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288 Results Found

  • Article
  • Open Access
5 Citations
4,052 Views
18 Pages

A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure

  • Deuk-Su Kim,
  • Yang Joo Kang,
  • Kyung Jin Lee,
  • Lu Qiao,
  • Kinarm Ko,
  • Dae Heon Kim,
  • Soon Chul Myeung and
  • Kisung Ko

The antigen–antibody complex (AAC) has novel functions for immunomodulation, encouraging the application of diverse quaternary protein structures for vaccination. In this study, GA733 antigen and anti-GA733 antibody proteins were both co-expres...

  • Communication
  • Open Access
3 Citations
2,467 Views
10 Pages

12 December 2020

Novel multi-component composites composed of the biodegradable polymer poly(ethylene adipate) (PEA), the water-soluble polymer poly(ethylene oxide) (PEO), poly(vinyl acetate) (PVAc), and a supramolecular-like inclusion complex (IC) made by α-cy...

  • Article
  • Open Access
2 Citations
2,171 Views
9 Pages

28 April 2021

Linear complexity is an important criterion to characterize the unpredictability of pseudo-random sequences, and large linear complexity corresponds to high cryptographic strength. Pseudo-random Sequences with a large linear complexity property are o...

  • Feature Paper
  • Commentary
  • Open Access
15 Citations
4,007 Views
17 Pages

31 July 2018

Although the interpretation of Quaternary records of interrelated environmental–ecological–human processes is necessarily complex, it is often addressed using too-simple deterministic approaches. This paper suggests a holistic framework c...

  • Review
  • Open Access
2 Citations
2,547 Views
17 Pages

The quality prediction of quaternary structure models of a protein complex, in the absence of its true structure, is known as the Estimation of Model Accuracy (EMA). EMA is useful for ranking predicted protein complex structures and using them approp...

  • Article
  • Open Access
2 Citations
3,023 Views
13 Pages

28 January 2022

Crystallization remains a bottleneck for determining the three-dimensional X-ray structure of proteins. Many parameters influence the complexity of protein crystallization. Therefore, it is not easy to systematically examine all of these parameters i...

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,937 Views
19 Pages

Heme Binding to HupZ with a C-Terminal Tag from Group A Streptococcus

  • Ephrahime S. Traore,
  • Jiasong Li,
  • Tapiwa Chiura,
  • Jiafeng Geng,
  • Ankita J. Sachla,
  • Francis Yoshimoto,
  • Zehava Eichenbaum,
  • Ian Davis,
  • Piotr J. Mak and
  • Aimin Liu

21 January 2021

HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His6 tag exhibits a weak heme degradation activity. Here, we revisited and charac...

  • Article
  • Open Access
2 Citations
2,857 Views
16 Pages

Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy

  • Yvonne Lerchbammer-Kreith,
  • Michaela Hejl,
  • Nadine S. Sommerfeld,
  • Xian Weng-Jiang,
  • Uchechukwu Odunze,
  • Ryan D. Mellor,
  • David G. Workman,
  • Michael A. Jakupec,
  • Andreas G. Schätzlein and
  • Ijeoma F. Uchegbu
  • + 2 authors

19 July 2023

Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and has been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of cisplatin, carboplat...

  • Article
  • Open Access
72 Citations
11,905 Views
10 Pages

28 February 2003

The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex wit...

  • Article
  • Open Access
6 Citations
3,929 Views
29 Pages

14 October 2022

In what are now the warm deserts of the American Southwest, direct effects of changing climate on plant distributions are typically viewed as the principal driver of vegetation changes that followed the late Pleistocene–Holocene transition (LPH...

  • Article
  • Open Access
27 Citations
6,843 Views
19 Pages

20 August 2018

In this study, quaternary-ammonium-functionalized metal–organic frameworks (MOFs) Et-N-Cu(BDC-NH2)(DMF), were prepared, characterized, and applied for the highly effective removal of metal cyanide complexes, including Pd(CN)42−, Co(CN)63&...

