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Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty
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Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 28 October 2025 | Viewed by 849

Special Issue Editor

Dr. Andrea Volpin

E-Mail Website
Guest Editor
Department of Trauma and Orthopaedics, NHS Grampian, University of Aberdeen, Aberdeen, UK
Interests: arthroscopic surgery; hip and knee arthroplasty; sport medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advancements in medical technology and surgical techniques have transformed the landscape of hip and knee arthroplasty, enhancing patient outcomes and expanding the scope of treatment options. This Special Issue focuses on the latest innovations, clinical approaches, and long-term results associated with these critical procedures.

Topics of interest include, but are not limited to, the following:

  • Emerging technologies in arthroplasty, such as robotics and AI-driven systems.
  • Optimizing perioperative care to improve patient recovery.
  • New materials and implant designs to enhance joint longevity.
  • Comparative studies on minimally invasive versus traditional surgical techniques.
  • Addressing challenges such as prosthetic infections and revision surgeries.
  • Insights into patient-specific care strategies and their impact on clinical outcomes.

We warmly invite submissions from researchers, clinicians, and industry experts, aiming at fostering a multidisciplinary exchange of ideas and knowledge that will shape the future of hip and knee arthroplasty.

Dr. Andrea Volpin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hip arthroplasty
  • knee arthroplasty
  • joint replacement
  • clinical outcomes
  • surgical innovation
  • patient recovery
  • prosthetics
  • perioperative care

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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20 pages, 439 KB  
Systematic Review
Outcomes of Iso-Elastic Acetabular Cup in Primary Total Hip Arthroplasty with 5-Year Minimum Follow-Up: A Systematic Review
by Vincenzo Longobardi, Marco Minelli, Giacomo Pietrogrande, Giuseppe Anzillotti, Federico Della Rocca and Mattia Loppini
J. Clin. Med. 2025, 14(18), 6621; https://doi.org/10.3390/jcm14186621 - 19 Sep 2025
Viewed by 240
Abstract
Background: Long-term survivorship in total hip arthroplasty (THA) is influenced by implant stability and stress distribution to surrounding bone. Isoelastic acetabular components are monoblock polyethylene cups with a low elastic modulus, which were developed to reduce stress shielding and enhance periacetabular bone preservation. [...] Read more.
Background: Long-term survivorship in total hip arthroplasty (THA) is influenced by implant stability and stress distribution to surrounding bone. Isoelastic acetabular components are monoblock polyethylene cups with a low elastic modulus, which were developed to reduce stress shielding and enhance periacetabular bone preservation. This systematic review aimed to evaluate the mid- to long-term clinical outcomes, wear rate, and survivorship of isoelastic cups in primary THA with a minimum follow-up of five years. Materials and methods: A systematic literature search was performed in April 2025 across PubMed, Embase, Cochrane Library, and Google Scholar following PRISMA 2020 guidelines. Inclusion criteria comprised clinical studies on isoelastic acetabular cups in primary THA with a minimum of five years of follow-up. Data on survivorship, complications, clinical outcomes, wear, and radiological performance were extracted and analyzed. Risk of bias in each study was assessed through the Newcastle–Ottawa Scale (NOS) for observational studies and the Cochrane Risk of Bias 2 (RoB 2) tool for randomized controlled trials. Results: Twelve studies, encompassing 1491 hips, met the inclusion criteria. Mean follow-up was 8.1 years. Overall implant survival rate ranged from 82.7% to 100%. Mean Harris Hip Score was 92.6, with low reported pain and high satisfaction. Mean annual wear was 0.05 mm/year. Vitamin E-infused highly cross-linked polyethylene (VEHXLPE) cups demonstrated lower femoral head penetration compared to UHMWPE. A randomized trial showed reduced bone loss in the polar region with isoelastic cups versus modular titanium cups (4.9% versus 15.9%, p = 0.005). Complication and revision rates were low, though heterogeneity in cup positioning reporting and variable follow-up durations were noted. Conclusions: Isoelastic acetabular components demonstrate excellent survivorship, low wear rates, and favorable clinical outcomes at mid- to long-term follow-up. High-quality, long-term comparative studies are needed to confirm these findings across broader patient populations. Full article
(This article belongs to the Special Issue Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty)
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19 pages, 406 KB  
Systematic Review
Risk Factors for Iliopsoas Impingement Following Total Hip Arthroplasty: A Systematic Review
by Marco Minelli, Vincenzo Longobardi, Alessandro Del Monaco, Alessio D’Addona, Pierangelo Za, Federico Della Rocca and Mattia Loppini
J. Clin. Med. 2025, 14(18), 6376; https://doi.org/10.3390/jcm14186376 - 10 Sep 2025
Viewed by 386
Abstract
Background: Iliopsoas impingement (IPI) is an increasingly recognized cause of persistent groin pain following total hip arthroplasty (THA), often resulting from mechanical conflict between the iliopsoas tendon and the anterior rim of the acetabular component. Despite its clinical relevance, risk factors contributing to [...] Read more.
Background: Iliopsoas impingement (IPI) is an increasingly recognized cause of persistent groin pain following total hip arthroplasty (THA), often resulting from mechanical conflict between the iliopsoas tendon and the anterior rim of the acetabular component. Despite its clinical relevance, risk factors contributing to IPI remain poorly defined. Methods: A systematic search of PubMed, Embase, Scopus, and the Cochrane Library was conducted according to PRISMA guidelines. Studies were eligible if they evaluated adult patients undergoing primary THA and reported at least one risk factor associated with IPI. Only studies with a clearly defined clinical diagnosis of IPI were included. Data extraction and risk of bias assessments were performed independently by two reviewers. Risk of bias in each study was assessed through the Newcastle-Ottawa Scale. Results: Twelve observational studies met the inclusion criteria. Diagnosis of IPI was based on clinical symptoms of anterior groin pain exacerbated by hip flexion; 9 studies confirmed diagnosis with anesthetic injections. Key surgical risk factors included anterior cup prominence (ORs 1.16–35.20), oversized cups (cup-to-head ratio > 1.2, OR = 5.39, or ≥6 mm difference, OR = 26.00), decreased cup inclination, collared stem protrusion (OR = 13.89), and acetabular screw protrusion > 6.4 mm. Patient-specific risk factors included female sex (ORs 2.56, 2.79), higher BMI (OR = 1.07), younger age, previous hip arthroscopy (OR = 9.60) and spinal fusion (OR = 4.60). The anterolateral approach was also associated with higher IPI risk when compared to the posterior approach (OR = 4.20). Conclusions: IPI after THA is a multifactorial complication influenced by modifiable surgical variables and patient-specific anatomy. Careful preoperative planning, precise implant positioning, and attention to individual risk factors are essential to reduce IPI incidence and improve outcomes. Full article
(This article belongs to the Special Issue Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty)
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