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1,697 Results Found

  • Article
  • Open Access
1 Citations
10,160 Views
16 Pages

5 June 2015

Central to the Mental Capacity Act 2005 (MCA) is the claim that a conferral of incapacity may not be based on the wisdom of a decision alone. This paper problematizes this position. Values-based medicine is drawn on to explore the process of capacity...

  • Article
  • Open Access
1 Citations
2,222 Views
13 Pages

12 December 2024

Background: This study presents a systematic approach using a natural language processing (NLP) algorithm to assess the necessity of routine imaging after central venous catheter (CVC) placement and removal. With pneumothorax being a key complication...

  • Review
  • Open Access
19 Citations
7,138 Views
11 Pages

5 November 2018

The pricing of targeted medicines continues to be a major area of contention in healthcare economics. This issue is further complicated by redefining the role of molecular testing in precision medicine. Currently, whilst pricing of clinical laborator...

  • Review
  • Open Access
66 Citations
29,231 Views
10 Pages

4 September 2017

‘Value-based’ outcomes, pricing, and reimbursement are widely discussed as health sector reforms these days. In this paper, we discuss their meaning and relationship in the context of personalized healthcare, defined as receipt of care conditional on...

  • Review
  • Open Access
5 Citations
2,185 Views
14 Pages

30 October 2024

The transformation of healthcare from a fee-for-service model to value-based care is particularly crucial in managing complex and rare diseases like sarcoma, where data fragmentation and variability present significant challenges. This manuscript rev...

  • Article
  • Open Access
400 Views
16 Pages

The Pharmaceutical Innovativeness Index: Supporting Value-Based Economic Regulation of Innovative Medicines

  • Ludmila Peres Gargano,
  • Marcus Carvalho Borin,
  • Wallace Mateus Prata,
  • Juliana Alvares-Teodoro,
  • Francisco de Assis Acurcio,
  • Roberto F. Iunes and
  • Augusto Afonso Guerra

The regulation of new medicine prices must balance financial sustainability with equitable access to innovation. Value-Based Pricing (VBP) strategies seek to align drug prices with their clinical and societal impact. The Pharmaceutical Innovativeness...

  • Viewpoint
  • Open Access
3 Citations
2,988 Views
14 Pages

Relevance and Premises of Values-Based Practice for Decision Making in Brain Health

  • Panagiotis Alexopoulos,
  • Iracema Leroi,
  • Irina Kinchin,
  • Alison J. Canty,
  • Jayashree Dasgupta,
  • Joyla A. Furlano and
  • Aline Nogueira Haas

Brain health is a complex concept, shaped by a plethora of determinants related to physical health, healthy environments, safety and security, learning and social connection, as well as access to quality healthcare services. Decision-making in this c...

  • Article
  • Open Access
17 Citations
452 Views
8 Pages

Establishing the Cost of Implementing a Performance-Based, Managed Entry Agreement for a Hypothetical CAR T-Cell Therapy

  • Panos Kefalas,
  • Omar Ali,
  • Jesper Jørgensen,
  • Nick Merryfield,
  • Tim Richardson,
  • Adam Meads,
  • Laura Mungapen and
  • Matthew Durdy

Background: Market access stakeholders consider the adoption of Managed Entry Agreements (MEAs), however a clearly described methodology to quantify their implementation burden is not available in the public domain. Objective: To quantify the cost of...

  • Article
  • Open Access
7 Citations
6,865 Views
9 Pages

The USA is steadily moving towards a health system that emphasizes ‘wellness’ over ‘sickness’ care. An effective wellness program utilizes a ‘population health’ approach that ensures that all patients who seek care from a health system receive the se...

  • Perspective
  • Open Access
12 Citations
2,722 Views
9 Pages

The Next Frontier in Sarcoma Care: Digital Health, AI, and the Quest for Precision Medicine

  • Bruno Fuchs,
  • Gabriela Studer,
  • Beata Bode-Lesniewska,
  • Philip Heesen and
  • on behalf of the Swiss Sarcoma Network

25 October 2023

The landscape of sarcoma care is on the cusp of a transformative era, spurred by the convergence of digital health and artificial intelligence (AI). This perspectives article explores the multifaceted opportunities and challenges in leveraging these...