  • Article
  • Open Access
15 Citations
7,243 Views
14 Pages

19 February 2018

An amphoteric random copolymer (P(SA)91) composed of anionic sodium 2-acrylamido-2-methylpropanesulfonate (AMPS, S) and cationic 3-acrylamidopropyl trimethylammonium chloride (APTAC, A) was prepared via reversible addition-fragmentation chain transfe...

  • Article
  • Open Access
6 Citations
4,080 Views
17 Pages

21 February 2022

In central Tunisia, anthropic activities, such as groundwater abstraction for irrigation, have resulted in excessive groundwater level declines of the Mio-Plio-Quaternary aquifer hosted in Kairouan Plain. Besides, the two dams El Houareb and Sidi Saa...

  • Article
  • Open Access
4 Citations
2,575 Views
19 Pages

14 March 2022

The Quaternary stratigraphic unit is an important underground space resource for sustainable urban development. It is of great significance to understand the spatial variation characteristics of the Quaternary stratigraphic structure and its internal...

  • Article
  • Open Access
5 Citations
5,071 Views
11 Pages

PClass: Protein Quaternary Structure Classification by Using Bootstrapping Strategy as Model Selection

  • Chi-Chou Huang,
  • Chi-Chang Chang,
  • Chi-Wei Chen,
  • Shao-yu Ho,
  • Hsung-Pin Chang and
  • Yen-Wei Chu

14 February 2018

Protein quaternary structure complex is also known as a multimer, which plays an important role in a cell. The dimer structure of transcription factors is involved in gene regulation, but the trimer structure of virus-infection-associated glycoprotei...

  • Feature Paper
  • Review
  • Open Access
13 Citations
5,541 Views
17 Pages

Contiguous Quaternary Carbons: A Selection of Total Syntheses

  • Alina Eggert,
  • Christoph Etling,
  • Dennis Lübken,
  • Marius Saxarra and
  • Markus Kalesse

24 August 2020

Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs o...

  • Article
  • Open Access
82 Citations
6,326 Views
9 Pages

24 November 2018

This study examines one of the limitations of CALPHAD databases when applied to high entropy alloys and complex concentrated alloys. We estimate the level of the thermodynamic description, which is still sufficient to correctly predict thermodynamic...

  • Article
  • Open Access
1,807 Views
18 Pages

Structural Expansion of Catalytic RNA Nanostructures through Oligomerization of a Cyclic Trimer of Engineered Ribozymes

  • Mst. Ayesha Siddika,
  • Hiroki Oi,
  • Kumi Hidaka,
  • Hiroshi Sugiyama,
  • Masayuki Endo,
  • Shigeyoshi Matsumura and
  • Yoshiya Ikawa

6 September 2023

The multimolecular assembly of three-dimensionally structured proteins forms their quaternary structures, some of which have high geometric symmetry. The size and complexity of protein quaternary structures often increase in a hierarchical manner, wi...

  • Article
  • Open Access
3 Citations
1,649 Views
12 Pages

20 May 2023

Supercapacitors have a wide range of applications in high-technology fields. The desolvation of organic electrolyte cations affects the capacity size and conductivity of supercapacitors. However, few relevant studies have been published in this field...

  • Review
  • Open Access
1 Citations
2,045 Views
19 Pages

26 February 2024

Marine geological studies of Naples Bay are discussed and reviewed, focusing on the application of the seismo-stratigraphic concepts to a Late Quaternary volcanic area. The Naples Bay represents an active volcanic area in which the interactions betwe...

  • Article
  • Open Access
13 Citations
3,850 Views
12 Pages

Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins

  • Zelma Faisal,
  • Sándor Kunsági-Máté,
  • Beáta Lemli,
  • Lajos Szente,
  • Dominik Bergmann,
  • Hans-Ulrich Humpf and
  • Miklós Poór

Citrinin (CIT) is a nephrotoxic mycotoxin produced by Aspergillus, Penicillium, and Monascus genera. It appears as a contaminant in grains, fruits, and spices. After oral exposure to CIT, its major urinary metabolite, dihydrocitrinone (DHC) is formed...

