202 Results Found

Nitrogen (N) is an essential determinant of strawberry growth and productivity. However, plants exhibit varying preferences for sources of nitrogen, which ultimately affects its use efficiency. Thus, it is imperative to determine the preferred N sour...

Reducing fertilizer-N rate, applying a nitrification inhibitor (NI), and incorporating straw are widely recommended to improve N use efficiency of crops and decrease N losses. A field ¹⁵N tracer study was conducted to compare their effectiveness on f...

Global estimates show that less than half the nitrogen fertiliser inputs to agricultural soil are taken up by crops. The remaining inorganic nutrients follow several pathways, with run off into nearby waterbodies being particularly problematic, contr...

Si availability may be altered by bamboo expansion when other trees are replaced by bamboo due to the influence of plant communities on the quantity of phytoliths and Si accumulation. It has been shown that Si availability can modify nutrient-use eff...

A maize pot experiment was conducted to compare the difference of N distribution between bulk and rhizospheric soil after chemical fertilizer with or without soil straw amendment at an equivalent N rate using a ¹⁵N cross-labeling technique. Soil N po...

Simple and economical measurement of air change rates can be achieved with a passive-type tracer gas doser and sampler. However, this is made more complex by the fact many buildings are not a single fully mixed zone. This means many measurements are...

Background: Multiple techniques exist for the preoperative localization of small, deeply located solid or subsolid pulmonary nodules to guide limited thoracoscopic resection. This study aims to conduct a multi-institutional comparison of three differ...

The recent development of dedicated prostate-specific membrane antigen (PSMA) targeted radioligands shows the potential to change and improve the diagnosis and therapy of prostate cancer. There is an increasing number of prospective trials to further...

Purpose: The preclinical evaluation of 3-l- and 3-d-[¹⁸F]FPhe in comparison to [¹⁸F]FET, an established tracer for tumor imaging. Methods: In vitro studies were conducted with MCF-7, PC-3, and U87 MG human tumor cell lines. In vivo µPET studies...

In this paper, the motion of the n-vortex system as it collapses to a point in finite time is studied. The motion of vortices is described by the set of ordinary differential equations that we are able to solve analytically. The explicit formula for...

Prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals have become some of the most promising tools for the diagnosis and therapy prostate cancer (PCa). The structure of existing PSMA-targeted PET tracers still needs to be optimized...

Prostate-specific membrane antigen (PSMA) is a well-validated prostate cancer marker but reported PSMA-targeted tracers derived from the Lys-urea-Glu pharmacophore including the clinically validated [^99mTc]Tc-EDDA/HYNIC-iPSMA have high off-target upt...

This paper reports the analysis of the feasibility to characterise the air leakage and the mechanical ventilation avoiding the intrusiveness of the traditional measurement techniques of the corresponding indicators in buildings. The viability of obta...

The benefits of PET imaging of tumor hypoxia in patient management has been demonstrated in many examples and with various tracers over the last years. Although, the optimal hypoxia imaging agent has yet to be found, 2-nitroimidazole (azomycin) sugar...

Positron emission tomography is the imaging modality of choice when it comes to the high sensitivity detection of key markers of thrombosis and inflammation, such as activated platelets. We, previously, generated a fluorine-18 labelled single-chain a...

Recent advancements in PET/CT, including the emergence of long axial field-of-view (LAFOV) PET/CT scanners, have increased PET sensitivity substantially. Consequently, there has been a significant reduction in the required tracer activity, shifting t...

(1) Introduction: Near-infrared fluorescence (NIRF) combined with tumour-targeted tracers, such as bevacizumab-800CW, could aid surgical decision-making. This study explored the use of IRDye800CW, conjugated to bevacizumab, with four commercially ava...

In mammals, nitric oxide (NO) is generated either by the nitric oxide synthase (NOS) enzymes from arginine or by the reduction of nitrate to nitrite by tissue xanthine oxidoreductase (XOR) and the microbiome and further reducing nitrite to NO by XOR...

Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system of mammals and is involved in several physiological processes through NPY Y₁, Y₂, Y₄ and Y₅ receptors. Of those, the Y₂ receptor has particular relevance for its...

(1) This study compared [⁶⁸Ga]PentixaFor uptake in active arterial segments with corresponding [¹⁸F]FDG arterial uptake as well as the relationship with cardiac [⁶⁸Ga]PentixaFor uptake. (2) Method: Tracer uptake on atherosclerotic lesions in the larg...

In this study, a homogeneous fluorescence polarization immunoassay (FPIA) for the detection of hazardous aquatic toxin okadaic acid (OA) contaminating environmental waters was for the first time developed. A conjugate of the analyte with a fluorophor...

Background/Objective: Acute and chronic pain affect millions of individuals, yet there are currently no molecular imaging tools to directly assess pain-related mechanisms in the central nervous system (CNS). The voltage-gated sodium channel Na_V1.8 pl...

Background/Objectives: Small molecules that interfere with the interaction between acetylated protein tails and the tandem bromodomains of BET (bromodomain and extra-terminal) family proteins are pivotal in modulating immune/inflammatory and neoplast...

Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, and different amyloid species...

Abstract: Stable isotope tracers were first applied to evaluate the Microcystis cell assimilation efficiency of Sinanodonta bivalves, since the past identification method has been limited to tracking the changes of each chl-a, clearity, and nutrient....

Background: High physiological 16α-[¹⁸F]-fluoro-17β-estradiol ([¹⁸F]-FES) uptake in the abdomen is a limitation of this positron emission tomography (PET) tracer. Therefore, we investigated the effect of food intake prior to PET acquisitio...