  • Article
  • Open Access
2 Citations
2,716 Views
25 Pages

Global health systems face shortages of resources and, above all, money, with a simultaneous increase in health spending, as well as doubts about their effectiveness. In addition, there is a growing sense of greater achievement of the essential goal...

  • Review
  • Open Access
5 Citations
2,389 Views
16 Pages

Real-World-Time Data and RCT Synergy: Advancing Personalized Medicine and Sarcoma Care through Digital Innovation

  • Philip Heesen,
  • Georg Schelling,
  • Mirko Birbaumer,
  • Ruben Jäger,
  • Beata Bode,
  • Gabriela Studer and
  • Bruno Fuchs

11 July 2024

This manuscript examines the synergistic potential of prospective real-world/time data/evidence (RWTD/E) and randomized controlled trials (RCTs) to enrich healthcare research and operational insights, with a particular focus on its impact within the...

  • Article
  • Open Access
3 Citations
2,105 Views
19 Pages

Quantity and measure value transfer is widely used to examine the correlation between the quality of Chinese herbs, Chinese herbal intermediates, and Chinese patent medicines. This study performed a quantity and measure value transfer analysis to ass...

  • Article
  • Open Access
6 Citations
2,776 Views
14 Pages

Why Do Customers Want to Buy COVID-19 Medicines? Evidence from Thai Citizens

  • Long Kim,
  • Siwarit Pongsakornrungsilp,
  • Pimlapas Pongsakornrungsilp,
  • Teerasak Jindabot and
  • Vikas Kumar

Purchase intention has been acknowledged as an important factor influencing businesses’ sales performances and sustainability. Thus, finding factors that influence purchase intention is essential to all relevant businesses. Based on the current...

  • Article
  • Open Access
27 Citations
683 Views
13 Pages

Background & objectives: Despite the wide interest surrounding drug repurposing, no common terminology has been yet agreed for these products and their full potential value is not always recognised and rewarded, creating a disincentive for furthe...

  • Review
  • Open Access
17 Citations
7,823 Views
18 Pages

Commercialization Potential of Six Selected Medicinal Plants Commonly Used for Childhood Diseases in South Africa: A Review

  • Peter Tshepiso Ndhlovu,
  • Abiodun Olusola Omotayo,
  • Wilfred Otang-Mbeng and
  • Adeyemi Oladapo Aremu

24 December 2021

Globally, the potential of medicinal plants is increasingly being recognized due to their relative availability, particularly in rural areas. This review explored the ethnobotanical and economic values of six selected medicinal plants widely used to...

  • Communication
  • Open Access
2,567 Views
11 Pages

Prediction of Efficacy of Taeumjowi-Tang for Treatment of Metabolic Risk Factors Based on Machine Learning

  • Bum Ju Lee,
  • Mi Hong Yim,
  • Youngju Jeon,
  • Jun Su Jang,
  • Ji Ho So,
  • Joong Il Kim,
  • Woosu Choi,
  • Jihye Kim,
  • Jiwon Yoon and
  • Min Ji Kim
  • + 4 authors

19 September 2021

Herbal medicine is widely prescribed worldwide. To date, however, studies on the prediction of efficacy of herbal medicine based on machine learning have very rarely been reported. The objectives of this study are to predict the efficacy of Taeumjowi...

  • Article
  • Open Access
11 Citations
2,535 Views
10 Pages

1 July 2024

Drug discovery based on medicinal plants remains an important source of bioactive compounds, many of which have been the basis for new chemical structures for the pharmaceutical and food industries. According to the World Health Organization, about 8...

  • Article
  • Open Access
40 Citations
5,409 Views
11 Pages

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

  • Xiaohong Shang,
  • Ding Huang,
  • Ying Wang,
  • Liang Xiao,
  • Ruhong Ming,
  • Wendan Zeng,
  • Sheng Cao,
  • Liuying Lu,
  • Zhengdan Wu and
  • Huabing Yan

30 October 2021

Pueraria lobata and its variety P. lobata var. thomsonii are both traditional Chinese medicines that have high nutritional and medical value; whereas another variety, P. lobata var. montana has low nutritional and medicinal value and can cause ecolog...