  • Article
  • Open Access
2,026 Views
21 Pages

Accelerated Iron Evolution in Quaternary Red Soils through Anthropogenic Land Use Activities

  • Cheng-Cheng Zhang,
  • Zhong-Xiu Sun,
  • Ying-Ying Jiang and
  • Si-Yi Duan

30 July 2024

Iron in soil exists in various valence states and is prone to changes with alterations in soil environmental conditions. Its migration and transformation are crucial for soil formation and understanding soil evolution. This study focuses on Quaternar...

  • Article
  • Open Access
5 Citations
3,137 Views
17 Pages

Quantum Information in the Protein Codes, 3-Manifolds and the Kummer Surface

  • Michel Planat,
  • Raymond Aschheim,
  • Marcelo M. Amaral,
  • Fang Fang and
  • Klee Irwin

26 June 2021

Every protein consists of a linear sequence over an alphabet of 20 letters/amino acids. The sequence unfolds in the 3-dimensional space through secondary (local foldings), tertiary (bonds) and quaternary (disjoint multiple) structures. The mere exist...

  • Communication
  • Open Access
9 Citations
8,523 Views
13 Pages

Three different ionene polymers with varying quaternary ammonium moieties were used as a proof of concept for the formulation of antisense oligonucleotides, which are capable of inhibiting Renilla luciferase messenger ribonucleic acid (mRNA). Cationi...

  • Article
  • Open Access
7 Citations
3,077 Views
22 Pages

20 October 2021

Alpine topography is formed by a complex series of geomorphological processes that result in a vast number of different landforms. The youngest and most diverse landforms are various Quaternary sedimentary bodies, each characterised by its unique lan...

  • Article
  • Open Access
1 Citations
2,946 Views
12 Pages

Molecular Dynamic Simulation Search for Possible Amphiphilic Drug Discovery for Covid-19

  • Umer Daood,
  • Divya Gopinath,
  • Malikarjuna Rao Pichika,
  • Kit-Kay Mak and
  • Liang Lin Seow

12 April 2021

To determine whether quaternary ammonium (k21) binds to Severe Acute Respiratory Syndrome–Coronavirus 2 (SARS-CoV-2) spike protein via computational molecular docking simulations, the crystal structure of the SARS-CoV-2 spike receptor-binding domain...

  • Article
  • Open Access
12 Citations
5,135 Views
21 Pages

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

  • Brenda Rosa,
  • Marialaura Marchetti,
  • Gianluca Paredi,
  • Heinz Amenitsch,
  • Nina Franko,
  • Roberto Benoni,
  • Barbara Giabbai,
  • Maria Giovanna De Marino,
  • Andrea Mozzarelli and
  • Luca Ronda
  • + 3 authors

21 October 2019

The formation of multienzymatic complexes allows for the fine tuning of many aspects of enzymatic functions, such as efficiency, localization, stability, and moonlighting. Here, we investigated, in solution, the structure of bacterial cysteine syntha...

  • Article
  • Open Access
17 Citations
5,318 Views
15 Pages

Enhanced Performance of Zn/Br Flow Battery Using N-Methyl-N-Propylmorpholinium Bromide as Complexing Agent

  • Uxua Jiménez-Blasco,
  • Eduardo Moreno,
  • Maura Cólera,
  • Pilar Díaz-Carrasco,
  • José C. Arrebola,
  • Alvaro Caballero,
  • Julián Morales and
  • Óscar A. Vargas

27 August 2021

Redox flow batteries (RFB) are one of the most interesting technologies in the field of energy storage, since they allow the decoupling of power and capacity. Zinc–bromine flow batteries (ZBFB) are a type of hybrid RFB, as the capacity depends on the...

  • Article
  • Open Access
9 Citations
2,176 Views
23 Pages

Groundwater is an important freshwater resource in the world and serves as the main source of water for mining areas in Northern China. Coal mining may cause changes in water quality. As such, to identify ways to prevent water contamination, this stu...

  • Article
  • Open Access
6 Citations
4,244 Views
27 Pages

30 August 2023

The Mediterranean coastal aquifer system of the Grombalia basin (NE Tunisia) offers immense potential as a source of fresh water for agriculture, industry, and drinking water supply. Nonetheless, due to its intricate hydrogeological characteristics a...

