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  • Article
  • Open Access
4 Citations
2,710 Views
11 Pages

Redo DAIR: The Game Is Seldom Worth the Candle

  • Ignacio Sancho,
  • Iñaki Otermin-Maya,
  • Jorge Gutiérrez-Dubois,
  • Ignacio Aláez,
  • Julián Librero,
  • Maria Eugenia Portillo and
  • Ángel Hidalgo-Ovejero

Debridement, antibiotics and implant retention (DAIR) remains a commonly utilized technique in the treatment of acute prosthetic joint infections despite its inconsistent outcomes. The performance of a second DAIR after a failed first debridement is...

(This article belongs to the Special Issue Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research - 2nd Volume)
  • Article
  • Open Access
1 Citations
677 Views
12 Pages

Results of Deep Surgical Site Infections Treated with the Debridement, Antibiotics, and Implant Retention (DAIR) Protocol: 25 Cases

  • Ali İhsan Ökten,
  • Saygı Uygur,
  • Emre Bilgin,
  • Abdullah Kılıç,
  • Kemal Şüheda Özkavaklı,
  • Fatih Çiçek,
  • Erencan Kılcı,
  • Mehmet Babaoğlan,
  • Şahin Sancaktar and
  • Ali Harmanoğullarından
  • + 1 author

18 June 2026

Background/Objectives: There is no consensus on whether it is possible to preserve implant retention during deep surgical site infections (SSIs), and there is no widely accepted treatment protocol to date for these patients. The aim of this study is...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
19 Citations
3,679 Views
10 Pages

The Benefice of Mobile Parts’ Exchange in the Management of Infected Total Joint Arthroplasties with Prosthesis Retention (DAIR Procedure)

  • Stefanie Hirsiger,
  • Michael Betz,
  • Dimitrios Stafylakis,
  • Tobias Götschi,
  • Daniel Lew and
  • Ilker Uçkay

9 February 2019

Background: The management of prosthetic joint infections (PJI) with debridement and retention of the implant (DAIR) has its rules. Some authors claim that lacking the exchange of mobile prosthetic parts is doomed to failure, while others regard it a...

(This article belongs to the Special Issue Complications in Total Joint Arthroplasties)
  • Article
  • Open Access
10 Citations
3,073 Views
13 Pages

3 November 2023

It is unknown how rifampicin resistance in staphylococci causing a periprosthetic joint infection (PJI) affects outcomes after debridement, antibiotics, and implant retention (DAIR). We thus aimed to compare the risk of relapse in DAIR-treated early...

(This article belongs to the Special Issue Advances in Orthopedic Infection Management and Antibiotic Treatment)
  • Article
  • Open Access
1 Citations
1,087 Views
13 Pages

17 May 2026

Background: This study aims to assess how patient comorbidities and risk factors influence treatment outcomes of periprosthetic joint infection (PJI). The role of timing for DAIR intervention, administration of antibiotics, and the microbiological pr...

(This article belongs to the Special Issue Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty)
  • Article
  • Open Access
10 Citations
2,924 Views
13 Pages

Accuracy of a Novel Preoperative Failure Risk Model for Debridement Antibiotics and Implant Retention (DAIR) in Acute Prosthetic Joint Infection

  • Ignacio Sancho,
  • Iñaki Otermin-Maya,
  • Jorge Gutiérrez-Dubois,
  • Ignacio Aláez,
  • Ángel Hidalgo-Ovejero,
  • Julián Librero and
  • María Eugenia Portillo

Given the variable success of the debridement, antibiotics and implant retention (DAIR) procedure in patients with acute prosthetic joint infection (PJI), an accurate selection of candidates is critical. In this study, we set about calculating the pr...

(This article belongs to the Special Issue Diagnosis and Treatment of Periprosthetic Joint Infections)
  • Article
  • Open Access
4 Citations
2,429 Views
14 Pages

Microbiological Profiles of Patients with Acute Periprosthetic Joint Infection Undergoing Debridement, Antibiotics, Irrigation and Implant Retention (DAIR)

  • Alberto Alfieri Zellner,
  • Niclas Watzlawik,
  • Jonas Roos,
  • Gunnar Thorben Rembert Hischebeth,
  • Ernst Molitor,
  • Alexander Franz and
  • Frank Sebastian Fröschen

Background: Periprosthetic joint infection (PJI) is one of the most serious complications following total joint arthroplasty. The debridement, antibiotics, irrigation, and implant retention (DAIR) procedure is commonly employed to treat acute, early-...

