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294 Results Found

  • Article
  • Open Access
2,326 Views
12 Pages

17 September 2021

As water in a rainwater regulating reservoir at the Sankyo landfill site in Nagasaki City tends to be alkalized and to exceed the pH upper limit of 7.5, measures to suppress the alkalization should be implemented. Inhibiting photosynthesis in algae i...

  • Review
  • Open Access
3,444 Views
15 Pages

Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy

  • Masahide Isowa,
  • Reo Hamaguchi,
  • Ryoko Narui,
  • Hiromasa Morikawa,
  • Toshihiro Okamoto and
  • Hiromi Wada

Cancer treatment is a significant focus in medicine, owing to the increasing global incidence of cancers. Patients with advanced cancers that do not respond to conventional therapies have limited options and an unfavorable prognosis. Consequently, re...

  • Article
  • Open Access
6 Citations
5,919 Views
11 Pages

Potential of Alkalization Therapy for the Management of Metastatic Pancreatic Cancer: A Retrospective Study

  • Masahide Isowa,
  • Reo Hamaguchi,
  • Ryoko Narui,
  • Hiromasa Morikawa,
  • Toshihiro Okamoto and
  • Hiromi Wada

21 December 2023

Current treatments for patients with pancreatic cancer offer limited benefits. In this study, we applied alkalization therapy, which was efficacious for other solid tumors at our clinic, to stage 4 pancreatic cancer patients, and investigated its eff...

  • Article
  • Open Access
15 Citations
4,398 Views
17 Pages

Mapping the Levels of Soil Salination and Alkalization by Integrating Machining Learning Methods and Soil-Forming Factors

  • Yang Yan,
  • Kader Kayem,
  • Ye Hao,
  • Zhou Shi,
  • Chao Zhang,
  • Jie Peng,
  • Weiyang Liu,
  • Qiang Zuo,
  • Wenjun Ji and
  • Baoguo Li

23 June 2022

Accurate updating of soil salination and alkalization maps based on remote sensing images and machining learning methods plays an essential role in food security, biodiversity, and desertification. However, there is still a lack of research on using...

  • Article
  • Open Access
336 Views
24 Pages

9 January 2026

Since the number of existing steel-reinforced concrete buildings affected by carbonation-induced corrosion is steadily increasing, there is a high demand for durable repair methods. Chemical re-alkalization (CRA) represents one such approach, relying...

  • Review
  • Open Access
3 Citations
2,399 Views
15 Pages

How Does Cancer Occur? How Should It Be Treated? Treatment from the Perspective of Alkalization Therapy Based on Science-Based Medicine

  • Reo Hamaguchi,
  • Masahide Isowa,
  • Ryoko Narui,
  • Hiromasa Morikawa,
  • Toshihiro Okamoto and
  • Hiromi Wada

26 September 2024

This review article investigates the relationship between mitochondrial dysfunction and cancer progression, emphasizing the metabolic shifts that promote tumor growth. Mitochondria are crucial for cellular energy production, but they also play a sign...

  • Article
  • Open Access
2 Citations
966 Views
27 Pages

With the increasing number of existing buildings, the implementation of durability-preserving repair procedures is becoming increasingly important. The chemical re-alkalization (CRA) enables the protection of reinforced concrete structures exposed to...

  • Article
  • Open Access
3 Citations
1,679 Views
13 Pages

13 December 2024

Background. Acetyl phosphate (AcP) is a microbial intermediate involved in the central bacterial metabolism. In bacteria, it also functions as a donor of acetyl and phosphoryl groups in the nonenzymatic protein acetylation and signal transduction. In...

  • Article
  • Open Access
4 Citations
2,152 Views
13 Pages

26 July 2023

To improve the utilization efficiency of rape straw, anaerobic calcium oxide (CaO) alkalization was conducted, and advanced molecular spectroscopy was applied, to detect the internal molecular structural changes. Rape straw was treated with different...

