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67 Results Found

  • Review
  • Open Access
29 Citations
4,881 Views
18 Pages

Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

  • Jack Junchi Xu,
  • Mikkel Taudorf,
  • Peter Sommer Ulriksen,
  • Michael Patrick Achiam and ,
  • Timothy Andrew Resch,
  • Michael Bachmann Nielsen,
  • Lars Birger Lönn and
  • Kristoffer Lindskov Hansen
  • + 3 authors+ 0 author

13 October 2020

Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointe...

(This article belongs to the Special Issue New Trends in Vascular Imaging)
  • Article
  • Open Access
4 Citations
3,631 Views
14 Pages

2 May 2024

The aim of this study is to determine the total iodine content in Korean abalone (Haliotis discus hannai) and to investigate the bioavailability of iodine using an in vitro method. This research paper focuses on total iodine quantification in abalone...

(This article belongs to the Section Food Analytical Methods)
  • Article
  • Open Access
2 Citations
2,758 Views
13 Pages

Artificial Intelligence-Assisted Lung Perfusion Quantification from Spectral CT Iodine Map in Pulmonary Embolism

  • Reza Piri,
  • Parisa Seyedhosseini,
  • Samir Jawad,
  • Emilie Sonne-Holm and ,
  • Camilla Stedstrup Mosgaard,
  • Ekim Seven,
  • Kristian Eskesen,
  • Ole Peter Kristiansen,
  • Søren Fanø and
  • Peter Sommer Ulriksen
  • + 11 authors+ 6 authors

Introduction: This study evaluated the performance of automated dual-energy computed tomography (DECT)-based quantification of perfusion defects (PDs) in acute pulmonary embolism and examined its correlation with clinical parameters. Methods: We retr...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
1 Citations
596 Views
23 Pages

Diagnostic Value and Operational Recommendations for Late Iodine Enhancement and ECV Quantification in Single-Energy Computed Tomography: A Narrative Review

  • Simone Steffani,
  • Mariagrazia Piscione,
  • Dario Gaudio,
  • Giorgia Meghnagi and ,
  • Viviana Montella,
  • Francesco Fiorini,
  • Andrea Micillo,
  • Corrado Tagliati,
  • Luigi Asmundo and
  • Mario Laudazi
  • + 7 authors+ 2 authors

12 August 2026

While traditionally focused on coronary anatomy, cardiac computed tomography now enables non-invasive myocardial tissue characterization. By evaluating late iodine enhancement (LIE) and extracellular volume (ECV), single-energy CT (SECT) provides a v...

(This article belongs to the Special Issue Computed Tomography Imaging in Medical Diagnosis, Third Edition)
  • Article
  • Open Access
4 Citations
2,848 Views
10 Pages

Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography

  • Jan Borggrefe,
  • Max Philipp Gebest,
  • Myriam Hauger,
  • Daniel Ruess and ,
  • Anastasios Mpotsaris,
  • Christoph Kabbasch,
  • Lenhard Pennig,
  • Kai Roman Laukamp,
  • Lukas Goertz and
  • Jonas Doerner
  • + 6 authors+ 1 author

15 October 2022

Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective...

(This article belongs to the Special Issue Advancements in Neuroimaging)
  • Article
  • Open Access
3 Citations
2,914 Views
13 Pages

Spectral Differentiation of Hyperdense Non-Vascular and Vascular Renal Lesions Without Solid Components in Contrast-Enhanced Photon-Counting Detector CT Scans—A Pilot Study

  • Judith Becker,
  • Laura-Marie Feitelson,
  • Franka Risch,
  • Luca Canalini and ,
  • David Kaufmann,
  • Ramona Wudy,
  • Bertram Jehs,
  • Mark Haerting,
  • Claudia Wollny and
  • Stefanie Bette
  • + 9 authors+ 4 authors

Introduction: The number of incidental renal lesions identified in CT scans of the abdomen is increasing. Objective: The aim of this study was to determine whether hyperdense renal lesions without solid components in a portal venous CT scan can be cl...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
2,705 Views
11 Pages

28 October 2023

The purpose of our study is to determine a threshold for iodine quantification to distinguish definitely non-enhancing benign renal lesions from potential enhancing masses on portal venous dual-layer spectral computed tomography (CT) to reduce the ne...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Review
  • Open Access
43 Citations
10,274 Views
18 Pages

5 October 2019

Iodine intake must be boosted during pregnancy to meet the demands for increased production and placental transfer of thyroid hormone essential for optimal foetal development. Failure to meet this challenge results in irreversible brain damage, manif...