(This article belongs to the Special Issue Orthopedic Infections: Epidemiology and Antimicrobial Treatment)
  • Article
  • Open Access
1,314 Views
21 Pages

The Mursa Protocol: A Novel Multimodal Antiseptic-Based DAIR Strategy for Early Hip Periprosthetic Joint Infection

  • Slavko Čičak,
  • Josip Kocur,
  • Dino Gregorović,
  • David Matić,
  • Dalibor Kristek,
  • Damjan Dimnjaković,
  • Matej Tomić,
  • Ivan Sabol,
  • Petra Čičak and
  • Ivana Haršanji Drenjančević
  • + 2 authors

Background: Debridement, antibiotics, and implant retention (DAIR) is an established treatment for early periprosthetic joint infection (PJI) following hip arthroplasty; however, reported success rates remain highly variable, particularly in patients...

(This article belongs to the Special Issue Periprosthetic Joint Infections: Antimicrobial Biomaterials and Antibiotic Treatment)
  • Article
  • Open Access
3 Citations
1,835 Views
9 Pages

Synovial Glucose and Serum-to-Synovial Glucose Predict Failure After Acute Postoperative Infection in Total Knee Arthroplasty

  • Marta Sabater-Martos,
  • Laia Boadas,
  • Laura Morata,
  • Alex Soriano and
  • Juan Carlos Martínez-Pastor

20 April 2025

Background: The treatment of periprosthetic joint infection (PJI) involves various strategies, with debridement, antibiotic, and implant retention (DAIR) being a preferred method for acute infections due to its lower morbidity. However, DAIR success...

(This article belongs to the Special Issue Advancements in Total Joint Arthroplasty: Innovations, Outcomes and Challenges)
  • Article
  • Open Access
13 Citations
3,003 Views
9 Pages

One of the most commonly used treatments for acute prosthetic joint infection (PJI) is DAIR (debridement, antibiotics and implant retention), which comprises the debridement and the retention of the implant, followed by antibiotic treatment. The effi...

(This article belongs to the Special Issue Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research - 2nd Volume)
  • Article
  • Open Access
754 Views
9 Pages

Debridement, Antibiotics and Implant Retention in the Management of Periprosthetic Joint Infection: One-Year Outcomes, Epidemiology and Predictors of Failure

  • Caterina Rocchi,
  • Alberto Bulgarelli,
  • Vincenzo Di Matteo,
  • Katia Chiappetta,
  • Wim H. C. Rijnen,
  • Guido Grappiolo and
  • Mattia Loppini

12 May 2026

Background: Debridement, antibiotics, and implant retention (DAIR) is the treatment of choice for early and acute hematogenous periprosthetic joint infections (PJIs), but its success rates vary widely. The primary outcome of this study was to assess...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
6 Citations
3,829 Views
13 Pages

Is Negative Pressure Wound Therapy with Instillation Suitable for the Treatment of Acute Periprosthetic Hip Joint Infection?

  • Nicholas A. Beckmann,
  • Maximilian G. Hanslmeier,
  • Georg W. Omlor,
  • Manuel Feisst,
  • Michael W. Maier and
  • Burkhard Lehner

23 July 2021

Background: Periprosthetic joint infection (PJI) can be devastating for the patient and demanding for the surgeon. In acute PJI, attempts are made to retain the prosthesis by debridement of the infected tissue, targeted antibiotic therapy and an exch...

(This article belongs to the Special Issue Advances in Understanding the Pathogenesis and Pathophysiology of Orthopaedic-Related Infections)
  • Review
  • Open Access
8 Citations
3,209 Views
12 Pages

Diagnosis and Treatment of Acute Periprosthetic Infections with the BioFire® System within a Time-Dependent and Bacterium-Dependent Protocol: Review and Prosthesis-Saving Protocol

  • Rudy Sangaletti,
  • Luca Andriollo,
  • Alice Montagna,
  • Simone Franzoni,
  • Paolo Colombini,
  • Loris Perticarini,
  • Francesco Benazzo and
  • Stefano Marco Paolo Rossi

12 September 2024

Despite ongoing efforts to enhance diagnostic and treatment processes, the success rate for eradicating infections, particularly prosthetic joint infections (PJIs), currently stands at around 50%. For acute infections occurring shortly after arthropl...

