5-Pentadecyl-2-((p-tolylimino)methyl)phenol has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-amino-1-methyl-aniline in 1,4-dioxane under reflux. The structure of the synthesized compound was assigned on the basis of eleme...
A novel protein, PID-5, has been shown to be a requirement for germline immortality and has recently been implicated in RNA-induced epigenetic silencing in the Caenorhabditis elegans embryo. Importantly, it has been shown to contain both an eTudor an...
Six undescribed polyhydroxy p-terphenyls, namely asperterphenyllins A–F, were isolated from an endophytic fungus Aspergillus candidus LDJ-5. Their structures were determined by NMR and MS data. Differing from the previously reported p-terphenyls, asp...
The recent development of high-throughput technologies based on RNA sequencing has allowed a better description of the role of post-transcriptional regulation in gene expression. In particular, the development of degradome approaches based on the cap...
The purpose of this study was to assess the ability of Bacillus aryabhattai RAF 5 to produce P(3HB) under conditions of periodic medium renewal (PMR). The producer was isolated and confirmed using transmission electron microscopy (TEM), which reveale...
The selective production of p-xylene and other aromatics starting from sugars and bioderived ethylene offers great promise and can eliminate the need for separation of xylene isomers, as well as decreasing dependency on fossil resources and CO2 emiss...
This study aimed to assess the relationship between chosen antioxidants, namely selenoprotein P (SELENOP), peroxiredoxin-5 (Prdx-5), renalase and selected cardiovascular consequences tested in ambulatory blood pressure monitoring (ABPM) and echocardi...
Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro. Here, engineered ribozymes w...
Colorectal cancer (CRC) is the second deadliest cancer worldwide despite significant advances in both diagnosis and therapy. The high incidence of CRC and its poor prognosis, partially attributed to multi-drug resistance and antiapoptotic activity of...
A unique method to prepare Zn-P co-modified hierarchical ZSM-5 zeolites was developed. The ZSM-5 zeolite was directly synthesized by a dry gel conversion without adding any templates or seeds. Afterwards, the hierarchical structure was endowed to the...
Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractiv...
Five undescribed pentaketide derivatives, (R)-6,8-dihydroxy-4,5-dimethyl-3-methylidene-3,4-dihydro-1H-2-benzopyran-1-one (1), [(3S,4R)-3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-3,4-dihydro-1H-isochromen-3-yl]methyl acetate (2), (R)-5, 7-dimethoxy-3-...
To a cold solution of 5-trifluoromethyl-2,4-dihydropyrazol-3-one [1,2] (0.76 g, 5 mmol) in ethanol (25 ml) containing sodium acetate (0.82 g, 10 mol), p-tolyldiazonium chloride [ca. 5 mmol; prepared by adding a solution of sodium nitrite (5 mmol / 2...
A reaction of 3-chloroisothiazole-5-carbonitrile with 1-iodo-4-methylbenzene (2 equiv.) produced 3-chloro-4-(p-tolyl)isothiazole-5-carbonitrile in a 60% yield. The compound was fully characterized.
The synthesis of 4-(1H-tetrazol-5-yl)-2-(p-tolyl)quinoline 4 as a possible modification of the biphenyltetrazole substructure of losartan 1 is described. The transformation of 2-(p-tolyl)quinoline-4-carbonitrile 3 to the corresponding tetrazole 4 was...
5-[p-(2-Bromo-1-ethoxy)]phenyl-10,15,20-triphenylporphyrin (1) was prepared by previously published method [1].[...]
By strategic use of the valence difference between hard gold(III) and soft gold(I) catalysts, one-pot synthesis of (Z)-5-benzylidene-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole (15) from propargylic alcohol (9) and p-toluamide (13) was achieved via gold(...
The members of the p53 family comprise p53, p63, and p73, and full-length isoforms of the p53 family have a tumor suppressor function. However, p53, but not p63 or p73, has a high mutation rate in cancers causing it to lose its tumor suppressor funct...
p-Cresyl sulfate (PCS) is a uremic toxin that causes cardiovascular injury and progression in patients with chronic kidney disease (CKD). Peripheral arterial stiffness (PAS) as measured using the brachial-ankle pulse wave velocity (baPWV) is consider...
Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain. In this study, p16, p53, and pRb proteins were detected and quantified by immunohistoch...
A graph G is said to be perfect if ω(H)=χ(H) for every induced subgraph H of G, where ω(H) and χ(H) denote the clique number and the chromatic number of H. We say that a graph G admits a perfect division if its vertex set can be p...
In recent years, (p,q)-special polynomials, such as p,q-Euler, p,q-Genocchi, p,q-Bernoulli, and p,q-Frobenius-Euler, have been studied and investigated by many mathematicians, as well physicists. It is important that any polynomial have explicit form...
Glioblastoma (GBM), the most common primary brain tumor, is a complex and extremely aggressive disease. Despite recent advances in molecular biology, there is a lack of biomarkers, which would improve GBM’s diagnosis, prognosis, and therapy. He...
