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668 Results Found

  • Article
  • Open Access
3 Citations
1,899 Views
22 Pages

The dual-population differential evolution (DDE) algorithm is an optimization technique that simultaneously maintains two populations to balance global and local search. It has been demonstrated to outperform single-population differential evolution...

  • Article
  • Open Access
18 Citations
4,516 Views
41 Pages

Multi-Strategy Enhanced Crested Porcupine Optimizer: CAPCPO

  • Haijun Liu,
  • Rui Zhou,
  • Xiaoyong Zhong,
  • Yuan Yao,
  • Weifeng Shan,
  • Jing Yuan,
  • Jian Xiao,
  • Yan Ma,
  • Kunpeng Zhang and
  • Zhibin Wang

1 October 2024

Metaheuristic algorithms are widely used in engineering problems due to their high efficiency and simplicity. However, engineering challenges often involve multiple control variables, which present significant obstacles for metaheuristic algorithms....

  • Article
  • Open Access
1 Citations
1,336 Views
17 Pages

Flood Control Optimization Scheduling of Cascade Reservoirs in the Middle Reaches of the Gan River Based on ECDE Algorithm

  • Zhongzheng He,
  • Lei Cao,
  • Xiuyu Xin,
  • Bowen Wei,
  • Tianfu Wen,
  • Chao Wang,
  • Jisi Fu and
  • Bin Xiong

12 December 2024

When using a differential evolution algorithm to solve the joint flood optimization scheduling problem of cascade reservoirs, a greedy random optimization strategy is prone to premature convergence. Therefore, a new, improved Elite Conservative Diffe...

  • Article
  • Open Access
1 Citations
1,127 Views
35 Pages

To address the challenges of low optimization efficiency and premature convergence in existing algorithms for unmanned aerial vehicle (UAV) 3D path planning under complex operational constraints, this study proposes an enhanced honey badger algorithm...

  • Article
  • Open Access
8 Citations
3,588 Views
33 Pages

Differential evolution (DE) is a simple, effective, and robust algorithm, which has demonstrated excellent performance in dealing with global optimization problems. However, different search strategies are designed for different fitness landscape con...

  • Article
  • Open Access
805 Views
41 Pages

To address the insufficient global search efficiency of the original Whale Optimization Algorithm (WOA), this paper proposes an enhanced variant (ImWOA) integrating three strategies. First, a dynamic cluster center-guided search mechanism based on K-...

  • Article
  • Open Access
25 Citations
2,726 Views
30 Pages

Rural community population forecasting has important guiding significance to rural construction and development. In this study, a novel grey Bernoulli model combined with an improved Aquila Optimizer (IAO) was used to forecast rural community populat...

  • Article
  • Open Access
577 Views
47 Pages

A Multi-Strategy Improved Zebra Optimization Algorithm for AGV Path Planning

  • Cunji Zhang,
  • Chuangeng Chen,
  • Jiaqi Lu,
  • Xuan Jing and
  • Wei Liu

The Zebra Optimization Algorithm (ZOA) is a metaheuristic algorithm inspired by the collective behavior of zebras in the wild. Like many other swarm intelligence algorithms, the ZOA faces several limitations, including slow convergence, susceptibilit...

  • Article
  • Open Access
108 Views
23 Pages

11 December 2025

Multimodal optimization is characterized by the dual imperative of achieving global peak diversity and local precision enhancement for discovered solutions. An adaptive memetic differential evolution is proposed in this work based on the virtual popu...

  • Article
  • Open Access
10 Citations
3,942 Views
19 Pages

14 January 2022

To overcome the shortcomings of the harmony search algorithm, such as its slow convergence rate and poor global search ability, a reward population-based differential genetic harmony search algorithm is proposed. In this algorithm, a population is di...

  • Article
  • Open Access
3 Citations
1,856 Views
30 Pages

31 July 2023

Differential evolution (DE) is one of the most popular and widely used optimizers among the community of evolutionary computation. Despite numerous works having been conducted on the improvement of DE performance, there are still some defects, such a...