(This article belongs to the Special Issue Molecular Research on Osteoarthritis and Osteoporosis)
  • Article
  • Open Access
3 Citations
5,353 Views
10 Pages

A Longer Duration of Intravenous Antibiotic Treatment for Patients with Early Periprosthetic Joint Infections Is Not Associated with a Lower Failure Rate

  • Janneke Meijer,
  • Alex Soriano,
  • Wierd Zijlstra,
  • Bas ten Have,
  • Saad Tarabichi,
  • Paul Jutte,
  • Javad Parvizi and
  • Marjan Wouthuyzen-Bakker

Background: In recent years, many studies have demonstrated the efficacy of an early switch to oral antibiotics after surgical treatment in orthopedic-related infections. However, large analyses on periprosthetic joint infections (PJIs) are lacking....

(This article belongs to the Special Issue Antimicrobial Therapeutics for Bone and Periprosthetic Joint Infection)
  • Article
  • Open Access
54 Citations
5,538 Views
12 Pages

What Factors Affect Outcome in the Treatment of Fracture-Related Infection?

  • Martin McNally,
  • Ruth Corrigan,
  • Jonathan Sliepen,
  • Maria Dudareva,
  • Rob Rentenaar,
  • Frank IJpma,
  • Bridget L. Atkins,
  • Marjan Wouthuyzen-Bakker and
  • Geertje Govaert

This international, multi-center study investigated the effect of individual components of surgery on the clinical outcomes of patients treated for fracture-related infection (FRI). All patients with surgically treated FRIs, confirmed by the FRI cons...

(This article belongs to the Special Issue Fracture-Related Infection: An Update on Antimicrobial Therapy)
  • Article
  • Open Access
1 Citations
2,407 Views
11 Pages

Acute Prosthetic Joint Infections with Poor Outcome Caused by Staphylococcus Aureus Strains Producing the Panton–Valentine Leukocidin

  • Martina Maritati,
  • Marco Manfrini,
  • Maria Rosa Iaquinta,
  • Alessandro Trentini,
  • Silva Seraceni,
  • Matteo Guarino,
  • Anna Costanzini,
  • Roberto De Giorgio,
  • Gustavo Alberto Zanoli and
  • Carlo Contini
  • + 3 authors

The aim of this study was to investigate whether the presence of Staphylococcus aureus (SA) producing the Panton–Valentine leukocidin (PVL) affects the outcome of Prosthetic Joint Infection (PJI). Patients with acute and chronic PJI sustained b...

(This article belongs to the Topic Biomarker Development and Application)
  • Article
  • Open Access
24 Citations
5,030 Views
9 Pages

Debridement, Antibiotic Pearls, and Retention of the Implant (DAPRI) in the Treatment of Early Periprosthetic Joint Infections: A Consecutive Series

  • Pier Francesco Indelli,
  • Stefano Ghirardelli,
  • Pieralberto Valpiana,
  • Lorenzo Bini,
  • Michele Festini and
  • Ferdinando Iannotti

Introduction: Periprosthetic joint infections (PJI) represent a devastating consequence following total joint arthroplasty (TJA). In this study, the authors describe a modified surgical technique developed to enhance the classical irrigation and debr...

(This article belongs to the Section Bacterial Pathogens)
  • Review
  • Open Access
3 Citations
6,615 Views
20 Pages

Treatment Duration in Bacterial Prosthetic Joint Infections: A Narrative Review of Current Evidence

  • Hajer Harrabi,
  • Christel Mamona-Kilu,
  • Eloïse Meyer,
  • Emma d’Anglejan Chatillon,
  • Nathalie Dournon,
  • Frédérique Bouchand,
  • Clara Duran,
  • Véronique Perronne,
  • Karim Jaffal and
  • Aurélien Dinh

25 October 2025

Background/Objectives: The optimal duration of antibiotic therapy for bacterial prosthetic joint infections (PJI) remains a topic of considerable debate. Current recommendations are often based on limited evidence and expert consensus. Emerging data...