Four-dimensional visualization, i.e., three-dimensional space plus time, of fluid flow and its interactions in geological materials using positron emission tomography (PET) requires suitable radiotracers that exhibit the desired physicochemical inter...

Neck management in patients with early-stage, clinically node-negative oral squamous cell carcinoma (OSCC) remains a matter of discussion. Sentinel lymph node biopsy (SLNB) represents a treatment alternative to avoid elective neck dissection (END) in...

The melanin-concentrating hormone (MCH) system is a new target for the treatment of human disorders. Since the knowledge of the MCH system's involvement in a variety of pathologies (obesity, diabetes, and deregulation of metabolic feedback mechanism)...

Compared to quinoline-based fibroblast activation protein (FAP)-targeted radiotracers, pyridine-based FAP-targeted tracers are expected to have faster pharmacokinetics due to their smaller molecular size and higher hydrophilicity, which we hypothesiz...

Background/Objectives: 18F-fluorocholine is a positron emission tomography (PET) tracer earlier found to be a marker of macrophage content in carotid plaques. We aimed to assess the feasibility of 18F-choline PET-MRI to non-invasively localize vulner...

The serum neutralization (SN) test has been regarded as the “gold standard” for seroconversion following foot-and-mouth disease virus (FMDV) vaccination, although a high-level biosafety laboratory is necessary. ELISA is one alternative, a...

The fibrillary aggregation of α-synuclein is a hallmark of Parkinson’s disease (PD) and a potential target for diagnostics and therapeutics. Although substantial effort has been devoted to the development of positron emission tomography (...

The discovery of endogenous peptide ligands for morphine binding sites occurred in parallel with the identification of three subclasses of opioid receptor (OR), traditionally designated as μ, δ, and κ, along with the more recently defi...

Background: Head and neck squamous cell carcinoma (HNSCC) is common, and its incidence is increasing, particularly in HIV-infected individuals who present with more aggressive disease. Despite aggressive treatment, the prognosis remains poor because...

Early detection and treatment of cancers can significantly increase patient prognosis and enhance the quality of life of affected patients. The emerging significance of the tumor microenvironment (TME) as a new frontier for cancer diagnosis and thera...

Sarcopenia is a multifactorial disease that limits autonomy for the growing elderly population. An optimal amount of dietary protein has shown to be important to maintain muscle mass during aging. Yet, the optimal distribution of that dietary protein...

Background/Objectives: This study evaluated a novel PET tracer, ⁶⁸Ga-NOTA-CYT-200, which targets human granzyme B (GZB) as a biomarker for cytotoxic T-cell activation in a clinically relevant model of melanoma-bearing mice with a humanized immune sys...

Barrett’s esophagus (BE) is the precursor of esophageal adenocarcinoma (EAC). Dysplastic BE (DBE) has a higher progression risk to EAC compared to non-dysplastic BE (NDBE). However, the miss rates for the endoscopic detection of DBE remain high...

Understanding soil production of the trace gas carbonyl sulfide (OCS) is key to its use as a tracer of ecosystem function. Underlying its application is the observation that vascular plants consume atmospheric OCS via their stomatal pores in proporti...

Introduction: Positron emission tomography/computer tomography (PET/CT) targeting the prostate-specific membrane antigen (PSMA) is crucial for the assessment of adequate PSMA expression in patients with metastatic castration-resistant prostate cancer...

Dysregulated metabolism is a hallmark of cancer cells and is driven in part by specific genetic alterations in various oncogenes or tumor suppressors. The retinoblastoma protein (pRb) is a tumor suppressor that canonically regulates cell cycle progre...

Tropical floodplain wetlands are found in low-lying areas that are periodically inundated. During wet periods, these wetlands can receive large amounts of suspended and dissolved material from the catchment, including many potential pollutants. In th...

Purpose: The skeletal muscle has been proposed to contribute to the progressive loss of motor neurons typical of amyotrophic lateral sclerosis (ALS). However, this mechanism has not yet been clarified due to the lack of suitable imaging tools. Here,...

To date, ¹⁴C tracer studies using accelerator mass spectrometry (AMS) have not yet resolved lipid-soluble analytes into individual lipoprotein density subclasses. The objective of this work was to develop a reliable method for lipoprotein separation...

Ammonium (NH₄⁺) toxicity impairs plant growth, but nitrate (NO₃⁻) can mitigate this effect through unresolved mechanisms. Using leaf δ¹³C values (photosynthetic capacity) and a bidirectional ¹⁵N tracer (NH₄⁺ assimilation efficiency and so...

Gliricidia (Gliricidia sepium) is a tree legume that has great potential for use in agriculture because of its multiple-use characteristics. However, there is little information in the literature about the effect of agrisilvicultural systems on nitro...

To study the processes that govern the post-depositional mobility of metals in the estuarine sediment, five sediment cores were sampled in the Krka River estuary (Croatia). The obtained concentration ranges in the pore water were 0.057–49.7 &mu...

As plastic mulching is widely used for maize production on Loess Plateau, study of the fate of fertilizer nitrogen (N) in rain-fed croplands is of great significance. Field experiments were conducted during 2015–2016 at a typical dry-land farm...

Seed treatments are frequently applied for the management of early-season pests, including seed-borne pathogens. However, to be effective against internal pathogens, the active ingredient must be able to penetrate the seed coat. Tomato seeds were the...