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91 Results Found

  • Article
  • Open Access
1 Citations
1,826 Views
14 Pages

An ETD Method for Vulnerable American Options

  • Rafael Company,
  • Vera N. Egorova and
  • Lucas Jódar

17 February 2024

This paper introduces the exponential time differencing (ETD) technique as a numerical method to efficiently solve vulnerable American options pricing. We address several challenges, including removing cross-derivative terms through appropriate trans...

  • Communication
  • Open Access
2,149 Views
11 Pages

3 July 2025

Embedded printing of soft materials relies on yield-stress support matrices to prevent sagging and enable freeform fabrication. The rheological parameters of the matrix material directly influence critical printing outcomes such as strand positioning...

  • Article
  • Open Access
20 Citations
4,119 Views
11 Pages

Eustachian Tube Function Assessment after Radiofrequency Turbinate Reduction in Atopic and Non-Atopic Patients

  • Francesco Martines,
  • Francesco Dispenza,
  • Federico Sireci,
  • Salvatore Gallina and
  • Pietro Salvago

(1) Background: Inferior turbinates’ hypertrophy is often associated with Eustachian tube dysfunction (ETD); radiofrequency turbinate reduction (RTR) may provide a long-term improvement of nasal obstruction and ETD-related symptoms. (2) Aim: Th...

  • Article
  • Open Access
15 Citations
1,718 Views
13 Pages

18 January 2010

The aim of present investigation was 1) to evaluate the in vivo bioavailability of an Etodolac (ETD)-β-cyclodextrin (β-CD) inclusion complex system prepared by kneading and spray drying techniques in rats, 2) to study the pharmacodynamic parameters i...

  • Article
  • Open Access
1 Citations
2,442 Views
21 Pages

First Investigation of a Eustachian Tube Stent in Experimentally Induced Eustachian Tube Dysfunction

  • Katharina Schmitt,
  • Malena Timm,
  • Philipp Krüger,
  • Niels Oppel,
  • Alexandra Napp,
  • Friederike Pohl,
  • Robert Schuon,
  • Lisa Kötter,
  • Marion Bankstahl and
  • Gerrit Paasche
  • + 2 authors

Unmet needs in the treatment of chronic otitis media and Eustachian tube dysfunction (ETD) triggered the development of stents for the Eustachian tube (ET). In this study, for the first time, stents were placed in an artificially blocked ET to evalua...

  • Article
  • Open Access
267 Views
17 Pages

Otologic Axis and Sleep-Disordered Breathing in Achondroplasia: Age-Structured Cohort Findings

  • Cristina Popescu,
  • Rebecca-Cristiana Serban,
  • Andreea Mituț-Velișcu,
  • Andrei Costache,
  • Raluca-Ioana Teleanu,
  • Diana Ionescu,
  • Cristian Arsenie,
  • Renata-Maria Varut,
  • Ion-Dorin Pluta and
  • Ioana Streață
  • + 1 author

Background/Objectives: Achondroplasia is linked to distinctive ear–nose–throat (ENT) morbidity, yet quantitative age-structured profiles and actionable correlates remain incompletely defined. This study mapped ENT phenotypes in a consecut...

  • Article
  • Open Access
2 Citations
2,867 Views
25 Pages

Long-Term Preclinical Evaluation of a Permanent Stent Developed for the Human Eustachian Tube

  • Katharina Schmitt,
  • Malena Timm,
  • Philipp Krüger,
  • Niels Oppel,
  • Alexandra Napp,
  • Friederike Pohl,
  • Robert Schuon,
  • Andreas Kampmann,
  • Lisa Kötter and
  • Gerrit Paasche
  • + 3 authors

The Eustachian tube (ET) is a bottleneck when it comes to middle ear (ME) health. If its function is impaired, this can lead to serious consequences for the patient, such as hearing problems or deafness. Therefore, this study investigated a tapered n...

