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43 Results Found

  • Article
  • Open Access
19 Citations
6,210 Views
15 Pages

Individuals with autism spectrum disorder (ASD) are characterized by impairments in flexibly acquiring and maintaining new information, as well as in applying learned information for problem solving. However, the neural mechanism underpinning such im...

(This article belongs to the Section Neurobiology and Clinical Neuroscience)
  • Article
  • Open Access
1,215 Views
24 Pages

Hot and Cool Executive Functions in Middle Childhood: Evidence for a Weak but Process-Specific Relationship

  • Eva Košíková,
  • Daniela Turoňová,
  • Ľubica Konrádová and
  • Barbora Mesárošová

19 August 2026

Background: Executive functions (EFs) are cognitive and emotional abilities that underpin goal-directed behavior, decision-making, and problem-solving. EFs can be categorized into two broad types, Hot EFs and Cool EFs, distinguished by their relation...

(This article belongs to the Section Pediatric Neurology & Neurodevelopmental Disorders)
  • Article
  • Open Access
1 Citations
2,787 Views
20 Pages

When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals

  • Xikun Zhang,
  • Yue Li,
  • Qikai Zhang,
  • Yuan Wang and ,
  • Jifan Zhou and
  • Meng Zhang
  • + 1 author+ 0 author

5 September 2025

Cognitive flexibility—the ability to adapt cognitive strategies and behavioral responses in changing environments—is a key component of executive function, supporting rule updating and conflict resolution. Individuals with substance addic...

(This article belongs to the Section Cognition)
  • Article
  • Open Access
6 Citations
4,999 Views
22 Pages

Children with developmental language disorder (DLD) demonstrate deficits in executive functioning; however, the specific components of executive functioning that are affected in this population are not well understood. This study evaluated set shifti...

(This article belongs to the Special Issue Neural Basis of Executive Control)
  • Article
  • Open Access
4 Citations
1,606 Views
14 Pages

High-Density Lipoprotein Correlates with Cognitive Functioning in Schizophrenic Women

  • Maria Staniek,
  • Pawel Kapelski,
  • Przemyslaw Zakowicz,
  • Aleksandra Rajewska-Rager and ,
  • Karolina Wasicka-Przewozna and
  • Maria Skibinska
  • + 1 author+ 0 author

(1) Background: Schizophrenia is a chronic and progressive neuropsychiatric illness. Apart from positive and negative symptoms, 98% of the population diagnosed with schizophrenia have impaired cognitive functioning, which significantly influences the...

(This article belongs to the Special Issue Cognitive Dysfunction in Schizophrenia)
  • Article
  • Open Access
3 Citations
2,465 Views
22 Pages

8 October 2024

Background/Objectives: Previous research indicates that children with Developmental Language Disorder (DLD) face challenges learning from feedback, resulting in suboptimal performance and learning outcomes. Feedback processing, a key developing execu...

(This article belongs to the Section Pediatric Neurology & Neurodevelopmental Disorders)
  • Review
  • Open Access
37 Citations
12,652 Views
32 Pages

A Meta-Analysis of Relationships between Measures of Wisconsin Card Sorting and Intelligence

  • Bruno Kopp,
  • Natasha Maldonado,
  • Jannik F. Scheffels,
  • Merle Hendel and
  • Florian Lange

29 November 2019

The Wisconsin Card Sorting Test (WCST) represents a widely utilized neuropsychological assessment technique for executive function. This meta-analysis examined the discriminant validity of the WCST for the assessment of mental shifting, considered as...

(This article belongs to the Special Issue Collection on Cognitive Neuroscience)
  • Review
  • Open Access
17 Citations
7,285 Views
18 Pages

1 October 2020

This review aimed at providing a brief and comprehensive summary of recent research regarding the use of the Wisconsin Card-Sorting Test (WCST) to assess executive function in patients with traumatic brain injury (TBI). A bibliographical search, perf...

