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Antibiotics
Special Issues
Periprosthetic Joint Infections: Antimicrobial Biomaterials and Antibiotic Treatment
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Periprosthetic Joint Infections: Antimicrobial Biomaterials and Antibiotic Treatment

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 835

Special Issue Editor

Prof. Dr. Konstantinos Anagnostakos

E-Mail Website
Guest Editor
Abteilung für Gelenkchirurgie und Sporttraumatologie, Nardini Klinikum St. Elisabeth, Zweibrücken, Germany
Interests: primary and revision joint arthroplasty of hip and knee; diagnostics and therapy of bone and joint infections; local antibiotic therapy; antibiotic-loaded bone cement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Collegaues,

The last International Consensus Meeting in Istanbul taught us something key: there is major global interest in prevention, diagnosis, antibiotic therapy, and surgical treatment in periprosthetic joint infections (PJIs). Advances, innovations, and new techniques have enhanced the management of PJIs over the last two decades, but there is still a long way to go.

I am excited to be collaborating with Antibiotics to bring you this Special Issue on PJIs. Articles related to antimicrobial biomaterials, associated in vitro and clinical studies, surgical techniques, local and systemic antibiotic therapy, and more will be considered for publication. Original research articles are welcome, as well as review articles.

I am looking forward to working with you.

Prof. Dr. Konstantinos Anagnostakos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periprosthetic joint infection (PJI)
  • local antibiotic therapy
  • systemic antibiotic therapy
  • bone cement
  • antibiotic carrier
  • one-stage treatment
  • two-stage treatment

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Published Papers (1 paper)

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Research

16 pages, 1788 KB  
Article
Biofilm Formation Patterns of S. epidermidis (RP62A) and S. aureus (UAMS-1) Are Defined by Orthopaedic Implant Materials and Surface Wear
by Tatyana Sevastyanova, Cornelia Loy, Barbara Schneider-Wald, Klaus Notarbartolo, Gregor Reisig, Stefanie Gaiser, Ali Darwich, Mohamad Bdeir, Alexander Blümke, Sascha Gravius and Andreas Schilder
Antibiotics 2026, 15(4), 338; https://doi.org/10.3390/antibiotics15040338 - 26 Mar 2026
Viewed by 597
Abstract
Background/Objectives: Staphylococcus epidermidis (RP62A) and Staphylococcus aureus (UAMS-1) are clinically relevant pathogens frequently implicated in implant-associated infections due to their ability to form biofilms. RP62A is typically linked to persistent, chronic, low-grade infections, whereas UAMS-1 is associated with acute, invasive disease. Both [...] Read more.
Background/Objectives: Staphylococcus epidermidis (RP62A) and Staphylococcus aureus (UAMS-1) are clinically relevant pathogens frequently implicated in implant-associated infections due to their ability to form biofilms. RP62A is typically linked to persistent, chronic, low-grade infections, whereas UAMS-1 is associated with acute, invasive disease. Both strains serve as representative models for chronic and acute periprosthetic joint infections (PJIs). The objective of this study was to examine and compare in vitro biofilm formation by RP62A and UAMS-1 on orthopaedic materials/disc surfaces of defined composition. Methods: In vitro biofilm formation assays were performed using orthopaedic disc surfaces composed of cobalt–chromium alloy (CoCr), titanium alloy (Ti), and polyethylene (PE) after 72 h of incubation. Biofilm biomass was quantified using crystal violet staining, with absorbance measured at OD570. A polystyrene (PS) surface served as a control. Additionally, retrieved orthopaedic explant components were used as substrates for in vitro biofilm assays, in which RP62A was incubated for 72 h on the explanted surfaces. Supporting assays on glass slides were conducted to examine strain-specific biofilm-related architecture. Results: In vitro biofilm mass quantification assays showed strong biofilm formation by RP62A across all tested surfaces, with the highest absorbance on CoCr (OD570 = 5.80 ± 0.19). Notably, biofilm formation on CoCr was 76% higher compared to PS (p < 0.0001). No significant differences were observed among all three surface discs (p > 0.1). Biofilm formation was highest on PE for UAMS-1 (OD570 = 1.29 ± 0.09) and was significantly greater than on Ti (178%, p < 0.001) and CoCr (196%, p < 0.0001). In the in vitro assays performed on retrieved explant components, RP62A showed pronounced biofilm accumulation on polyethylene tibial inserts, particularly in regions of mechanical wear and friction. Supporting assays on glass slides were performed to examine strain-specific surface microstructural, revealing dense network-like structures for RP62A and thinner, discontinuous layers for UAMS-1. Conclusions: RP62A formed dense biofilms in vitro on multiple orthopaedic implant materials and retrieved explant components, consistent with its association with chronic periprosthetic joint infections. Increased biofilm accumulation was observed on mechanically worn polyethylene surfaces. In contrast, UAMS-1 showed lower biofilm formation on metallic disc surfaces, indicating strain- and material-dependent differences. These findings highlight the relevance of implant material selection and surface integrity for strategies targeting biofilm-associated implant infections. Full article
(This article belongs to the Special Issue Periprosthetic Joint Infections: Antimicrobial Biomaterials and Antibiotic Treatment)
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