Additive manufacturing has become a very important manufacturing method in the last years. With additive manufacturing, a higher level of function integration can be achieved compared to traditional manufacturing technologies. However, the manufactur...
Background: Drought, N deficiency and herbivory are considered the most important stressors caused by climate change in the agro- and eco-systems and varied in space and time shaping highly dynamic and heterogeneous stressful environments. This study...
Damage to human health caused by As-contaminated water can be prevented using proper As-removal techniques, such as employing excellent arsenic adsorbents. In this study, the combined addition of Mg- and Ca-based adsorbents was investigated for the e...
The genus Sarocladium comprises fungal species closely related to Acremonium, with S. kiliense and S. strictum being medically important. These species can cause infections in both immunocompetent and immunocompromised individuals. The current detect...
The paper presents a developed methodology of short-term forecasting for heat production in combined heat and power (CHP) plants using a big data-driven model. An accurate prediction of an hourly heat load in the day-ahead horizon allows a better pla...
Mycobacterium avium is an opportunistic pathogen and a leading contributor to nontuberculous mycobacterial infections in immunocompromised individuals. However, treatment duration, antibiotic toxicity, and resistance present challenges in the managem...
Osteolytic bone disease is a hallmark of multiple myeloma (MM) mediated by MM cell proliferation, increased osteoclast activity, and suppressed osteoblast function. The proteasome inhibitor bortezomib targets MM cells and improves bone health in MM p...
Background: All the processes leading to neurodegeneration cannot be addressed with just one medication. Combinations of drugs affecting various disease mechanisms concurrently could demonstrate improved effect in slowing the course of Parkinson&rsqu...
Wire arc additive manufacturing (WAAM) involves the deposition of weld beads layer by layer using an electric arc energy source. However, during this procedure, the properties of each layer may differ because of unequal thermal distribution, resultin...
Despite continuous advances in therapy, malignant melanoma is still among the deadliest types of cancer. At the same time, owing to its high plasticity and immunogenicity, melanoma is regarded as a model tumor entity when testing new treatment approa...
The reliability of concrete structures is closely related to the durability of the concrete materials stable under external environmental conditions. The present study is aimed at analysing the effect of a prospective hardening additive containing ca...
Artocarpus lakoocha (Al) and Glycyrrhiza glabra (Gg) extracts have been reported to show tyrosinase inhibitory activity and melanin pigment reduction. This is the first study to assess the combination of Al and Gg extracts in enhancing inhibition of...
Automated processing techniques such as automated fiber placement (AFP) or automated tape laying (ATL) are well known nowadays. However, there is still a lot of potential for these methods to achieve better results, especially for large and complex c...
Wastewater from the tofu industry contains many pollutants that are very harmful to the environment, significantly endangering aquatic life and producing a pungent odor. This study aims to prepare a polyvinylidene fluoride (PVDF) membrane with the ad...
It is well-documented that CL316,243 (a β3 agonist) or rosiglitazone (a PPARγ agonist) can induce white adipocyte populations to brown-like adipocytes, thus increasing energy consumption and combating obesity. However, whether there is a combined eff...
Background: This study aimed to verify whether adding a combination of additives (blend) to the diet of dairy calves after weaning can improve animal performance and health and influence the profile of ruminal short-chain fatty acids and intestinal m...
Ochratoxin A (OTA) and Zearalenone (ZEA) are widespread mycotoxins that contaminate foodstuffs simultaneously, but sufficient data regarding their mixed toxicities are lacking. This study aims to analyze the style of combined effects of OTA and ZEA o...
6 May 2022
Plastics, as a polymer material, have long been a source of environmental concern. This paper uses polystyrene plastics as the research object, and the relative contribution of each component of plastic additives to plastic degradation is screened us...
Genotoxic data of substances that could be used as food additives are required by the European Food Safety Authority. In this sense, the use of an extract from grapevine shoots containing a stilbene richness of 99% (ST-99), due to its antioxidant and...
Acrylonitrile Butadiene Styrene (ABS) is a common thermoplastic polymer that has been widely employed in the manufacturing industry due to its impact resistance, tensile strength, and rigidity. Additive manufacturing (AM) is a promising manufacturing...
The construction industry is the main consumer of mineral resources. At the same time, the Portland cement (PC) industry occupies a leading position, using expensive, high-quality raw materials. This is due to the high rate of construction in differe...
18 November 2022
The quantification of the effects of global changes on soil nutrients is crucial for the prediction of future terrestrial ecosystem changes. Combined with 100 articles and 1129 observations from all over China, the meta-analysis method was applied to...
In the past decades, many studies have examined the nature of the interaction between mycotoxins in biological models classifying interaction effects as antagonisms, additive effects, or synergisms based on a comparison of the observed effect with th...
Despite the significant advances in targeted- and immuno-therapies, lung and breast cancer are at the top list of cancer incidence and mortality worldwide as of 2020. Combination therapy consisting of a mixture of different drugs taken at once is cur...
