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5,336 Results Found

  • Article
  • Open Access
12 Citations
3,063 Views
13 Pages

10 December 2022

Surface morphology and surface roughness are very important properties used to assess the quality of grind-hardening surfaces. In this study, grind-hardening tests for 42CrMo steel were designed using the response surface methodology to reveal the su...

  • Article
  • Open Access
665 Views
19 Pages

20 November 2025

This study analyzes the influence of material extrusion (MEX) 3D printing and ironing parameters on parts made of polylactic acid (PLA), such as top surface roughness and flatness. Surface ironing is one of the post-processing methods. It is an inter...

  • Article
  • Open Access
20 Citations
5,633 Views
22 Pages

Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation

  • Ilia Goemaere,
  • Deep Punj,
  • Aranit Harizaj,
  • Jessica Woolston,
  • Sofie Thys,
  • Karen Sterck,
  • Stefaan C. De Smedt,
  • Winnok H. De Vos and
  • Kevin Braeckmans

5 February 2023

Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to the application of photoporation is the optimization of several process parameters, such as laser fluence and sensitizing particle concentrat...

  • Article
  • Open Access
11 Citations
2,079 Views
13 Pages

Microparameters Calibration for Discrete Element Method Based on Gaussian Processes Response Surface Methodology

  • Zhihao Jin,
  • Weiche Chang,
  • Yuan Li,
  • Kezhong Wang,
  • Dongjue Fan and
  • Liang Zhao

10 October 2023

Microparameter calibration is an important problem that must be solved in the discrete element method. The Gaussian process (GP) response surface methodology was proposed to calibrate the microparameters based on the Bayesian principle in machine-lea...

  • Article
  • Open Access
31 Citations
6,873 Views
13 Pages

18 April 2018

Response surface methodology is used to optimize the leaching process for refractory flotation copper tailings. The proportion of the refractory combination oxide copper (chrysocolla) is 64.84%. At present, few studies have examined the leaching of...

  • Extended Abstract
  • Open Access
7 Citations
1,710 Views
2 Pages

Evaluation and Optimization of Polysaccharides and Ferulic Acid Solubility in NADES Using Surface Response Methodology

  • Carmen-Valentina Nicolae,
  • Bogdan Trică,
  • Sanda-Maria Doncea,
  • Ioana Cristina Marinaș,
  • Florin Oancea and
  • Diana Constantinescu-Aruxandei

Response surface methodology (RSM) is an experimental approach composed of statistical and
mathematical tools that aims to develop [...]

  • Article
  • Open Access
21 Citations
5,472 Views
19 Pages

Optimization of Ammonia Oxidation Using Response Surface Methodology

  • Marek Inger,
  • Agnieszka Dobrzyńska-Inger,
  • Jakub Rajewski and
  • Marcin Wilk

9 March 2019

In this paper, the design of experiments and response surface methodology were proposed to study ammonia oxidation process. The following independent variables were selected: the reactor’s load, the temperature of reaction and the number of cat...

  • Article
  • Open Access
2 Citations
2,208 Views
15 Pages

Optimization of the Pentachlorophenol Adsorption by Organo-Clays Based on Response Surface Methodology

  • Soufiane El Mahmoudi,
  • Abdellah Elmchaouri,
  • Assya El kaimech and
  • Antonio Gil

14 October 2022

The aim of this study is to optimize the adsorption of pentachlorophenol (PCP) using an organo-clay under the response surface methodology. The adsorbent was selected from a montmorillonite exchanged by various cations, such as Fe3+, Al3+, Zn2+, Mg2+...

  • Article
  • Open Access
19 Citations
10,844 Views
32 Pages

Researchers conduct experiments to discover factors influencing the experimental subjects, so the experimental design is essential. The response surface methodology (RSM) is a special experimental design used to evaluate factors significantly affecti...

  • Article
  • Open Access
2 Citations
3,758 Views
14 Pages

Optimisation of Stingless Bee Honey Nanoemulsions Using Response Surface Methodology

  • Azri Shahir Rozman,
  • Norhashila Hashim,
  • Bernard Maringgal and
  • Khalina Abdan

9 September 2021

Nanoemulsions (NEs) have been used in a wide range of products, such as those produced by the food, cosmetics, and pharmaceutical industries, due to their stability and long shelf life. In the present study, stingless bee honey (SBH) NEs were formula...