(This article belongs to the Special Issue Orthopedic Infections: Epidemiology and Antimicrobial Treatment)
  • Systematic Review
  • Open Access
215 Views
17 Pages

Clinical Outcomes and Safety Associated with Adjunctive Antibiotic-Loaded Calcium Sulphate Beads in Hip and Knee Periprosthetic Joint Infection: A Systematic Review

  • Abdulelah K. Alqawlaq,
  • Ruwaydah Hamoud M. Alruways,
  • Wesal Abdulrahman Alqurashi,
  • Ola Mustafa Altaib,
  • Ayman Awlia,
  • Ahmed Bannan,
  • Moayd A. Awad,
  • Bandar Hetaimish,
  • Mohammed R. Algethami and
  • Ramy Samargandi

27 September 2026

Background/Objectives: Antibiotic-loaded calcium sulphate beads (CSBs) are biodegradable local antibiotic carriers used as an adjunct to surgical and systemic antimicrobial treatment of periprosthetic joint infection (PJI). Their incremental clinical...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
29 Citations
6,277 Views
16 Pages

3DAirSig: A Framework for Enabling In-Air Signatures Using a Multi-Modal Depth Sensor

  • Jameel Malik,
  • Ahmed Elhayek,
  • Sheraz Ahmed,
  • Faisal Shafait,
  • Muhammad Imran Malik and
  • Didier Stricker

10 November 2018

In-air signature is a new modality which is essential for user authentication and access control in noncontact mode and has been actively studied in recent years. However, it has been treated as a conventional online signature, which is essentially a...

(This article belongs to the Special Issue Artificial Intelligence and Machine Learning in Sensors Networks)
  • Review
  • Open Access
26 Citations
7,224 Views
19 Pages

Pediatric Extra-Renal Nephroblastoma (Wilms’ Tumor): A Systematic Case-Based Review

  • Akzhol Karim,
  • Kundyz Shaikhyzada,
  • Nazgul Abulkhanova,
  • Akzhunis Altyn,
  • Bakytkali Ibraimov,
  • Dair Nurgaliyev and
  • Dimitri Poddighe

29 April 2023

Wilms Tumor (WT) is one of the most common renal tumors in the pediatric population. Occasionally, WT can primarily develop outside the kidneys (Extra-Renal Wilms Tumor, ERWT). Most pediatric ERWTs develop in the abdominal cavity and pelvis, whereas...

(This article belongs to the Section Pediatric Oncology)
  • Article
  • Open Access
3 Citations
1,688 Views
18 Pages

12 November 2024

Large-scale superconductor applications necessitate a superconducting matrix with pinning sites (PSs) that immobilize vortices at elevated temperatures and magnetic fields. While previous works focused on the single addition of nanoparticles, the sim...

(This article belongs to the Section Nanoelectronics, Nanosensors and Devices)
  • Article
  • Open Access
191 Views
18 Pages

Eleven-Year Trends in Stillbirth, Neonatal and Infant Mortality and Birthweight-Specific Risk: A BABIES Matrix Analysis from a Tertiary Maternity Center in Kazakhstan, 2015–2025

  • Ardak Ayazbekov,
  • Saken Khaidarov,
  • Mukhabat Nartayeva,
  • Venera Israilova,
  • Assel Arginbekova,
  • Aliya Aubakirova,
  • Zhulduz Galiyeva,
  • Aliya Meirmanova,
  • Gulmira Rapilbekova and
  • Dair Seisembekov

22 September 2026

Background/Objectives: Long-run facility-level perinatal data from Central Asia are scarce. We described eleven years of stillbirth, neonatal, infant and perinatal mortality at one tertiary maternity center in Kazakhstan, and used the Birthweight and...

(This article belongs to the Special Issue Addressing Challenges in Pediatric Critical Care Medicine (2nd Edition))
  • Article
  • Open Access
316 Views
28 Pages

Associations of Mediterranean Diet Adherence with Cardiometabolic Outcomes, Psychological Symptoms, and Health-Related Quality of Life Among Adults Attending Primary Care Centres in Navarra, Spain: A Cross-Sectional Study

  • Julieth Paola Sulaiman Rojas,
  • José Abellán Alemán,
  • Gonzalo Luis Alonso Salinas,
  • Miladi del Socorro Golac Rabanal,
  • Cédric Marco Detchart,
  • Isabel Arrechea Irigoyen,
  • Manuela García Sánchez,
  • Daime Pérez Feíto,
  • Virginia Íñiguez García and
  • Alcibíades Segundo Díaz Vera
  • + 10 authors

25 September 2026

Background/Objectives: Mediterranean diet adherence has been associated with cardiometabolic and psychological health, but evidence integrating these outcomes with health-related quality of life in primary care populations remains limited. This study...