(This article belongs to the Special Issue Mild and Moderate Traumatic Brain Injuries: Diagnosis, Assessment Tools, Management and Factors Influencing Recovery)
  • Article
  • Open Access
4,318 Views
13 Pages

Performance of the Wisconsin Card Sorting Test in Oncopediatric Patients in an Oncology Unit in Cali, Colombia: A Cross-Sectional Observational Study

  • Ángela María Jiménez Urrego,
  • Valeria Santa,
  • Manuel José Guerrero Gómez,
  • Angie Carolina Guerrero Benitez and ,
  • Tania Romo-González and
  • Alejandro Botero Carvajal
  • + 1 author+ 0 author

13 July 2024

Background: In 2020, the prevalence of cancer rose to 844,778 cases among the population aged 0–19 years. Approximately 90% of individuals under 18 years of age reside in low- and middle-income countries, where cancer survivors report adverse o...

  • Article
  • Open Access
9 Citations
4,291 Views
13 Pages

Effects of Pet Insects on Cognitive Function among the Elderly: An fMRI Study

  • Ji-Yeon Park,
  • Hae-Jin Ko,
  • A-Sol Kim,
  • Ha-Na Moon and ,
  • Hye-In Choi,
  • Jin-Hee Kim,
  • Yongmin Chang and
  • Seong-Hyun Kim
  • + 3 authors+ 0 author

16 October 2019

Animal-assisted therapy has positive effects on cognitive function, depression, performance ability, and social functioning in elderly patients. The aim of this study was to evaluate the effects of rearing pet insects on the cognitive function of hea...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
1 Citations
1,295 Views
20 Pages

20 October 2025

New brain imaging modalities and neuropsychological testing tools are used to study neuronal changes in brain injuries such as mild traumatic brain injury (mTBI). Here we utilized diffusion tensor imaging (DTI) parameters and Wisconsin Card Sorting T...

(This article belongs to the Special Issue Traumatic Brain Injury (TBI))
  • Article
  • Open Access
3 Citations
4,005 Views
9 Pages

An Item Response Theory Analysis of the Wisconsin Card Sorting Test in Normal Aging, Alzheimer’s Disease and Parkinson’s Disease: Neurophysiological Approach

  • Juan Luis Sánchez-Rodríguez,
  • Raúl Juárez-Vela,
  • Iván Santolalla-Arnedo,
  • Regina Ruiz de Viñaspre-Hernandez and
  • Juan Luis Sánchez-González

29 March 2022

The Wisconsin Card Sorting Test (WCST) is widely used to assess executive function, specifically mental flexibility. Item Response Theory (IRT) has several advantages over classical test theory, including the invariance of the measure. This study aim...

  • Article
  • Open Access
8 Citations
3,877 Views
24 Pages

A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis

  • Alexander Steinke,
  • Florian Lange,
  • Caroline Seer,
  • Susanne Petri and
  • Bruno Kopp

11 August 2020

Executive dysfunction is a well-documented, yet nonspecific corollary of various neurological diseases and psychiatric disorders. Here, we applied computational modeling of latent cognition for executive control in amyotrophic lateral sclerosis (ALS)...

(This article belongs to the Special Issue Clinical and Imaging Assessment of Cognitive Dysfunction in Neurological and Psychiatric Disorders)
  • Feature Paper
  • Article
  • Open Access
13 Citations
4,918 Views
11 Pages

12 November 2020

The literature to date is limited regarding the implantation of VR in healthy young individuals with a focus on cognitive function. Thirty healthy males aged between 22.8 and 24.3 years volunteered to participate in the study randomly and were assign...

(This article belongs to the Special Issue Artificial Intelligence (AI) and Virtual Reality (VR) in Biomechanics)
  • Article
  • Open Access
15 Citations
7,382 Views
17 Pages

Multiple Levels of Control Processes for Wisconsin Card Sorts: An Observational Study

  • Bruno Kopp,
  • Alexander Steinke,
  • Malte Bertram,
  • Thomas Skripuletz and
  • Florian Lange

We explored short-term behavioral plasticity on the Modified Wisconsin Card Sorting Test (M-WCST) by deriving novel error metrics by stratifying traditional set loss and perseverative errors. Separating the rule set and the response set allowed for t...

