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Open AccessArticle

Reusable Standardized Universal Interface Module (RSUIM) for Generic Organ-on-a-Chip Applications

by Qiyue Sun 1,2,3, Jianghua Pei 1,2,3, Qinyu Li 1,2,3, Kai Niu 1,2,3 and Xiaolin Wang 1,2,3,4,*
1
Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
2
National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
3
Key Laboratory of Thin Film and Microfabrication Technology (Ministry of Education), Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
4
Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(12), 849; https://doi.org/10.3390/mi10120849
Received: 11 November 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Lab-on-a-Chip)
The modular-based multi-organ-on-a-chip enables more stable and flexible configuration to better mimic the complex biological phenomena for versatile biomedical applications. However, the existing magnetic-based interconnection modes are mainly realized by directly embedding and/or fixing magnets into the modular microfluidic devices for single use only, which will inevitably increase the complexity and cost during the manufacturing process. Here, we present a novel design of a reusable standardized universal interface module (RSUIM), which is highly suitable for generic organ-on-chip applications and their integration into multi-organ systems. Both pasting-based and clamping-based interconnection modes are developed in a plug-and-play manner without fluidic leakage. Furthermore, due to the flexibility of the modular design, it is simple to integrate multiple assembled modular devices through parallel configuration into a high throughput platform. To test its effectiveness, experiments on the construction of both the microvascular network and vascularized tumor model are performed by using the integration of the generic vascularized organ-on-a-chip module and pasting-based RSUIM, and their quantitative analysis results on the reproducibility and anti-cancer drug screening validation are further performed. We believe that this RSUIM design will become a standard and critical accessory for a broad range of organ-on-a-chip applications and is easy for commercialization with low cost. View Full-Text
Keywords: microfluidics; vascularization; organ-on-a-chip; tissue engineering; interface module microfluidics; vascularization; organ-on-a-chip; tissue engineering; interface module
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MDPI and ACS Style

Sun, Q.; Pei, J.; Li, Q.; Niu, K.; Wang, X. Reusable Standardized Universal Interface Module (RSUIM) for Generic Organ-on-a-Chip Applications. Micromachines 2019, 10, 849.

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