Imaging Inflammation in Atherosclerosis with CXCR4-Directed [68Ga]PentixaFor PET/MRI—Compared with [18F]FDG PET/MRI
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Imaging Procedures
2.3. Imaging Analysis
2.4. Statistical Analysis
3. Results
3.1. Comparison of [68Ga]PentixaFor and [18F]FDG Uptake: Lesion-Based Analysis
3.2. Comparison of [68Ga]PentixaFor and [18F]FDG Uptake: Patient-Based Analysis
3.3. Pearson Correlation between Tracer Uptake of Plaques and Myocardial CXCR4 Expression
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Patient Characteristics (n = 19) | |
Age (y) | 68 ± 10 |
Gender | 11 male/8 female |
BMI (kg/m2) | 27.1 |
Cardiovascular Risk Factors (n, %) | |
Hypertension | 4 (21%) |
Dyslipidemia | 4 (21%) |
Diabetes | 2 (11%) |
Smoking | 5 (26%) |
CRP (≥3 mg/L) | 2 (11%) |
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Lu, X.; Calabretta, R.; Wadsak, W.; Haug, A.R.; Mayerhöfer, M.; Raderer, M.; Zhang, X.; Li, J.; Hacker, M.; Li, X. Imaging Inflammation in Atherosclerosis with CXCR4-Directed [68Ga]PentixaFor PET/MRI—Compared with [18F]FDG PET/MRI. Life 2022, 12, 1039. https://doi.org/10.3390/life12071039
Lu X, Calabretta R, Wadsak W, Haug AR, Mayerhöfer M, Raderer M, Zhang X, Li J, Hacker M, Li X. Imaging Inflammation in Atherosclerosis with CXCR4-Directed [68Ga]PentixaFor PET/MRI—Compared with [18F]FDG PET/MRI. Life. 2022; 12(7):1039. https://doi.org/10.3390/life12071039
Chicago/Turabian StyleLu, Xia, Raffaella Calabretta, Wolfgang Wadsak, Alexander R. Haug, Marius Mayerhöfer, Markus Raderer, Xiaoli Zhang, Jingle Li, Marcus Hacker, and Xiang Li. 2022. "Imaging Inflammation in Atherosclerosis with CXCR4-Directed [68Ga]PentixaFor PET/MRI—Compared with [18F]FDG PET/MRI" Life 12, no. 7: 1039. https://doi.org/10.3390/life12071039