(This article belongs to the Section Nutritional Epidemiology)
  • Article
  • Open Access
15 Citations
4,375 Views
13 Pages

Implant Removal in the Management of Prosthetic Joint Infection by Staphylococcus aureus: Outcome and Predictors of Failure in a Large Retrospective Multicenter Study

  • Joan Gómez-Junyent,
  • Jaime Lora-Tamayo,
  • Josu Baraia-Etxaburu,
  • Mar Sánchez-Somolinos,
  • Jose Antonio Iribarren,
  • Dolors Rodriguez-Pardo,
  • Julia Praena-Segovia,
  • Luisa Sorlí,
  • Alberto Bahamonde and
  • Oscar Murillo
  • + 11 authors

Objectives: To compare the characteristics and outcomes of cases with acute prosthetic joint infection (PJI; early post-surgical or hematogenous) by Staphylococcus aureus managed with implant removal (IRm) or debridement and retention (DAIR). To anal...

(This article belongs to the Special Issue Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research)
  • Article
  • Open Access
2 Citations
3,104 Views
9 Pages

Introduction: Periprosthetic joint infection (PJI) remains a serious complication after total knee arthroplasty (TKA). While debridement, antibiotics, and implant retention (DAIR) are considered for acute PJI, success rates vary. This study aims to a...

(This article belongs to the Section Antibiotic Therapy in Infectious Diseases)
  • Article
  • Open Access
416 Views
16 Pages

12 June 2026

Background: Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) is a serious complication associated with substantial morbidity and healthcare costs. Although two-stage revision arthroplasty is widely accepted as a standard t...

(This article belongs to the Special Issue Clinical Management of Knee Arthroplasty)
  • Review
  • Open Access
17 Citations
5,240 Views
15 Pages

Risk Factors and Management of Prosthetic Joint Infections in Megaprostheses—A Review of the Literature

  • Marcos R. Gonzalez,
  • Juan Pretell-Mazzini and
  • Santiago A. Lozano-Calderon

Prosthetic joint infection (PJI) is the most common mode of failure of megaprostheses, yet the literature on the topic is scarce, and studies report conflicting data regarding the optimal treatment strategy. Patients with megaprostheses PJI are often...

(This article belongs to the Special Issue Advances in Orthopedic Infection Management and Antibiotic Treatment)
  • Review
  • Open Access
84 Citations
9,361 Views
20 Pages

Local Antibiotic Delivery Options in Prosthetic Joint Infection

  • William Steadman,
  • Paul R. Chapman,
  • Michael Schuetz,
  • Beat Schmutz,
  • Andrej Trampuz and
  • Kevin Tetsworth

Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally. Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes and enhance biofilm eradication. These antibiotics can...

  • Review
  • Open Access
2,937 Views
14 Pages

Prevention and Treatment of Surgical Site Infections in Orthopaedic Surgery: An Italian Delphi Consensus on Risk Stratification and Wound Irrigation Strategies

  • Pier Francesco Indelli,
  • Massimiliano De Paolis,
  • Arcangelo Russo,
  • Massimo Fantoni,
  • Augusto Palermo,
  • Giovanni Pomponio,
  • Alessandro Scalise,
  • Domenico Tigani,
  • Bruno Violante and
  • Pierluigi Viale
  • + 2 authors

24 February 2026

Introduction: Surgical site infections (SSIs) and prosthetic joint infections remain among the most serious complications in orthopedic surgery, and chemical debridement is recommended for all septic revisions. The combination of polyhexanide (PHMB)...