  • Article
  • Open Access
11 Citations
1,495 Views
20 Pages

11 September 2024

Many factors (material properties, drill bit type and size, drill bit wear, drilling parameters used, and machine-tool characteristics) affect the efficiency of the drilling process, which could be quantified through the delamination factor, thrust f...

  • Article
  • Open Access
3 Citations
2,644 Views
13 Pages

10 November 2022

This study describes a novel heat sink design approach employs the field synergy concept and multitarget response surface methodology (RSM). The multiobjective response surface methodology can be used to determine the simulation equations that will m...

  • Article
  • Open Access
1,538 Views
12 Pages

Modeling Conidiospore Production of Trichoderma harzianum Using Artificial Neural Networks and Response Surface Methodology

  • Maria Guadalupe Serna-Diaz,
  • Alejandro Tellez-Jurado,
  • Juan Carlos Seck-Tuoh-Mora,
  • Norberto Hernández-Romero and
  • Joselito Medina-Marin

20 June 2024

An alternative to facing plagues without affecting ecosystems is the use of biocontrols that keep crops free of harmful organisms. There are some studies showing the use of conidiospores of Trichoderma harzianum as a medium for the biological control...

  • Article
  • Open Access
5 Citations
1,753 Views
16 Pages

16 October 2023

Plywood is a wood-based composite with many applications in construction, shipbuilding, and furniture production. One of the basic plywood processing and mandatory operations is drilling. Up to now, considerable and very diverse thematic research has...

  • Article
  • Open Access
2,001 Views
26 Pages

This study investigates multi-objective optimization of end-milling parameters for AISI D2 cold-worked tool steel using GC1130-coated carbide inserts under wet machining, focusing on cutting speed and feed rate per tooth values beyond manufacturer re...

  • Article
  • Open Access
9 Citations
2,420 Views
14 Pages

17 April 2024

An investigation of the ultrasound-assisted extraction (UAE) of polyphenol-rich aqueous extracts from blackberry, chokeberry and raspberry pomaces was carried out. The aim of the study was to choose optimal conditions for UAE in order to obtain extra...

  • Article
  • Open Access
23 Citations
5,122 Views
10 Pages

Surface Hydrophobic Modification of Microcrystalline Cellulose by Poly(methylhydro)siloxane Using Response Surface Methodology

  • Yulin Xie,
  • Siquan Cai,
  • Zhen Hou,
  • Weihua Li,
  • Yan Wang,
  • Xinxiang Zhang and
  • Wenbin Yang

3 December 2018

Poly(methylhydro)siloxane (PMHS) and n-hexane were used as modifiers and solvents, respectively, to prepare surface modification of microcrystalline cellulose (MCC). The response surface methodology was used to optimize the effects of reaction condit...

  • Article
  • Open Access
25 Citations
8,201 Views
9 Pages

Optimization of Enzymatic Process for Vanillin Extraction Using Response Surface Methodology

  • Fenglin Gu,
  • Fei Xu,
  • Lehe Tan,
  • Huasong Wu,
  • Zhong Chu and
  • Qinghuang Wang

25 July 2012

Vanillin was extracted from vanilla beans using pretreatment with cellulase to produce enzymatic hydrolysis, and response surface methodology (RSM) was applied to optimize the processing parameters of this extraction. The effects of heating time, enz...

  • Article
  • Open Access
236 Views
16 Pages

21 February 2026

With the development of manufacturing towards stricter precision requirements and increasingly complex geometric shapes, dimensional accuracy has become a key factor affecting precision engineering components used in many industries. Effective coolin...

  • Article
  • Open Access
12 Citations
4,044 Views
21 Pages

Kinetics and Optimization by Response Surface Methodology of Aerobic Bioremediation. Geoelectrical Parameter Monitoring

  • Carla Maria Raffa,
  • Fulvia Chiampo,
  • Alberto Godio,
  • Andrea Vergnano,
  • Francesca Bosco and
  • Barbara Ruffino

5 January 2020

This study aimed to investigate the kinetics of an aerobic bioremediation process of diesel oil removal by indigenous microorganisms, and to define the optimal operative conditions by means of response surface methodology. This was carried out by set...

  • Article
  • Open Access
32 Citations
5,617 Views
14 Pages

8 December 2023

Response surface methodology (RSM) is one of the most effective design of experiments (DoE) methods for analyzing and optimizing experiments with limited data. However, the performance of RSM is highly dependent on the quality of the experimental dat...