(This article belongs to the Special Issue Collection on Cognitive Neuroscience)
  • Article
  • Open Access
28 Citations
8,577 Views
15 Pages

Self-administered computerized assessment has the potential to increase the reach of neuropsychological assessment. The present study reports the first split-half reliability estimates for a self-administered computerized variant of the Wisconsin Car...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
2 Citations
1,290 Views
12 Pages

From Accelerometer to Cognition: Hand Motion Can Reflect Effects of Cardiac Coherence on Cognitive Flexibility

  • Alix Bouni,
  • Laurent M. Arsac,
  • Olivier Chevalerias and
  • Véronique Deschodt-Arsac

7 May 2025

Hand displacements during task-directed movements are not random, but exhibit fractal behavior. Wearable sensing e.g., accelerometer-derived hand movement fluctuations, could add a significant contribution to cognitive and behavioral sciences, by acc...

(This article belongs to the Special Issue Wearable Sensing Technology for Physiological and Behavioral Human Monitoring—2nd Edition)
  • Review
  • Open Access
17 Citations
7,183 Views
24 Pages

17 December 2020

Cognitive inflexibility is a well-documented, yet non-specific corollary of many neurological diseases. Computational modeling of covert cognitive processes supporting cognitive flexibility may provide progress toward nosologically specific aspects o...

  • Article
  • Open Access
4 Citations
3,281 Views
11 Pages

Cognitive Flexibility in Hospitalized Patients with Severe or Extreme Anorexia Nervosa: A Case-Control Study

  • Simone Daugaard Hemmingsen,
  • Nicolaj Daugaard,
  • Magnus Sjögren,
  • Mia Beck Lichtenstein and ,
  • Claire Gudex,
  • Frederikke Piil and
  • René Klinkby Støving
  • + 2 authors+ 0 author

15 June 2023

Objective: To investigate whether cognitive inflexibility could be identified using the Wisconsin Card Sorting Test (WCST) in patients with severe and extreme anorexia nervosa (AN) compared to healthy control participants (HCs). Method: We used the W...

(This article belongs to the Special Issue Biomarkers and Clinical Research in Eating Disorders)
  • Article
  • Open Access
26 Citations
5,624 Views
14 Pages

Background: Studies have implicated hypofrontality in the pathogenesis of impaired theory of mind (ToM) and executive function (EF) in major depressive disorder (MDD). These symptoms are usually resistant to treatment. Repetitive transcranial magneti...

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)
  • Article
  • Open Access
19 Citations
6,328 Views
15 Pages

Cerebellar GABA Levels and Cognitive Interference in Parkinson’s disease and Healthy Comparators

  • Federica Piras,
  • Daniela Vecchio,
  • Francesca Assogna,
  • Clelia Pellicano and ,
  • Valentina Ciullo,
  • Nerisa Banaj,
  • Richard A. E. Edden,
  • Francesco E. Pontieri,
  • Fabrizio Piras and
  • Gianfranco Spalletta
  • + 5 authors+ 0 author

28 December 2020

The neuroanatomical and molecular substrates for cognitive impairment in Parkinson Disease (PD) are far from clear. Evidence suggests a non-dopaminergic basis, and a crucial role for cerebellum in cognitive control in PD. We investigated whether a PD...

(This article belongs to the Special Issue Personalized Medicine for Parkinson's Disease: New Concepts and Future of Individualized Management)
  • Article
  • Open Access
11 Citations
2,892 Views
11 Pages

Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine

  • Sang-Hwa Lee,
  • Yeonkyeong Lee,
  • Minji Song,
  • Jae Jun Lee and
  • Jong-Hee Sohn

24 June 2021

Neuroimaging and neuropsychological investigations have indicated that migraineurs exhibit frontal lobe-related cognitive impairment. We investigated whether orbitofrontal and dorsolateral functioning differed between individuals with episodic migrai...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
9 Citations
3,024 Views
22 Pages

Adaptive Cognitive Control in Prematurely Born Children: An HD-EEG Investigation

  • Giovanni Mento,
  • Lisa Toffoli,
  • Letizia Della Longa,
  • Teresa Farroni and ,
  • Fiorella Del Popolo Cristaldi and
  • Gian Marco Duma
  • + 1 author+ 0 author

13 August 2022

Preterm birth is a neurodevelopmental risk condition often associated with cognitive control (CC) impairment. Recent evidence showed that CC can be implicitly adapted through associative learning. In the present study we investigated the ability to f...