  • Article
  • Open Access
60 Citations
5,868 Views
24 Pages

Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers

  • Luning Dong,
  • Yaping Mai,
  • Qiang Liu,
  • Wannian Zhang and
  • Jianhong Yang

The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by preparing ternary solid dispersion (TSD) systems containing alkalizers, and to explore the modulating mechanism of alkalizers in solid dispersion systems. GA TSD...

  • Article
  • Open Access
9 Citations
2,251 Views
13 Pages

Sensitivity-Enhanced, Room-Temperature Detection of NH3 with Alkalized Ti3C2Tx MXene

  • Yi Tan,
  • Jinxia Xu,
  • Qiliang Li,
  • Wanting Zhang,
  • Chong Lu,
  • Xingjuan Song,
  • Lingyun Liu and
  • Ying Chen

15 April 2024

A layered Ti3C2Tx MXene structure was prepared by etching MAX-phase Ti3AlC2 with hydro-fluoric acid (HF), followed by alkalization in sodium hydroxide (NaOH) solutions of varying concentrations and for varying durations. Compared to sensors utilizing...

  • Article
  • Open Access
2 Citations
985 Views
11 Pages

An Electrochemical Method for Alkalizing the Rotor Cooling Water of a Synchronous Condenser

  • Xiaochun Chen,
  • Wei Li,
  • Xiantao Gu,
  • Duyi He,
  • Weicheng Fu,
  • Yuxiang Gao,
  • Yaoming Wang and
  • Junying Yan

4 March 2025

Rotor cooling water is a pivotal element for the safe operation of a synchronous condenser in an ultrahigh-voltage grid. To decrease the dissolved oxygen and carbon dioxide contents, tremendous efforts have been dedicated to regulating the solution p...

  • Article
  • Open Access
2 Citations
2,328 Views
12 Pages

21 May 2023

This investigation is motivated by interest in nanostructured FeOOH anodes for aqueous asymmetric supercapacitors operating in Na2SO4 electrolyte. The research goal is the fabrication of anodes with high active mass loading of 40 mg cm−2, high...

  • Article
  • Open Access
2 Citations
2,798 Views
11 Pages

29 October 2021

Most of the diamond deposits in China are in the North China Craton. In addition to gem diamonds in kimberlite, a large number of microdiamonds have also been discovered in alkaline dolerites. These microdiamonds show very different characteristics f...

  • Article
  • Open Access
6 Citations
2,696 Views
14 Pages

Heterologous Expression, Purification and Characterization of an Alkalic Thermophilic β-Mannanase CcMan5C from Coprinopsis cinerea

  • Songling Yan,
  • Baiyun Duan,
  • Cuicui Liu,
  • Guiyou Liu,
  • Liqin Kang,
  • Lei Sun,
  • Lin Yi,
  • Zhenqing Zhang,
  • Zhonghua Liu and
  • Sheng Yuan

20 March 2023

A endo-1,4-β-mannanase (CcMan5C) gene was cloned from Coprinopsis cinerea and heterologously expressed in Pichia pastoris, and the recombinant enzyme was purified by Ni-affinity chromatography and identified by matrix-assisted laser desorption/i...

  • Article
  • Open Access
11 Citations
3,122 Views
11 Pages

Alkalizing Properties of Six Calcium-Silicate Endodontic Biomaterials

  • Katarzyna Kot,
  • Łukasz Kucharski,
  • Ewa Marek,
  • Krzysztof Safranow and
  • Mariusz Lipski

19 September 2022

Introduction: Calcium silicate-based cements (CSC), are self-setting hydraulic biomaterials widely used for reparative procedures in dentistry and endodontics. These materials possess physical properties, such as ion release, porosity, solubility, an...

  • Article
  • Open Access
35 Citations
4,541 Views
17 Pages

Photocatalytic Degradation and Antibacterial Properties of Fe3+-Doped Alkalized Carbon Nitride

  • Ying Gao,
  • Jizhou Duan,
  • Xiaofan Zhai,
  • Fang Guan,
  • Xiutong Wang,
  • Jie Zhang and
  • Baorong Hou

4 September 2020

Discovering novel materials and improving the properties of existing materials are the main goals in the field of photocatalysis to increase the potential application of the materials. In this paper, a modified graphitic carbon nitride (g-C3N4) photo...