  • Article
  • Open Access
7 Citations
2,795 Views
17 Pages

Dual-Energy CT Iodine Uptake of Head and Neck: Definition of Reference Values in a Big Data Cohort

  • Ibrahim Yel,
  • Giuseppe Mauro Bucolo,
  • Scherwin Mahmoudi,
  • Vitali Koch and ,
  • Aynur Gökduman,
  • Tommaso D′Angelo,
  • Leon David Grünewald,
  • Mirela Dimitrova,
  • Katrin Eichler and
  • Christian Booz
  • + 6 authors+ 1 author

26 February 2024

Background: Despite a considerable amount of literature on dual-energy CT (DECT) iodine uptake of the head and neck, the physiologic iodine uptake of this region has not been defined yet. This study aims to establish reference values for the iodine u...

(This article belongs to the Special Issue Advances in Computed Tomography Imaging for Clinical Diagnosis)
  • Article
  • Open Access
13 Citations
3,585 Views
10 Pages

Value of Dual-Energy CT Perfusion Analysis in Patients with Acute Pancreatitis: Correlation and Discriminative Diagnostic Accuracy with Varying Disease Severity

  • Scherwin Mahmoudi,
  • Simon Martin,
  • Vitali Koch,
  • Leon David Gruenewald and ,
  • Simon Bernatz,
  • Tommaso D’Angelo,
  • Thomas J. Vogl,
  • Christian Booz and
  • Ibrahim Yel
  • + 4 authors+ 0 author

27 October 2022

Background: This study investigates the correlation and discriminative diagnostic accuracy of dual-energy CT (DECT)-derived imaging biomarkers in patients with acute pancreatitis of varying severity. Methods: In this retrospective study, we included...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
38 Citations
6,601 Views
11 Pages

Virtual Non-Contrast versus True Non-Contrast Computed Tomography: Initial Experiences with a Photon Counting Scanner Approved for Clinical Use

  • Julius Henning Niehoff,
  • Matthias Michael Woeltjen,
  • Kai Roman Laukamp,
  • Jan Borggrefe and
  • Jan Robert Kroeger

16 December 2021

The present study evaluates the diagnostic reliability of virtual non-contrast (VNC) images acquired with the first photon counting CT scanner that is approved for clinical use by comparing quantitative image properties of VNC and true non-contrast (...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
6,267 Views
8 Pages

A Method for Determining the Content of Glycoproteins in Biological Samples

  • Yang Gao,
  • Duoduo Xu,
  • Hongyue Li,
  • Xianling Yang and ,
  • Mingxing Wang and
  • Qipin Gao
  • + 1 author+ 0 author

26 November 2016

The glycoprotein purified from the mycelium extract of Tremella fuciformis was marked with iodine through the iodine substitution reaction. The content of iodine, which is indicative of the amount of the marked tremella glycoprotein (ITG), was detect...

(This article belongs to the Special Issue Natural Polysaccharides)
  • Review
  • Open Access
1,473 Views
41 Pages

Understanding Photon-Counting CT: Physics, Detector Technology, and Image Reconstructions

  • Arosh Shavinda Perera Molligoda Arachchige and
  • Fatemeh Darvizeh

2 September 2026

Photon-counting computed tomography (PCCT) represents a detector-level transformation in CT imaging. Unlike conventional energy-integrating detectors, photon-counting detectors directly convert individual X-ray interactions into electrical pulses and...