  • Article
  • Open Access
9 Citations
3,775 Views
14 Pages

Medium Optimization for GA4 Production by Gibberella fujikuroi Using Response Surface Methodology

  • Bingxuan Wang,
  • Kainan Yin,
  • Choufei Wu,
  • Liang Wang,
  • Lianghong Yin and
  • Haiping Lin

Gibberellin is an important plant growth regulator that has been widely used in agricultural production with great market prospects. However, the low yield from Gibberella fujikuroi restricts its application. To improve the production of gibberellin...

  • Article
  • Open Access
6 Citations
4,542 Views
17 Pages

Selenium and Tellurium Separation: Copper Cementation Evaluation Using Response Surface Methodology

  • Seyedreza Hosseinipour,
  • Eskandar Keshavarz Alamdari and
  • Nima Sadeghi

29 October 2022

In recent years, high demands for Se and Te in the solar panels and semiconductors industry have encouraged its extraction from primary and secondary sources. However, the two elements’ similar chemical and physical properties make pure element...

  • Article
  • Open Access
8 Citations
3,893 Views
12 Pages

A Response Surface Methodology Study for Chlorella vulgaris Mixotrophic Culture Optimization

  • Sandra Milena Rincon,
  • Haluk Beyenal and
  • Hernán Mauricio Romero

Glycerol is a carbon source that produces good biomass under mixotrophic conditions. Enhancing the composition of culture media in algae biomass production improves growth rates, biomass yield, nutrient utilization efficiency, and overall cost-effect...

  • Article
  • Open Access
5 Citations
8,782 Views
11 Pages

Ecofriendly Ultrasonic Rust Removal: An Empirical Optimization Based on Response Surface Methodology

  • Lijie Zhang,
  • Bing He,
  • Shengnan Wang,
  • Guangcun Wang and
  • Xiaoming Yuan

16 September 2021

This study shows that the hard-to-remove rust layer on the guide sleeve surface of a used cylinder can be removed using a specially developed, environmentally friendly formula for cleaning rust. Furthermore, we studied the rust removal technology tha...

  • Article
  • Open Access
25 Citations
4,969 Views
16 Pages

Extraction Optimization of Mucilage from Seeds of Mimosa pudica by Response Surface Methodology

  • Syed Nasir Abbas Bukhari,
  • Arshad Ali,
  • Muhammad Ajaz Hussain,
  • Muhammad Tayyab,
  • Nasser F. Alotaibi,
  • Mervat A. Elsherif,
  • Kashaf Junaid and
  • Hasan Ejaz

6 May 2022

Mimosa pudica seed mucilage (MPM) is composed of glucuronoxylan, which is a swellable, pH-responsive and non-toxic biomaterial. Herein, we aimed to extract MPM from M. pudica seeds (MP seeds) to ascertain optimization of extraction conditions to get...

  • Feature Paper
  • Article
  • Open Access
10 Citations
2,760 Views
12 Pages

6 January 2023

In this study, the degradation of bisphenol A (BPA) by a magnetite (Fe3O4)/persulfate (PS) system was investigated. The effects of magnetite dosage, PS concentration, BPA concentration, and pH on Fe3O4-activated PS in degrading BPA were investigated...

  • Article
  • Open Access
30 Citations
8,526 Views
11 Pages

Response Surface Methodology for the Optimisation of Electrochemical Biosensors for Heavy Metals Detection

  • Giuseppe Egidio De Benedetto,
  • Sabrina Di Masi,
  • Antonio Pennetta and
  • Cosimino Malitesta

13 February 2019

Herein, we report the application of a chemometric tool for the optimisation of electrochemical biosensor performances. The experimental design was performed based on the responses of an amperometric biosensor developed for metal ions detection using...

  • Article
  • Open Access
39 Citations
6,663 Views
15 Pages

Design and Optimization of Flexible Polypyrrole/Bacterial Cellulose Conductive Nanocomposites Using Response Surface Methodology

  • Yasong Chen,
  • Fuying Wang,
  • Lipan Dong,
  • Zheng Li,
  • Li Chen,
  • Xinhai He,
  • Jixian Gong,
  • Jianfei Zhang and
  • Qiujin Li

2 June 2019

Flexible conductive materials have greatly promoted the rapid development of intelligent and wearable textiles. This article reports the design of flexible polypyrrole/bacterial cellulose (PPy/BC) conductive nanocomposites by in situ chemical polymer...

  • Article
  • Open Access
43 Citations
8,101 Views
9 Pages

13 November 2012

Response surface methodology (RSM) was employed to optimize the extracellular lipase production by Burkholderia sp. HL-10. Preliminary tests showed that olive oil, tryptone and Tween-80 exhibited significant effects on the lipase production. The opti...