Wind offers an environmentally sustainable energy resource that has seen increasing global adoption in recent years. However, its intermittent, unstable and stochastic nature hampers its representation among other renewable energy sources. This work...
14 April 2015
The xenoestrogens nonylphenol (NP) and bisphenol A (BPA) are regarded as endocrine disrupting chemicals (EDCs) which have widespread occurrence in our daily life. In the present study, the purpose was to analyze the combined effects of NP and BPA on...
The administration of combinations of drugs is a method widely used in the treatment of different pathologies as it can lead to an increase in the therapeutic effect and a reduction in the dose compared to the administration of single drugs. For thes...
Sore throat, commonly associated with pharyngitis and tonsillitis, is primarily caused by bacterial pathogens. Conventional therapies rely on antibiotics and anti-inflammatory drugs; however, concerns about adverse effects, antibiotic resistance, and...
Essential oils (EOs) have been long recognized for their antibacterial, antifungal, antiviral, insecticidal and antioxidant properties. They are widely used in medicine and the food industry for these purposes. The increased interest in alternative n...
Experimental and computational studies were conducted to predict failure loads of specimens containing different-sized holes made using the additive manufacturing (AM) technique. Two different types of test specimens were prepared. Flat specimens, ma...
The role of surface protective additives becomes vital when operating conditions become severe and moving components operate in a boundary lubrication regime. After protecting film is slowly removed by rubbing, it can regenerate through the tribochem...
Background/Objectives: Direct-acting antivirals vary by lineage and face rapid resistance. We identified the oxazole-4-carboxamide lead KB-2777 and aimed to define its in vitro activity across α/β-coronaviruses, time-of-addition (TOA) prof...
Influenza virus infections and their associated morbidity and mortality are a major threat to global health. Vaccination is an effective influenza prevention measure; however, the effectiveness is challenged by the rapid changes in the influenza viru...
In this work, an innovative manufacturing approach that includes a fully linked and integrated manufacturing system consisting of a laser-based directed energy deposition (DED-LB/M) module and a forming press is presented. The alternating additive ma...
The purpose of this study was to determine the effectiveness of a phytobiotic-prebiotic feed additive (PPFA, which contains a combination of chicory and extracts of carob pulp and fenugreek) in the diets of fattening pigs on growth indicators, carcas...
With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further r...
Surgery, radiotherapy, and chemotherapy are essential treatment modalities to target cancer cells, but they frequently cause damage to the normal tissue, potentially leading to side effects. As proton beam radiotherapy (PBT) can precisely spare norma...
Heat stress is one of the major threats to wheat production in many wheat-growing areas of the world as it causes severe yield loss at the reproductive stage. In the current study, 28 crosses were developed using 11 parental lines, including 7 female...
Additive manufacturing is one of the continuously developing areas of technology that still requires reliable monitoring and quality assessment of obtained products. Considering the relatively long time necessary for manufacturing larger products, on...
Compelling evidence suggests that pyroglutamate-modified Aβ (pGlu3-Aβ; AβN3pG) peptides play a pivotal role in the development and progression of Alzheimer’s disease (AD). Approaches targeting pGlu3-Aβ by glutaminyl cyclase (QC) inhibition (Varogluta...
Bacterial drug resistance to antibiotics is growing globally at unprecedented levels, and strategies to overcome treatment deficiencies are continuously developing. In our approach, we utilized metal nanoparticles, silver nanoparticles (AgNPs), known...
Synthetic amorphous silica (SAS) is used in a plethora of applications and included in many daily products to which humans are exposed via inhalation, ingestion, or skin contact. This poses the question of their potential toxicity, particularly towar...
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatme...
Understanding the impact of gene action and combining ability on targeted traits in a hybrid breeding program is imperative. The objective of this study was to estimate the genetic effect and combining ability of S2 super sweet corn lines on caroteno...
With the increasing development of civil engineering in large cities, more and more excavations and surcharge loadings are being constructed or planned adjacent to existing building piles in crowded urban areas. Previous study on pile deformation has...
Additive manufacturing, particularly Stereolithography (SLA), has gained widespread attention thanks to its ability to produce intricate parts with high precision and customization capacity. Nevertheless, the inherent low mechanical properties of SLA...
Isocitrate dehydrogenases (IDHs) are enzymes that catalyze the oxidative decarboxylation of isocitrate, producing α-ketoglutarate (αKG) and CO2. The discovery of IDH1 and IDH2 mutations in several malignancies has brought to the approval...
Excessive lateral forces and the deformation of pile groups caused by adjacent surcharge loading and excavation can potentially lead to the failure or collapse of nearby pile foundations. This paper presents a simplified analytical method to investig...
Skeletal muscle tissue (SMT) has a highly hierarchical and anisotropic morphology, featuring aligned and parallel structures at multiple levels. Various factors, including trauma and disease conditions, can compromise the functionality of skeletal mu...
Object detection is an important process in surveillance system to locate objects and it is considered as major application in computer vision. The Convolution Neural Network (CNN) based models have been developed by many researchers for object detec...
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