3,855 Results Found

Mining interspecies interactions remain a challenge due to the complex nature of microbial communities and the need for computational power to handle big data. Our meta-analysis indicates that genetic potential alone does not resolve all issues invol...

With the emergence of multidrug-resistant organisms, combining medicinal plants with synthetic or orthodox medicines against resistant bacteria becomes necessary. In this study, interactions between methanolic extract of Acacia mearnsii and eight ant...

The mechanical and barrier properties of plant-based enteric polymer films were enhanced by synergistic interactions between binary gum mixtures and adding plasticizers. The results indicated that the best ratio of gellan gum (GG) and xanthan gum (XG...

The core driving force behind innovation in intelligent construction technology is synergistic relationships. It has become common practice to promote synergistic innovation through agent interaction and knowledge coupling in the development of intel...

In the current work, the synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of current preclinical research findings. The prognosis for lung cancer patients is poor, with a 5-year survival r...

Coordinating ecosystem services (ESs) and socioeconomic development is crucial for sustainability. This study examined Hebei Province, China, a representative region within the Beijing–Tianjin–Hebei area with diverse ecosystems and sharp...

Coastal areas have been increasingly affected by human activities, marine pollution and climate change are among the most important pressures affecting these environments. Human-induced pressures occur in a cumulative way and generate additive, antag...

Complex diseases such as type 2 diabetes are influenced by both environmental and genetic risk factors, leading to a growing interest in identifying gene–environment (G × E) interactions. A three-step variable selection method for single-...

This study aims to explore the feasibility of using pea protein isolate (PPI)/sodium alginate (SA) complex as a sugar substitute to develop low sugar plant fat cream. Firstly, this study analyzed the influence of SA on the structure and physicochemic...

Furfurylated wood has many advantages, such as decay resistance, dimensional stability, hardness, etc. However, furfurylation increases the brittleness and decreases the flexural resistance of wood, which greatly limits its application. Therefore, ca...

Human–machine interaction is now deeply integrated into our daily lives. However, the rigidity and high-power supply of traditional devices limit their further development. Herein, a high-performance flexible piezoelectric sensor (HFPS) based o...

Objectives: Interactions between mechanical ventilation (MV) and carbapenem interventions were investigated for the risk of Clostridium difficile infection (CDI) in critically ill patients undergoing concurrent carbapenem therapy. Methods: Taiwan’s N...

Background: In response to the urgent need for new antibiotics targeting high-priority MDR pathogens, bacteriophages (phages) have emerged as promising non-traditional antimicrobial agents. Phages are viruses that infect bacteria and induce cell lysi...

Candida auris is an emergent fungal pathogen that causes severe infectious outbreaks globally. The public health concern when dealing with this pathogen is mainly due to reduced susceptibility to current antifungal drugs. A valuable alternative to ov...

New and existing components of retaining structures are often combined in the width section. When combining the design and use requirements of the existing and new structures, the synergistic interactions between the existing and new structures and t...

Cannabidiol (CBD), a nonpsychoactive phytocannabinoid, has recently emerged as a potential cytotoxic agent in addition to its ameliorative activity in chemotherapy-associated side effects. In this work, the potential interactions of CBD with docetaxe...

The conventional endo–exo synergism model has extensively been supported in literature, which is based on the perception that endoglucanases (EGs) expose or create accessible sites on the cellulose chain to facilitate the action of processive cellobi...

In light of the significance of Food Supply Chains (FSCs) in attaining the United Nations’ 17 Sustainable Development Goals (SDGs), a greater focus on synergistic interactions between these SDGs is called for. Although there is research within this a...

Tumor heterogeneity leads to drug resistance in cancer treatment with the crucial role of sphingolipids in cell fate and stress signaling. We analyzed sphingolipid metabolism and autophagic flux to study chemotherapeutic interactions on the A549 lung...

Interactions between the novel hypomethylating agent (HMA) thio-deoxycytidine (T-dCyd) and the BCL-2 antagonist ABT-199 (venetoclax) have been examined in human myelodysplastic syndrome (MDS) cells. The cells were exposed to agents alone or in combin...

Bacterial biofilms are critical contributors to chronic infections and antimicrobial resistance. Among the diverse extracellular matrix components, extracellular DNA (eDNA) and amyloid proteins have recently emerged as pivotal structural and function...

The incidence of superficial infections, including oral candidiasis, has recently increased significantly. Their treatment is quite difficult due to the growing resistance of Candida spp. to antifungal agents. Therefore, it is necessary to search for...

Polyprenols separated from lipids are promising new components from Ginkgo biloba L. leaves (GBL). In this paper, ginkgo lipids were isolated by extraction with petroleum ether, saponification, and molecular distillation. Eight known compounds: isoph...

Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacolo...

Nonrenewable energy sources dominate global energy production, but their depletion and environmental impact pose serious challenges. The need for alternative and eco-friendly energy sources is increasingly evident. In this regard, utilizing knowledge...