  • Article
  • Open Access
32 Citations
10,015 Views
19 Pages

Quantitative Ethnobotanical Analysis of Medicinal Plants of High-Temperature Areas of Southern Punjab, Pakistan

  • Muhammad Usman,
  • Allah Ditta,
  • Faridah Hanum Ibrahim,
  • Ghulam Murtaza,
  • Muhammad Nawaz Rajpar,
  • Sajid Mehmood,
  • Mohd Nazre Bin Saleh,
  • Muhammad Imtiaz,
  • Seemab Akram and
  • Waseem Razzaq Khan

22 September 2021

Lack of proper infrastructure and the poor economic conditions of rural communities make them dependent on herbal medicines. Thus, there is a need to obtain and conserve the historic and traditional knowledge about the medicinal importance of differe...

  • Review
  • Open Access
7 Citations
1,938 Views
17 Pages

Pharmaceutical Pricing and Reimbursement Policies in Algeria, Morocco, and Tunisia: Comparative Analysis

  • Hajer Dahmani,
  • Ines Fradi,
  • Leila Achour,
  • Mondher Toumi and
  • Maghreb Research Group

Objectives: In this paper, we outline and compare pharmaceutical pricing and reimbursement policies for in-patent prescription medicines in three Maghreb countries, Algeria, Morocco, and Tunisia, and explore possible improvements in their pricing and...

  • Article
  • Open Access
42 Citations
13,002 Views
27 Pages

Medicinal Plants Used in the Ejisu-Juaben Municipality, Southern Ghana: An Ethnobotanical Study

  • Kwame Sarpong Appiah,
  • Clement Peprah Oppong,
  • Hossein Korrani Mardani,
  • Richard Ansong Omari,
  • Sylvia Kpabitey,
  • Christiana Adukwei Amoatey,
  • Siaw Onwona-Agyeman,
  • Yosei Oikawa,
  • Keisuke Katsura and
  • Yoshiharu Fujii

20 December 2018

Background: The in-depth traditional knowledge of medicinal plants is at risk of extinction due to the dependency on oral transmission, and as such, there is an urgent need to document such knowledge. This study aimed to document indigenous uses of m...

  • Article
  • Open Access
4 Citations
2,704 Views
13 Pages

13 March 2023

The development of Dai medicine is relatively slow, and Zanthoxylum has great economic and medicinal value. It is still difficult to obtain medicinal components from the low-polarity parts of Zanthoxylum belonging to Dai medicine. In this study, we i...

  • Article
  • Open Access
2,573 Views
13 Pages

The Effects of Medical Students’ Learning Approach and Career Values on Their Specialty Preference

  • Venkat Rao Vishnumolakala,
  • Adam H. Larson,
  • Sheila S. Qureshi,
  • Abdulrahman Al-Abdulmalek and
  • Abdulaziz Al-Thani

6 December 2024

Recent studies have identified various factors influencing how medical students choose medical specialties. An important factor that has been overlooked is learning approach. For Qatar-based medical students aspiring to train overseas, specialty pref...

  • Article
  • Open Access
15 Citations
6,620 Views
27 Pages

Indigenous trade of medicinal plants in South Africa is a multi-million-rand industry and is still highly relevant in terms of primary health care. The purpose of this study was to identify today’s most traded medicinal barks, traditionally and conte...

  • Commentary
  • Open Access
3 Citations
2,751 Views
14 Pages

27 September 2023

Child and adult obesity continue to be major health concerns in the United States and can contribute to the development of chronic diseases. Culinary medicine, which incorporates teaching kitchens and gardens, may be a useful strategy for preventing...

  • Article
  • Open Access
12 Citations
6,474 Views
19 Pages

15 November 2018

Species of the Cochlospermaceae, a small mostly pantropical plant family, were evaluated at a continental scale for medicinal uses in traditional medicine. This ethnobotanical information was placed in a phylogenetic framework to make informed predic...