(This article belongs to the Special Issue Clinical Advances in Trauma and Orthopaedic Surgery)
  • Article
  • Open Access
2,194 Views
12 Pages

The Management of Periprosthetic Joint Infections: The Transformative Impact of Calcium Sulfate Carriers in Orthopedic Surgery and Their Role in Enhancing Patient Outcomes

  • Elisa Troiano,
  • Simone Alongi,
  • Cristina Rosa Coco,
  • Cristina Latino,
  • Tiziano Giacché,
  • Stefano Giannotti and
  • Nicola Mondanelli

27 February 2026

Background/Objectives: The prevalence of joint replacement surgeries has significantly increased over the last century, leading to a corresponding rise in complications, particularly periprosthetic joint infection (PJI). The management of a PJI invol...

(This article belongs to the Special Issue State of Art in Hip, Knee and Shoulder Replacement (Volume 2))
  • Case Report
  • Open Access
1 Citations
1,451 Views
10 Pages

Application of Molecular Diagnostics in Periprosthetic Joint Infection Microorganism Identification Following Screening Colonoscopy: A Case Report and Review of the Literature

  • Pieralberto Valpiana,
  • Andrea Giordano Salvi,
  • Michele Paolo Festini Capello,
  • Fjorela Qordja,
  • Sebastian Schaller,
  • Jaeah Kim and
  • Pier Francesco Indelli

21 November 2025

Background: Culture-negative periprosthetic joint infections (PJIs) are dramatically increasing in prevalence. The success rate of implant-saving procedures in acute PJI cases is closely correlated with prompt diagnosis, rapid isolation/identificatio...

(This article belongs to the Section Orthopedics and Rehabilitation)
  • Article
  • Open Access
12 Citations
4,407 Views
13 Pages

Impact of a Novel Antiseptic Lavage Solution on Acute Periprosthetic Joint Infection in Hip and Knee Arthroplasty

  • Luca Andriollo,
  • Rudy Sangaletti,
  • Calogero Velluto,
  • Loris Perticarini,
  • Francesco Benazzo and
  • Stefano Marco Paolo Rossi

24 May 2024

Background: Periprosthetic joint infection (PJI) represents a challenge following hip or knee arthroplasty, demanding immediate intervention to prevent implant failure and systemic issues. Bacterial biofilm development on orthopedic devices worsens P...

(This article belongs to the Special Issue Knee Arthroplasty Surgery: Management and Future Opportunities)
  • Article
  • Open Access
19 Citations
8,935 Views
16 Pages

10 February 2017

Denitrifying bioreactors are an agricultural best management practice developed in the midwestern United States to treat agricultural drainage water enriched with nitrate‐nitrogen (NO3N). The practice is spreading rapidly to agricultural regions wit...

  • Article
  • Open Access
6 Citations
3,664 Views
10 Pages

Antibiotic-Loaded Calcium Sulphate Beads for Treatment of Acute Periprosthetic Joint Infection in Total Knee Arthroplasty: Results Based on Risk Stratification

  • Edward J. McPherson,
  • Madhav Chowdhry,
  • Matthew V. Dipane,
  • Benedikt Marahrens,
  • Diego Dela Pena and
  • Alexandra I. Stavrakis

25 February 2025

Background: A post-operative or late acute periprosthetic joint infection (PJI) after Total Knee Arthroplasty (TKA) requires a protocol of aggressive joint Debridement, modular implant Exchange, Component Retention, and post-operative Antimicrobial t...

(This article belongs to the Special Issue Total Joint Arthroplasty: Management and Future Opportunities)
  • Review
  • Open Access
9 Citations
5,637 Views
9 Pages

Early Management for Fracture-Related Infection: A Literature Review

  • Giovanni Vicenti,
  • Claudio Buono,
  • Federica Albano,
  • Teresa Ladogana,
  • Elisa Pesare,
  • Giulia Colasuonno,
  • Anna Claudia Passarelli and
  • Giuseppe Solarino

Fracture-related infections (FRIs), as shown in the literature, represent one of the main complications of trauma surgery. They are a consequence of an implant-related “biofilm” formation and are a challenge for surgeons, microbiologists,...

