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Advances in the Purinergic System

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 498

Special Issue Editor


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Guest Editor
Graduate Program in Medical Sciences, Federal University of Fronteira Sul, Chapecó 89815-899, SC, Brazil
Interests: oxidative stress; purinergic system; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The purinergic system plays a crucial role in various physiological and pathological processes, including neurotransmission, inflammation, pain, and immune response. In recent years, significant advances have expanded our understanding of the functions and mechanisms of purinergic receptors and their implications in neurodegenerative, cardiovascular diseases, and cancer. This Special Issue aims to gather research articles and reviews that explore new discoveries and therapeutic approaches related to the Purinergic System. We welcome studies on the identification of novel ligands, the development of new drugs, as well as investigations into the modulation of purinergic receptors in pathological contexts. This thematic Special Issue seeks to highlight the most recent scientific contributions that may open new avenues for disease treatment and provide a comprehensive overview of advances in the field of purinergic signaling.

Dr. Margarete Dulce Bagatini
Guest Editor

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Keywords

  • purinergic system
  • receptors
  • ectonucleotidases
  • CD39
  • CD73
  • purinergic signaling

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Published Papers (1 paper)

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Research

16 pages, 1359 KiB  
Article
Dysregulation of Purinergic Signaling Sustains Chronic Inflammation and Oxidative Imbalance in Patients After PitNET Surgical Resection
by Geile Fistarol, Luiz A. de Oliveira, Gilnei B. da Silva, Daiane Manica, Marceli C. Hanauer, Paula Dallagnol, Rafael A. Narzetti, Maria L. Bergamini, Vitória C. de Melo, Tais Vidal, Micheli M. Pillat, Jussara de Lima, Marcelo L. V. da Cunha, Marielle L. Makiyama, Filomena Marafon, Aniela P. Kempka, Ariane Zamoner and Margarete D. Bagatini
Int. J. Mol. Sci. 2025, 26(14), 6890; https://doi.org/10.3390/ijms26146890 - 17 Jul 2025
Viewed by 218
Abstract
Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial tumors. Evidence suggests that these types of tumors may have high recurrence rates. In this context, the purinergic system, oxidative stress, and inflammation are important signaling pathways involved in the cancer’s pathophysiology. This study [...] Read more.
Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial tumors. Evidence suggests that these types of tumors may have high recurrence rates. In this context, the purinergic system, oxidative stress, and inflammation are important signaling pathways involved in the cancer’s pathophysiology. This study aimed to evaluate the sociodemographic and diagnostic profiles, as well as assess the purinergic signaling, immunological, and redox profiles, of patients after PitNET resection. We collected sociodemographic data and the patients’ diagnostic profiles. We also collected blood samples to analyze glycemia, triglycerides, albumin, and ATP levels. The ectonucleotidase activity was determined in peripheral blood mononuclear cells (PBMCs). In addition, we evaluated their redox and immunological profiles. There was a prevalence of gonadotropic macroadenoma derived from PIT-1 cells. We found that patients included in the PitNET group had increased glycemia, serum ATP levels, and ATP hydrolysis in PBMCs. Analyzing their immunological profiles, we found that patients had increased levels of IL-6, IL-10, and TNF, while the IL-27 level was decreased. Regarding their redox profiles, PitNET patients had increased levels of ROS and protein carbonylation. Unexpectedly, patients also showed increased levels of non-protein thiols (NPSHs), total thiols (PSHs), and ascorbic acid. Thus, the dysregulation of purinergic signaling sustained chronic inflammation and oxidative imbalance in PitNET patients for a long time after surgical resection. These data suggest that patients with PitNETs require long-term accompanying to prevent cancer recurrence prognosis. The biomarkers highlighted in this study may be good tools to help the medical approaches. Full article
(This article belongs to the Special Issue Advances in the Purinergic System)
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