Inflammaging: The Immunology of Aging, 2nd Edition

Topic Information

Dear Colleagues,

Inflammaging or age-related inflammation occurs as a natural process resulting from oxidative stress, cell damage, or a dysregulated immune response and is contributed to in part by lifestyle factors such as poor diet, lack of sleep, lack of exercise, and stress. Moreover, inflammaging is believed to be the predecessor to a variety of diseases, such as neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease. In addition, increased visceral fat and obesity, associated with poor diet, contribute to the inflammaging process that results in metabolic diseases, including diabetes and metabolic syndromes (hypertension and hypercholesterolemia). We invite all scientists working on the immunology of age-related conditions or diseases to participate in this Topic. Original research articles, reviews, or shorter perspective articles on all aspects related to the immunology of aging and age-related processes are welcome. Articles with insights from a cell and molecular biological perspective are especially welcome. Relevant topics include but are not limited to inflammaging and oxidative stress, age-related cardiovascular diseases, the role of extracellular vesicle biology in inflammaging, inflammasome regulation in aging and age-related diseases, inflammation and neurodegeneration, inflammation and joint degeneration, inflammaging and the gut microbiome, and inflammaging and cancer.

Dr. Brianna Cyr
Dr. Juan Pablo de Rivero Vaccari
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomolecules biomolecules	4.8	9.2	2011	17.9 Days	CHF 2700	Submit
Cells cells	5.2	10.5	2012	15.5 Days	CHF 2700	Submit
Geriatrics geriatrics	2.1	3.4	2016	27.3 Days	CHF 1800	Submit
Immuno immuno	2.5	3.7	2021	28.8 Days	CHF 1200	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	17.8 Days	CHF 2900	Submit

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Published Papers (2 papers)

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All IJMS Cells Biomolecules Geriatrics Immuno

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Open AccessArticle

Exploratory Analysis of Inflammatory Biomarkers and Their Association with Psychological Burden in Mexican Informal Caregivers: A Cross-Sectional Study in the Emergency Department

by José Juan Gómez-Ramos, Natali Montoya-Mendoza, Ana Miriam Saldaña-Cruz, Sergio Gabriel Gallardo-Moya, Omar Karim López-Barajas, Rafael Chávez-Moreno and Alejandro Marín-Medina

Int. J. Mol. Sci. 2026, 27(7), 3316; https://doi.org/10.3390/ijms27073316 - 7 Apr 2026

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Abstract

This cross-sectional exploratory study aimed to explore the association between inflammatory biomarkers and multidimensional psychological burden in informal primary caregivers of dependent older adults in an emergency department. We included 78 caregivers and up to 89 controls. Multidimensional psychological burden (perceived stress, depression, [...] Read more.

This cross-sectional exploratory study aimed to explore the association between inflammatory biomarkers and multidimensional psychological burden in informal primary caregivers of dependent older adults in an emergency department. We included 78 caregivers and up to 89 controls. Multidimensional psychological burden (perceived stress, depression, anxiety, and caregiver burden) was assessed using standardized instruments. Morning serum levels of cortisol, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive Protein, were measured. Statistical analyses included between-group comparisons (Mann–Whitney U test), correlations (Spearman rank correlation coefficient), and hierarchical block regression adjusted for obesity, diabetes, and hypertension in the caregiver group. Multiplicity was addressed using the False Discovery Rate (FDR) procedure, and the findings were validated through 1000 bootstrap resamples. Caregivers had significantly higher levels of TNF-α compared to controls (p = 0.021), a finding confirmed by bootstrap analysis (95% CI: −2.6730 to −0.2940). IL-6 levels were positively correlated with trait anxiety (p = 0.007) and caregiver burden (p = 0.019). Comorbidity-adjusted hierarchical regression confirmed significant associations between IL-6 levels and trait anxiety and caregiver burden (ΔR² = 0.123, p = 0.007), although these associations did not remain significant after adjustment for FDR. Caregivers showed elevated levels of TNF-α and exploratory associations between IL-6, trait anxiety, and caregiver burden, justifying confirmation in studies with a larger number of participants. Full article

(This article belongs to the Topic Inflammaging: The Immunology of Aging, 2nd Edition)

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32 pages, 2661 KB  

Open AccessReview

The Matrisome as an Immunomodulator: A Role Far Beyond Its Structural Support

by Taihao Quan

Biomolecules 2026, 16(3), 408; https://doi.org/10.3390/biom16030408 - 10 Mar 2026

Viewed by 794

Abstract

The extracellular matrix (ECM) is a dynamic and complex three-dimensional network that provides structural support and mechanical stability to tissues. The complete repertoire of ECM and associated proteins has recently been cataloged as matrisome, which encompasses both core structural components and ECM-associated proteins. [...] Read more.

The extracellular matrix (ECM) is a dynamic and complex three-dimensional network that provides structural support and mechanical stability to tissues. The complete repertoire of ECM and associated proteins has recently been cataloged as matrisome, which encompasses both core structural components and ECM-associated proteins. Advances in ECM biology have overturned the traditional view of the ECM as a purely passive scaffold, revealing its active involvement in a wide range of biological processes. Among these, the ECM plays a critical regulatory role in inflammation. This review examines the bidirectional interplay between the matrisome and inflammatory processes, highlighting how matrisome components shape inflammatory responses and how inflammation, in turn, drives matrisome remodeling. A deeper understanding of matrisome–inflammation interactions will provide important insights into immunopathology and may inform the development of novel therapeutic strategies. Full article

(This article belongs to the Topic Inflammaging: The Immunology of Aging, 2nd Edition)

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