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Antibiotics
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Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and...
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Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2121

Special Issue Editors

Prof. Dr. Guillem Bori

E-Mail Website
Guest Editor
Department of Orthopaedics, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain
Interests: knee arthroplasty; hip arthroplasty; bone and joint infection
Dr. Carlo L. Romanò

E-Mail Website
Guest Editor
Romano Institute ShPK, Tirana, Albania
Interests: knee arthroplasty; hip arthroplasty; bone and joint infection

Special Issue Information

Dear Colleagues,

We are delighted to extend a warm invitation to authors and experts in the field of orthopedics and arthroplasty to contribute their valuable insights to our upcoming Special Issue entitled "Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments".

This Special Issue aims to serve as a comprehensive platform for the exchange of cutting-edge research and innovative approaches in the realm of one-stage revision arthroplasty. With the increasing prevalence of prosthetic joint infections, the integration of local antibacterial implant protection techniques, coupled with advancements in antibiotic and surgical treatments, has become paramount in ensuring successful outcomes for patients undergoing revision procedures.

We welcome original research articles, reviews, case studies, and perspectives that delve into the latest developments, challenges, and breakthroughs in the field. By contributing to this Special Issue, authors will have the opportunity to shape the discourse around best practices, novel strategies, and emerging technologies in the context of one-stage revision arthroplasty.

Your expertise and contributions will undoubtedly enrich the collective knowledge base, fostering advancements that directly impact patient care and outcomes.

We look forward to receiving your submissions and collaborating to create an insightful and impactful Special Issue.

Best regards,

Prof. Dr. Guillem Bori
Dr. Carlo L. Romanò
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • knee arthroplasty
  • hip arthroplasty
  • shoulder arthroplasty
  • antibiotic treatment
  • one-stage revision arthroplasty
  • antibacterial coating

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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13 pages, 991 KiB  
Article
The Accuracy of Empirical Antibiotic Treatment for Periprosthetic Joint Infections in Total Shoulder and Knee Arthroplasties
by Katrin Freller, Hannah Punz, Clemens Schopper, Tobias Gotterbarm, Antonio Klasan and Stella Stevoska
Antibiotics 2025, 14(5), 447; https://doi.org/10.3390/antibiotics14050447 - 28 Apr 2025
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Abstract
Introduction: Periprosthetic joint infections (PJIs) remain a major challenge in orthopedic and trauma surgeries. The microbial resistance profiles and the optimal choice of empirical antibiotic therapy in shoulder arthroplasty revision are less well characterized compared to those in knee or hip arthroplasty revision. [...] Read more.
Introduction: Periprosthetic joint infections (PJIs) remain a major challenge in orthopedic and trauma surgeries. The microbial resistance profiles and the optimal choice of empirical antibiotic therapy in shoulder arthroplasty revision are less well characterized compared to those in knee or hip arthroplasty revision. Materials and Methods: This retrospective study constitutes a novel comparative analysis, providing valuable insights into the presence of joint-specific pathogen resistance and the empirical treatment accuracy of shoulder and knee arthroplasties. A review of all the revision cases following primary shoulder and knee arthroplasties conducted between January 2012 and December 2023 was performed. Cases that required revision because of PJIs were identified, and microbial cultures were analyzed to determine the presence of pathogens and their resistance profiles. Results: The most administered postoperative empirical antibiotics were cefuroxime and amoxicillin–sulbactam. A statistically significant difference in the prevalence of anerobic pathogens was observed between total shoulder arthroplasty and knee arthroplasty. Furthermore, a statistically significant difference was observed in the sensitivities of pathogens to metronidazole (p < 0.001) and erythromycin (p = 0.014). Conclusions: This study demonstrates microbiological and antimicrobial resistance differences between PJI TSA and TKA cases. Full article
(This article belongs to the Special Issue Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments)
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Review

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11 pages, 651 KiB  
Review
Enhancing Pathogen Detection in Implant-Related Infections through Chemical Antibiofilm Strategies: A Comprehensive Review
by Fabiana Giarritiello, Carlo Luca Romanò, Guenter Lob, Joseph Benevenia, Hiroyuki Tsuchiya, Emanuele Zappia and Lorenzo Drago
Antibiotics 2024, 13(7), 678; https://doi.org/10.3390/antibiotics13070678 - 22 Jul 2024
Cited by 1 | Viewed by 1670
Abstract
Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide [...] Read more.
Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections. Full article
(This article belongs to the Special Issue Single-Stage Management of Musculo-Skeletal Infections: Local Antibacterial Protection, Antibiotics, and Surgical Treatments)
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