(This article belongs to the Section Optical Sensors)
  • Article
  • Open Access
11 Citations
3,307 Views
11 Pages

Detection of Incomplete Irreversible Electroporation (IRE) and Microwave Ablation (MWA) of Hepatocellular Carcinoma (HCC) Using Iodine Quantification in Dual Energy Computed Tomography (DECT)

  • Wolf Bäumler,
  • Lukas Philipp Beyer,
  • Lukas Lürken,
  • Philipp Wiggermann and ,
  • Christian Stroszczynski,
  • Marco Dollinger and
  • Andreas Schicho
  • + 2 authors+ 0 author

Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this study was to identify cases with insufficient ablation and...

(This article belongs to the Special Issue Recent Advances in Liver Diseases Diagnosis)
  • Article
  • Open Access
1 Citations
808 Views
10 Pages

Effect of Age and Sex on Normalized Automated DECT-Derived Pulmonary Iodine Concentration

  • Thomas Schömig,
  • Andrii Sabov,
  • David Zopfs,
  • Nedim Christoph Beste and ,
  • Florian J. Fintelmann,
  • Alexander Christian Bunck,
  • David Maintz,
  • Roman Johannes Gertz and
  • Nils Große Hokamp
  • + 4 authors+ 0 author

Background/Objectives: Dual-energy CT (DECT) enables iodine quantification as a snapshot perfusion indicator. Understanding pulmonary iodine distribution in lung-healthy individuals is crucial for clinical applications. This study aimed to automate i...

(This article belongs to the Special Issue Advances in Computed Tomography Imaging for Clinical Diagnosis—2nd Edition)
  • Article
  • Open Access
7 Citations
3,778 Views
13 Pages

Microfluidic Paper-Based Device Incorporated with Silica Nanoparticles for Iodide Quantification in Marine Source Dietary Supplements

  • Mafalda G. Pereira,
  • Ana Machado,
  • Andreia Leite,
  • Maria Rangel and ,
  • Adriano Bordalo,
  • António O. S. S. Rangel and
  • Raquel B. R. Mesquita
  • + 2 authors+ 0 author

5 February 2024

Iodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodin...

(This article belongs to the Special Issue Design and Application of Sensors Based on Nanomaterials in Clinical, Food and Environmental Analysis)
  • Review
  • Open Access
23 Citations
11,936 Views
30 Pages

Spectral CT: Current Liver Applications

  • Ana P. Borges,
  • Célia Antunes and
  • Filipe Caseiro-Alves

Using two different energy levels, dual-energy computed tomography (DECT) allows for material differentiation, improves image quality and iodine conspicuity, and allows researchers the opportunity to determine iodine contrast and radiation dose reduc...

(This article belongs to the Special Issue Imaging Diagnosis in Abdomen)
  • Communication
  • Open Access
2 Citations
3,453 Views
8 Pages

31 December 2025

Iodine deficiency is the leading preventable cause of neurological damage worldwide. Dairy foods represent an important dietary iodine source. This study aimed to assess iodine concentration in milk, ricotta cheese, and yogurt, and to evaluate their...

(This article belongs to the Section Milk and Human Health)
  • Article
  • Open Access
10 Citations
5,086 Views
13 Pages

HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women

  • Aniceta A. Mikulska,
  • Dorota Filipowicz,
  • Franciszek K. Główka,
  • Ewelina Szczepanek-Parulska and ,
  • Marek Ruchała,
  • Michał Bartecki and
  • Marta Karaźniewicz-Łada
  • + 2 authors+ 0 author

10 November 2021

Iodine is an essential component for fetal neurodevelopment and maternal thyroid function. Urine iodine is the most widely used indicator of iodine status. In this study, a novel validated ion-pair HPLC–UV method was developed to measure iodine conce...

(This article belongs to the Special Issue Analysis of Drugs and Biologically Active Compounds Using Chromatographic and Electromigration Techniques)
  • Article
  • Open Access
5 Citations
2,944 Views
11 Pages

Visual and Quantitative Evaluation of Low-Concentration Bismuth in Dual-Contrast Imaging of Iodine and Bismuth Using Clinical Photon-Counting CT

  • Afrouz Ataei,
  • Vasantha Vasan,
  • Todd C. Soesbe,
  • Cecelia C. Brewington and ,
  • Zhongxing Zhou,
  • Lifeng Yu,
  • Kristina A. Hallam and
  • Liqiang Ren
  • + 3 authors+ 0 author

1 June 2024

Simultaneous dual-contrast imaging of iodine and bismuth has shown promise in prior phantom and animal studies utilizing spectral CT. However, it is noted that in previous studies, Pepto-Bismol has frequently been employed as the source of bismuth, e...