  • Article
  • Open Access
61 Citations
7,401 Views
11 Pages

14 June 2019

Adulteration of extra virgin olive oil (EVOO) with cheaper edible oils is of considerable concern in the olive oil industry. The potential of Raman spectroscopy combined with multivariate statistics has been investigated for evaluating the authentici...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,538 Views
27 Pages

Integrative Approach for Groundwater Pollution Risk Assessment Coupling Hydrogeological, Physicochemical and Socioeconomic Conditions in Southwest of the Damascus Basin

  • Nazeer Asmael,
  • Jessica D. Villanueva,
  • Nicolas Peyraube,
  • Mohamed Baalousha,
  • Frédéric Huneau,
  • Alain Dupuy and
  • Philippe Le Coustumer

28 April 2021

Groundwater is the main resource for irrigation and drinking supply in most parts of Syria, as for most Mediterranean countries, however this resource suffers from mismanagement. In the study area (northeast of Mt. Hermon), the lack of information ma...

  • Article
  • Open Access
31 Citations
9,639 Views
13 Pages

Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations

  • Saeko Yanaka,
  • Rina Yogo,
  • Rintaro Inoue,
  • Masaaki Sugiyama,
  • Satoru G. Itoh,
  • Hisashi Okumura,
  • Yohei Miyanoiri,
  • Hirokazu Yagi,
  • Tadashi Satoh and
  • Takumi Yamaguchi
  • + 1 author

The Fc portion of immunoglobulin G (IgG) is a horseshoe-shaped homodimer, which interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions are critically dependent on the pair of N-glycans packed between...

  • Article
  • Open Access
2 Citations
1,531 Views
11 Pages

7 August 2023

Supercapacitors have many applications in new energy and other high-tech fields. The desolvation effect on ions affects the capacity size of supercapacitors, and there are few relevant studies published in this field at present. In this experiment, b...

  • Article
  • Open Access
7 Citations
2,660 Views
14 Pages

4 December 2022

The formation of inherently chiral calix[4]arenes by the intramolecular cyclization approach suffers from a limited number of suitable substrates for these reactions. Here, we report an easy way to prepare one class of such compounds: calixquinolines...

  • Article
  • Open Access
9 Citations
5,295 Views
18 Pages

18 February 2020

Estimating sound velocity in seabed sediment of shallow near-shore areas submerged after the Last Glacial Maximum is often difficult due to the heterogeneous sedimentary composition resulting from sea-level changes affecting the sedimentary environme...

  • Review
  • Open Access
24 Citations
9,808 Views
21 Pages

10 May 2018

Viruses are simple agents exhibiting complex reproductive mechanisms. Decades of research have provided crucial basic insights, antiviral medication and moderately successful gene therapy trials. The most infectious viral particle is, however, not al...

  • Article
  • Open Access
6 Citations
3,030 Views
15 Pages

Tunable Viscoelastic Properties of Sodium Polyacrylate Solution via CO2-Responsive Switchable Water

  • Dianguo Wu,
  • Yiwen Shi,
  • Kun Lv,
  • Bing Wei,
  • Youyi Zhu,
  • Hongyao Yin and
  • Yujun Feng

24 June 2021

Upon stimulus by CO2, CO2-switchable viscoelastic fluids experience a deliberate transition between non-viscous and highly viscous solution states. Despite attracting considerable recent attention, most such fluids have not been applied at a large- s...

  • Article
  • Open Access
2,643 Views
12 Pages

28 September 2021

Poly(methyl acrylate)-b-poly(N-vinyl pyrrolidone/maleic anhydride/styrene) (PMA-b-P (NVP/MAH/St)) quaternary amphiphilic block copolymer prepared by reversible addition-fragmentation chain transfer (RAFT) was used to improve the anti-hydrolysis and d...

  • Review
  • Open Access
5 Citations
3,200 Views
22 Pages

10 March 2023

Ischia shows intriguing and complex geology, which has been deeply investigated. In this paper, a reappraisal of the Quaternary geologic evolution of Ischia based on literature data is advised, concentrating on the volcanology of the island, based on...