  • Article
  • Open Access
19 Citations
8,439 Views
18 Pages

Optimal Control of Heterogeneous Mutating Viruses

  • Elena Gubar,
  • Vladislav Taynitskiy and
  • Quanyan Zhu

13 December 2018

Different strains of influenza viruses spread in human populations during every epidemic season. As the size of an infected population increases, the virus can mutate itself and grow in strength. The traditional epidemic SIR model does not capture vi...

  • Article
  • Open Access
5 Citations
1,441 Views
17 Pages

The Path Planning of Mobile Robots Based on an Improved Genetic Algorithm

  • Zheng Zhang,
  • Haobo Yang,
  • Xusheng Bai,
  • Shuo Zhang and
  • Chaobin Xu

27 March 2025

In the field of mobile robot path planning, traditional genetic algorithms face issues such as slow convergence, lack of dynamic adaptability, and uncertain mutation directionality. To address these issues, a dichotomy-based multi-step method was use...

  • Article
  • Open Access
18 Citations
3,539 Views
15 Pages

30 March 2023

In real-world production processes, the same enterprise often has multiple factories or one factory has multiple production lines, and multiple objectives need to be considered in the production process. A dual-population genetic algorithm with Q-lea...

  • Review
  • Open Access
10 Citations
9,717 Views
18 Pages

20 November 2024

Background/Objectives: Antisense oligonucleotide (ASO)-mediated exon-skipping is an effective approach to restore the disrupted reading frame of the dystrophin gene for the treatment of Duchenne muscular dystrophy (DMD). Currently, four FDA-approved...

  • Article
  • Open Access
3 Citations
1,946 Views
19 Pages

Differential Evolution and Agglomerative-Clustering-Based Mutation Strategy for Complex Numerical Optimization Problems

  • Tassawar Ali,
  • Hikmat Ullah Khan,
  • Tasswar Iqbal,
  • Fawaz Khaled Alarfaj,
  • Abdullah Mohammad Alomair and
  • Naif Almusallam

20 May 2023

Differential evolution is an evolutionary algorithm that is used to solve complex numerical optimization problems. Differential evolution balances exploration and exploitation to find the best genes for the objective function. However, finding this b...

  • Review
  • Open Access
3 Citations
4,272 Views
18 Pages

Clinical Significance of Early-Onset Alzheimer’s Mutations in Asian and Western Populations: A Scoping Review

  • Prevathe Poniah,
  • Aswir Abdul Rashed,
  • Julaina Abdul Jalil and
  • Ernie Zuraida Ali

17 March 2025

Background/Objectives: Background: Early-onset Alzheimer’s disease (EOAD) is primarily inherited in an autosomal dominant pattern, with mutations in the APP, PSEN1, and PSEN2 genes being central contributors. Diagnosing Alzheimer’s poses...

  • Article
  • Open Access
1 Citations
1,564 Views
24 Pages

It Takes Two to Make a Thing Go Right: Epistasis, Two-Component Response Systems, and Bacterial Adaptation

  • Brittany R. Sanders,
  • Lauren S. Thomas,
  • Naya M. Lewis,
  • Zaria A. Ferguson,
  • Joseph L. Graves and
  • Misty D. Thomas

Understanding the interplay between genotype and fitness is a core question in evolutionary biology. Here, we address this challenge in the context of microbial adaptation to environmental stressors. This study explores the role of epistasis in bacte...

  • Article
  • Open Access
38 Citations
7,624 Views
14 Pages

Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer

  • Klara Lhotova,
  • Lenka Stolarova,
  • Petra Zemankova,
  • Michal Vocka,
  • Marketa Janatova,
  • Marianna Borecka,
  • Marta Cerna,
  • Sandra Jelinkova,
  • Jan Kral and
  • Zuzana Volkova
  • + 20 authors

13 April 2020

Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and a frequent association with breast cancer (BC). Genetic testing facilitates treatment and preventive strategies reducing OC mortality in...