  • Systematic Review
  • Open Access
1 Citations
5,502 Views
17 Pages

Balloon Eustachian Tuboplasty: A Systematic Review of Technique, Safety, and Clinical Outcomes in Chronic Obstructive Eustachian Tube Dysfunction

  • Katarzyna Gołota,
  • Katarzyna Czerwaty,
  • Karolina Dżaman,
  • Dawid Szczepański,
  • Nils Ludwig and
  • Mirosław J. Szczepański

Background/Objectives: Obstructive Eustachian tube dysfunction (OETD) is common in adults and may lead to middle-ear conditions such as atelectasis and cholesteatoma. The ETDQ-7 questionnaire is used to assess symptom severity. Balloon dilation of th...

  • Article
  • Open Access
1,308 Views
14 Pages

5 November 2024

A main circuit ground fault (MCGF) is a typical system fault in an electrical traction drive system (ETDS). When two or more MCGFs occur, it will cause serious accidents. Therefore, it is particularly important to detect and handle MCGFs in a timely...

  • Article
  • Open Access
18 Citations
4,976 Views
15 Pages

3 March 2021

The EU-27 fishing fleet consumed 2.02 billion liters of fuel to catch 4.48 million tons of fish, valued at €6.7 billion in 2018. The profitability of the EU fishing fleet shows an increasing trend, partly due to the improvements in the energy efficie...

  • Article
  • Open Access
9 Citations
6,332 Views
34 Pages

Top-Down Proteomics of Medicinal Cannabis

  • Delphine Vincent,
  • Steve Binos,
  • Simone Rochfort and
  • German Spangenberg

24 September 2019

The revised legislation on medicinal cannabis has triggered a surge of research studies in this space. Yet, cannabis proteomics is lagging. In a previous study, we optimised the protein extraction of mature buds for bottom-up proteomics. In this foll...

  • Article
  • Open Access
639 Views
19 Pages

20 June 2025

Differences in environmental conditions due to slope topography result in differences in evapotranspiration along slopes, but it is unclear how changes in environmental conditions affect the variations in evapotranspiration along slopes. Therefore, w...

  • Systematic Review
  • Open Access
4 Citations
4,412 Views
11 Pages

Endoscopic Sinus Surgery Significantly Reduces Eustachian Tube Dysfunction Symptoms in Patients with Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis

  • Kai-Shan Yang,
  • Wei-Chih Chen,
  • Ching-Nung Wu,
  • Yin-Shen Wee,
  • Ching-Shuen Wang,
  • Cheng-Chih Wu and
  • Sheng-Dean Luo

(1) Background: Eustachian tube dysfunction (ETD) is a frequently observed clinical manifestation of chronic rhinosinusitis (CRS). This systematic review aimed to evaluate the function of the Eustachian tube following endoscopic sinus surgery (ESS) i...

  • Article
  • Open Access
5 Citations
2,628 Views
9 Pages

6 September 2022

Background and objectives: The optic nerve sheath diameter (ONSD) is indicative of elevated intracranial pressure. However, the usefulness of the ONSD for predicting neurologic outcomes in cardiac arrest survivals has been debatable. Reportedly, the...

  • Article
  • Open Access
16 Citations
8,551 Views
18 Pages

23 May 2014

Multimedia fate and transport models are used to evaluate the long range transport potential (LRTP) of organic pollutants, often by calculating their characteristic travel distance (CTD). We calculated the CTD of several polycyclic aromatic hydrocarb...

  • Review
  • Open Access
6 Citations
5,608 Views
27 Pages

17 February 2025

This paper provides a consolidated discussion and proposes significant measures in improving and advancing the performance of synchronous machines employed in electric traction applications designed for passenger electric vehicles (EVs). The paper qu...

  • Article
  • Open Access
1 Citations
2,457 Views
20 Pages

Analysis Strategy for Identifying the O-Linked Glycan Profile and O-glycosylation Sites on Recombinant Human Follicle Stimulating Hormone-C-terminal Peptide (rhFSH-CTP)

  • Xinyue Hu,
  • Yuxing Xiang,
  • Xiaoming Zhang,
  • Yue Sun,
  • Yi Li,
  • Lvyin Wang,
  • Ping Lv,
  • Zhen Long,
  • Chenggang Liang and
  • Jing Li

O-glycosylation is a common post-translational modification on extracellular and secreted proteins driving biochemical and biophysical interactions at the cell surface. Glycosylation affects drug immunogenicity, efficacy, and clearance, making it a c...

