Networks of droplets, in which aqueous compartments are separated by lipid bilayers, have shown great potential as a model for biological transmembrane communication. We present a microfluidic system which allows for on-demand generation of droplets...
Collagen type I has become a practical cornerstone for constructing biologically meaningful barrier interfaces in microfluidic systems. Its fibrillar architecture, native ligand display, and susceptibility to cell-mediated remodeling support epitheli...
Regeneration of the osteochondral interface is essential for effective articular cartilage repair and the prevention of graft delamination. In this study, we developed a microfluidic culture device for the spatial regulation of mesenchymal stem cell...
This work characterizes the orientation behavior of nematic liquid crystals in pressure-driven flows of microfluidic channels at interfaces between the flow and microchannel walls. The impact of flow velocity and microchannel geometry on the orientat...
Nowadays, researchers are focusing on sorting, characterizing and detecting micron or submicron particles or bacteria in microfluidic chips. However, some contradictions hinder the applications of conventional microfluidic chips, including the low wo...
Reliable world-to-chip connections remain a critical challenge in PDMS-based microfluidic devices, particularly under high-pressure flow conditions. In this work, we present a simple, low-cost, and reproducible method to directly mold male Luer cone...
As the range of applications of organs-on-chips is broadening, the evaluation of aerosol-based therapies using a lung-on-a-chip model has become an attractive approach. Inhalation therapies are not only minimally invasive but also provide optimal pha...
The investigation of clandestine laboratories poses serious hazards for first responders, emergency services, investigators and the surrounding public due to the risk of exposure to volatile organic compounds (VOCs) used in the manufacture of illicit...
Assembled water-in-oil droplets bounded by lipid bilayers are used in synthetic biology as minimal models of cell tissue. Microfluidic devices successfully generate monodispersed droplets and assemble them via droplet interface bilayesr (DIB) formati...
Chemosensory protein based olfactory biosensors are expected to play a significant role in next-generation volatile organic compound (VOC) detection systems due to their ultra-high sensitivity and selectivity. As these biosensors can perform most eff...
Microfluidics is a technique that uses channels of tiny sizes to process small amounts of fluid, which can be used in biochemical detection, information technology, and other fields. In the process of microfluidic development, there are many problems...
A digital microfluidic modular interface (chip-to-chip interface) which possesses an electrode with an orifice to vertically transport core–shell droplets is presented. The electrodes were geometrically designed to promote droplet deformation and sus...
World-to-chip interfacing remains a critical issue for microfluidic devices. Current solutions to connect tubing to rigid microfluidic chips remain expensive, laborious, or require specialized skills and precision machining. Here, we report reusable,...
Sweat analysis represents an emerging non-invasive approach for health monitoring, yet its practical application is hindered by challenges such as insufficient natural sweat secretion and inefficient collection. To overcome these limitations, this st...
This review presents a series of measurements of the surface and interfacial tensions we have been able to make using the micropipette technique. These include: equilibrium tensions at the air-water surface and oil-water interface, as well as equilib...
The microvasculature is the primary conduit through which the human body transmits oxygen, nutrients, and other biological information to its peripheral tissues. It does this through bidirectional communication between the blood, consisting of plasma...
Intracortical neural probes are both a powerful tool in basic neuroscience studies of brain function and a critical component of brain computer interfaces (BCIs) designed to restore function to paralyzed patients. Intracortical neural probes can be u...
Additive manufacturing (AM) enables the fabrication of complex three-dimensional architectures, yet the performance of many printed components is ultimately governed by their surfaces and interfaces. Functional coatings and surface-engineering strate...
Practical gas–liquid interfacing is paramount in microfluidic technology, particularly in developing microfluidic gas sensors. We have created an easily replicable membrane-based closed microfluidic platform (MB-MP) to achieve in situ gas&ndash...
This paper reports a transwell insert-embedded microfluidic device capable of culturing cells at an air-liquid interface (ALI), mimicking the in vivo alveolar epithelium microenvironment. Integration of a commercially available transwell insert makes...
Pressure is one basic parameter involved in microfluidic systems. In this study, we developed an easy capillary-based method for measuring fluid pressure at one or multiple locations in a microchannel. The principal component is a commonly used capil...
Blood flows in microcirculation are determined by the mechanical properties of blood samples, which have been used to screen the status or progress of diseases. To achieve this, it is necessary to measure the viscoelasticity of blood samples under a...
This work presents a sustainable and rapid method for halogenated pesticide analysis without chromatographic separation. The system is composed of a microfluidic open interface (MOI) for solid-phase microextraction (SPME) liquid phase desorption, con...
Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fe...
On-chip microfluidics are advanced in vitro models that simulate lung tissue’s native 3D environment more closely than static 2D models to investigate the complex lung architecture and multifactorial processes that lead to pulmonary disease. Cu...
Filling of liquid samples is realized in a microfluidic device with applications including analytical systems, biomedical devices, and systems for fundamental research. The filling of a disk-shaped polydimethylsiloxane (PDMS) microchamber by liquid i...