  • Article
  • Open Access
15 Citations
8,500 Views
20 Pages

23 July 2015

We study evolutionary dynamics in a population of individuals engaged in pairwise social interactions, encoded as iterated games. We consider evolution within the space of memory-1strategies, and we characterize all evolutionary robust outcomes, as w...

  • Article
  • Open Access
20 Citations
3,091 Views
20 Pages

Dual-Population Adaptive Differential Evolution Algorithm L-NTADE

  • Vladimir Stanovov,
  • Shakhnaz Akhmedova and
  • Eugene Semenkin

9 December 2022

This study proposes a dual-population algorithmic scheme for differential evolution and specific mutation strategy. The first population contains the newest individuals, and is continuously updated, whereas the other keeps the top individuals through...

  • Article
  • Open Access
8 Citations
4,072 Views
15 Pages

14 December 2021

Understanding the resistance spectrum and underlying genetic mechanisms is critical for managing herbicide-resistant populations. In this study, resistance to acetyl CoA carboxylase (ACCase) and acetolactate synthase (ALS) inhibitors was investigated...

  • Article
  • Open Access
14 Citations
3,295 Views
10 Pages

Pesticide Resistance and Related Mutation Frequencies of Tetranychus urticae in Hainan, China

  • Tian Tian,
  • Mingmei Wu,
  • Yan Zhang,
  • Dandan Xu,
  • Mingyue Wu,
  • Wen Xie,
  • Qi Su and
  • Shaoli Wang

The two-spotted spider mite, Tetranychus urticae, is an important pest of horticultural crops worldwide and has developed resistance against multiple kinds of pesticides. To date, information on the resistance to pesticides is inadequate for T. urtic...

  • Article
  • Open Access
4 Citations
3,101 Views
11 Pages

27 February 2023

Goosegrass (Eleusine indica (L.) Gaertn.) is one of the most vicious weeds worldwide, competing with crops and greatly reducing their yields. Glyphosate, a non-selective, broad spectrum, post-emergence herbicide has inevitably induced severe resistan...

  • Review
  • Open Access
38 Citations
7,944 Views
18 Pages

16 March 2020

A substantial increase in yield of food crops is crucial to feeding the burgeoning global population. There is a need to introduce new breeding strategies that will accelerate the average phenotypic values of crop plants. The use of induced mutations...

  • Article
  • Open Access
455 Views
23 Pages

27 October 2025

For numerous years, researchers have extensively explored real parameter single-objective optimization by evolutionary computation. Among the various types of evolutionary algorithms, Differential Evolution (DE) performs outstandingly. Recently, the...

  • Article
  • Open Access
646 Views
32 Pages

Dynamic Heterogeneous Search-Mutation Structure-Based Equilibrium Optimizer

  • Xiangdong Wu,
  • Kaoru Hirota,
  • Yaping Dai and
  • Shuai Shao

8 May 2025

Aiming at the issues of population diversity attenuation, insufficient search efficiency, and susceptibility to a local optimum in the equilibrium optimizer (EO), a dynamic heterogeneous search-mutation structure-based equilibrium optimizer (DHSMEO)...

  • Article
  • Open Access
5 Citations
2,876 Views
20 Pages

Multi-Population Differential Evolution Algorithm with Uniform Local Search

  • Xujie Tan,
  • Seong-Yoon Shin,
  • Kwang-Seong Shin and
  • Guangxing Wang

12 August 2022

Differential evolution (DE) is a very effective stochastic optimization algorithm based on population for solving various real-world problems. The quality of solutions to these problems is mainly determined by the combination of mutation strategies a...

