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Open AccessArticle

Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (S)-1-(3-Methoxyphenyl)ethylamine

1
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, Germany
2
Sulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, Switzerland
*
Author to whom correspondence should be addressed.
Crystals 2020, 10(5), 345; https://doi.org/10.3390/cryst10050345
Received: 27 February 2020 / Revised: 22 April 2020 / Accepted: 23 April 2020 / Published: 27 April 2020
(This article belongs to the Special Issue Advances in Industrial Crystallization)
An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (S)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stage Alzheimer’s disease. The three-part vessel system developed for this purpose consists of a membrane reactor for the continuous synthesis of the product amine, a saturator vessel for the continuous supply of the amine donor isopropylammonium and the precipitating reagent 3,3-diphenylpropionate and a crystallizer in which the product amine can continuously precipitate as (S)-1-(3-methoxyphenyl)ethylammonium-3,3-diphenylpropionate. View Full-Text
Keywords: amine; biocatalysis; enzyme; process intensification; crystallization; enantioselective amine; biocatalysis; enzyme; process intensification; crystallization; enantioselective
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Hülsewede, D.; Temmel, E.; Kumm, P.; von Langermann, J. Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (S)-1-(3-Methoxyphenyl)ethylamine. Crystals 2020, 10, 345.

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