(This article belongs to the Special Issue Orthopedic Implant-Associated Infections: Unlocking the Secrets of Prevention and Treatment)
  • Systematic Review
  • Open Access
22 Citations
3,525 Views
16 Pages

Total Ankle Replacement Infections: A Systematic Review of the Literature

  • Renato Zunarelli,
  • Michele Fiore,
  • Gianluca Lonardo,
  • Andrea Pace,
  • Valentina Persiani,
  • Massimiliano De Paolis and
  • Andrea Sambri

15 December 2023

Periprosthetic infection (PJI) after TAR is a serious complication, often requiring further surgery, including revision arthroplasty, conversion to ankle arthrodesis, or even amputation. This systematic review aims to summarize the current evidence o...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
12 Citations
3,025 Views
15 Pages

Microbiological and Molecular Features Associated with Persistent and Relapsing Staphylococcus aureus Prosthetic Joint Infection

  • Irene Muñoz-Gallego,
  • María Ángeles Meléndez-Carmona,
  • Jaime Lora-Tamayo,
  • Carlos Garrido-Allepuz,
  • Fernando Chaves,
  • Virginia Sebastián and
  • Esther Viedma

Background: Persistent and relapsing prosthetic joint infection (PJI) due to Staphylococcus aureus presents a clinical challenge. This study aimed to provide an extensive description of phenotypic and genomic changes that could be related to persiste...

(This article belongs to the Special Issue Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research - 2nd Volume)
  • Systematic Review
  • Open Access
17 Citations
4,879 Views
11 Pages

Debridement, Antibiotics and Implant Retention: A Systematic Review of Strategies for Treatment of Early Infections after Revision Total Knee Arthroplasty

  • Caspar W. J. Hulleman,
  • Tommy S. de Windt,
  • Karin Veerman,
  • Jon H. M. Goosen,
  • Frank-Christiaan B. M. Wagenaar and
  • Gijs G. van Hellemondt

31 July 2023

Goal: The purpose of this review is to provide a systematic and comprehensive overview of the available literature on the treatment of an early prosthetic joint infection (PJI) after revision total knee arthroplasty (TKA) and provide treatment guidel...

(This article belongs to the Special Issue Knee Arthroplasty: Therapeutic and Management Strategies)
  • Review
  • Open Access
9 Citations
4,156 Views
13 Pages

Debridement, Antibiotic Pearls, and Retention of the Implant (DAPRI) in the Treatment of Early Periprosthetic Knee Joint Infections: A Literature Review

  • Giovanni Vicenti,
  • Elisa Pesare,
  • Giulia Colasuonno,
  • Claudio Buono,
  • Federica Albano,
  • Teresa Ladogana,
  • Anna Claudia Passarelli and
  • Giuseppe Solarino

(1) Background: Periprosthetic joint infections (PJIs) are severe and frightening complications in orthopaedic surgery, and they are generally divided into three categories: early infections (those occurring within the first 4–6 weeks), delayed...

(This article belongs to the Special Issue Orthopedic Implant-Associated Infections: Unlocking the Secrets of Prevention and Treatment)
  • Article
  • Open Access
3 Citations
1,910 Views
8 Pages

Periprosthetic Joint Infection in Unicompartmental vs. Total Knee Arthroplasty: Microbiological Spectrum and Management Outcomes

  • Ali Said Nazlıgül,
  • Şahan Güven,
  • Yasin Erdoğan,
  • Ahmet Fırat,
  • Metin Doğan and
  • Mustafa Akkaya

Background/Objectives: Periprosthetic joint infection (PJI) is a severe complication following both total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA). While the microbiological profile of TKA PJI has been well characterized,...

(This article belongs to the Special Issue Periprosthetic Joint Infection: Understanding the Epidemiology, Pathogenesis, Diagnosis and Treatment Options)
  • Review
  • Open Access
6 Citations
3,451 Views
13 Pages

Fungal prosthetic joint infection (fPJI) is one of the orthopaedic pathologies where there is no clear evidence, guidelines or algorithm to guide the surgeon in its management. This is in addition to the difficulty with which these infections are dia...

(This article belongs to the Special Issue Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments)
  • Article
  • Open Access
7 Citations
1,480 Views
10 Pages

The Impact of Antibiotic Therapy Options and Multidisciplinary Approach in Prosthetic Joint Infections

  • João Lucas,
  • José Queirós,
  • Daniel Soares,
  • André Carvalho,
  • Filipa Pereira,
  • Cláudia Santos,
  • Ricardo Sousa and
  • Miguel Araújo Abreu

Periprosthetic joint infection (PJI) remains one of the most challenging complications of arthroplasty. Optimal antibiotic strategies and the role of multidisciplinary teams (MDT) are not fully defined. We retrospectively analyzed 86 PJI surgical pro...