  • Article
  • Open Access
45 Citations
6,523 Views
20 Pages

Genetic Epidemiology and Clinical Features of Hereditary Hearing Impairment in the Taiwanese Population

  • Chen-Chi Wu,
  • Cheng-Yu Tsai,
  • Yi-Hsin Lin,
  • Pey-Yu Chen,
  • Pei-Hsuan Lin,
  • Yen-Fu Cheng,
  • Che-Ming Wu,
  • Yin-Hung Lin,
  • Chee-Yee Lee and
  • Jargalkhuu Erdenechuluun
  • + 3 authors

1 October 2019

Hereditary hearing impairment (HHI) is a common but heterogeneous clinical entity caused by mutations in a plethora of deafness genes. Research over the past few decades has shown that the genetic epidemiology of HHI varies significantly across popul...

  • Article
  • Open Access
490 Views
12 Pages

Molecular Surveillance of Pyrethroid Resistance Kdr Alleles T917I and L920F in Head and Body Lice from Nigeria

  • Joshua Kamani,
  • Shimon Harrus,
  • Bukar Laminu,
  • Yaarit Nachum-Biala,
  • Mike Shand,
  • Gonzalo Roca-Acevedo and
  • Ariel Ceferino Toloza

Pediculosis produced by the presence of the human head louse (Pediculus humanus capitis DeGeer, 1767) and the body louse (Pediculus humanus humanus L., 1758) remains a neglected tropical disease in Nigeria, where permethrin-based pediculicides are wi...

  • Article
  • Open Access
2 Citations
7,391 Views
17 Pages

14 January 2019

Mutation-generated variation in behavior is thought to promote the evolution of cooperation. Here, we study this by distinguishing two effects of mutation in evolutionary games of the finitely repeated Prisoner’s Dilemma in infinite asexual populatio...

  • Article
  • Open Access
1 Citations
1,152 Views
30 Pages

To address the drawbacks of the traditional snake optimization method, such as a random population initialization, slow convergence speed, and low accuracy, an adaptive t-distribution mixed mutation snake optimization strategy is proposed. Initially,...

  • Article
  • Open Access
1 Citations
1,826 Views
18 Pages

Path Planning for Conformal Antenna Surface Detection Based on Improved Genetic Algorithm

  • Yifan Ding,
  • Xiaodong Du,
  • Changrui Wang,
  • Wei Tian,
  • Chao Deng,
  • Ke Li and
  • Zihang Wang

20 September 2023

The conformal antenna is a precision device installed on the wing of an aircraft, and its components are distributed on a curved surface. Quality detection is required after assembly. In solving the path planning problem for conformal antenna surface...

  • Article
  • Open Access
2,653 Views
14 Pages

No Difference in the Prevalence of HIV-1 gag Cytotoxic T-Lymphocyte-Associated Escape Mutations in Viral Sequences from Early and Late Parts of the HIV-1 Subtype C Pandemic in Botswana

  • Baitshepi Mokaleng,
  • Wonderful Tatenda Choga,
  • Ontlametse Thato Bareng,
  • Dorcas Maruapula,
  • Doreen Ditshwanelo,
  • Nametso Kelentse,
  • Patrick Mokgethi,
  • Natasha Onalenna Moraka,
  • Modisa Sekhamo Motswaledi and
  • Leabaneng Tawe
  • + 4 authors

19 May 2023

HIV is known to accumulate escape mutations in the gag gene in response to the immune response from cytotoxic T lymphocytes (CTLs). These mutations can occur within an individual as well as at a population level. The population of Botswana exhibits a...

  • Article
  • Open Access
2 Citations
1,951 Views
17 Pages

Acaricide Resistance Monitoring and Structural Insights for Precision Tetranychus urticae Management

  • Said Kewedar,
  • Qi-Ren Chen,
  • Timothy W. Moural,
  • Carah Lo,
  • Elsie Umbel,
  • Peter J. Forrence,
  • Douglas B. Walsh and
  • Fang Zhu

23 April 2025

The two-spotted spider mite (Tetranychus urticae) is a highly destructive and economically significant pest in agricultural, horticultural, and ornamental agroecosystems worldwide, including hop (Humulus lupulus) and mint (Mentha spp.) fields in the...