(This article belongs to the Special Issue Recent Advances in X-Ray Sensing and Imaging)
  • Article
  • Open Access
7 Citations
6,810 Views
11 Pages

Differentiation of Hamartomas and Malignant Lung Tumors in Single-Phased Dual-Energy Computed Tomography

  • Moritz T. Winkelmann,
  • Sebastian Gassenmaier,
  • Sven S. Walter,
  • Christoph Artzner and ,
  • Konstantin Nikolaou and
  • Malte N. Bongers
  • + 1 author+ 0 author

11 February 2024

This study investigated the efficacy of single-phase dual-energy CT (DECT) in differentiating pulmonary hamartomas from malignant lung lesions using virtual non-contrast (VNC), iodine, and fat quantification. Forty-six patients with 47 pulmonary lesi...

(This article belongs to the Section Cancer Imaging)
  • Article
  • Open Access
31 Citations
3,631 Views
10 Pages

Iodine Map Radiomics in Breast Cancer: Prediction of Metastatic Status

  • Lukas Lenga,
  • Simon Bernatz,
  • Simon S. Martin,
  • Christian Booz and ,
  • Christine Solbach,
  • Rotraud Mulert-Ernst,
  • Thomas J. Vogl and
  • Doris Leithner
  • + 3 authors+ 0 author

18 May 2021

Dual-energy CT (DECT) iodine maps enable quantification of iodine concentrations as a marker for tissue vascularization. We investigated whether iodine map radiomic features derived from staging DECT enable prediction of breast cancer metastatic stat...

(This article belongs to the Special Issue Clinical Studies on Imaging Biomarkers)
  • Article
  • Open Access
21 Citations
4,597 Views
14 Pages

20 July 2021

Papillary thyroid cancer (PTC) and poorly differentiated thyroid cancer (PDTC) are treated with radioiodine to reduce recurrence and to treat the spread of disease. Adequate iodine accumulation in cancer tissue, iodine avidity, is important for treat...

(This article belongs to the Special Issue Molecular Alterations in Thyroid Cancer – with Special Focus on Diagnosis, Prognosis and Treatment)
  • Article
  • Open Access
6 Citations
4,190 Views
11 Pages

The sorption affinity of iodide on organo-bentonite, modified with hexadecyl pyridinium (HDPy), was investigated with the iodine–starch method coupled with UV/Vis absorption spectroscopy. The iodine–starch complex method was optimized in...

(This article belongs to the Special Issue Advanced Colorimetric and Fluorescent Sensors and Their Application in Detection)
  • Review
  • Open Access
11 Citations
5,103 Views
12 Pages

Positron Emission Tomography Radiopharmaceuticals in Differentiated Thyroid Cancer

  • Chaninart Sakulpisuti,
  • Putthiporn Charoenphun and
  • Wichana Chamroonrat

3 August 2022

Differentiated thyroid cancer (DTC), arising from thyroid follicular epithelial cells, is the most common type of thyroid cancer. Despite the well-known utilization of radioiodine treatment in DTC, i.e., iodine-131, radioiodine imaging in DTC is typi...

(This article belongs to the Special Issue Radiopharmaceuticals for PET Imaging - Issue B)
  • Article
  • Open Access
383 Views
16 Pages

24 September 2026

The simultaneous determination of bromine and iodine in biological and feed-related samples by inductively coupled plasma mass spectrometry (ICP-MS) is challenged by matrix effects, analyte carryover, and the potential loss of volatile halogen specie...

  • Article
  • Open Access
2 Citations
4,919 Views
13 Pages

Potassium iodate and potassium iodide are commonly fortified in iodized table salt, which must be continuously monitored to maintain quality. Our study reported an optimized detection method for total iodine in iodized table salt using 0.5 M sodium b...