  • Article
  • Open Access
6 Citations
4,050 Views
7 Pages

The nine-step test is a classical method for evaluating Eustachian tube function. It directly assesses the patient’s capacity to equilibrate middle ear pressure by swallowing. However, there are insufficient studies to appraise its diagnostic p...

  • Article
  • Open Access
1 Citations
1,820 Views
13 Pages

Chronic Nasal Disease and Eustachian Tube Function: What Is the Role of Tubomanometry?

  • Sofia Anastasiadou,
  • Polyzois Bountzis,
  • Dimitrios-Evangelos Gkogkos,
  • Petros Karkos,
  • Jannis Constantinidis,
  • Stefanos Triaridis and
  • George Psillas

8 November 2024

Background/objectives: Eustachian tube dysfunction (ETD) presents complex diagnostic challenges in otolaryngology, compounded by concurrent chronic nasal disease. Patient-reported outcome measures (PROMs) often assess ETD severity due to its elusive...

  • Article
  • Open Access
8 Citations
2,695 Views
25 Pages

Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug

  • Anna Czajkowska-Kośnik,
  • Iwona Misztalewska-Turkowicz,
  • Agnieszka Zofia Wilczewska,
  • Anna Basa and
  • Katarzyna Winnicka

7 August 2024

Poor water solubility of drugs is a limiting factor for their bioavailability and pharmacological activity. Many approaches are known to improve drug solubility, and among them, the physical method, solid dispersions (SDs), is applied. SDs are physic...

  • Review
  • Open Access
13 Citations
5,578 Views
23 Pages

Data-Driven Approaches for Energy Theft Detection: A Comprehensive Review

  • Soohyun Kim,
  • Youngghyu Sun,
  • Seongwoo Lee,
  • Joonho Seon,
  • Byungsun Hwang,
  • Jeongho Kim,
  • Jinwook Kim,
  • Kyounghun Kim and
  • Jinyoung Kim

20 June 2024

The transition to smart grids has served to transform traditional power systems into data-driven power systems. The purpose of this transition is to enable effective energy management and system reliability through an analysis that is centered on ene...

  • Article
  • Open Access
2,758 Views
13 Pages

Aviation security increasingly relies on explosive trace detectors (ETDs), particularly those employing ion mobility spectrometry (IMS). However, few studies have systematically compared the performance of IMS-based ETDs, especially in terms of measu...

  • Article
  • Open Access
6 Citations
3,042 Views
17 Pages

This work aimed to enhance the purposing profile of Etodolac (ETD) in Human Hepatocellular Carcinoma (HCC) HepG2 cells using sodium deoxycholate stabilized zein nanospheres (ETD-SDZN NSs). ETD-SDZN NSs were formulated using the nan-precipitation meth...

  • Article
  • Open Access
842 Views
26 Pages

How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac?

  • Anna Czajkowska-Kośnik,
  • Radosław A. Wach,
  • Eliza Wolska and
  • Katarzyna Winnicka

Background: Solid dispersions (SDs) of etodolac (ETD), a poorly water-soluble drug model, were developed to enhance its solubility and dissolution rate by employing various preparation methods and hydrophilic or amphiphilic polymers. Methods: Polyvin...

  • Article
  • Open Access
4,393 Views
12 Pages

Eustachian tube dysfunction (ETD) affects a significant portion of the population, manifesting symptoms that impact the quality of life. Despite the prevalence of ETD, there remains a notable gap in comprehensive studies exploring the condition&rsquo...

  • Article
  • Open Access
55 Citations
5,585 Views
24 Pages

A Combined Deep Learning and Ensemble Learning Methodology to Avoid Electricity Theft in Smart Grids

  • Zeeshan Aslam,
  • Nadeem Javaid,
  • Ashfaq Ahmad,
  • Abrar Ahmed and
  • Sardar Muhammad Gulfam

26 October 2020

Electricity is widely used around 80% of the world. Electricity theft has dangerous effects on utilities in terms of power efficiency and costs billions of dollars per annum. The enhancement of the traditional grids gave rise to smart grids that enab...