  • Article
  • Open Access
30 Citations
6,641 Views
10 Pages

11 February 2021

The intestinal pH can greatly influence the stability and absorption of oral drugs. Therefore, knowledge of intestinal pH is necessary to understand the conditions for drug delivery. This has previously been measured in humans and rats. However, info...

  • Article
  • Open Access
45 Citations
5,514 Views
10 Pages

19 October 2022

This study aimed to investigate the short- and long-term solubility, alkalizing potential, and suitability for warm-vertical compaction of AH Plus Bioceramic Sealer (AHBC), and Total Fill BC Sealer (TFBC) compared to the epoxy-resin sealer AH Plus (A...

  • Article
  • Open Access
40 Citations
7,146 Views
16 Pages

25 April 2019

Manure is a substantial source of ammonia volatilization into the atmosphere before and after soil application. The purpose of the study was to investigate the effects of temperature and alkalization treatments on the release of ammonia and ammonia r...

  • Article
  • Open Access
4 Citations
2,833 Views
20 Pages

A Survey on Potentially Beneficial and Hazardous Bioactive Compounds in Cocoa Powder Samples Sourced from the European Market

  • Luigi Esposito,
  • Matteo Perillo,
  • Carla Daniela Di Mattia,
  • Annalisa Scroccarello,
  • Flavio Della Pelle,
  • Dario Compagnone,
  • Giampiero Sacchetti,
  • Dino Mastrocola and
  • Maria Martuscelli

3 August 2024

Cocoa (Theobroma cacao, L.) represents an important market that gained relevance and became an esteemed commodity thanks to cocoa powder, chocolate, and other related products. This work analyzed 59 cocoa powder samples from the European market. Thre...

  • Article
  • Open Access
1 Citations
1,493 Views
13 Pages

Mechanical and Structural Properties of Biocomposites Reinforced with Bagasse Fibers from Sugarcane Overexpressing Sucrose Synthesis

  • Rahma Rei Sakura,
  • Bambang Sugiharto,
  • Widhi Dyah Sawitri,
  • Mochamad Asrofi,
  • Salahuddin Junus,
  • Dedi Dwilaksana and
  • Wahyu Syahrul Fauzi

18 September 2025

In this study, the mechanical and structural properties of biocomposites fabricated using transgenic sugarcane bagasse overexpressing sucrose synthesis were investigated. The bagasse fibers were extracted from the transgenic and non-transgenic (NT) s...

  • Article
  • Open Access
9 Citations
5,415 Views
16 Pages

20 September 2018

A chronic magnesium deficiency may be one of the causes of lifestyle-related diseases such as hypertension and diabetes. Serum Mg2+ concentration is strictly controlled by the reabsorption pathway in the renal tubules, but little is known about how M...

  • Article
  • Open Access
10 Citations
4,135 Views
10 Pages

8 February 2018

In this study, we completed a simple low-temperature synthesis of nest-like titanium oxide (TiO2) microspheres with exposed (001) facets. For the first time, the photocatalytic performance was enhanced by sodium hydroxide (NaOH) alkalization. The cha...

  • Article
  • Open Access
14 Citations
3,503 Views
14 Pages

14 August 2022

Human microbiota produces metabolites that may enter the bloodstream and exert systemic influence on various functions including mitochondrial. Mitochondria are not only a target for microbial metabolites, but also themselves, due to the inhibition o...

  • Article
  • Open Access
2 Citations
1,588 Views
19 Pages

Characteristics of Stable Carbon and Nitrogen Isotopes in Different Ecological Plant Groups and Sediments Collected from 14 Softwater Lakes in Poland

  • Eugeniusz Pronin,
  • Krzysztof Banaś,
  • Rafał Chmara,
  • Rafał Ronowski,
  • Marek Merdalski,
  • Anne-Lise Santoni and
  • Olivier Mathieu

26 November 2024

Softwater lakes with specific, rare, and protected aquatic plant vegetation are very sensitive to increased trophic and water chemical changes, especially alkalization. These changes might be reflected in the stable carbon and nitrogen isotopes of th...

