Background: The Mediterranean Diet (MedDiet) is a global benchmark for the prevention of cardiometabolic diseases and healthy aging, with Olea europaea L. (O. europaea L.) and Citrus bergamia Risso et Poiteau (bergamot) serving as primary sources of...
The olive tree (Olea europaea L.) holds a prominent place in Mediterranean cultural and agricultural landscapes, including Italy, which hosts a vast germplasm of almost 600 cultivars. Characterising this biodiversity is important for conservation, su...
Potato starch (Solanum spp.) undergoes structural and functional modifications during traditional Andean chuño production; however, the integrated effects of processing history, cultivar-associated characteristics, and field-based environmenta...
Salinity stress impairs maize growth by inducing osmotic stress, pigment degradation, and ionic imbalance, particularly during early seedling development. This study investigated the morpho-physiological and ionic responses of different maize genotyp...
The Coffea canephora market has grown significantly, driven by its economic relevance and improvements in beverage quality. Developing varieties adapted to local edaphoclimatic conditions is essential for supporting smallholder farmers, increasing pr...
Background/Objectives: Preeclampsia (PE) is the primary cause of maternal and perinatal morbidity and mortality on a global scale. It is driven by a multifactorial aetiology, in which genetic factors involved in blood pressure regulation, including t...
Water scarcity is a key constraint for commercial Eucalyptus plantations, particularly given the increasing frequency of droughts driven by climate change. This study assessed annual transpiration (Tr) and water use efficiency (WUE) across eight geno...
Some fungal endophytes of forest trees are recognized as beneficial symbionts against stresses. In previous works, two elm endophytes from the classes Cystobasidiomycetes and Eurotiomycetes promoted host resistance to abiotic stress, and another elm...
Characterizing the morphological variability in root system architecture (RSA) during the sensitive pre-flowering growth stage is important for crop performance. To assess this variation, eight bambara groundnut single genotypes derived from landrace...
The increasing popularity of pomegranate (Punica granatum L.), driven by the awareness of its nutraceutical properties and excellent environmental adaptability, is promoting a global expansion of its production area. This investigation reports the va...
Durum wheat (Triticum durum Desf.) underpins semolina value chains in water-limited regions, yet Peru remains import-dependent due to constrained local adaptation. We evaluated eleven elite lines plus the commercial variety ‘INIA 412 Atahualpa&...
Background/Objectives: Previous studies suggest that there is a genetically determined component of fat oxidation at rest and during exercise. To date, the FTO gene has been proposed as a candidate gene to affect fat oxidation during exercise because...
Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant vascular disorder primarily caused by pathogenic variants in the ENG and ACVRL1 genes. Although genotype–phenotype correlations are well established at the pop...
Waterlogging at the tillering stage, a key early vegetative growth stage, is increasingly limiting wheat productivity worldwide, but the physiological mechanisms underlying genotypic tolerance are not fully understood. To address this, 23 bread wheat...
Background/Objective: Voriconazole exhibits nonlinear pharmacokinetics and wide interindividual variability driven by CYP2C19 phenotype and clinical covariates, necessitating early therapeutic drug monitoring (TDM). This study aimed to assess how the...
Drought has become one of the main factors of crop yield losses worldwide. This negatively affects the plant industry, decreasing crop yields, and it may result in resource deficits in different sectors of the world economy and its national branches....
Several studies have investigated the role of genetics in anterior cruciate ligament (ACL) rupture, often returning conflicting results. The present pilot study aimed to analyze the association between six Single Nucleotide Polymorphisms (SNPs) (rs18...
Hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy, represents a paradigmatic condition for precision cardiovascular medicine. Once regarded as a monogenic autosomal dominant disorder driven by rare sarcomeric variants, HCM i...
The current state-centric analysis of Official Variety Trials (OVTs) restricts the identification of stable performance zones across political boundaries. This study employed multivariate statistical learning techniques to delineate soybean (Glycine ...
Background: Forensic DNA phenotyping (FDP) enables the inference of externally visible characteristics (EVCs) and biogeographic ancestry when conventional STR profiling is inconclusive. The ForenSeq™ Imagen kit (107 SNPs) integrates phenotype-,...
Spring drought is a major constraint in Mediterranean wheat production, where elevated temperatures and evapotranspiration after heading limit soil water availability during critical generative stages. This study investigated how post-heading drought...
Hemp seeds (Cannabis sativa L.) are a rich source of phenolic compounds with antioxidant and antimicrobial potential. Still, their genotype-dependent variability and ability to enhance antibiotic efficacy remain insufficiently explored. This study co...
Bowen disease (BD), or squamous cell carcinoma (SCC) in situ, represents a histologically defined but biologically heterogeneous group of intraepithelial neoplasms arising across different epithelial compartments. Human papillomavirus (HPV) plays a w...
Background/Objectives: Vancomycin-resistant (VRE) and vancomycin-variable (VVE) Enterococcus spp. represent an increasing clinical challenge due to limited treatment options and the potential for undetected dissemination of such resistance genes. Dat...
