A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design principles that have been establi...
We present the modification of ethylene-propylene rubber (EPM) with vinyltetra-methydisiloxane (VTMDS) via reactive extrusion to create a new silicone-based material with the potential for high-performance applications in the automotive, industrial a...
This paper displays the potential of an in-line PAT system for early phase product development during pharmaceutical continuous manufacturing following a Quality by Design (QbD) framework. Hot melt extrusion (HME) is used as continuous manufacturing...
Fed-batch process intensification with a significantly shorter culture duration or higher titer for monoclonal antibody (mAb) production by Chinese hamster ovary (CHO) cells can be achieved by implementing perfusion operation at the N-1 stage for bio...
Background/Objectives: Continuous manufacturing is gaining importance in the nanopharmaceutical field, offering improved process efficiency and product consistency. To fully leverage its potential, the integration of Process Analytical Technology (PA...
The study of the
This paper extends the idea of subordination from the theory of fuzzy sets to the geometry theory of analytic functions with a single complex variable. The purpose of this work is to define fuzzy subordination and illustrate its main characteristics....
Applying the operator of
The topic concerning the introduction and investigation of new classes of analytic functions using subordination techniques for obtaining certain geometric properties alongside coefficient estimates and inclusion relations is enriched by the results...
Bi-univalent functions associated with the leaf-like domain within the open unit disk are investigated and a new subclass is introduced and studied in the research presented here. This is achieved by applying the subordination principle for analytic...
Certain characteristics of univalent functions with negative coefficients of the form
We propose a model for the QCD running coupling constant based on the analytical inverse QCD coupling constant concept with an additional regularization in the low momentum region. Analyticity in the
We report on the cure characterization, based on inline monitoring of the dielectric parameters, of a commercially available epoxy phenol resin molding compound with a high glass transition temperature (>195 °C), which is suitable for the direct p...
Downstream of pharmaceutical proteins, such as monoclonal antibodies, is mainly done by chromatography, where concentration determination of coeluting components presents a major problem. Inline concentration measurements (ICM) by Ultraviolet/Visible...
This study explores the potential of Raman spectroscopy as a screening tool for fault detection in dairy processing, focusing its application on milk rennet coagulation. Multivariate Statistical Process Control techniques were employed to analyze spe...
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids and solids. However, in a process environment, maintaining a sufficient sample exchange and cleaning of the sensitiv...
The scale-up process of the high solid content (up to 67 wt%) emulsion polymerisation of vinyl acetate and Versa®10 from 1 L over 10 L to 100 L was investigated. An emulsion copolymerisation of vinyl acetate and neodecanoic acid vinyl ester in a...
Lithium-ion batteries are a key technology for electromobility; thus, quality control in cell production is a central aspect for the success of electric vehicles. The detection of defects and poor insulation behavior of the separator is essential for...
Infrared attenuated total reflection (ATR) spectroscopy is a common laboratory technique for the analysis of highly absorbing liquids or solid samples. However, ATR spectroscopy is rarely found in industrial processes, where inline measurement, conti...
Melamine-formaldehyde (MF) resins are widely used as surface finishes for engineered wood-based panels in decorative laminates. Since no additional glue is applied in lamination, the overall residual curing capacity of MF resins is of great technolog...
Extracellular vesicles (EVs) are relatively recently discovered biological nanoparticles that mediate intercellular communication. The development of new methods for the isolation and characterization of EVs is crucial to support further studies on t...
A statistical design of experiments for a rotary fluidized bed agglomeration process is performed to improve both the knowledge of the process and the influence of the process parameters. Agglomerates of a pharmaceutical formulation are manufactured...
Raman spectroscopy is a useful tool for polymorphic form-monitoring during the crystallization process. However, its application to solute concentration estimation in two-phase systems like crystallization is rare, as the Raman signal is influenced b...
Inline analytics in industrial processes reduce operating costs and production rejection. Dedicated sensors enable inline process monitoring and control tailored to the application of interest. Nuclear Magnetic Resonance is a well-known analytical te...
Lithium is of major importance for many areas of technology, especially batteries, and is therefore relevant to both the industrial and private sectors. High-performance, ideally inline-compatible analytics are important for economical and environmen...
The importance of and demand for lithium are high and are expected to further increase. Therefore, efficient lithium exploitation processes are essential, for example, Li extraction from brines. Powerful analytical methods are needed, especially with...