  • Article
  • Open Access
6 Citations
3,921 Views
10 Pages

Evaluation of Allelopathic Potentials from Medicinal Plant Species in Phnom Kulen National Park, Cambodia by the Sandwich Method

  • Yourk Sothearith,
  • Kwame Sarpong Appiah,
  • Takashi Motobayashi,
  • Izumi Watanabe,
  • Chan Somaly,
  • Akifumi Sugiyama and
  • Yoshiharu Fujii

30 December 2020

Phnom Kulen National Park, in north-western Cambodia, has huge richness in biodiversity and medicinal value. One hundred and ninety-five (195) medicinal plant species were collected from the national park to examine allelopathic potentials by using t...

  • Article
  • Open Access
2 Citations
2,695 Views
14 Pages

A RAND/UCLA-Modified VAS Study on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine

  • Sergio Pillon,
  • Georgia Gomatou,
  • Evangelos Dimakakos,
  • Agata Stanek,
  • Zsolt Pecsvarady,
  • Matija Kozak,
  • Jean-Claude Wautrecht,
  • Katalin Farkas,
  • Gerit-Holger Schernthaner and
  • Mariella Catalano
  • + 28 authors

18 March 2024

Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicin...

  • Article
  • Open Access
6 Citations
4,624 Views
15 Pages

19 October 2017

Screening of bioactive components is important for modernization and quality control of herbal medicines, while the traditional bioassay-guided phytochemical approach is time-consuming and laborious. The presented study proposes a strategy for rapid...

  • Article
  • Open Access
10 Citations
8,321 Views
8 Pages

Low Field NMR Determination of pKa Values for Hydrophilic Drugs for Students in Medicinal Chemistry

  • Aleksandra Zivkovic,
  • Jan Josef Bandolik,
  • Alexander Jan Skerhut,
  • Christina Coesfeld,
  • Miomir Raos,
  • Nenad Zivkovic,
  • Vlastimir Nikolic and
  • Holger Stark

For an interdisciplinary approach on different topics of medicinal and analytical chemistry, we applied a known experimental pKa value determination method on the field of the bench top nuclear magnetic resonance (NMR) spectrometry of some known biol...

  • Article
  • Open Access
9 Citations
5,311 Views
17 Pages

LC-HRMS-Based Profiling: Antibacterial and Lipase Inhibitory Activities of Some Medicinal Plants for the Remedy of Obesity

  • Basanta Kumar Sapkota,
  • Karan Khadayat,
  • Babita Aryal,
  • Jyoti Bashyal,
  • Shankar Jaisi and
  • Niranjan Parajuli

8 September 2022

Globally, obesity is a serious health concern that causes numerous diseases, including type 2 diabetes, hypertension, cardiovascular diseases, etc. Medicinal plants have been used to aid in weight loss since ancient times. Thus, this research is focu...

  • Article
  • Open Access
12 Citations
5,667 Views
15 Pages

Polyploid Induction and Karyotype Analysis of Dendrobium officinale

  • Yang Liu,
  • Shan-De Duan,
  • Yin Jia,
  • Li-Hong Hao,
  • Di-Ying Xiang,
  • Duan-Fen Chen and
  • Shan-Ce Niu

Dendrobium officinale Kimura et Migo is an orchid with both medicinal and edible values and a high economic value. The wild resources of D. officinale are in an endangered state. Compared with the wild D. officinale, cultivated D. officinale exhibits...

  • Article
  • Open Access
25 Citations
17,676 Views
15 Pages

Prices, Availability and Affordability of Medicines with Value-Added Tax Exemption: A Cross-Sectional Survey in the Philippines

  • Krizzia Lambojon,
  • Jie Chang,
  • Amna Saeed,
  • Khezar Hayat,
  • Pengchao Li,
  • Minghuan Jiang,
  • Naveel Atif,
  • Gebrehaweria Kassa Desalegn,
  • Faiz Ullah Khan and
  • Yu Fang

Background: Developing countries, such as the Philippines, started implementing policies to improve access to medicines, which is a vital step toward universal healthcare coverage. This study aimed to evaluate the prices, availability and affordabili...