(This article belongs to the Special Issue Green Analytical Chemistry: Current Trends and Future Developments)
  • Article
  • Open Access
9 Citations
4,335 Views
15 Pages

Development of Methods Derived from Iodine-Induced Specific Cleavage for Identification and Quantitation of DNA Phosphorothioate Modifications

  • Sucheng Zhu,
  • Tao Zheng,
  • Lingxin Kong,
  • Jinli Li and ,
  • Bo Cao,
  • Michael S. DeMott,
  • Yihua Sun,
  • Ying Chen,
  • Zixin Deng and
  • Delin You
  • + 6 authors+ 1 author

28 October 2020

DNA phosphorothioate (PT) modification is a novel modification that occurs on the DNA backbone, which refers to a non-bridging phosphate oxygen replaced by sulfur. This exclusive DNA modification widely distributes in bacteria but has not been found...

(This article belongs to the Collection DNA Repair and Immune Response)
  • Article
  • Open Access
2 Citations
2,190 Views
13 Pages

Correlation of Spectral CT-Based Iodine Concentration Parameters with LI-RADS Classification of Suspected Hepatocellular Carcinoma Nodules in Cirrhotic Patients

  • Antonio Celestino,
  • Paolo Marra,
  • Alessandro Barbaro,
  • Carlotta Gargiulo and ,
  • Riccardo Muglia,
  • Giuseppe Muscogiuri,
  • Pietro Andrea Bonaffini and
  • Sandro Sironi
  • + 3 authors+ 0 author

Background: The LI-RADS classification is widely used for the hepatocellular carcinoma (HCC) risk stratification of liver nodules in cirrhotic patients. The evaluation of nodule enhancement, which is a major criterion, commonly relies on qualitative...

(This article belongs to the Special Issue Recent Advances in Computed Tomography Imaging for Clinical Diagnosis)
  • Article
  • Open Access
36 Citations
42,981 Views
12 Pages

Optimized Spectrophotometry Method for Starch Quantification

  • Palina Bahdanovich,
  • Kevin Axelrod,
  • Andrey Y. Khlystov and
  • Vera Samburova

26 October 2022

Starch is a polysaccharide that is abundantly found in nature and is generally used as an energy source and energy storage in many biological and environmental processes. Naturally, starch tends to be in miniscule amounts, creating a necessity for qu...

(This article belongs to the Collection Analytical and Applied Chemistry: The Challenges and Opportunities for Growth in the 21st Century)
  • Article
  • Open Access
437 Views
23 Pages

Comparative Mineral Profile and Safety Assessment of Arctic Storm-Cast Macroalgae: Implications for Human Health Risk Evaluation

  • Ekaterina D. Obluchinskaya,
  • Olga N. Pozharitskaya,
  • Anna V. Daurtseva and
  • Alexander N. Shikov

24 July 2026

Storm-cast macroalgae represent a vast, underutilized biomass in the Arctic. This study evaluates the mineral composition, safety, and nutritional potential of storm-cast versus attached macroalgae from the Barents and White Seas to determine their s...

(This article belongs to the Special Issue Harnessing Microalgae and Seaweed for the Food Sector, 2nd Edition)
  • Article
  • Open Access
8 Citations
3,628 Views
11 Pages

Dual-Energy CT Material Decomposition: The Value in the Detection of Lymph Node Metastasis from Breast Cancer

  • Ibrahim Yel,
  • Tommaso D’Angelo,
  • Leon D. Gruenewald,
  • Vitali Koch and ,
  • Rejane Golbach,
  • Scherwin Mahmoudi,
  • Giorgio Ascenti,
  • Alfredo Blandino,
  • Thomas J. Vogl and
  • Giuseppe M. Bucolo
  • + 6 authors+ 1 author

21 February 2024

Purpose: To evaluate the diagnostic performance of a dual-energy computed tomography (DECT)-based material decomposition algorithm for iodine quantification and fat fraction analysis to detect lymph node metastases in breast cancer patients. Material...

