61 Results Found

The ribosome CAR interaction surface behaves as an extension of the decoding center A site and has H-bond interactions with the +1 codon, which is next in line to enter the A site. Through molecular dynamic simulations, we investigated the codon sequ...

The interaction between a deflected car tyre and a road surface was modelled under normal and overloaded conditions. The model incorporates the detailed geometry of the car wheel, including a metallic rim reinforcement, a hyper-elastic composite tyre...

The ribosome CAR interaction surface is hypothesized to provide a layer of translation regulation through hydrogen-bonding to the +1 mRNA codon that is next to enter the ribosome A site during translocation. The CAR surface consists of three residues...

Chimeric antigen receptor (CAR) gene-modified T cells (CAR T cells) can eradicate B cell malignancies via recognition of surface-expressed B lineage antigens. Antigen escape remains a major mechanism of relapse and is a key barrier for expanding the...

Megakaryocytes (MKs) release platelets into the lumen of bone marrow (BM) sinusoids while remaining to reside within the BM. The morphogenetic events of this complex process are still not fully understood. We combined confocal laser scanning microsco...

This study was inspired by the unique multi-scale and multi-level ‘brick-and-mortar’ (B&M) structure of nacre layers. We prepared the B&M, environmentally-friendly graphene oxide-carrageenan (GO-Car) nanocomposite films using the following st...

With the rapid advancement of autonomous vehicles, a transformative transportation paradigm is emerging in the automotive industry, necessitating a re-evaluation of how users engage with and utilize these evolving settings. This research paper introd...

The risk of trains being hit by tornadoes in China continues to increase due to the increasing density of railway lines and the shortening of the train departure intervals and the increasing probability of extreme weather phenomena caused by global c...

This paper presents a study on the flow dynamics involving vehicle interactions. In order to do so, this study first explores aerodynamic prediction capabilities of popular turbulence models used in computational fluid dynamics simulations involving...

Chimeric Antigen Receptor T (CAR-T) cell therapy has dramatically changed prognosis and treatment of relapsed and refractory hematologic malignancies. Currently the 6 FDA approved products target various surface antigens. While CAR-T therapy achieves...

Mesoporous carriers have been extensively applied to improve the dissolution velocity and bioavailability of insoluble drugs. The goal of this work was to compare the drug-loading efficiency (LE) and drug-dissolution properties of mesoporous silica n...

Sensors and actuators are fundamental units in Cyber–Physical and Internet of Things systems. Because they are included in a variety of systems, using many technologies, it is very useful to characterize their functions abstractly by describing...

Decades of evidence suggest that alterations in the adhesion properties of neoplastic cells endow them with an invasive and migratory phenotype. Tight junctions (TJs) are present in endothelial and epithelial cells. Tumors arise from such tissues, th...

The development of the automotive sector and the increasing number of vehicles all over the world poses multiple threats to the environment. One of them, probably not so emphasized as others, is the enormous amount of post-consumer car tires. Due to...

Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising treatment strategy, however, therapeutic success against solid tumors such as neuroblastoma remains modest. Recurrence of antigen-poor tumor variants often ultimately results i...

Wheels and wheel houses contribute up to 25% of the total aerodynamic drag of passenger cars and interact in a complex way with their surroundings. Rims and tires induce complex flow separation mechanisms in a highly unsteady regime and the proximity...

A longstanding challenge is to understand how ribosomes parse mRNA open reading frames (ORFs). Significantly, GCN codons are over-represented in the initial codons of ORFs of prokaryote and eukaryote mRNAs. We describe a ribosome rRNA-protein surface...

Natural killer (NK) cells are crucial components of innate immunity, known for their potent tumor surveillance abilities. Chimeric antigen receptors (CARs) have shown promise in cancer targeting, but optimizing CAR designs for NK cell functionality r...

For complex systems, it is not easy to obtain optimal designs for the hardware architecture and control configurations. Every design aspect influences the final performance, and often the interactions of the different components cannot be clearly det...

This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural biology, biophysics, cells, and tissues imaging towards development of various medical diagnostic tools, drug design, and other medical applications. Classica...

The most important task of the tire is to ensure driving safety by optimally transmitting the required longitudinal and lateral driving forces. Although great progress has been made in the past in the development of new materials and patterns, many q...

This paper presents a novel work for classification of road surfaces using deep learning method-based convolutional neural network (CNN) architecture. With the development of advanced driver assistance system (ADAS) and autonomous driving technologie...

This paper presents a comprehensive study on the vibration-based wear evolution characterisation by coupling the dynamic behaviour, surface roughness, and lubrication effects under rolling-sliding contact. Initially, a dynamic model is developed to e...

The injection of CO₂ into coal reservoirs occurs in its supercritical state (ScCO₂), which significantly alters the pore structure and chemical composition of coal, thereby influencing the adsorption and diffusion behavior of methane (CH₄). Understan...

