Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it. Researc...
The durability of C3S-C3A paste with varied C3A content (0%, 5%, 10%, and 20%) against sulfate attack at various attack ages (3 d, 7 d, 28 d, and 180 d) was investigated in this study through the examinations of corrosion product composition, Ca/Si a...
As an evolutionary ancient component of the metazoan immune defense toolkit, the complement system can modulate cells and humoral responses of both innate and (in jawed vertebrates) adaptive immunity. All the three known complement-activation pathway...
The concurrent dissolution and early hydration of tricalcium aluminate (C3A) and tetracalcium aluminoferrite (C4AF) critically govern early-stage reaction dynamics in Portland cement systems. However, their mutual kinetic interactions during reaction...
The hydration of C3A-gypsum systems was studied in the presence of various types of sulfates such as gypsum, hemihydrate and Na2SO4 in the first hour. The BET method combined with a DSC analysis enabled us to quantitatively characterize the amount of...
The Complement C3a Receptor (C3aR) plays a multifaceted role along the varying temporal phases of brain injury following cerebral ischemia. C3aR is a G-protein-coupled receptor (GPCR) that binds to its ligand, C3a an anaphylatoxin generated during ac...
The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today. Currently, t...
The complement system plays a crucial role in cancer development. Our study investigated the role of C3a anaphylatoxin on the tumor microenvironment. Our models consisted of mesenchymal stem cells (MSC-like, 3T3-L1), macrophages (Raw 264.7 Blue, (RB)...
Neuromyelitis optica spectrum disorder (NMOSD) is associated with pathological aquaporin-4 immunoglobulin G (AQP4-IgG), which cause brain damage. However, the impact of AQP4-IgG on retinal tissue remains unclear. Additionally, dysregulated complement...
The sub-clinical form of mastitis is difficult to detect and causes huge economic loss to the dairy industry. It has become a threat to public health at large, thus there is a need for definite diagnosis of the disease. Therefore, this study was unde...
This paper presents a study related to the biological degradation of a tricalcium aluminate (C3A) phase treated with reactive media from the agricultural industry. During one month of setting and hardening, synthetic C3A was subjected to corrosion in...
The complement (C) innate immune system has been shown to be activated in the tumor microenvironment of various cancers. The C may support tumor growth by modulating the immune response and promoting angiogenesis through the actions of C anaphylatoxi...
Influence of polycarboxylate superplasticizers (PCs) with different functional units on the hydration heat and hydration products of C3A-gypsum was investigated. Three kinds of PCs with different monomers were discussed. It was seen that PCs mainly s...
Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae. We pr...
Cryptosporidium parvum is an important zoonotic protozoon that threatens the health of humans and animals, but the interaction mechanisms between C. parvum and hosts are poorly understood. Our previous study indicated that the expression levels of C3...
To investigate the ion activities of cells based on light-addressable potentiometric sensor (LAPS) platform, various high-dielectric constant sensing membrane were investigated the visibility and potential issue. Three different kinds of well-proven...
SARS-CoV-2 infection may result in severe pneumonia leading to mechanical ventilation and intensive care (ICU) treatment. Complement activation was verified in COVID-19 and implicated as a contributor to COVID-19 pathogenesis. This study assessed the...
Affinity membranes have the potential to enhance the specific adsorption of toxins, however, they suffer from insufficient hemocompatibility and low therapeutic efficiency during blood detoxification therapy. Herein, we combine an affinity membrane w...
To investigate the effect of ZrC on the ablative properties of C/SiC composites in a high-temperature environment, the oxidative ablation of C/SiC and C/SiC-ZrC composites at high-temperatures was examined through ablation tests. In this study, two c...
Motivation: High-resolution Hi-C data, capable of detecting chromatin features below the level of Topologically Associating Domains (TADs), significantly enhance our understanding of gene regulation. Micro-C, a variant of Hi-C incorporating a microco...
To understand the influence of single loading time on the cyclic ablation of carbide modified C/C composites, a C/C-SiC-ZrC composite was impacted by plasma at 2600 K for 50 s under reciprocating 0.5 (C0.5) and 5 s (C5), respectively. The composites...
Chemical structures are mathematically modeled using chemical graphs. The graph invariants including algebraic polynomials and topological indices are related to the topological structure of molecules. Hosoya polynomial is a distance based algebraic...
To reveal the ablation performance of C/SiC-ZrC composites under different ablation modes, C/SiC-ZrC composites were prepared using chemical vapor deposition, precursor infiltration, and pyrolysis. Single ablation and cyclic ablation tests were condu...
Copper-catalyzed and organocopper-involved reactions are of great significance in organic synthesis. To have a deep understanding of the reaction mechanisms, the structural characterizations of organocopper intermediates become indispensable. Meanwhi...
Carnitine palmitoyltransferase (CPT) II deficiency is a long-chain fatty acid oxidation disorder. It manifests as (1) a lethal neonatal form, (2) a hypoglycemic form, or (3) a myopathic form. The second form can cause sudden infant death and is more...
The functionalization of C–H bonds has become a major thread of research in organic synthesis that can be assessed from different angles, for instance depending on the type of catalyst employed or the overall transformation that is carried out....