(This article belongs to the Special Issue Advances in Computed Tomography Imaging for Clinical Diagnosis—2nd Edition)
  • Article
  • Open Access
6 Citations
2,615 Views
13 Pages

Image Characteristics of Virtual Non-Contrast Series Derived from Photon-Counting Detector Coronary CT Angiography—Prerequisites for and Feasibility of Calcium Quantification

  • Franziska M. Braun,
  • Franka Risch,
  • Josua A. Decker,
  • Piotr Woźnicki and ,
  • Stefanie Bette,
  • Judith Becker,
  • Katharina Rippel,
  • Christian Scheurig-Münkler,
  • Thomas J. Kröncke and
  • Florian Schwarz
  • + 5 authors+ 0 author

8 November 2023

In photon-counting detector CT (PCD-CT), coronary artery calcium scoring (CACS) can be performed using virtual non-contrast (VNC) series derived from coronary CT angiography (CCTA) datasets. Our study analyzed image characteristics of VNC series in t...

(This article belongs to the Special Issue Advances in Computed Tomography Imaging for Clinical Diagnosis)
  • Technical Note
  • Open Access
81 Citations
13,420 Views
9 Pages

9 January 2014

Reliable, rapid and inexpensive detection of cellulolytic enzymes that can be used for a wide variety of biological and environmental samples are currently in high demand. Here, a new cellulase detection protocol is described that circumvents problem...

(This article belongs to the Section Biochemistry)
  • Review
  • Open Access
192 Citations
16,662 Views
23 Pages

Mineral Biofortification of Vegetables as a Tool to Improve Human Diet

  • Camila Vanessa Buturi,
  • Rosario Paolo Mauro,
  • Vincenzo Fogliano,
  • Cherubino Leonardi and
  • Francesco Giuffrida

21 January 2021

Vegetables represent pillars of good nutrition since they provide important phytochemicals such as fiber, vitamins, antioxidants, as well as minerals. Biofortification proposes a promising strategy to increase the content of specific compounds. As mi...

(This article belongs to the Special Issue Nutraceuticals and Functional Foods: Bridging Health and Food under a New Perspective)
  • Review
  • Open Access
18 Citations
5,163 Views
21 Pages

Utility of Dual-Energy Computed Tomography in Clinical Conundra

  • Ahmad Abu-Omar,
  • Nicolas Murray,
  • Ismail T. Ali,
  • Faisal Khosa and ,
  • Sarah Barrett,
  • Adnan Sheikh,
  • Savvas Nicolaou,
  • Stefania Tamburrini,
  • Francesca Iacobellis and
  • Mariano Scaglione
  • + 9 authors+ 4 authors

Advancing medical technology revolutionizes our ability to diagnose various disease processes. Conventional Single-Energy Computed Tomography (SECT) has multiple inherent limitations for providing definite diagnoses in certain clinical contexts. Dual...

(This article belongs to the Special Issue Advances in Computed Tomography Imaging for Clinical Diagnosis)
  • Review
  • Open Access
11 Citations
10,038 Views
13 Pages

Delayed Enhancement in Cardiac CT: A Potential Alternative to Cardiac MRI? Technical Updates and Clinical Considerations

  • Domenico De Stefano,
  • Federica Vaccarino,
  • Domiziana Santucci,
  • Marco Parillo and ,
  • Antonio Nenna,
  • Francesco Loreni,
  • Chiara Ferrisi,
  • Omar Giacinto,
  • Raffaele Barbato and
  • Eliodoro Faiella
  • + 10 authors+ 5 authors

17 May 2024

Despite cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) being the current gold standard for non-invasive myocardial characterization and fibrosis quantification, its accessibility is limited, particularly in acute settings and...

(This article belongs to the Special Issue Biomedical Imaging Technologies for Cardiovascular Disease—3rd Edition)
  • Review
  • Open Access
6 Citations
5,400 Views
18 Pages

Head and Neck Squamous Cell Carcinoma: Insights from Dual-Energy Computed Tomography (DECT)

  • Eleonora Bicci,
  • Antonio Di Finizio,
  • Leonardo Calamandrei,
  • Francesca Treballi and ,
  • Francesco Mungai,
  • Stefania Tamburrini,
  • Giacomo Sica,
  • Cosimo Nardi,
  • Luigi Bonasera and
  • Vittorio Miele
  • + 5 authors+ 0 author

11 November 2024

Head and neck cancer represents the seventh most common neoplasm worldwide, with squamous cell carcinoma being the most represented histologic variant. The rising incidence of the neoplastic pathology of this district, coupled with the drastic change...