  • Article
  • Open Access
6 Citations
2,855 Views
11 Pages

Gender and Sex in Medical Practice: An Exploratory Study on Knowledge, Behavior, and Attitude among Sicilian Physicians

  • Giuseppina Campisi,
  • Fortunato Buttacavoli,
  • Massimo Attanasio,
  • Mirella Milioto,
  • Silvia Radosti,
  • Salvatore Amato and
  • Vera Panzarella

Personalized medicine is a new paradigm in health care, and the concept of socio-cultural gender, as opposed to biological sex, emerged in several medical approaches. This exploratory study aimed to investigate the knowledge of sex and gender in clin...

  • Commentary
  • Open Access
57 Citations
10,040 Views
5 Pages

16 October 2017

Clinical practice guidelines have been developed for many common conditions based on data from randomized controlled trials. When medicine is informed solely by clinical practice guidelines, however, the patient is not treated as an individual, but r...

  • Article
  • Open Access
26 Citations
8,726 Views
10 Pages

Standardization of Cassia spectabilis with Respect to Authenticity, Assay and Chemical Constituent Analysis

  • Angeline Torey,
  • Sreenivasan Sasidharan,
  • Chen Yeng and
  • Lachimanan Yoga Latha

10 May 2010

Quality control standardizations of the various medicinal plants used in traditional medicine is becoming more important today in view of the commercialization of formulations based on these plants. An attempt at standardization of Cassia spectabilis...

  • Article
  • Open Access
37 Citations
9,192 Views
15 Pages

Physical Properties of the Extracellular Matrix of Decellularized Porcine Liver

  • Hiroyuki Ijima,
  • Shintaro Nakamura,
  • Ronald Bual,
  • Nana Shirakigawa and
  • Shuichi Tanoue

1 May 2018

The decellularization of organs has attracted attention as a new functional methodology for regenerative medicine based on tissue engineering. In previous work we developed an L-ECM (Extracellular Matrix) as a substrate-solubilized decellularized liv...

  • Review
  • Open Access
29 Citations
25,152 Views
30 Pages

Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

  • Henry Lowe,
  • Blair Steele,
  • Joseph Bryant,
  • Emadelden Fouad,
  • Ngeh Toyang and
  • Wilfred Ngwa

25 January 2021

Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microb...

  • Review
  • Open Access
553 Views
24 Pages

Advances and Perspectives in Comprehensive Assessment of Medicinal–Ornamental Multifunctional Plants

  • Xiaowen Feng,
  • Lijie Wen,
  • Yunqing Cui,
  • Xueming Wang,
  • Ziming Ren,
  • Yihan Ye,
  • Yiping Xia and
  • Danqing Li

China is rich in medicinal–ornamental plants with multifunctional uses, making a significant contribution to global landscaping, environmental beautification, and the health industry. In the post-pandemic era, there is an increasing focus on im...

  • Review
  • Open Access
19 Citations
6,105 Views
17 Pages

Influence of Hypothermic Storage Fluids on Mesenchymal Stem Cell Stability: A Comprehensive Review and Personal Experience

  • Aneta Ścieżyńska,
  • Marta Soszyńska,
  • Patrycja Szpak,
  • Natalia Krześniak,
  • Jacek Malejczyk and
  • Ilona Kalaszczyńska

28 April 2021

Mesenchymal stem cells have generated a great deal of interest due to their potential use in regenerative medicine and tissue engineering. Examples illustrating their therapeutic value across various in vivo models are demonstrated in the literature....

  • Article
  • Open Access
5 Citations
3,244 Views
22 Pages

On Approximating the pIC50 Value of COVID-19 Medicines In Silico with Artificial Neural Networks

  • Sandi Baressi Šegota,
  • Ivan Lorencin,
  • Zoran Kovač and
  • Zlatan Car

In the case of pandemics such as COVID-19, the rapid development of medicines addressing the symptoms is necessary to alleviate the pressure on the medical system. One of the key steps in medicine evaluation is the determination of pIC50 factor, whic...

  • Review
  • Open Access
32 Citations
11,656 Views
34 Pages

Medicinal plants represent a big reservoir for discovering new drugs against all kinds of diseases including inflammation. In spite the large number of promising anti-inflammatory plant extracts and isolated components, research on medicinal plants p...