Background: While enteroviruses (EVs) are recognized causes of diverse illnesses, little is known about the epidemiology and molecular characteristics of uncommon enterovirus C (EV-C) types, including EV-C104, EV-C105, and EV-C109. Methods: We conduc...
In this paper, we present a new concept of the generalized core orthogonality (called the C-S orthogonality) for two generalized core invertible matrices A and B. A is said to be C-S orthogonal to B if
α(1,2)fucosyltransferase (Se enzyme) encoded by FUT2 is involved in the secretor status of ABH(O) blood group antigens. The sedel2 allele is one of the non-functional FUT2 (se) alleles in which 9.3 kb, containing the entire coding region of FUT...
NTnC-like green fluorescent genetically encoded calcium indicators (GECIs) with two calcium ion binding sites were constructed using the insertion of truncated troponin C (TnC) from Opsanus tau into green fluorescent proteins (GFPs). These GECIs are...
Continuous SiC fiber-reinforced Ti2AlNb matrix composites have a great potential for high-temperature aviation structure applications, and their properties strongly depend on the microstructure of the interfacial reaction layer. Notably, introducing...
Fulfilling the direct inert C–H bond functionalization of raw materials that are earth-abundant and commercially available for the synthesis of diverse targeted organic compounds is very desirable and its implementation would mean a great reduction o...
The reaction mechanism of the gas-phase Pt atom with C3H8 has been systematically investigated on the singlet and triplet potential energy surfaces at CCSD(T)//BPW91/6-311++G(d, p), Lanl2dz level. Pt atom prefers the attack of primary over secondary...
In this paper, we investigate
Carbon/carbon (C/C)-SiC composite materials have a series of outstanding advantages, such as a light weight, resistance to thermal degradation, excellent friction performance, and good stability in complex environments. In order to improve the wear r...
Developing a green, practical and efficient method for the formation of C–C and C–Heteroatom bonds is an important topic in modern organic synthetic chemistry. In recent years, the I2/DMSO catalytic system has attracted wide attention bec...
A ZrSi2-SiC/SiC gradient coating system was designed to reduce the thermal stress of anti-oxidation coatings for C/C composites and prolong their anti-oxidation time at a high temperature. The SiC transition layer was prepared by pack cementation and...
The fruits of Cornus mas and Cornus officinalis have been known and appreciated in folk medicine for years and have a high biological value, which is mainly connected with their polyphenols and iridoids content. However, hybrids of C. mas × C. offici...
The effect of 8 MeV proton irradiation on n-3C-SiC epitaxial layers grown by sublimation on semi-insulating 4H-SiC substrates has been studied. Changes in sample parameters were recorded using the Hall-effect method and judged from photoluminescence...
The carbon-carbon bond formation has always been one of the most important reactions in C1 resource utilization. Compared to traditional organic synthesis methods, biocatalytic C-C bond formation offers a green and potent alternative for C1 transform...
To optimize the ablation resistance of ZrC coating, ZrC-SiC dispersive biphasic coating was prepared by chemical vapor co-deposition. The ablation resistances of the coatings were carried out by oxyacetylene flame tests. Compared with double-layered...
Myocardial injury is associated with inflammation and fibrosis. Cardiac myosin-binding protein-C (cMyBP-C) is cleaved by µ-calpain upon myocardial injury, releasing C0-C1f, an N-terminal peptide of cMyBP-C. Previously, we reported that the presence o...
Tricalcium aluminate (Ca3Al2O6: C3A) is the most reactive clinker phase in Portland cement. In this study, the effect of the sequence of mixing of C3A with gypsum and water on the hydration kinetics and phase assemblage is investigated. Three mixing...
In this paper, we aimed to improve the oxidation and ablation resistance of carbon fiber-reinforced carbon (CFC) composites at temperatures above 2000 °C. C/C–SiC–ZrB2 ultra-high temperature ceramic composites were fabricated through a complicated li...
Carbon-fiber-reinforced carbon and silicon carbide (C/C-SiC) composites were prepared using chemical vapor infiltration (CVI) combined with reactive melt infiltration (RMI). The microstructure and flexural properties of C/C-SiC composites after oxida...
Carbon fiber-reinforced multi-layered pyrocarbon–silicon carbide matrix (C/C–SiC) composites are widely used in aerospace structures. The complicated spatial architecture and material heterogeneity of C/C–SiC composites constitute the challenge for t...
In situ synthesis feasibility of ZrB2-SiC-ZrC composite coatings on ZrC ceramics by reactive plasma spraying (RPS) was investigated. To help to understand the phase evolution during plasma spraying process, reaction behavior in the ZrH2-Si-B4C system...
Zirconia has recently been used as an efficient catalyst in the conversion of syngas. The crystalline phases of ZrO2 in ZrO2/HZSM-5 bi-functional catalysts have important effects on C–O activation and C–C coupling in converting syngas int...
The growth of 3C-SiC shows technological challenges, such as high supersaturation, a silicon-rich gas phase and a high vertical temperature gradient. We have developed a transfer method creating high-quality 3C-SiC-on-SiC (100) seeding stacks, suitab...
Vitamin C (L-ascorbic acid, AA) is an essential cellular antioxidant and cofactor for several α-ketoglutarate-dependent dioxygenases. As an antioxidant, AA interacts with vitamin E to control oxidative stress. While several reports suggest an i...
of 4,520