  • Article
  • Open Access
1,540 Views
14 Pages

3 December 2025

A rapid ultra-high-performance liquid chromatography method with diode-array (DAD) and tandem mass spectrometric (MS/MS) detection was developed and, for the first time, applied for the determination of potassium iodide in ophthalmic formulations. Th...

(This article belongs to the Section Biomedical Engineering)
  • Article
  • Open Access
1,340 Views
21 Pages

Deterministic Pilot Risk–Benefit Assessment of Latvian Inland Fish: Safe Weekly Consumption Guidance

  • Janis Rusko,
  • Elizabete Murniece,
  • Santa Sibule,
  • Ilva Lazda and ,
  • Dzintars Zacs,
  • Ruta Medne and
  • Inese Siksna
  • + 2 authors+ 0 author

5 March 2026

Fish consumption provides nutritional benefits but can also contribute to exposures to bioaccumulative contaminants, requiring guidance that integrates both dimensions. We conducted a deterministic pilot risk–benefit assessment of Latvian inlan...

(This article belongs to the Special Issue Food Safety and Quality in Aquaculture and Fisheries Products)
  • Article
  • Open Access
2 Citations
3,068 Views
24 Pages

A Novel and Reliable Pixel Response Correction Method (DAC-Shifting) for Spectral Photon-Counting CT Imaging

  • Navrit Johan Singh Bal,
  • Imaiyan Chitra Ragupathy,
  • Trine Tramm and
  • Jasper Nijkamp

22 July 2024

Spectral photon-counting cone-beam computed tomography (CT) imaging is challenged by individual pixel response behaviours, which lead to noisy projection images and subsequent image artefacts like rings. Existing methods to correct for this either us...

  • Review
  • Open Access
13 Citations
3,889 Views
15 Pages

Coronary Computed Tomography Angiography: Beyond Obstructive Coronary Artery Disease

  • Elisabetta Tonet,
  • Alberto Boccadoro,
  • Marco Micillo,
  • Marta Cocco and ,
  • Alberto Cossu,
  • Graziella Pompei,
  • Melchiore Giganti and
  • Gianluca Campo
  • + 3 authors+ 0 author

26 April 2023

Nowadays, coronary computed tomography angiography (CCTA) has a role of paramount importance in the diagnostic algorithm of ischemic heart disease (IHD), both in stable coronary artery disease (CAD) and acute chest pain. Alongside the quantification...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
8 Citations
13,385 Views
29 Pages

Comparative Study of Chaga (Inonotus obliquus) Dietary Supplements Using Complementary Analytical Techniques

  • Coleton Windsor,
  • Anna E. Kreynes,
  • Jeff S. Chilton,
  • William A. Chioffi and ,
  • Arun Krishnamurthy and
  • Melissa Ishii
  • + 1 author+ 0 author

Chaga (Inonotus obliquus) is an increasingly used natural product in botanical dietary supplements, valued for its bioactive compounds. However, inconsistent standardized analytical methods raise concerns over product authenticity, mislabeling, and q...

(This article belongs to the Special Issue Bioactive Compounds of Natural Origin)
  • Article
  • Open Access
26 Citations
3,832 Views
10 Pages

Diagnostic Performance of Extracellular Volume Quantified by Dual-Layer Dual-Energy CT for Detection of Acute Myocarditis

  • Salim Aymeric Si-Mohamed,
  • Lauria Marie Restier,
  • Arthur Branchu,
  • Sara Boccalini and ,
  • Anaelle Congi,
  • Arthur Ziegler,
  • Danka Tomasevic,
  • Thomas Bochaton,
  • Loic Boussel and
  • Philippe Charles Douek
  • + 5 authors+ 0 author

26 July 2021

Background: Myocardial extracellular volume (ECV) is a marker of the myocarditis inflammation burden and can be used for acute myocarditis diagnosis. Dual-energy computed tomography (DECT) enables its quantification with high concordance with cardiac...

