with Regime Switching: An Application to COVID-19 Pandemic

  • Manuel L. Esquível,
  • Nadezhda P. Krasii,
  • Gracinda R. Guerreiro and
  • Paula Patrício

15 December 2021

We study—with existence and unicity results—a variant of the SIR model for an infectious disease incorporating both the possibility of a death outcome—in a short period of time—and a regime switch that can account for the miti...

(This article belongs to the Special Issue Probability, Statistics and Applied Mathematics)
  • Article
  • Open Access
536 Views
22 Pages

TyG-Centered Endocrine–Metabolic Architecture in Patients with Thyroid Dysfunction: A Systems Phenotyping Study

  • Mirela Frandes,
  • Adriana Gherbon,
  • Anca Tudor,
  • Oana Albai and ,
  • Mihaela Maria Vlad and
  • Călin Muntean
  • + 1 author+ 0 author

Background: Metabolic dysfunction is a complex process arising from coordinated interactions among insulin resistance, dyslipidemia, hepatic dysfunction, obesity, low-grade inflammation, and endocrine alterations. The triglyceride–glucose (TyG)...

(This article belongs to the Special Issue Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome: 2nd Edition)
  • Article
  • Open Access
2 Citations
2,370 Views
36 Pages

Hopf Bifurcation and Optimal Control in an Ebola Epidemic Model with Immunity Loss and Multiple Delays

  • Halet Ismail,
  • Lingeshwaran Shangerganesh,
  • Ahmed Hussein Msmali,
  • Said Bourazza and
  • Mutum Zico Meetei

19 April 2025

This paper studies the effects of resource limitations, immunity decay, and delays on an Ebola epidemic model and an optimal control strategy. The model includes two types of delays: a delay in the incubation period of infected individuals and a dela...

(This article belongs to the Section Mathematical Analysis)
  • Article
  • Open Access
15 Citations
7,108 Views
12 Pages

Modeling Transmission Dynamics of Tuberculosis–HIV Co-Infection in South Africa

  • Simeon Adeyemo,
  • Adekunle Sangotola and
  • Olga Korosteleva

10 October 2023

South Africa has the highest number of people living with the human immunodeficiency virus (HIV) in the world, accounting for nearly one in five people living with HIV globally. As of 2021, 8 million people in South Africa were infected with HIV, whi...

  • Article
  • Open Access
6 Citations
4,682 Views
32 Pages

4 May 2022

Modeling the number of individuals in different states is a principal tool in the event of an epidemic. The natural transition of individuals between possible states often includes deliberate interference such as isolation or vaccination. Thus, the m...

  • Article
  • Open Access
33 Citations
5,393 Views
21 Pages

Data Analytics and Mathematical Modeling for Simulating the Dynamics of COVID-19 Epidemic—A Case Study of India

  • Himanshu Gupta,
  • Saurav Kumar,
  • Drishti Yadav,
  • Om Prakash Verma and ,
  • Tarun Kumar Sharma,
  • Chang Wook Ahn and
  • Jong-Hyun Lee
  • + 2 authors+ 0 author

The global explosion of the COVID-19 pandemic has created worldwide unprecedented health and economic challenges which stimulated one of the biggest annual migrations globally. In the Indian context, even after proactive decisions taken by the Govern...

(This article belongs to the Special Issue Evolutionary Machine Learning for Nature-Inspired Problem Solving)
  • Article
  • Open Access
41 Citations
11,839 Views
19 Pages

COVID-19 Vaccination Scenarios: A Cost-Effectiveness Analysis for Turkey

  • Arnold Hagens,
  • Ahmet Çağkan İnkaya,
  • Kasirga Yildirak,
  • Mesut Sancar and ,
  • Jurjen van der Schans,
  • Aylin Acar Sancar,
  • Serhat Ünal,
  • Maarten Postma and
  • Selen Yeğenoğlu
  • + 4 authors+ 0 author

18 April 2021

As of March 2021, COVID-19 has claimed the lives of more than 2.7 million people worldwide. Vaccination has started in most countries around the world. In this study, we estimated the cost-effectiveness of strategies for COVID-19 vaccination for Turk...

(This article belongs to the Special Issue Health Economics of Vaccines 2.0)
  • Feature Paper
  • Article
  • Open Access
30 Citations
6,592 Views
15 Pages

Characterisation of Omicron Variant during COVID-19 Pandemic and the Impact of Vaccination, Transmission Rate, Mortality, and Reinfection in South Africa, Germany, and Brazil

  • Carolina Ribeiro Xavier,
  • Rafael Sachetto Oliveira,
  • Vinícius da Fonseca Vieira,
  • Marcelo Lobosco and
  • Rodrigo Weber dos Santos

26 April 2022

Several variants of SARS-CoV-2 have been identified in different parts of the world, including Gamma, detected in Brazil, Delta, detected in India, and the recent Omicron variant, detected in South Africa. The emergence of a new variant is a cause of...

(This article belongs to the Special Issue Bioinformatics and High-Performance Computing Methods for Deciphering and Fighting COVID-19)
  • Article
  • Open Access
2 Citations
2,265 Views
15 Pages

Exploring Genetic Heterogeneity in Type 2 Diabetes Subtypes

  • Yanina Timasheva,
  • Olga Kochetova,
  • Zhanna Balkhiyarova,
  • Diana Avzaletdinova and ,
  • Gulnaz Korytina,
  • Tatiana Kochetova and
  • Arie Nouwen
  • + 2 authors+ 0 author

25 September 2025

Background/Objectives: Type 2 diabetes (T2D) is a clinically and genetically heterogeneous disease. In this study, we aimed to stratify patients with T2D from the Volga-Ural region of Eurasia into distinct subgroups based on clinical characteristics...

(This article belongs to the Section Human Genomics and Genetic Diseases)
  • Article
  • Open Access
11 Citations
3,443 Views
17 Pages

The residual agricultural plastic film in China is not easily recovered due to the thinness and poor mechanical properties of domestic films, and a large amount of plastic film remaining in farmland soil poses a great threat to soil quality and crop...

(This article belongs to the Section Agricultural Technology)