Management of the common bed bug (Cimex lectularius L.) necessitates the use of multiple control techniques. In addition to synthetic pesticides and mechanical interventions, plant-derived essential oils represent one of the control options. Mixtures...

The introduction of allelopathic cover crops for green manuring or mulching is a regular practice in Integrated Weed Management. In this context, the alternative use of the abundant phytotoxic residues of allelopathic plants from the agroecosystem, e...

Tree nuts are rich in polar (phenolic compounds) and non-polar (tocols) antioxidants, with recognized effects in the prevention of diseases such as cancer. These biomolecules possess antiproliferative activity on cancer cells; however, the combined e...

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural “straight” strategy which has evolved by nature to obtain more efficacy at low c...

This study investigated the phytochemical characteristics, antibacterial activity, and synergistic potential of essential oils derived from Romanian lavender. Gas Chromatography–Mass Spectrometry (GC/MS) analysis revealed that linalool is the m...

Background: Treatment of device-related infections by drug-resistant Staphylococcus aureus can be challenging, and combination therapy has been proposed as a potential solution. We compared the effectiveness of levofloxacin–rifampin and ciprofl...

The development of novel antimicrobial peptides (AMPs) with broad-spectrum activity represents a promising strategy to overcome multidrug resistance in pathogenic bacteria. In this study, we investigated the antimicrobial activity of three designed p...

The pinewood nematode (PWN) Bursaphelenchus xylophilus is a major threat to pine forests. Research on sustainable pest management strategies is now a priority. Essential oils (EOs) are biodegradable, complex mixtures of volatiles that can show l...

Insect vector-borne diseases pose serious health problems, so there is a high demand for efficient molecules that could reduce transmission. Using molecular docking and molecular dynamics (MD) simulation, we studied a series of compounds acting on hu...

Metal oxide nanoparticle -reinforced polymers have received considerable attention due to their favorable mechanical properties compared to neat materials. However, the effect of nanoscale reinforcements of the interface on the composites’ mech...

Laurus nobilis L. (laurel, Lauraceae) and Prunus armeniaca L. (apricot, Rosaceae) are important industrial crops and display significant biological properties, including antimicrobial activity. In this work, essential oils (EOs) prepared from the lea...

To improve the gelation performance of konjac glucomannan (KGM) thermo-irreversible gel in the condition of alkaline, this study investigated the interactions between KGM and curdlan (CUD) in terms of the sol state and gelation process. The apparent...

Nutritional status performs an essential role in agriculture, affecting productivity and keeping crops functioning properly. Despite being required in smaller amounts, micronutrients are also needed for adequate growth, namely Zn (zinc) with regulato...

In recent years, drug-resistant and multidrug-resistant fungal strains have been more frequently isolated in clinical practice. This phenomenon is responsible for difficulties in the treatment of infections. Therefore, the development of new antifung...

Synergistic effects during hybrid laser-arc welding may cause increased process efficiencies. However, the basic interactions behind these effects are still being discussed, with some contradictory reports. In this study, particular welding parameter...

The aroma of an instant white tea (IWT) was extracted through simultaneous distillation–extraction (SDE) and analyzed by sensory evaluation, gas chromatography-mass spectrometry-olfactometry (GC-MS-O), aroma reconstruction, omission test and sy...

The increased incidence of mixed infections requires that the scientific community develop novel antimicrobial molecules. Essential oils and their bioactive pure compounds have been found to exhibit a wide range of remarkable biological activities an...

The elimination of thiophenic sulfides from fuel oils is essential for both environmental protection and industrial catalysis. However, conventional hydrodesulfurization encounters difficulties due to severe operating conditions and limited efficacy...

The role of the epidermal growth factor receptor (EGFR) in tumor progression and survival is often underplayed. Its expression and/or dysregulation is associated with disease advancement and poor patient outcome as well as drug resistance in breast c...

Several intrinsically disordered proteins (IDPs) are capable to adopt stable structures without interacting with a folded partner. When the folding of all interacting partners happens at the same time, coupled with the interaction in a synergistic ma...

Background: The World Health Organization (WHO) has proposed the use of integrative medicine to achieve extended healthcare coverage in developing countries facing high morbidity. Traditional remedies are frequently employed to prevent and treat infe...

Sitophilus zeamais, a major pest of stored grains, causes significant post-harvest losses and challenges effective control. While synthetic insecticides pose risks of resistance and toxicity, essential oils (EOs) offer a safer alternative. However, t...

Analgesic drugs in a combination-form can achieve greater efficacy with lesser side effects compared to either drug alone. The combination of drugs acting at different targets or mechanisms of action has been recognized as an alternative approach for...

Evidence has shown that exposure to environmental pollutants such as microcystins (MCs), arsenic (As), and cadmium (Cd) can lead to the occurrence and development of chronic kidney disease (CKD). There is a synergistic effect between MCs and Cd. Howe...

Environmental risk assessment (ERA) for pesticide approval in the context of predatory insects remains inadequate as it often overlooks the influence of agricultural practices. An increasing number of studies have shown that prolonged and synergistic...