(This article belongs to the Special Issue Cardiovascular and Thoracic Imaging: Trends, Perspectives and Prospects)
  • Article
  • Open Access
1,010 Views
15 Pages

Spectral Precision: The Added Value of Dual-Energy CT for Axillary Lymph Node Characterization in Breast Cancer

  • Susanna Guerrini,
  • Giulio Bagnacci,
  • Paola Morrone,
  • Cecilia Zampieri and ,
  • Chiara Esposito,
  • Iacopo Capitoni,
  • Nunzia Di Meglio,
  • Armando Perrella,
  • Francesco Gentili and
  • Maria Antonietta Mazzei
  • + 7 authors+ 2 authors

23 January 2026

Background/Objectives: To develop and validate a predictive model that combines morphological features and dual-energy CT (DECT) parameters to non-invasively distinguish metastatic from benign axillary lymph nodes in patients with breast cancer (BC)....

(This article belongs to the Special Issue Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging)
  • Article
  • Open Access
8 Citations
3,257 Views
16 Pages

17 April 2023

Background and Objective: Tyrosine kinase inhibitors (TKIs) are used for the treatment of different types of cancers. The current study describes, for the first time, the ultraviolet-visible spectrophotometric investigation of charge transfer complex...

  • Review
  • Open Access
6 Citations
3,014 Views
15 Pages

The Role of Dual-Energy CT in Differentiating Adrenal Adenomas from Metastases: A Comprehensive Narrative Review

  • Francesco Tiralongo,
  • Cristina Mosconi,
  • Pietro Valerio Foti,
  • Aldo Eugenio Calogero and ,
  • Sandro La Vignera,
  • Corrado Ini’,
  • Davide Giuseppe Castiglione,
  • Emanuele David,
  • Stefania Tamburrini and
  • Antonio Basile
  • + 7 authors+ 2 authors

28 March 2025

Dual-energy CT (DECT) has emerged as a novel imaging modality that offers a multiparametric approach for noninvasive adrenal lesion characterization. This narrative review examines recent advances in DECT—including virtual non-contrast imaging,...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
478 Views
14 Pages

From Iodine Maps to Brain Window Images: Quantitative Visibility Thresholds of Iodine Staining Using Photon-Counting CT—A Retrospective Observational Study

  • Marie-Christine Pali,
  • Stephanie Mangesius,
  • Constantin Emanuel Eisenschink,
  • Philipp Deisl and ,
  • Lukas Neumann,
  • Michael Knoflach,
  • Raimund Pechlaner,
  • Bernhard Glodny,
  • Lukas Lenhart and
  • Astrid Ellen Grams
  • + 6 authors+ 1 author

9 September 2026

Objectives: We aimed to determine quantitative photon-counting CT (PCCT)-derived iodine map (IM) attenuation associated with visual detectability of parenchymal hyperattenuation on conventional brain window (BW) images after mechanical thrombectomy (...

(This article belongs to the Special Issue Photon-Counting CT in Clinical Application)
  • Communication
  • Open Access
28 Citations
7,872 Views
7 Pages

Easily Fabricated Microfluidic Devices Using Permanent Marker Inks for Enzyme Assays

  • Coreen Gallibu,
  • Chrisha Gallibu,
  • Ani Avoundjian and
  • Frank A. Gomez

12 January 2016

In this communication, we describe microfluidic paper analytical devices (μPADs) easily fabricated from commercially available Sharpie ink permanent markers on chromatography paper to colorimetrically detect glucose using glucose oxidase (GOx). Here,...

(This article belongs to the Special Issue Paper-Based Microfluidic Devices for Point-of-Care Diagnostics)
  • Article
  • Open Access
14 Citations
4,805 Views
14 Pages

Vegetable oils have been utilized for centuries in the food, cosmetic, and pharmaceutical industries, and they contribute beneficially to overall human health, to active skincare, and to effective treatments. Monitoring of the vegetable oils is carri...

(This article belongs to the Special Issue Chemometrics in Analytical Chemistry)

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