  • Article
  • Open Access
4 Citations
1,714 Views
15 Pages

An Intelligent Cost-Reference Particle Filter with Resampling of Multi-Population Cooperation

  • Xinyu Zhang,
  • Mengjiao Ren,
  • Jiemin Duan,
  • Yingmin Yi,
  • Biyu Lei and
  • Shuyue Wu

22 July 2023

Although the cost-reference particle filter (CRPF) has a good advantage in solving the state estimation problem with unknown noise statistical characteristics, its estimation accuracy is still affected by the lack of particle diversity and sensitivit...

  • Article
  • Open Access
6 Citations
2,823 Views
17 Pages

Sequencing during Times of Change: Evaluating SARS-CoV-2 Clinical Samples during the Transition from the Delta to Omicron Wave

  • Shuchen Feng,
  • Mudassir S. Ali,
  • Monika Evdokimova,
  • Gail E. Reid,
  • Nina M. Clark,
  • Susan L. Uprichard and
  • Susan C. Baker

28 June 2022

The pandemic of SARS-CoV-2 is characterized by the emergence of new variants of concern (VOCs) that supplant previous waves of infection. Here, we describe our investigation of the lineages and host-specific mutations identified in a particularly vul...

  • Review
  • Open Access
16 Citations
6,358 Views
20 Pages

BRCA Mutations and Fertility Preservation

  • Joana Dias Nunes,
  • Isabelle Demeestere and
  • Melody Devos

22 December 2023

Hereditary cancers mostly affect the adolescent and young adult population (AYA) at reproductive age. Mutations in BReast CAncer (BRCA) genes are responsible for the majority of cases of hereditary breast and ovarian cancer. BRCA1 and BRCA2 act as tu...

  • Article
  • Open Access
1 Citations
1,917 Views
20 Pages

23 April 2024

To tackle the problem of the brain storm optimization (BSO) algorithm’s suboptimal capability for avoiding local optima, which contributes to its inadequate optimization precision, we developed a flock decision mutation approach that substantia...

  • Article
  • Open Access
11 Citations
3,919 Views
17 Pages

Genetic and Phenotypic Analysis of Phage-Resistant Mutant Fitness Triggered by Phage–Host Interactions

  • Yanze Mi,
  • Yile He,
  • Jinhui Mi,
  • Yunfei Huang,
  • Huahao Fan,
  • Lihua Song,
  • Xiaoping An,
  • Shan Xu,
  • Mengzhe Li and
  • Yigang Tong

26 October 2023

The emergence of phage-resistant bacterial strains is one of the biggest challenges for phage therapy. However, the emerging phage-resistant bacteria are often accompanied by adaptive trade-offs, which supports a therapeutic strategy called “ph...

  • Article
  • Open Access
4 Citations
1,568 Views
25 Pages

Grouping Genetic Algorithms (GGAs) are among the most outstanding methods for solving NP-hard combinatorial optimization problems by efficiently grouping sets of items. Their performance depends on problem-specific heuristics and a balance between ex...

  • Article
  • Open Access
8 Citations
3,001 Views
13 Pages

Development of Ethyl Methanesulfonate Mutant Edamame Soybean (Glycine max (L.) Merr.) Populations and Forward and Reverse Genetic Screening for Early-Flowering Mutants

  • Natsume Koshika,
  • Naohiro Shioya,
  • Takashi Fujimura,
  • Rina Oguchi,
  • Chie Ota,
  • Emi Kato,
  • Reiko Takahashi,
  • Shuichi Kimura,
  • Shinsuke Furuno and
  • Koichi Saito
  • + 3 authors

13 July 2022

Induced mutation is a viable breeding strategy that is widely utilized in the development of elite plant varieties. We aimed to improve a variety of edamame by constructing novel mutant populations using the ethyl methanesulfonate in soybeans (Glycin...