  • Proceeding Paper
  • Open Access
1,223 Views
13 Pages

28 February 2025

Rapid prototyping, particularly in 3D printing, has highlighted the potential of ramie fiber as a reinforcing material for filaments. However, ramie’s high hydrophilicity limits its compatibility. Chemical treatments such as NaOH alkalization a...

  • Article
  • Open Access
1 Citations
792 Views
18 Pages

Biochar is increasingly being applied to improve various degraded soils. However, studies on its use in ameliorating saline–alkaline grasslands remain limited. This study conducted experimental trials using soil collected from an alkalized mead...

  • Article
  • Open Access
10 Citations
5,541 Views
25 Pages

Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

  • Joachim T. Siaw,
  • Jonatan L. Gabre,
  • Ezgi Uçkun,
  • Marc Vigny,
  • Wancun Zhang,
  • Jimmy Van den Eynden,
  • Bengt Hallberg,
  • Ruth H. Palmer and
  • Jikui Guan

15 April 2021

Aberrant activation of anaplastic lymphoma kinase (ALK) drives neuroblastoma (NB). Previous work identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to AL...

  • Article
  • Open Access
18 Citations
5,644 Views
21 Pages

21 April 2020

Slurry treatments such as acidification and alkalization have proven to be promising solutions to reduce gaseous emission produced by farm animals. The optimization of these technologies requires detailed knowledge of how and to what extent the buffe...

  • Communication
  • Open Access
4 Citations
3,337 Views
11 Pages

Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

  • Anna A. Kudriaeva,
  • George A. Saratov,
  • Alena N. Kaminskaya,
  • Vasiliy I. Vladimirov,
  • Petro Yu Barzilovich and
  • Alexey A. Belogurov

24 November 2020

Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a do...

  • Article
  • Open Access
7 Citations
3,338 Views
20 Pages

31 March 2021

The accessory mineral assemblage (AMA) of igneous cumulate xenoliths in volcanoclastic deposits and lava flows in the Carpathian back-arc basin testifies to the composition of intrusive complexes sampled by Upper Miocene-Pliocene basalt volcanoes. Th...

  • Article
  • Open Access
1 Citations
1,552 Views
23 Pages

Background: Aneratrigine, a potent selective Nav1.7 inhibitor, faced challenges in developing a clinically viable oral formulation due to its poor aqueous solubility in acidic gastric conditions (0.06 mg/mL at pH 1.2), leading to limited bioavailabil...

  • Article
  • Open Access
8 Citations
3,815 Views
20 Pages

26 January 2023

Honeycomb-like Ni(OH)2/Ni3S2/Ni foam (NF) was fabricated via a two-step hydrothermal process and subsequent alkalization. Ni3S2 with a honeycombed structure was in-situ synthesized on the NF surface by a hydrothermal process. MOF-derived Ni(OH)2 nano...

  • Review
  • Open Access
127 Citations
12,618 Views
16 Pages

Environmental pollution, such as air, water, and soil pollution, has become the most serious issue. Soil pollution is a major concern as it generally affects the lands and makes them non-fertile. The main cause of soil pollution is agro-waste. It may...

  • Article
  • Open Access
17 Citations
2,812 Views
12 Pages

Na+/H+ Exchangers Involve in Regulating the pH-Sensitive Ion Channels in Mouse Sperm

  • Hang Kang,
  • Min Liu,
  • Wei Zhang,
  • Rong-Zu Huang,
  • Na Zhao,
  • Chen Chen and
  • Xu-Hui Zeng

5 February 2021

Sperm-specific K+ ion channel (KSper) and Ca2+ ion channel (CatSper), whose elimination causes male infertility in mice, determine the membrane potential and Ca2+ influx, respectively. KSper and CatSper can be activated by cytosolic alkalization, whi...