In this article, a novel miniature Fabry-Perot twist/rotation sensor using a four core fiber and quadruple interferometer setup is presented and demonstrated. Detailed sensor modeling, analytical evaluation and test measurement assessment were conduc...
A mono-segmented sequential injection lab-at-valve (SI-LAV) system for the determination of albumin, glucose, and creatinine, three key biomarkers in diabetes screening and diagnosis, was developed as a single system for multi-analyte analysis. The m...
Process monitoring and control require dedicated and reliable measures which reflect the status of the process under investigation. Although nuclear magnetic resonance is known to be a versatile analytical technique, it is only seldomly found in proc...
The pharmaceutical industry has witnessed exponential growth in production volumes, driven by factors such as an aging global population and the COVID-19 pandemic. To meet the demand for high product quality alongside increased productivity, there is...
Objectives: This study aims to develop a tablet press machine (TPM) integrated with machine learning (ML) and deep learning (DL) models for in-line detection of defective tablets as a Process Analytical Technology (PAT) tool. This study aimed to pred...
The chemical synthesis of polysiloxanes from monomeric starting materials involves a series of hydrolysis, condensation and modification reactions with complex monomeric and oligomeric reaction mixtures. Real-time monitoring and precise process contr...
In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a s...
An in-line process analytical technology that measures drag force exerted by wet mass in a high-shear granulator on a thin cylindrical probe enabled real-time identification of distinct stages in high-shear wet granulation of acetaminophen. The techn...
Control of milk concentrate viscosity and total solids (TS) content prior to spray drying can improve dairy ingredient manufacture. However, the availability of hygienic and appropriately pressure rated process viscometers for inline monitoring of vi...
Polyhydroxyalkanoates (PHAs) are biodegradable plastic-like materials with versatile properties. Plant oils are excellent carbon sources for a cost-effective PHA production, due to their high carbon content, large availability, and comparatively low...
Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ pr...
A simplified design of an inline transition between microstrip and rectangular waveguide is presented in this paper. The transition makes use of a dielectric filled rectangular waveguide (DFRW) as an intermediate step, which simplifies manufacturing...
This paper presents a miniature, all-silica, flow-injection sensor. The sensor consists of an optical fiber-coupled microcell for spectral absorption measurements and a microfluidic reagent injection system. The proposed sensor operates in back refle...
The high solids semicontinuous emulsion polymerization of polyvinyl acetate using poly (vinyl alcohol-co-vinyl acetate) as protective colloid is investigated by optical spectroscopy. The suitability of Photon Density Wave (PDW) spectroscopy as inline...
The ability to measure and capture real-time unit operational data has significant benefits during dairy processing, whether it is the basics, such as measuring temperature, pressure, and flow rates, or more recent developments in the case of in-line...
A microfluidic film bulk acoustic wave resonator gas sensor (mFBAR) adapted specifically as an in-line detector in gas chromatography was described. This miniaturized vapor sensor was a non-destructive detector with very low dead volume (0.02 μL). It...
In the development of therapeutic proteins, analytical assessment of structural stability and integrity constitutes an important activity, as protein stability and integrity influence drug efficacy, and ultimately patient safety. Existing analytical...
This study presents an innovative inline metasurface design for selective wavelength transmission and focusing. When integrated into optical fibers, it improves the stability and compatibility with techniques like wavelength division multiplexing and...
Background: This study demonstrates the application of the sequential design of experiments (DoE) approach within the quality by design (QbD) framework to optimize extrusion processes through screening, optimization, and robustness testing. Methods:...
The connection of macrosystems with microsystems for in-line measurements is important in different biotechnological processes as it enables precise and accurate monitoring of process parameters at a small scale, which can provide valuable insights i...
Contact–impact phenomena caused by joint clearances can significantly alter the dynamic response of high-speed mechanical systems, yet fewer studies combine analytical impact-force modeling, virtual prototyping, and experimental observations fo...
Hash tables are the fundamental data structure for analytical database workloads, such as aggregation, joining, set filtering and records deduplication. The performance aspects of hash tables differ drastically with respect to what kind of data are b...
Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offl...
(1) Background: Portable NIR spectrometers gain more and more ground in the field of Process Analytical Technology due to the easy on-site flexibility and interfacing versatility. These advantages that originate from the instrument miniaturization, a...
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