  • Article
  • Open Access
7 Citations
4,022 Views
19 Pages

Development of an In Vivo Model for Eustachian Tube Dysfunction

  • Niels Oppel,
  • Malena Ezzat,
  • Philipp Krüger,
  • Katharina Schmitt,
  • Alexandra Napp,
  • Friederike Pohl,
  • Andre Bleich,
  • Thomas Lenarz,
  • Tobias Stein and
  • Robert Schuon
  • + 1 author

Otitis media is often connected to Eustachian tube dysfunction (ETD). Until now, there was no large animal model available for the examination of new treatment methods such as stents for the Eustachian tube (ET). Thus, the aim of the study was to dev...

  • Review
  • Open Access
5 Citations
3,964 Views
17 Pages

New Frontiers of Electronic Theses and Dissertations

  • Joachim Schöpfel,
  • Michael Boock,
  • Behrooz Rasuli and
  • Brenda van Wyk

(1) Background: Since the 1990s, theses and dissertations—a key part of scientific communication—have evolved significantly with advances in information and communication technologies. (2) Methods: This study reviews 99 publications exami...

  • Article
  • Open Access
1 Citations
3,511 Views
10 Pages

Balloon Eustachian Tuboplasty Combined or Not with Myringotomy in Eustachian Tube Dysfunction

  • Wei-Chieh Lin,
  • Yao-Wen Chang,
  • Ting-Ya Kang,
  • Ciou-Nan Ye,
  • Hung-Pin Wu and
  • Chung-Ching Lin

25 October 2023

Background: Eustachian tube dysfunction (ETD) is a common disorder causing ear pressure, pain, and hearing loss. Balloon Eustachian tuboplasty (BET) is an emerging technique for dilating the Eustachian tube and treating ETD. Whether adding myringotom...

  • Article
  • Open Access
28 Citations
4,383 Views
20 Pages

Synthetic Theft Attacks and Long Short Term Memory-Based Preprocessing for Electricity Theft Detection Using Gated Recurrent Unit

  • Pamir,
  • Nadeem Javaid,
  • Saher Javaid,
  • Muhammad Asif,
  • Muhammad Umar Javed,
  • Adamu Sani Yahaya and
  • Sheraz Aslam

10 April 2022

Electricity theft is one of the challenging problems in smart grids. The power utilities around the globe face huge economic loss due to ET. The traditional electricity theft detection (ETD) models confront several challenges, such as highly imbalanc...

  • Article
  • Open Access
1 Citations
2,582 Views
22 Pages

Microporation-Mediated Transdermal Delivery of In Situ Gel Incorporating Etodolac-Loaded PLGA Nanoparticles for Management of Rheumatoid Arthritis

  • Heba M. El Sorogy,
  • Sahar M. Fayez,
  • Islam A. Khalil,
  • Gehad A. Abdel Jaleel,
  • Ahmed M. Fayez,
  • Hesham A. Eliwa and
  • Hoda E. Teba

Management of rheumatoid arthritis (RA) requires long-term administration of different medications since there has been no cure until now. Etodolac (ETD) is a nonsteroidal anti-inflammatory drug commonly used for RA management. However, its long-term...

  • Article
  • Open Access
636 Views
15 Pages

29 September 2025

Background: Optic nerve sheath diameter (ONSD) and its ratio to eyeball transverse diameter (ETD; ONSD/ETD) are potential markers for elevated intracranial pressure in comatose survivors of out-of-hospital cardiac arrest (OHCA). However, their progno...

  • Article
  • Open Access
354 Views
17 Pages

Prevalence and Interplay of Modifiable and Genetic Determinants of Eustachian Tube Dysfunction Among Saudi Adults: A Nationwide Study

  • Mohammad A. Jareebi,
  • Riyadh A. Jahlan,
  • Abdulrahman A. Otaif,
  • Abdulelah A. Otaif,
  • Abdulrahman A. Daghreeri,
  • Mashael S. Mahnashi,
  • Raghad W. Al Nahwe,
  • Yahya A. Maslamani,
  • Ali Y. Mashragi and
  • Ahmed A. Bahri
  • + 5 authors

Background/Objectives: Eustachian Tube Dysfunction (ETD) is a prevalent condition affecting middle ear pressure regulation, yet nationwide epidemiological data in Saudi Arabia remain limited. This study aimed to assess the prevalence of ETD and ident...

