Background: GRIN-related disorders (GRD), the so-called grinpathies, is a group of rare encephalopathies caused by mutations affecting GRIN genes (mostly GRIN1, GRIN2A and GRIN2B genes), which encode for the GluN subunit of the N-methyl D-aspartate (...
Fibromyalgia (FM) is a chronic pain syndrome characterized by central sensitization, in which glutamatergic and purinergic signaling pathways are thought to play critical roles. This study aimed to evaluate the diagnostic potential of serum glutamate...
Background: Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution...
Glutamate, the major excitatory neurotransmitter, plays a ubiquitous role in most aspects of normal brain functioning. Its indispensable position is paradoxically doubled by a high excitotoxic potential following disruption of its dynamic equilibrium...
This paper presents a systematic investigation into the design and performance of layered polymer gradient refractive index (GRIN) lenses. A material-driven optimization algorithm is proposed, which uses physical volume fractions of the constituent p...
Background: The GRIN2A gene and its product protein have been linked to a wide spectrum of neurodevelopmental disorders named GRIN2A-related disorders. Clinical presentation is highly variable and characteristically includes acquired cognitive, behav...
The GluN2B subunit of N-methyl-D-aspartate receptors plays an important role in the physiology of different neurodevelopmental diseases. Genetic variations in the GluN2B coding gene (GRIN2B) have consistently been linked to West syndrome, intellectua...
Purpose: Previous studies have found the neurodegeneration and atrophy of glaucomatous lateral geniculate nucleus (LGN), but the mechanism is still unknown. Circular RNA (circRNA) plays some important roles in physiological and pathological progressi...
The paper shows that it is possible to obtain reliable information on the dependence of the radial distribution of longitudinal birefringence in glass cylindrical elements with a radial distribution of refractive index (GRIN lenses) on the basis of t...
We analytically investigate the feasibility of long graded-index (GRIN)-lens-based microendoscopes through wavefront shaping. Following the very well-defined ray trajectories in a GRIN lens, mode-dependent phase delay is first determined. Then, the p...
This paper proposes a graded effective refractive indexes (GRIN) dielectric lens for 5G applications. The inhomogeneous holes in the dielectric plate are perforated to provide GRIN in the proposed lens. The constructed lens employs a collection of sl...
Background: As the most lethal neuroendocrine tumor, small cell lung cancer (SCLC) can drive its progression by hijacking neuronal mechanisms. At the core of this neural integration is the N-methyl-D-aspartate receptor (NMDAR) complex. However, its p...
Introduction: Major depressive disorder (MDD) is a common comorbidity of type 2 diabetes (T2D) with low rates of treatment response to antidepressants. The pathophysiology of these conditions overlaps in N-methyl-d-aspartate receptors (NMDARs), which...
Background: Personal variations in genetic risk for schizophrenia relate to its phenotypic heterogeneity—both in disorder development and clinical manifestations. Abnormal glutamatergic neurotransmitter system functioning is integrated in the p...
A high-efficiency coupling method using the gradient-index (GRIN) fiber probe and hollow-core photonic crystal fiber (HC-PCF) is proposed to improve the response time and the sensitivity of gas sensors. A coupling efficiency model of the GRIN fiber p...
Three-dimensional (3D) microstructures used in the formation of optical traps on the optical axis in the near diffraction zone are calculated and studied. Subwavelength, variable-height annular gratings (a lattice period of 1.05λ) with a stand...
In order to enlarge the capability for in-plane manipulation of the Bloch surface wave (BSW), we investigate 2D gradient index (GRIN) optical components using a finite-difference time-domain (FDTD) numerical method. To ease difficulties in fabricatio...
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate channels that play a pivotal role in brain development and the regulation of learning and memory processes. De novo pathogenic variants in four genes encoding NMDA receptor subunits (GR...
Background: Treatment-resistant depression (TRD) affects up to 30–40% of patients with major depressive disorder and remains a major therapeutic challenge. Genetic and epigenetic factors are increasingly recognized as key contributors to both v...
Phononic crystals have the ability to manipulate the propagation of elastic waves in solids by generating unique dispersion characteristics. They can modify the conventional behavior of wave spreading in isotropic materials, known as attenuation, whi...
Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used...
GRIN2A has previously been identified as frequently mutated in tumor samples, leading to a hypothesized involvement of GRIN2A in tumorigenesis. Pathogenic GRIN2A germline variants, on the other hand lead, to neurodevelopmental disorders, with no evid...
Opioid use induces neurobiological adaptations throughout mesolimbic brain regions, such as the orbitofrontal cortex (OFC), which mediates decision-making and emotional–cognitive regulation. Previously, we showed that a circular RNA (circRNA) s...
A novel Fabry–Perot (F–P) interferometer model based on the ultra-small gradient-index (GRIN) fiber probe is investigated. The signal arm of the F–P interferometer is organically combined with the ultra-small GRIN fiber probe to est...
Antihistamines have potent efficacy to alleviate COVID-19 (Coronavirus disease 2019) symptoms such as anti-inflammation and as a pain reliever. However, the pharmacological mechanism(s), key target(s), and drug(s) are not documented well against COVI...