The precision guiding of endogenous or adoptively transferred lymphocytes to the solid tumour mass is obligatory for optimal anti-tumour effects and will improve patient safety. The recognition and elimination of the tumour is best achieved when anti...

On the basis of road tests, the authors assessed the feasibility of the vehicle body acceleration values for the purposes of assessing road surface characteristics in terms of its roughness. Short-term Fourier Transform (STFT) was used for the analys...

Prototyping during the early design phases has become an essential part of conceptualization and product development. Recent advances in digital design tools have enabled active user participation in the design process and direct interaction with pro...

The issue of movement stability remains highly relevant considering increasing vehicle speeds. The evaluation of vehicle stability parameters and the modeling of specific movement modes is a complex task, as no universal evaluation criteria have been...

An optimized driving comfort with a low interior noise level is an important intention in the passenger car development process. The interior noise level caused by the dynamic interaction between the rolling tyre and the rough road surface and transm...

Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to...

Tan spot disease, caused by Pyrenophora tritici-repentis, poses a significant threat to wheat production worldwide. Early detection and precise fungicide application are essential for effective disease management. This study explores the potential of...

A new robot-to-robot communication system is designed for operation in the middle of highways/roads to support mobile safety of approaching vehicles. Robot devices capable of directing a vehicle on a bypass route using the proposed vehicle guidance m...

Endothelial cell proliferation, migration, and intercellular interactions for blood vessel formation require coordinated signaling by a myriad of molecules. Following endothelial cell activation by growth factors and cytokines, a variety of signaling...

Exterior car-body parts are made of steel or aluminum sheets. Their formability and appearance after painting depends not only on the mechanical properties but also on their surface texture. The surface roughness characteristics, the roughness averag...

The nature of intra- and intermolecular non-covalent interactions was studied in four naphthalene derivatives commonly referred to as “proton sponges”. Special attention was paid to an intramolecular hydrogen bond present in the protonate...

Despite the introduction of novel agents such as proteasome inhibitors, immunomodulatory drugs, and autologous stem cell transplant, multiple myeloma (MM) largely remains an incurable disease. In recent years, monoclonal antibody-based treatment stra...

Galectins are a family of ß-galactoside-binding proteins that play a variety of roles in normal physiology. In cancer, their expression levels are typically elevated and often associated with poor prognosis. They are known to fuel a variety of...

This paper focuses on the modeling and analysis of a four-groove passenger car tire, size 235/55R19, using finite element analysis. The Mooney–Rivlin material model is employed to define the hyperelastic behavior of the tire rubber compounds fo...

In racing cars, a low ride height is crucial for inverted wings and ground-effect systems to function effectively, significantly enhancing aerodynamic performance but also increasing sensitivity to pitch and roll variations. However, the specific imp...

The utilization of post-consumer car tires is an essential issue from an ecological and economic point of view. One of the simplest and the least harmful methods is their material recycling resulting in ground tire rubber (GTR), which can be further...

This research paper focuses on a novel coupling of the aerodynamic and structural behaviour of a double-element composite front wing of a Formula One (F1) vehicle, which was simulated and studied for the first time here. To achieve this goal, a modif...

The urgent need for drastic reduction in emissions due to global warming demands a radical energy transition in transportation. The role of biofuels is fundamental to bridging the current situation towards a clean and sustainable future. In passenger...

One of the most frequent solid tumors in children is neuroblastoma, which has a variety of clinical behaviors that are mostly influenced by the biology of the tumor. Unique characteristics of neuroblastoma includes its early age of onset, its propens...

This work aims to offer a mathematical model for two-phase flow that investigates the interaction of Casson nanofluid and dust particles across a stretching surface. MHD Darcy–Forchheimer porous medium and Fourier’s law through Cattaneo&n...

Immunotherapy is now considered an innovative and strong strategy to beat metastatic, drug-resistant, or relapsing tumours. It is based on the manipulation of several mechanisms involved in the complex interplay between cancer cells and immune system...

The modern Internet of Autonomous Vehicles (IoVs) has enabled the development of autonomous vehicles that can interact with each other and their surroundings, facilitating real-time data exchange and communication between vehicles, infrastructure, an...

Myeloma tumor cells are particularly dependent on their microenvironment and sensitive to cellular antitumor immune response, including natural killer (NK) cells. These later are essential innate lymphocytes implicated in the control of viral infecti...

The central dogma treats the ribosome as a molecular machine that reads one mRNA codon at a time as it adds each amino acid to its growing peptide chain. However, this and previous studies suggest that ribosomes actually perceive pairs of adjacent co...

Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell–cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during...

The trajectory-tracking capability of autonomous mining trucks is critical for accomplishing transportation tasks efficiently. However, due to the diverse road surfaces and rugged terrains in open-pit mines, the existing vehicle dynamics models strug...