(This article belongs to the Special Issue Challenges of Biofilm-Associated Bone and Joint Infections)
  • Brief Report
  • Open Access
22 Citations
3,707 Views
7 Pages

12 September 2023

Periprosthetic joint infection (PJI) remains among the most challenging and costly complications. PJI rates vary from 0.39% to 3.9% after total knee arthroplasty (TKA). This study aimed to identify the causative microorganisms involved and to report...

(This article belongs to the Special Issue Advanced Knee Surgery)
  • Article
  • Open Access
4 Citations
2,776 Views
17 Pages

22 October 2023

The objective of vehicle search is to locate and identify vehicles in uncropped, real-world images, which is the combination of two tasks: vehicle detection and re-identification (Re-ID). As an emerging research topic, vehicle search plays a signific...

(This article belongs to the Section Vehicular Sensing)
  • Review
  • Open Access
15 Citations
5,381 Views
10 Pages

16 August 2024

Local antibiotic infusion has emerged as a promising adjunctive therapy, delivering high concentrations of antibiotics directly to the infection site. This approach aims to enhance eradication of pathogens while minimizing systemic side effects assoc...

(This article belongs to the Special Issue Current Trends in Hip Surgery)
  • Article
  • Open Access
579 Views
13 Pages

From Trends to Insights: Management of Periprosthetic Joint Infections in the Past Decade in The Netherlands

  • Floor C. A. Koelewijn,
  • Jesse W. P. Kuiper,
  • Ruben Scholten,
  • Jakob van Oldenrijk,
  • Matthijs P. Somford,
  • Duncan E. Meuffels and
  • Ewout S. Veltman

The prevention and optimal treatment of periprosthetic joint infections (PJI), including antibiotic prophylaxis and DAIR (debridement, antibiotics, and implant retention), is a controversial topic. This study evaluated treatment trends over the past...

(This article belongs to the Section Medical Microbiology)
  • Article
  • Open Access
5 Citations
5,088 Views
35 Pages

An Interactive Recommendation System for Decision Making Based on the Characterization of Cognitive Tasks

  • Teodoro Macias-Escobar,
  • Laura Cruz-Reyes,
  • César Medina-Trejo,
  • Claudia Gómez-Santillán,
  • Nelson Rangel-Valdez and
  • Héctor Fraire-Huacuja

The decision-making process can be complex and underestimated, where mismanagement could lead to poor results and excessive spending. This situation appears in highly complex multi-criteria problems such as the project portfolio selection (PPS) probl...

(This article belongs to the Special Issue Numerical and Evolutionary Optimization 2020)
  • Article
  • Open Access
9 Citations
2,623 Views
14 Pages

Patient-Reported Outcome on Quality of Life and Pain after Revision Arthroplasty for Periprosthetic Joint Infection: A Cross-Sectional Study

  • Chaofan Zhang,
  • Ziyu Liu,
  • Yunzhi Lin,
  • Yuanqing Cai,
  • Xuehui Zhang,
  • Zida Huang,
  • Ying Huang,
  • Wenbo Li,
  • Xinyu Fang and
  • Wenming Zhang

2 December 2022

This study aims to explore the quality of life (QOL) and pain after revision surgery for periprosthetic joint infection (PJI) based on patients’ reported outcomes. A cross-sectional questionnaire survey was conducted and 137 valid responses wer...

(This article belongs to the Section General Surgery)
  • Review
  • Open Access
16 Citations
10,736 Views
17 Pages

Appropriate Duration of Antimicrobial Treatment for Prosthetic Joint Infections: A Narrative Review

  • Jaime Lora-Tamayo,
  • Mikel Mancheño-Losa,
  • María Ángeles Meléndez-Carmona,
  • Pilar Hernández-Jiménez,
  • Natividad Benito and
  • Oscar Murillo

Prosthetic joint infections are considered difficult to treat they needing aggressive surgery and long antimicrobial treatments. However, the exact duration of these therapies has been established empirically. In the last years, several studies have...

(This article belongs to the Special Issue Antimicrobial Therapeutics for Bone and Periprosthetic Joint Infection)

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