An in-plane liquid gradient index (L-GRIN) microlens is designed for dynamically adjusting the beam focusing. The ethylene glycol solution (core liquid) withde-ionized (DI) water (cladding liquid) is co-injected into the lens chamber to form a gradie...
The Mediodorsal (MD) thalamus that represents a fundamental subcortical relay has been underrepresented in the studies focusing on the molecular changes in the brains of subjects with alcohol use disorder (AUD). In the current study, MD thalamic regi...
Infrared gradient refractive index (GRIN) material lenses have attracted much attention due to their continuously varying refractive index as a function of spatial coordinates in the medium. Herein, a glass accumulation thermal diffusion method was u...
The activation of the endocannabinoid system controls the release of many neurotransmitters involved in the brain reward pathways, including glutamate. Both endocannabinoid and glutamate systems are crucial for alcohol relapse. In the present study,...
Background: Children and adolescents with early-onset psychosis (EOP) have more rare genetic variants than individuals with adult-onset forms of the illness, implying that fewer EOP participants are needed for genetic discovery. The Schizophrenia Exo...
Climate change adaptation has become an important policy domain, as it has the potential to substantially reduce many of the adverse impacts of climate change. Several scientific terms and general concepts have been used to comprehend adaptation, inc...
In the field of vehicle lighting, due to the diode laser, its small size and high energy conversion efficiency, it can be effectively used as the headlight source of high beam. In recent years, it was adopted by European advanced car manufacturers as...
This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic GRIN2B gene variants and ina...
This paper demonstrates that a graded-index (GRIN) phononic lens, combined with a channel waveguide, can focus anti-symmetric Lamb waves for extraction by a detector with strong directional sensitivity. Guided ultrasonic wave inspection is commonly a...
Bisphenols (BPs) are widespread environmental endocrine disruptors, but their potential depression-related neurotoxicity has not been systematically assessed. Here, we combined machine learning (ML), network toxicology, molecular docking, and in vivo...
GRIN2B mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations dis...
Turbidity sensing is very common in the control of drinking water. Furthermore, turbidity measurements are applied in the chemical (e.g., process monitoring), pharmaceutical (e.g., drug discovery), and food industries (e.g., the filtration of wine an...
The genetic diversity and population structure of tomato (Solanum lycopersicum) were investigated to support breeding strategies and germplasm conservation. A total of 276 accessions from the USDA-GRIN collection were analyzed using single-nucleotide...
Background/Objectives: Preterm infants are at risk for developmental delays due to immature brain development and increased sensitivity to environmental stress. Genetic factors, such as polymorphisms in *OXTR* rs2268490, *COMT* rs4818, and *GRIN2B*,...
We describe the construction of an optical-space, cylindrical black hole induced by high pressure in a dense fluid. Using an approximate analogy between curved spacetime and optics in moving dielectric media, we derive the mass of the black hole thus...
Photoacoustic technology is a promising tool to provide morphological and functional information in biomedical research. To enhance the imaging efficiency, the reported photoacoustic probes have been designed coaxially involving complicated optical/a...
This study introduces a groundbreaking antenna system, the directive Metasurface Half-Maxwell Fish-Eye (MHMF) lens antenna, tailored specifically for Internet-of-Things (IoT) networks. Designed to operate at 60 GHz, this antenna ingeniously integrate...
Urban Green Spaces (UGSs) are considered the most effective tool to mitigate Urban Heat Islands (UHIs). The optical properties of the materials and the vegetation types of the UGSs affect their surface temperatures, directly influencing their cooling...
Gradient refractive index (GRIN) lenses have been widely used for many applications. However, the traditional manufacturing methods of GRIN lenses are very time-consuming and only suitable for macro-scale operations. In addition, those methods do not...
In this work, novel graphene/In2O3 (GR/In2O3) nanocubes were prepared via one-pot solvothermal treatment, reduction reaction, and successive annealing technology at 600 °C step by step. Interestingly, In2O3 with featured cubic morphology was obse...
Aiming at exploring vascular components in multiple sclerosis (MS) with brain outflow disturbance, we combined transcriptome analysis in MS internal jugular vein (IJV) wall with WES in MS families with vertical transmission of disease. Main results w...
Bisphenol A (BPA) is an organic synthetic compound that is most publicized as an endocrine-disrupting chemical (EDCs) due to its remarkable effects on signaling activity via multiple steroid hormone receptors. The environmental perturbations on signa...
Background/Objectives: Radiotherapy can cause severe and irreversible brain damage, including cognitive impairment, increased dementia risk, debilitating depression, and other neuropsychiatric disorders. Current radioprotective drugs face limitations...
Background/Objectives: Suicide is a significant public health concern with a multifactorial etiology. The biological background of suicide is not sufficiently explored, which encumbers suicide prevention. Epigenetic mechanisms may mediate environment...
This paper proposes a millimeter-wave lens antenna using 3-dimensional (3D) printing technology to reduce weight and provide stable gain performance. The antenna consists of a four-layer cylindrical gradient-index (GRIN) lens fed by a wideband Yagi a...
of 4