  • Article
  • Open Access
6 Citations
7,095 Views
13 Pages

A stereocontrolled approach to the cis-decalin framework of clerodane diterpenes and biologically active quinone sesquiterpenes is reported. Starting from an inexpensive optically pure tetrahydroindanone, Birch reductive alkylation builds two new con...

  • Communication
  • Open Access
646 Views
11 Pages

A package of upper Messinian volcaniclastic layers (UMVLs), exposed in the deep-water foreland basin system of the central Apennines (Italy), is the volcanic product of a rhyolitic eruption dated to 5.5 Ma. These UMVLs are an important marker for str...

  • Article
  • Open Access
2 Citations
2,824 Views
15 Pages

Evaluation of Alfalfa and Grass Species in Binary and Complex Mixtures on Performance under Soil Salinity Conditions

  • Enkhjargal Darambazar,
  • Kathy Larson,
  • Jeff Schoenau,
  • Gravel Wang,
  • Bill Biligetu,
  • Daalkhaijav Damiran and
  • Herbert A. Lardner

13 July 2022

The effect of synergies between saline-tolerant grass and legume species grown in saline soil, on yield, quality, composition, persistence, and weed suppression was studied in 2019–2021 in a moderately saline soil located in the dark brown soil...

  • Article
  • Open Access
815 Views
21 Pages

This study develops a dual-mode antibacterial orthodontic adhesive by integrating quaternary ammonium salt-modified large-pore mesoporous silica nanoparticles (QLMSN@CHX). The material integrates two antibacterial mechanisms: (1) contact killing via...

  • Article
  • Open Access
3 Citations
2,268 Views
15 Pages

Modified Diatomaceous Earth in Heparin Recovery from Porcine Intestinal Mucosa

  • Anushree Das,
  • Devang P. Khambhati,
  • Niko D. Longoria,
  • Alireza Tabibi,
  • Seyed Mohammad Davachi,
  • Kayli Dimas,
  • Yulianna Laurencin,
  • Lesly Carmona,
  • Pablo Zarate Avalos and
  • Mahmood Karimi Abdolmaleki

7 December 2023

Heparin, a highly sulfated glycosaminoglycan, is a naturally occurring anticoagulant that plays a vital role in various physiological processes. The remarkable structural complexity of heparin, consisting of repeating disaccharide units, makes it a c...

  • Feature Paper
  • Article
  • Open Access
9 Citations
5,831 Views
13 Pages

Sol-Gel-Synthesis of Nanoscopic Complex Metal Fluorides

  • Alexander Rehmer,
  • Kerstin Scheurell,
  • Gudrun Scholz and
  • Erhard Kemnitz

2 November 2017

The fluorolytic sol-gel synthesis for binary metal fluorides (AlF3, CaF2, MgF2) has been extended to ternary and quaternary alkaline earth metal fluorides (CaAlF5, Ca2AlF7, LiMgAlF6). The formation and crystallization of nanoscopic ternary CaAlF5 and...

  • Editorial
  • Open Access
9 Citations
3,088 Views
3 Pages

26 November 2018

A collection of papers appears under the title “Special External Effects on Fluvial System Evolution” in the journal, Quaternary. This is a new Special Issue under the aegis of the Fluvial Archives Group (FLAG), illustrating the recent pr...

  • Article
  • Open Access
15 Citations
4,277 Views
13 Pages

The k-nearest neighbors (KNN) algorithm is a non-parametric supervised machine learning classifier; which uses proximity and similarity to make classifications or predictions about the grouping of an individual data point. This ability makes the KNN...

  • Article
  • Open Access
1 Citations
1,981 Views
21 Pages

A Cartographic Landscape Analysis of the Geo-Ecological Condition of the Natural Reserve Object—Lake Doshne (Volyn Polissya, Ukraine)

  • Ivan Kirvel,
  • Vitalii Martyniuk,
  • Ivan Kovalchuk,
  • Ion Andronache,
  • Vasyl Korbutiak and
  • Ivan Zubkovych

18 September 2024

The cartographic landscape analysis of Lake Doshne employs geographic landscape methods, GIS cartographic modeling, and geo-ecological analysis. This study includes hydrochemical analysis of the lake’s water mass, focusing on saline blocks, tro...

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