After the observation of the strong near-threshold enhancement of proton-antiproton mass spectrum in J / ψ → γ p...
Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their en...
The TP53 gene is a critical tumor suppressor and key determinant of cell fate which regulates numerous cellular functions including DNA repair, cell cycle arrest, cellular senescence, apoptosis, autophagy and metabolism. In the last 15 years, the p53...
Given a positive integer n, a finite group G is called quasi-core-n if ⟨ x ⟩ / ⟨ x ⟩ G has order at most n for any element x in G, where ⟨ x ⟩ G is the normal core of ⟨ x ⟩ in G....
1 December 2006
Applications running over peer-to-peer (P2P) networks have exploded since the late 1990s. Research is needed into many aspects of P2P. These include architecture, application functionality, and the categories of digital works that are shared using P2...
One-pot synthesis of (E)-5-[bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole (9) from propargylic alcohol 5 and p-toluamide (6) was achieved via gold(III)-catalyzed propargylic substitution, followed by gold(III)-catalyzed bromocycliza...
The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all famil...
This paper gives a thorough characterization of chain rings with index of nilpotency 5 and residue field Fpm, where p represents a prime number, contributing valuable insights to the field of algebraic structures. It carefully identifies and categori...
In this paper, we introduce the ρ , q -analog of the p-adic factorial function. By utilizing some properties of ρ , q -numbers, we obtain several new and interesting identities and formulas. We then construct the p-adic &rho...
Let G be a graph. We denote the chromatic (clique) number of G by χ(G)(ω(G)). In this paper, we prove that (i) χ(G)≤2ω(G) if G is (P3∪P2, kite)-free, (ii) χ(G)≤ω2(G) if G is (P3∪P2, hammer)-free, (iii) &chi...
Low pasture biomass production and fodder scarcity are among the major challenges affecting productivity of dairy cattle farms in Sri Lanka. As a potential solution to this, two Napier hybrid cultivars, CO-5 and Sampoorna, were recently introduced, a...
The classical tests for combining p-values use suitable statistics T(P1,…,Pn), which are based on the assumption that the observed p-values are genuine, i.e., under null hypotheses, are observations from independent and identically distributed...
Wind turbines (WTs) are exposed to a dynamic/cyclic load environment, and are subjected to 1P/3P loads under operational conditions. Recent studies introduced the Sommerfeld Effect to explain the dynamic response amplification induced by 1P/3P loads....
Background: This study aimed to investigate the role of ROS/MAPK signaling pathways and the effects of baicalin in LPS-induced inflammatory responses in mice and porcine intestinal epithelial cells (IPEC-J2). Methods: In vivo, 18 male C57BL/6J mice w...
In this review we focus on the major isoforms of the tumor-suppressor protein p53, dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the DNA binding domain, have been regarded as the main cause for p53 inactivati...
This study aimed to investigate the expression of microRNAs (miRNAs) -146b-3p, -221-5p, -222-3p, and -21a-3p and the methylation pattern of the thyroid-stimulating hormone receptor (TSHR) gene in blood plasma samples from papillary thyroid cancer (PT...
Microglia cells represent the immune system of the central nervous system. They become activated by ATP released from damaged and inflamed tissue via purinergic receptors. Ionotropic purinergic P2X4 and P2X7 receptors have been shown to be involved i...
In this article, the (p,q)-analogs of the α-th fractional Fourier transform are provided, along with a discussion of their characteristics in specific classes of (p,q)-generalized functions. Two spaces of infinitely (p,q)-differentiable functio...
Inflammatory breast cancer (IBC) is a rare yet aggressive breast cancer variant, associated with a poor prognosis. The major challenge for IBC is misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression of microRNAs (...
Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess p...
S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function of S100P may involve binding-induced inactivation of p53. We used 1H-15N HSQC experiments and molec...
This paper summarizes the results of investigations into heterogeneous P23/P91 welds after long-term creep exposure at temperatures of 500, 550 and 600 °C. Two variants of welds were studied: In Weld A, the filler material corresponded to P91 ste...
Transactivation of p21 (cyclin-dependent kinase inhibitor 1A, CDKN1A) is closely related to the recruitment of transcription cofactors at the p53 responsive elements (p53REs) in its promoter region. Human chromatin remodeling enzyme INO80 can be recr...
Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge of pedophile activity in such networks remains limited, despite having important social consequences. Moreover, though there are different P2P systems in use,...
Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest. In canine lymphoma cells, methyl...
T-2 mycotoxins are known to induce toxic effects in animals. The kidneys are particularly vulnerable to oxidative stress induced by toxins, resulting in cellular damage, apoptosis, and disruptions to cell cycle regulation. Cyclin-dependent kinase inh...
The regularity of the n-P-V-rings and n-P-V’-rings is systematically investigated in this paper. Employing the notions of quasi-ideals, weakly left (or right) ideals, and generalized weak ideals, we focus on investigating the strong π-regula...
of 5,270