Background/Objectives: Healthcare systems face persistent challenges in improving efficiency, optimizing resources, and delivering high-quality care. Traditional continuous improvement methodologies often rely on subjective assessments, while data-dr...
Incorporating continuous carbon fibre-reinforced polymer (CCFRP) parts within additive manufacturing processes presents a significant advancement in the fabrication of robust lightweight parts, particularly relevant to aerospace, engineering, and var...
Small-scale continuous apparatuses for solid product manufacturing are receiving increasing interest due to the demand for the fast market availability of specialty chemical products manufactured in integrated and modular processing plants. Relevant...
Volatile markets and increasing demands for quality and fast availability of specialty chemical products have motivated the rise of small-scale, integrated, and modular continuous processing plants. As a significant unit operation used for product is...
In the modern manufacturing environment, the ability to collect and refine data in real time to deliver high-quality data is increasingly important in maintaining a competitive advantage and operational efficiency. This paper proposes a conceptual ar...
Substantial improvements have been made to cell culturing processes (e.g., higher product titer) in recent years by raising cell densities and optimizing cultivation time. However, this has been accompanied by an increase in product-related impuritie...
Total quality management (TQM) is a strategic philosophy that has adopted kaizen activities which drives the business to carry out activities effectively to yield the best desired output, hence, a profitable organization. The kaizen philosophy acts a...
Performance of integrated production scheduling and advanced process control with disturbances is summarized and reviewed with four progressive stages of scheduling and control integration and responsiveness to disturbances: open-loop segregated sche...
Continuous manufacturing of biologics (biopharmaceuticals) has been an area of active research and development for many reasons, ranging from the demand for operational streamlining to the requirement of achieving obvious economic benefits. At the sa...
As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and inte...
The administration of viral vectored vaccines remains one of the most effective ways to respond to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. However, pre-existing immunity to the viral vector hinders its potency, resulting in a...
With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for...
18 September 2025
Against the backdrop of accelerating global trade and rising consumer expectations, cross-border e-commerce must urgently increase consumers’ willingness to reuse them. This study uses social exchange theory (SET) and resource dependency theory...
A quantum photonic circuit with the ability to produce continuous variable quantum vortex states is proposed. This device produces two single-mode squeezed states which go through a Mach-Zehnder interferometer where photons are subtracted by means of...
This study proposes a reliable inline PAT concept for the simultaneous monitoring of different product components after chromatography. The feed for purification consisted of four main components, IgG monomer, dimer, and two lower molecular weight co...
In the present study, we developed an integrated process that combined high-temperature rolling and continuous bending as a single processing step, i.e., the HTR-CB process, and the process was carried out on Mg-3Al-1Zn magnesium alloy sheet in order...
Temperature control in a continuous stirred tank reactor (CSTR) poses significant challenges due to the process’s inherent nonlinearities and uncertain parameters. This study proposes an innovative solution by developing an adaptive nonlinear p...
Laser cleaning has received extensive attention due to its high efficiency, non-pollution and easy automation. However, how to improve the cleaning quality has become the focus of current research. In this paper, we used a pulsed laser for cleaning e...
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process. Compared with other oral...
In this research, optimization of the integrated biodiesel production process composed of transesterification of edible sunflower oil, catalyzed by commercial lipase, with simultaneous extraction of glycerol from the reaction mixture was performed. D...
An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (S)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug...
In recent years, the rapid development of three-dimensional (3D)-printed continuous fiber-reinforced polymer (CFRP) technology has provided novel strategies for customized manufacturing of high-performance composites. This review systematically summa...
Integrated continuous manufacturing processes of active pharmaceutical ingredients (API) provide key benefits concerning product quality control, scale-up capability, and a reduced time-to-market. Thereby, the crystallization step, which is used in a...
As one of the most direct indicators of the transparency between a human and an exoskeleton, interactive force has rarely been fused with electromyography (EMG) in the control of human-exoskeleton systems, the performances of which are largely determ...
Continuous fiber-reinforced material extrusion is an emerging additive manufacturing process that builds components layer by layer by extruding a continuous fiber-reinforced thermoplastic strand. This novel manufacturing process combines the benefits...