  • Article
  • Open Access
7 Citations
4,183 Views
20 Pages

6 December 2021

Resistance spot welding (RSW) with inserted strips, a recent variant of traditional RSW, was usually adopted in joining thin gage steels to lower the temperature developed at the electrode surface and to extend electrode life. In order to understand...

  • Article
  • Open Access
1,732 Views
27 Pages

Optimization of the Archimedean Spiral Hydrokinetic Turbine Design Using Response Surface Methodology

  • Juan Rengifo,
  • Laura Velásquez,
  • Edwin Chica and
  • Ainhoa Rubio-Clemente

21 July 2025

This research investigates enhancing the performance of an Archimedes screw-type hydrokinetic turbine (ASHT). A 3D transient computational model employing the six degrees of freedom (6-DOF) methodology within the ANSYS Fluent software 2022 R1, was se...

  • Article
  • Open Access
25 Citations
8,714 Views
23 Pages

22 July 2020

Inventory management plays a critical role in balancing supply availability with customer requirements and significantly contributes to the performance of the whole supply chain. It involves many different features, such as controlling and managing p...

  • Article
  • Open Access
6 Citations
3,067 Views
13 Pages

Tire–Pavement Interaction Simulation Based on Finite Element Model and Response Surface Methodology

  • Qingtao Zhang,
  • Lingxiao Shangguan,
  • Tao Li,
  • Xianyong Ma,
  • Yunfei Yin and
  • Zejiao Dong

18 September 2023

Acquiring accurate tire–pavement interaction information is crucial for pavement mechanical analysis and pavement maintenance. This paper combines the tire finite element model (FEM) and response surface methodology (RSM) to obtain tire–p...

  • Article
  • Open Access
18 Citations
3,050 Views
18 Pages

30 October 2022

Aluminum alloy is the second most abundant metal on Earth, known for its wide range of utilization in commercial goods due to its heat capacity and tensile strength. This study examines the effect of nose radius on the turning process. Further, it ex...

  • Article
  • Open Access
3 Citations
2,245 Views
14 Pages

The aim of the work was to determine important parameters of the course of π-A isotherms, which can determine the HLB (hydrophilic-lipophilic balance) value of surfactant mixtures with selected structural features, such as a straight or branched h...

  • Article
  • Open Access
12 Citations
2,352 Views
16 Pages

Multiobjective Collaborative Optimization of Argon Bottom Blowing in a Ladle Furnace Using Response Surface Methodology

  • Zicheng Xin,
  • Jiankun Sun,
  • Jiangshan Zhang,
  • Bingchang He,
  • Junguo Zhang and
  • Qing Liu

26 July 2022

In order to consider both the refining efficiency of the ladle furnace (LF) and the quality of molten steel, the water model experiment is carried out. In this study, the single factor analysis, central composite design principle, response surface me...

  • Article
  • Open Access
35 Citations
6,434 Views
21 Pages

Coagulation: Determination of Key Operating Parameters by Multi-Response Surface Methodology Using Desirability Functions

  • Marina Corral Bobadilla,
  • Rubén Lostado Lorza,
  • Rubén Escribano García,
  • Fátima Somovilla Gómez and
  • Eliseo P. Vergara González

25 February 2019

The clarification process removes colloidal particles that are suspended in waste water. The efficiency of this process is influenced by a series of inputs or parameters of the coagulation process, of which the most commonly used are initial turbidit...

  • Article
  • Open Access
12 Citations
5,532 Views
20 Pages

Optimization of Sintering Parameters of 316L Stainless Steel for In-Situ Nitrogen Absorption and Surface Nitriding Using Response Surface Methodology

  • Sadaqat Ali,
  • Ahmad Majdi Abdul Rani,
  • Riaz Ahmad Mufti,
  • Syed Waqar Ahmed,
  • Zeeshan Baig,
  • Sri Hastuty,
  • Muhammad Al’Hapis Abdul Razak and
  • Abdul Azeez Abdu Aliyu

5 March 2020

This research investigates the simultaneous sintering and surface nitriding of 316L stainless steel alloy using powder metallurgy method. The influence of sintering temperature and dwell time are investigated for maximum nitrogen absorption, densific...