  • Article
  • Open Access
19 Citations
5,896 Views
22 Pages

28 December 2022

Topical administration of drug is an attractive alternative to the oral administration as it provides a reduction in adverse reactions and an enhancement of therapeutic effects. The use of lipid carriers in hydrogel structures makes it possible to in...

  • Communication
  • Open Access
2 Citations
2,175 Views
9 Pages

10 October 2023

Pseudoxanthoma elasticum (PXE) is a heritable multisystem ectopic calcification disorder. The gene responsible for PXE, ABCC6, encodes ABCC6, a hepatic efflux transporter regulating extracellular inorganic pyrophosphate (PPi), a potent endogenous cal...

  • Article
  • Open Access
31 Citations
4,646 Views
17 Pages

Tax Policy, Environmental Concern and Level of Emission Reduction

  • Xuexian Gao,
  • Haidong Zheng,
  • Yan Zhang and
  • Naser Golsanami

17 February 2019

Regulators often use environmental policy to induce green initiatives by firms. This paper examines the emission-reduction-inducement effect of the environmental tax deduction (ETD) incentive by Stackelberg game models between an environmental regula...

  • Article
  • Open Access
7 Citations
3,546 Views
12 Pages

The purpose of this study was to determine whether the sensitivity advantage of intradermal dilutional testing (IDT) is clinically relevant in patients with obstructive Eustachian tube dysfunction (ETD) or otitis media with effusion (OME). This retro...

  • Article
  • Open Access
50 Citations
10,205 Views
13 Pages

Effects of Individual Tree Detection Error Sources on Forest Management Planning Calculations

  • Mikko Vastaranta,
  • Markus Holopainen,
  • Xiaowei Yu,
  • Juha Hyyppä,
  • Antti Mäkinen,
  • Jussi Rasinmäki,
  • Timo Melkas,
  • Harri Kaartinen and
  • Hannu Hyyppä

25 July 2011

The objective was to investigate the error sources of the airborne laser scanning based individual tree detection (ITD), and its effects on forest management planning calculations. The investigated error sources were detection of trees (etd), error i...

  • Article
  • Open Access
16 Citations
5,353 Views
21 Pages

15 April 2023

Evapotranspiration (ET) is an important channel for water transport and energy conversion in land–air systems, and the spatial quantification of actual ET is crucial for water resource management and scheduling in arid areas. Using the Surface...

  • Article
  • Open Access
13 Citations
4,846 Views
20 Pages

26 July 2020

An accurate estimation of evapotranspiration (ET) from crops is crucial in irrigation management, crop yield assessment, and optimal allocation of water resources, particularly in arid regions. This study explores the estimation of seasonal evapotran...

  • Article
  • Open Access
27 Citations
5,194 Views
34 Pages

Evapotranspiration Estimation in the Sahel Using a New Ensemble-Contextual Method

  • Aubin Allies,
  • Jérôme Demarty,
  • Albert Olioso,
  • Ibrahim Bouzou Moussa,
  • Hassane Bil-Assanou Issoufou,
  • Cécile Velluet,
  • Malik Bahir,
  • Ibrahim Maïnassara,
  • Monique Oï and
  • Bernard Cappelaere
  • + 1 author

24 January 2020

In many tropical areas, evapotranspiration is the most important but least known component of the water cycle. An innovative method, named E3S (for EVASPA S-SEBI Sahel), was developed to provide spatially-distributed estimates of daily actual evapotr...

  • Article
  • Open Access
19 Citations
3,827 Views
22 Pages

Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species

  • Juan C. Sáez,
  • Aníbal A. Vargas,
  • Diego E. Hernández,
  • Fernando C. Ortiz,
  • Christian Giaume and
  • Juan A. Orellana

Recent studies indicate that connexin hemichannels do not act as freely permeable non-selective pores, but they select permeants in an isoform-specific manner with cooperative, competitive and saturable kinetics. The aim of this study was to investig...