  • Article
  • Open Access
2 Citations
1,192 Views
4 Pages

New Challenges in Diagnosis of Haemoglobinopathies: Migration of Populations

  • John Old,
  • Adele Timbs,
  • Janice McCarthy,
  • Alice Gallienne,
  • Melanie Proven,
  • Michelle Rugless,
  • Herminio Lopez,
  • Jennifer Eglinton,
  • Dariusz Dziedzic and
  • Matthew Beardsall
  • + 2 authors

The current influx of economic migrants and asylum seekers from countries with a high prevalence of haemoglobinopathies creates new challenges for health care systems and diagnostic laboratories. The migration of carriers introduces new and novel hae...

  • Article
  • Open Access
2 Citations
3,572 Views
16 Pages

Influence of Ribavirin on Mumps Virus Population Diversity

  • Mirna Jurković,
  • Anamarija Slović,
  • Dubravko Forčić,
  • Jelena Ivančić-Jelečki,
  • Tanja Košutić-Gulija and
  • Maja Jagušić

17 December 2021

Frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications (e.g., aseptic meningitis or encephalitis) in patients with mumps indicate the need for the development of more efficient vaccines as well as specific...

  • Article
  • Open Access
24 Citations
4,417 Views
15 Pages

Zymoseptoria tritici (Zt) populations adapt under the selection pressure of fungicides applied for disease control. The primary objective of this study was to assess fungicide sensitivity in the Estonian Zt population. A total of 282 Zt isolates from...

  • Article
  • Open Access
1,471 Views
10 Pages

Detection of Genetic Variants in Thai Population by Trio-Based Whole-Genome Sequencing Study

  • Patcharin Boonin,
  • Sommon Klumsathian,
  • Nareenart Iemwimangsa,
  • Insee Sensorn,
  • Angkana Charoenyingwatana,
  • Wasun Chantratita and
  • Takol Chareonsirisuthigul

17 March 2025

This trio-based whole-genome sequencing (WGS) study enhances the accuracy of variant detection by leveraging parental genotypes, which facilitates the identification of de novo mutations and population-specific variants. Nonetheless, the comprehensiv...

  • Article
  • Open Access
3,339 Views
17 Pages

24 August 2025

Hearing loss is often caused by genetic and environmental factors, with inherited mutations responsible for 50–60% of cases. The GJB2 gene, encoding connexin 26, is a major contributor to nonsyndromic sensorineural hearing loss (NSHL) due to it...

  • Article
  • Open Access
5 Citations
2,746 Views
21 Pages

An Improved Gray Wolf Optimization Algorithm with a Novel Initialization Method for Community Detection

  • Yan Kang,
  • Zhongming Xu,
  • Haining Wang,
  • Yanchong Yuan,
  • Xuekun Yang and
  • Kang Pu

15 October 2022

Community discovery (CD) under complex networks is a hot discussion issue in network science research. Recently, many evolutionary methods have been introduced to detect communities of networks. However, evolutionary optimization-based community disc...

  • Review
  • Open Access
22 Citations
5,417 Views
16 Pages

16 January 2020

Soft tissue sarcoma (STS) is a rare component of malignant diseases. STS includes various histological subtypes, and there are some important differences among the different histological subtypes regarding the mutation profile and sensitivity to anti...

  • Article
  • Open Access
6 Citations
3,558 Views
13 Pages

Metabolic Resistance and Not Voltage-Gated Sodium Channel Gene Mutation Is Associated with Pyrethroid Resistance of Aedes albopictus (Skuse, 1894) from Cambodia

  • Sébastien Marcombe,
  • Bros Doeurk,
  • Phoutmany Thammavong,
  • Tuba Veseli,
  • Christian Heafield,
  • Molly-Ann Mills,
  • Sedra Kako,
  • Marcelly Ferreira Prado,
  • Shakira Thomson and
  • Saffron Millett
  • + 15 authors

15 May 2024

(1) Background: In Cambodia, Aedes albopictus is an important vector of the dengue virus. Vector control using insecticides is a major strategy implemented in managing mosquito-borne diseases. Resistance, however, threatens to undermine the use of in...

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