  • Article
  • Open Access
44 Citations
3,506 Views
22 Pages

17 February 2022

Producing high-strength self-compacting concrete (SCC) requires a low water-cement ratio (W/C). Hence, using a superplasticizer is necessary to attain the desired self-compacting properties at a fresh state. The use of low W/C results in very brittle...

  • Article
  • Open Access
3 Citations
2,159 Views
10 Pages

Kohlrabi is a valuable crop due to its substantial amount of macro- and micronutrients. It is mostly consumed in fresh form, as jam or fermented product. This current work aimed to optimize the spontaneous fermentation conditions of kohlrabi in order...

  • Article
  • Open Access
46 Citations
7,009 Views
10 Pages

16 January 2013

Response surface methodology (RSM) using a central composite design (CCD) was employed to optimize the conditions for extraction of antioxidants from black soybean (Glycine max var) sprouts. Three influencing factors: liquid-solid ratio, period of ul...

  • Article
  • Open Access
1,864 Views
13 Pages

3 August 2023

In order to reduce the production cost of the methane carbon dioxide reforming reaction, and improve its actual production efficiency, in this paper, the optimal working parameters of the methane carbon dioxide reforming reaction are studied. The inf...

  • Article
  • Open Access
8 Citations
2,634 Views
11 Pages

29 September 2022

In this paper, the response surface methodology (RSM) is used to predict the flashover voltage of a cap and pin 1512L insulator used by SONELGAZ Algerian Power Company (SPE). The pollution and conductivity are studied using a two-level central compos...

  • Article
  • Open Access
8 Citations
2,710 Views
14 Pages

2 March 2023

The characteristics of elderberries and their flowers as well as selected properties of chlorogenic acid related to phenolic compounds are described. The aim of this study was to optimize the content of chlorogenic acid in ethanol extracts of elderbe...

  • Article
  • Open Access
3 Citations
2,405 Views
18 Pages

Optimization of Composite Cavitation Nozzle Parameters Based on the Response Surface Methodology

  • Gao Huang,
  • Chengjun Qiu,
  • Mengtian Song,
  • Wei Qu,
  • Yuan Zhuang,
  • Kaixuan Chen,
  • Kaijie Huang,
  • Jiaqi Gao,
  • Jianfeng Hao and
  • Huili Hao

15 March 2024

Cavitation is typically observed when high-pressure submerged water jets are used. A composite nozzle, based on an organ pipe, can increase shear stress on the incoming flow, significantly enhancing cavitation performance by stacking Helmholtz caviti...

  • Article
  • Open Access
139 Citations
18,473 Views
12 Pages

21 May 2013

Astaxanthin is a novel carotenoid nutraceutical occurring in many crustaceans and red yeasts. It has exhibited various biological activities including prevention or amelioration of cardiovascular disease, gastric ulcer, hypertension, and diabetic nep...

  • Article
  • Open Access
2 Citations
1,104 Views
13 Pages

Optimization of Ultrasonic-Assisted Extraction of Diene Urushiol from Lacquer Tree Leaves Using Response Surface Methodology

  • Fengming Xia,
  • Haojiang He,
  • Jize Ma,
  • Yutian Jin,
  • Qing Qiao,
  • Peng Long,
  • Ping Li and
  • Rui Sun

Lacquer trees are an important economic tree species in China, and raw lacquer is its main secondary metabolite. Polyphenolic compounds are the primary components of raw lacquer, among which diene urushiol exhibits high inhibitory activity against th...

  • Article
  • Open Access
34 Citations
8,923 Views
12 Pages

Prediction of Thrust Force and Cutting Torque in Drilling Based on the Response Surface Methodology

  • Panagiotis Kyratsis,
  • Angelos P. Markopoulos,
  • Nikolaos Efkolidis,
  • Vasileios Maliagkas and
  • Konstantinos Kakoulis

In this research, experimental studies were based on drilling with solid carbide tools and the material used was Al7075. The study primarily focused on investigating the effects of machining parameters (cutting speed, feed rate, diameter of the tool)...

  • Feature Paper
  • Article
  • Open Access
34 Citations
4,188 Views
15 Pages

Optimization of Lutein Recovery from Tetraselmis suecica by Response Surface Methodology

  • Kang Hyun Lee,
  • Ye Won Jang,
  • Hansol Kim,
  • Jang-Seu Ki and
  • Hah Young Yoo

28 January 2021

Microalgae have been attracting attention as feedstock for biorefinery because they have various advantages, such as carbon fixation, high growth rate and high energy yield. The bioactive compounds and lutein contained in microalgae are known to be b...

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