The interplay between recombination rate, genetic drift and selection modulates variation in genome-wide ancestry. Understanding the selective processes at play is of prime importance toward predicting potential beneficial or negative effects of supp...
The extensive diversification of flower shape and organs underpins the adaptive success of angiosperms. Despite substantial knowledge of the molecular mechanisms controlling flower induction and development, few studies have quantified the variabilit...
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a rising prevalence, driven by multifactorial genetic and environmental factors. Among the genetic contributors identified, SCN2A, a critical gene encoding the...
Sheep show characteristics of phenotypic diversity and adaptation to diverse climatic regions. Previous studies indicated associations between copy number variations (CNVs) and climate-driven adaptive evolution in humans and other domestic animals. H...
REarranged during Transfection (RET) oncogenic rearrangements can occur in 1–2% of lung adenocarcinomas. While RET-driven NSCLC models have been developed using various approaches, no model based on patient-derived induced pluripotent stem cell...
Aronia melanocarpa (black chokeberry) is a medicinally valuable small fruit species, yet its commercial propagation remains limited by low rooting and genotype-specific responses. This study developed an efficient, callus-free micropropagation and ro...
Accurate prediction of cultivar performance across diverse environments is crucial for breeding and recommendation systems, helping to reduce the yield gap, the difference between potential and actual yields, which is often widened by poor cultivar s...
Drought stress is the most pervasive abiotic constraint on global crop productivity, with projected intensification under climate change threatening the yields of staple crops including wheat, rice, maize, and legumes. Conventional breeding approache...
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor remains the cornerstone of antithrombotic management after myocardial revascularization. However, the traditional “one-size-fits-all” approach to DAPT duration and intens...
This review provides a comprehensive overview of the genetic diversity and epidemiological potential of Yersinia pestis in Kazakhstan’s natural plague foci, emphasizing the link between genotypic variation and outbreak capacity. Integrating his...
The aim of the study was to identify canine parvovirus type 2 (CPV-2) subtypes circulating among a selected population of domestic dogs and cats in Sri Lanka and to investigate the evolutionary patterns among Sri Lankan viruses in the context of cont...
Analyzing the associations between genotypic changes and phenotypic traits on a genome-wide scale can contribute to understanding the functional roles of distinct genetic variations during breed development. We performed a whole-genome analysis of An...
One of the greatest impacts on the gastrointestinal microbiome is diet because the host and microbiome share the same food source. In addition, the effect of diet can diverge depending on the host genotype. Diets supplemented with phytochemicals foun...
The gut microbiome is a modifiable factor in cancer survivorship. Diet represents the most practical intervention for modulating the gut microbiome. However, diet–microbiome relationships in prostate-cancer survivors remain poorly characterized...
This study assessed how BDNF (brain-derived neurotrophic factor) and other genes involved in its signaling influence brain structure and clinical functioning in pre-diagnosis Huntington’s disease (HD). Parallel independent component analysis (pICA),...
When analyzing the long-term viability of small, declining populations, it is essential to recognize that inbreeding and the erosion of genetic diversity are primarily driven by the effective population size, which is often a fraction of the total ce...
Tree phenotypes vary because of genotype–climate interactions, and this variation influences host selection by tree-killing bark beetles. As climate-driven bark beetle outbreaks intensify, identifying phenotypic traits that best predict resista...
As an endemic Castanopsis species on Hainan Island, Castanopsis hainanensis Merr. is uniquely adapted to tropical climatic conditions and occupies a relatively narrow habitat range. Given its long generation times, limited dispersal capacity, and eco...
The use of biostimulants in agriculture is increasing; however, their effects on raspberry remain insufficiently understood. The aim of this study was to evaluate the impact of foliar-applied biostimulants on yield and growth in three primocane raspb...
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component (~70% heritability). Early identification of individuals at risk is crucial for early intervention or risk assessment. Although polygenic risk scores (PRS) have shown prom...
Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder caused by biallelic loss-of-function mutations in the ADA2 gene (formerly CECR1). First described in 2014, DADA2 has emerged as a paradigm for monogenic vasculitis,...
Crop response to nitrogen (N) fertilizer varies across space and time due to complex interactions among soil properties, weather, water availability, crop characteristics, and management practices, making the response to additional N difficult to pre...
Brassica rapa L. subsp. chinensis (pak choi) is an important leafy vegetable with increasing global relevance as a source of biologically active phytochemicals. Despite extensive research on individual compounds, a comprehensive and integrative under...
For over three decades, Proton Pump Inhibitors (PPIs) have served as the established primary therapy for acid-suppressive therapy; however, their clinical utility is frequently compromised by their slow onset of action, meal-time dependency, and meta...
Background: The reproducibility of research findings continues to be a challenge in many fields, including neurosciences. It is now required that biological variables such as sex and age be considered in preclinical and clinical research. Rodents are...
Plant defence elicitors have emerged as pivotal components of sustainable fruit crop protection, aligning with One Health principles by reducing chemical residues while enhancing ecosystem and human health. These exogenous agents—ranging from p...
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