The modular-based multi-organ-on-a-chip enables more stable and flexible configuration to better mimic the complex biological phenomena for versatile biomedical applications. However, the existing magnetic-based interconnection modes are mainly reali...
Digital microfluidics (DMF) platforms are automated sample-processing platforms that can electrically manipulate nanoliter-to-microliter-scale droplets to perform various droplet operations, such as transport, merging, splitting, and mixing. However,...
The defined formation and expansion of droplets are essential operations for droplet-based screening assays. The volumetric expansion of droplets causes a dilution of the ingredients. Dilution is required for the generation of concentration graduatio...
Air compliance has been used effectively to stabilize fluidic instability resulting from a syringe pump. It has also been employed to measure blood viscosity under constant shearing flows. However, due to a longer time delay, it is difficult to quant...
This work examines a type of rapid pore-filling event in multiphase flow through permeable media that is better known as Haines Jump. While existing microfluidic experiments on Haines Jump mostly seek to maintain quasi-steady states through very low...
This work describes the interfacing of electrowetting-on-dielectric based digital microfluidic (DMF) sample preparation devices with ambient mass spectrometry (MS) via desorption atmospheric pressure photoionization (DAPPI). The DMF droplet manipulat...
This study reports double-stacked planar bilayer lipid membranes (pBLMs) formed using a droplet contact method (DCM) for microfluidic formation with five-layered microchannels that have four micro guide pillars. pBLMs are valuable for analyzing membr...
A coaxial flow focusing PDMS (polydimethylsiloxane) microfluidic device has been designed and manufactured by soft lithography in order to experimentally study a miscible inner flow. We studied a coaxially focused inner flow (formed by an aqueous flu...
Micro manufacturing is dealing with the fabrication of structures in the order of 0 [...]
Techniques to develop three-dimensional cell culture models are rapidly expanding to bridge the gap between conventional cell culture and animal models. Organoid and spheroid cultures have distinct and overlapping purposes and differ in cellular sour...
Drops contained in an immiscible liquid phase are attractive as microreactors, enabling sound statistical analysis of reactions performed on ensembles of samples in a microfluidic device. Many applications have specific requirements for the values of...
Liquid crystals (LCs) with stimuli-responsive configuration transition and optical anisotropic properties have attracted enormous interest in the development of simple and label-free biosensors. The combination of microfluidics and the LCs offers gre...
Paper-based microfluidic systems have emerged as one of the most promising technologies for developing point-of-care diagnostic platforms (POCT) for detecting and monitoring various diseases. Saliva is a non-invasive biofluid easily collected, transp...
The evolution of an interface between two immiscible liquids in a three-branch symmetric microchannel is numerically and experimentally investigated. The main goals of the paper are to correlate the numeric data with the experimental results for the...
We developed a new approach to attach particles onto a conductive layer as a working electrode (WE) in a microfluidic electrochemical cell with three electrodes. Nafion, an efficient proton transfer molecule, is used to form a thin protection layer t...
Zeta potential (ζ potential) is a significant parameter to characterize the electric property of the electric double layer (EDL), which is important at the solid–liquid interface. Non-uniform ζ potential could be developed on a chemic...
This paper presents the effect of NaCl concentration on the operation of a water-gated field effect transistor (WG-FET) that uses 16-nm-thick single crystalline silicon (Si) film. In WG-FET, electrical double layer (EDL) formed at the water/silicon i...
The present study investigates passive microdroplet generation in a T-junction microchannel using microscopic observations, microscale particle image velocimetry (Micro-PIV) visualization, and lattice Boltzmann simulations. The key flow regimes, i.e....
The increasing power density of 2.5D and 3D chiplets imposes severe thermal constraints that have a direct impact on the performance and long-term reliability of high-performance computing systems. Stacked and laterally integrated dies, which generat...
The detection and analysis of cancer cell exosomes with high sensitivity and precision are pivotal for the early diagnosis and treatment strategies of prostate cancer. To this end, a microfluidic chip, equipped with a cactus-like array substrate (CAS...
Kanamycin (KanR) is a widely used antibiotic in human and veterinary medicine, as well as in food production and livestock breeding. However, its environmental residue and bioaccumulation in the food chain pose a great threat to human health. A real-...
Emulsifiers play a key role in the stabilization of foam bubbles. In food foams, biopolymers such as proteins are contributing to long-term stability through several effects such as increasing bulk viscosity and the formation of viscoelastic interfac...
Sorting and isolating specific cells from heterogeneous populations are crucial for many biomedical applications, including drug discovery and medical diagnostics. Conventional methods such as Fluorescent Activated Cell Sorting (FACS) and Magnetic Ac...
This review is focused on molecular momentum transport at fluid-solid interfaces mainly related to microfluidics and nanofluidics in micro-/nano-electro-mechanical systems (MEMS/NEMS). This broad subject covers molecular dynamics behaviors, boundary...
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