  • Article
  • Open Access
3 Citations
11,349 Views
28 Pages

An Automatic Chinese Medicine Dispensing Machine Using Shelf-Based Mechanism

  • Jin-Yuan Lin,
  • Jing-Min Lin,
  • Chin-Chuan Han,
  • Yu-Chi Wu and
  • Chao-Shu Chang

23 November 2019

Chinese medicine is a time-honored and deeply valued medical skill in the Chinese community. Although currently the scientific Chinese medicine powder is prevalent, its varieties are numerous and have similar appearance, color, and odor, resulting in...

  • Article
  • Open Access
12 Citations
8,400 Views
15 Pages

The Main Medicinal Plants in Arid Regions of Uzbekistan and Their Traditional Use in Folk Medicine

  • Ozodbek S. Abduraimov,
  • Wenjun Li,
  • Habibullo F. Shomurodov and
  • Ying Feng

15 August 2023

Seventy percent of the territory of Uzbekistan consists of arid regions. This situation is considered very favorable for plants adapted to a desert climate. Medicinal plants distributed in the arid regions of Uzbekistan have not been studied much. Me...

  • Article
  • Open Access
7 Citations
3,014 Views
11 Pages

Evaluation of a Prehospital Rotation by Senior Residents: A Web-Based Survey

  • Laurent Suppan,
  • Michèle Chan,
  • Birgit Gartner,
  • Simon Regard,
  • Mathieu Campana,
  • Ghislaine Chatellard,
  • Philippe Cottet,
  • Robert Larribau,
  • François Pierre Sarasin and
  • Marc Niquille

29 December 2020

The added value of prehospital emergency medicine is usually assessed by measuring patient-centered outcomes. Prehospital rotations might however also help senior residents acquire specific skills and knowledge. To assess the perceived added value of...

  • Article
  • Open Access
20 Citations
10,146 Views
13 Pages

Lifestyle Medicine and Economics: A Proposal for Research Priorities Informed by a Case Series of Disease Reversal

  • Kara A. Livingston,
  • Kelly J. Freeman,
  • Susan M. Friedman,
  • Ron W. Stout,
  • Liana S. Lianov,
  • David Drozek,
  • Jamie Shallow,
  • Dexter Shurney,
  • Padmaja M. Patel and
  • Thomas M. Campbell
  • + 3 authors

Chronic disease places an enormous economic burden on both individuals and the healthcare system, and existing fee-for-service models of healthcare prioritize symptom management, medications, and procedures over treating the root causes of disease th...

  • Article
  • Open Access
17 Citations
5,247 Views
13 Pages

Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts

  • Kiran Ali,
  • Arslan Ali,
  • Muhammad Noman Khan,
  • Saeedur Rahman,
  • Shaheen Faizi,
  • Muhammad Shaiq Ali,
  • Shaden A. M. Khalifa,
  • Hesham R. El-Seedi and
  • Syed Ghulam Musharraf

The discovery and identification of novel natural products of medicinal importance in the herbal medicine industry becomes a challenge. The complexity of this process can be reduced by dereplication strategies. The current study includes a method bas...

  • Article
  • Open Access
2 Citations
1,451 Views
11 Pages

Prediction of Chemical Composition and Sensory Information of Codonopsis Radix Based on Electronic Nose

  • Xingyu Guo,
  • Ruiqi Yang,
  • Yushi Wang,
  • Jiayu Wang,
  • Yashun Wang,
  • Huiqin Zou and
  • Yonghong Yan

Codonopsis Radix (CR), an important species of “medicine-food homology”, exhibits broad market prospects, underscoring the urgency and importance of research on its quality. This study specifically measured the alcohol-soluble extract and...

  • Proceeding Paper
  • Open Access
2 Citations
9,431 Views
5 Pages

Formulation Development of a Patient Friendly Dosage Form for Eye Drug Delivery: Kajal

  • Sandeep Waghulde,
  • Archana Pawar,
  • Minal Kadav,
  • Pratiksha Khade,
  • Mohan Kale,
  • Bharat Tekade,
  • Nilesh Gorde and
  • Pravin Naik

14 November 2018

Traditionally, kajal is known as kohl or surma and is used as eyeliner. Designing herbal kajal with medicinal plants as a cosmetics product is considered to bea novel, innovative technique. The main advantages of such a product are that it is patient...

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