  • Article
  • Open Access
17 Citations
5,491 Views
22 Pages

Targeting Lysosomes to Reverse Hydroquinone-Induced Autophagy Defects and Oxidative Damage in Human Retinal Pigment Epithelial Cells

  • Samuel Abokyi,
  • Sze-Wan Shan,
  • Christie Hang-I Lam,
  • Kirk Patrick Catral,
  • Feng Pan,
  • Henry Ho-Lung Chan,
  • Chi-Ho To and
  • Dennis Yan-Yin Tse

22 August 2021

In age-related macular degeneration (AMD), hydroquinone (HQ)-induced oxidative damage in retinal pigment epithelium (RPE) is believed to be an early event contributing to dysregulation of inflammatory cytokines and vascular endothelial growth factor...

  • Article
  • Open Access
61 Citations
6,198 Views
19 Pages

Effects of Irrigation Water Salinity on Soil Properties, N2O Emission and Yield of Spring Maize under Mulched Drip Irrigation

  • Chenchen Wei,
  • Fahu Li,
  • Peiling Yang,
  • Shumei Ren,
  • Shuaijie Wang,
  • Yu Wang,
  • Ziang Xu,
  • Yao Xu,
  • Rong Wei and
  • Yanxia Zhang

26 July 2019

Brackish water has been widely used to irrigate crops to compensate for insufficient freshwater water supply for agricultural use. The goal of this research was to determine an efficient brackish water use method to increase irrigation efficiency and...

  • Article
  • Open Access
2 Citations
1,152 Views
20 Pages

10 July 2025

Soil salinization severely limits global agricultural sustainability, particularly across the saline–alkaline landscapes of the Qinghai–Tibet Plateau. We examined how potassium fulvate (PF) modulates oat (Avena sativa L.) performance, soi...

  • Article
  • Open Access
15 Citations
6,612 Views
20 Pages

Physico-Chemical Property, Sensory Profile and Consumer Acceptability of Water Buffalo (Bubalus bubalis L.) Chocolate Milk Using Alkalized and Natural Cocoa Powder

  • Joel G. Juvinal,
  • Hans De Steur,
  • Joachim J. Schouteten,
  • Dimas Rahadian Aji Muhammad,
  • Alma A. De Leon,
  • Koen Dewettinck and
  • Xavier Gellynck

26 April 2023

Due to its nutritional quality and palatability, chocolate milk beverages are gaining popularity globally. Alkalized cocoa powder is mostly used in its production since it provides for more intense color and dispersibility, but it has a negative effe...

  • Article
  • Open Access
5 Citations
6,332 Views
18 Pages

4 March 2020

Pre-alkalization caused by dietary supplements such as sodium bicarbonate improves anaerobic exercise performance. However, the influence of a base-forming nutrition on anaerobic performance in hypoxia remains unknown. Herein, we investigated the eff...

  • Article
  • Open Access
17 Citations
3,821 Views
22 Pages

Alkalization of Kraft Pulps from Pine and Eucalyptus and Its Effect on Enzymatic Saccharification and Viscosity Control of Cellulose

  • Isabel Carrillo-Varela,
  • Claudia Vidal,
  • Sebastián Vidaurre,
  • Carolina Parra,
  • Ángela Machuca,
  • Rodrigo Briones and
  • Regis Teixeira Mendonça

31 July 2022

Bleached kraft pulps from eucalyptus and pine were subjected to cold caustic extraction (CCE) with NaOH (5, 10, 17.5, and 35%) for hemicelluloses removal and to increase cellulose accessibility. The effect of these changes was evaluated in enzymatic...

  • Article
  • Open Access
2 Citations
1,901 Views
23 Pages

7 October 2023

Ammonia emission rates from naturally ventilated livestock housing systems can be estimated in multiple ways. By coupling different modeling approaches towards a semi-mechanistic barn-scale ammonia emission model, we investigated the influence of uri...