Additive manufacturing using continuous carbon-fibre-reinforced polymer (CCFRP) presents an opportunity to create high-strength parts suitable for aerospace, engineering, and other industries. Continuous fibres reinforce the load-bearing path, enhanc...
Additive manufacturing of continuous carbon fibre-reinforced polymer (CCFRP) parts enables the production of high-strength parts for aerospace, engineering and other industries. Continuous fibres allow for parts to be reinforced along the load path,...
Industrial scale-up of hydrothermal supercritical water gasification process requires catalytic integration to reduce the high operational temperatures and pressures to enhance controlled chemical reaction pathways, product yields, and overall proces...
There have been considerable efforts on improving the lentiviral vector (LV) system and their production. However, there remains the persisting challenge of producing a sufficient quantity of LVs at manufacturing scale to support treatments beyond ea...
A summary of the relationship between the Langevin equation, Fokker-Planck-Kolmogorov forward equation (FPKfe) and the Feynman path integral descriptions of stochastic processes relevant for the solution of the continuous-discrete filtering problem i...
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for...
In the evolving landscape of pharmaceutical manufacturing, a comprehensive continuous production process is being crafted for the small-scale production of active pharmaceutical ingredients. This study focuses on continuous crystallization with separ...
For the study of the transition strategies of continuous chemical processes, both continuity and dynamic characteristics in the physical sense are critical. The continuous transition strategy has a higher information density and can describe the real...
Hydroponic farms produce wastewater that need to be treated before being released into the environment. A three-step screening process (microplate, batch, and semi-continuous flasks experiments) initially designed to select an efficient microalgae st...
The continual generation and discharge of waste are currently considered two of the main environmental problems worldwide. There are several waste management options that can be applied, though anaerobic digestion (AD) process technology seems to be...
Within emerging markets, ensuring the competitiveness of manufacturing companies is crucial to their success. The integration of new business possibilities, such as Product-Service-Systems (PSS) can provide one suitable solution. Especially within th...
In this work, a hybrid MPC (model predictive control)-PID (proportional-integral-derivative) control system has been designed for the continuous purification and processing framework of active pharmaceutical ingredients (APIs). The specific unit oper...
Integration of heat pumps combined with thermal energy storage provides a key pathway to decarbonizing the energy supply in the industry when the processes are not operated continuously. Yet, this integration of such novel systems introduces control...
Integrated computational materials engineering (ICME) is emerging as an increasingly powerful approach to integrate computational materials science tools into a holistic system and address the multiscale modeling challenges in the processing of advan...
An improved continuous-cycling method is proposed for the autotuning of the proportional–integral–derivative (PID) controller. The proposed method can identify the frequency response of the process at a preset phase angle without a modeling error. Mo...
Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography. Continuous affinity capture of adeno-associated viru...
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the...
In recent decades, metasurfaces have emerged as an exotic and appealing group of nanophotonic devices for versatile wave regulation with deep subwavelength thickness facilitating compact integration. However, the ability to dynamically control the wa...
Assessing impacts in innovation contexts/settings with the aim of fostering sustainability requires tackling complex issues. Literature shows that key sources of this complexity relate to the need to integrate the local context; identify the underlyi...
Vacuum crystallization with subsequent solid–liquid separation is a suitable method to produce and separate the temperature-sensitive protein lysozyme. The conventional process is performed batch-wise and on different devices, which in turn leads to...
Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat...
The Hazelett continuous casting and rolling process represents a leading-edge production method for cold-rolled aluminum sheet and strip billets in the world. Its solidification microstructure significantly influences the quality of billets produced...
Design decisions occur in all phases of product design and largely affect the merits of the final solution, which will ultimately determine the success or failure of the product in the market. Product design is a continuous process, and a large numbe...
Many products from the fine chemicals and pharmaceuticals industries are currently manufactured batch-wise in multi-product plants. However, this processing scheme suffers from severe drawbacks, such as a high specific energy demand, cleaning costs a...
In this work, a deep representation learning method is proposed to build continuous-valued representations of individual integrated circuit (IC) devices. These representations are used to render mixed-variable analog circuit sizing problems as contin...
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