  • Article
  • Open Access
1 Citations
1,077 Views
24 Pages

Real-Time Elbow and T-Junction Detection and Estimation Framework for In-Line Inspection in Natural Gas Pipelines Using 3D Point Cloud

  • Hoa-Hung Nguyen,
  • Jae-Hyun Park,
  • Jae-Jun Kim,
  • Kwanghyun Yoo,
  • Dong-Kyu Kim and
  • Han-You Jeong

20 March 2025

In-line inspection (ILI) is essential for maintaining the integrity of natural gas pipelines. In ILI, pipeline inspection gauges (PIGs) autonomously navigate through pipelines under real-time and resource-constrained conditions to measure pipeline ir...

  • Review
  • Open Access
3 Citations
6,865 Views
14 Pages

Eustachian Tube Dysfunction Diagnostic Pathway—What Is the Current State of the Art and How Relevant Is Chronic Nasal Disease?

  • Sofia Anastasiadou,
  • Polyzois Bountzis,
  • Dimitrios Evangelos Gkogkos,
  • Petros Karkos,
  • Jannis Constantinidis,
  • Stefanos Triaridis and
  • George Psillas

25 June 2024

Background: Eustachian tube dysfunction (ETD) presents a complex diagnostic challenge in otolaryngology, compounded by its multifaceted nature and overlapping symptoms with chronic nasal disease. This article examines the intricacies of ETD diagnosis...

  • Article
  • Open Access
1,934 Views
12 Pages

12 August 2024

The optic nerve sheath diameter (ONSD) can predict intracranial pressure and outcomes in neurological disease, but it remains unclear whether a small ONSD can be accurately measured on routine CT images with a slice thickness of approximately 4&ndash...

  • Article
  • Open Access
40 Citations
4,837 Views
19 Pages

Nanostructured Lipid Carriers Engineered as Topical Delivery of Etodolac: Optimization and Cytotoxicity Studies

  • Anna Czajkowska-Kośnik,
  • Emilia Szymańska,
  • Robert Czarnomysy,
  • Julia Jacyna,
  • Michał Markuszewski,
  • Anna Basa and
  • Katarzyna Winnicka

27 January 2021

Etodolac (ETD), a nonsteroidal anti-inflammatory drug, exhibits antinflammatory, analgesic, and antipyretic activity. The main type of ETD administration is oral route, which is associated with significant systemic side effects. Nanostructured lipid...

  • Article
  • Open Access
8 Citations
3,994 Views
14 Pages

Effectiveness of the Telemedical Lifestyle Intervention Program TeLIPro for Improvement of HbA1c in Type 2 Diabetes: A Randomized-Controlled Trial in a Real-Life Setting

  • Kerstin Kempf,
  • Clara Dubois,
  • Matthias Arnold,
  • Volker Amelung,
  • Nora Leppert,
  • Sibel Altin,
  • Markus Vomhof,
  • Andrea Icks and
  • Stephan Martin

12 September 2023

The effectiveness of the multimodal Telemedical Lifestyle Intervention Program (TeLIPro) was proven in the advanced stages of type 2 diabetes mellitus (T2DM). Since its therapeutic potential focusing on telemedical coaching without using a formula di...

  • Review
  • Open Access
2 Citations
2,947 Views
25 Pages

Hearing loss (HL) affects more than 1.5 billion people worldwide and remains a leading cause of disability across the lifespan. While genetic predispositions, otitis media (OM), and cholesteatoma are well-recognized contributors, Eustachian tube dysf...

  • Article
  • Open Access
507 Views
35 Pages

3D Simultaneous Inversion and Modeling of Full Tensor Gravity and Gravity Data for Salt Imaging

  • Carlos Ortiz-Alemán,
  • Sebastian López-Juárez,
  • Carlos Couder-Castañeda,
  • Alfredo Trujillo-Alcántara,
  • Jaime Meléndez-Martínez and
  • Andrés Ambros-Vargas

3 November 2025

In this study, we performed three-dimensional gravity modeling and inversion of the Vinton Dome, a well-known onshore salt structure located in southwestern Louisiana, USA, by simultaneously integrating Full Tensor Gravity (FTG) and conventional grav...

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