  • Article
  • Open Access
17 Citations
1,892 Views
12 Pages

16 July 2024

V2CTx MXenes have gained considerable attention in lithium ion batteries (LIBs) owing to their special two-dimensional (2D) construction with large lithium storage capability. However, engineering high-capacity V2CTx MXenes is still a great challenge...

  • Article
  • Open Access
17 Citations
2,559 Views
15 Pages

5 September 2023

This article investigates the effects of combining a novel protic ionic liquid-based fire retardant (FR) with alkalized hemp fiber. A pivotal importance of this study refers to the hydrophilic properties and limits regarding poor thermal resistance o...

  • Article
  • Open Access
9 Citations
3,392 Views
16 Pages

Successful Outcome of Phytostabilization in Cr(VI) Contaminated Soils Amended with Alkalizing Additives

  • Maja Radziemska,
  • Agnieszka Bęś,
  • Zygmunt M. Gusiatin,
  • Łukasz Sikorski,
  • Martin Brtnicky,
  • Grzegorz Majewski,
  • Ernesta Liniauskienė,
  • Václav Pecina,
  • Rahul Datta and
  • Zbigniew Mazur
  • + 1 author

This study analysed the effect of three alkalizing soil amendments (limestone, dolomite chalcedonite) on aided phytostabilization with Festuca rubra L. depending on the hexavalent chromium (Cr(VI)) level in contaminated soil. Four different levels of...

  • Article
  • Open Access
24 Citations
4,167 Views
18 Pages

Influence of Composition and Technological Factors on Variatropic Efficiency and Constructive Quality Coefficients of Lightweight Vibro-Centrifuged Concrete with Alkalized Mixing Water

  • Sergey A. Stel’makh,
  • Evgenii M. Shcherban’,
  • Alexey N. Beskopylny,
  • Levon R. Mailyan,
  • Besarion Meskhi,
  • Denis Butko and
  • Alla S. Smolyanichenko

6 October 2021

Alkalization technology and its application to obtain high-performance concrete compositions is an urgent scientific problem that opens opportunities for improving building structures. The article is devoted to the new technology of manufacturing rei...

  • Article
  • Open Access
14 Citations
6,001 Views
16 Pages

Low Plasma Appearance of (+)-Catechin and (−)-Catechin Compared with Epicatechin after Consumption of Beverages Prepared from Nonalkalized or Alkalized Cocoa—A Randomized, Double-Blind Trial

  • Sabine Ellinger,
  • Andreas Reusch,
  • Lisa Henckes,
  • Christina Ritter,
  • Benno F. Zimmermann,
  • Jörg Ellinger,
  • Rudolf Galensa,
  • Peter Stehle and
  • Hans-Peter Helfrich

16 January 2020

Flavan-3-ols are claimed to be responsible for the cardioprotective effects of cocoa. Alkalized cocoa powder (ALC), commonly used for many non-confectionary products, including beverages, provides less (+)-catechin, (−)-epicatechin, and procyan...

  • Article
  • Open Access
25 Citations
5,980 Views
10 Pages

13 November 2022

There is a large amount of saline-alkali land in China. Through the improvement and utilization of saline-alkali land to improve the carbon content in soil, it can not only become a reserve resource of cultivated land or grazing grassland, but also b...

  • Article
  • Open Access
24 Citations
8,049 Views
20 Pages

First Report of Pathogenic Bacterium Kalamiella piersonii Isolated from Urine of a Kidney Stone Patient: Draft Genome and Evidence for Role in Struvite Crystallization

  • Punchappady Devasya Rekha,
  • Asif Hameed,
  • Muhammed A. P. Manzoor,
  • Mangesh V. Suryavanshi,
  • Sudeep D. Ghate,
  • A. B. Arun,
  • Sneha S. Rao,
  • Athmika,
  • Sukesh Kumar Bajire and
  • C.-C. Young
  • + 1 author

29 August 2020

Uropathogenic bacteria are widely distributed in the environment and urinary tract infection is implicated in kidney stone disease. Here, we report on a urease negative bacterium Kalamiella piersonii (strain YU22) isolated from the urine of a struvit...

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