(This article belongs to the Special Issue Brain Correlates of Typical and Atypical Development)
  • Article
  • Open Access
24 Citations
9,894 Views
17 Pages

Risk Decision Making and Executive Function among Adolescents and Young Adults

  • Francisco Marquez-Ramos,
  • David Alarcon,
  • Josue G. Amian,
  • Cristina Fernandez-Portero and ,
  • Maria J. Arenilla-Villalba and
  • Jose Sanchez-Medina
  • + 1 author+ 0 author

8 February 2023

The dual theory establishes that the decision-making process relies on two different systems, the affective system and the executive function (EF), developed during adolescence. This study analyzes the relationship between the decision-making and EF...

(This article belongs to the Section Developmental Psychology)
  • Article
  • Open Access
30 Citations
8,135 Views
13 Pages

Impulsivity, Emotional Dysregulation and Executive Function Deficits Could Be Associated with Alcohol and Drug Abuse in Eating Disorders

  • María Lozano-Madrid,
  • Danielle Clark Bryan,
  • Roser Granero,
  • Isabel Sánchez and ,
  • Nadine Riesco,
  • Núria Mallorquí-Bagué,
  • Susana Jiménez-Murcia,
  • Janet Treasure and
  • Fernando Fernández-Aranda
  • + 4 authors+ 0 author

21 June 2020

Background: Empirical data suggests a high comorbid occurrence of eating disorders (EDs) and substance use disorders (SUDs), as well as neurological and psychological shared characteristics. However, no prior study has identified the neuropsychologic...

(This article belongs to the Special Issue Advances in Eating Disorders)
  • Article
  • Open Access
4 Citations
4,360 Views
15 Pages

Face memory impairments are common but heterogeneous in autism spectrum disorder (ASD), which may be influenced by co-occurrence with attention-deficit/hyperactivity disorder (ADHD). Here, we aimed to investigate the phenotype change of face memory i...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
587 Views
14 Pages

Neuropsychological Predictors of Treatment Dropout Among Intimate Partner Violence Perpetrators

  • Ángel Romero-Martínez,
  • Carolina Sarrate-Costa,
  • Marisol Lila and
  • Luis Moya-Albiol

Background: The interplay between intervention dropout and increased recidivism among men convicted of intimate partner violence (IPV) underscores the need for a model that investigates the underlying variables associated with IPV perpetrator dropout...

(This article belongs to the Section Studies on Cognitive Processes)
  • Article
  • Open Access
1 Citations
3,091 Views
26 Pages

An Expert Knowledge-Based System to Evaluate the Efficiency of Dry Construction Methods

  • Maria Kozlovska,
  • Adrian Duris,
  • Zuzana Strukova and
  • Alena Tazikova

26 October 2023

The issues that the construction sector currently faces with regard to productivity and efficiency are well acknowledged. In the construction industry, there is plenty of space for efficiency to improve, with an increasing number of new tools and met...

  • Article
  • Open Access
6 Citations
7,786 Views
12 Pages

Impact of Pomegranate Extract Supplementation on Physical and Cognitive Function in Community-Dwelling Older Adults Aged 55–70 Years: A Randomised Double-Blind Clinical Trial

  • Grace Farhat,
  • Jhama Malla,
  • Emad A. S. Al-Dujaili,
  • Jay Vadher and ,
  • Pradeepa Nayak and
  • Kenneth Drinkwater
  • + 1 author+ 0 author

17 February 2025

Background/objectives: Cognitive decline and loss of physical function are common concerns in older adults, with limited effective interventions available. This study aimed to assess the impact of pomegranate extract (PE) supplementation on cognitive...

(This article belongs to the Section Healthy Aging)
  • Article
  • Open Access
1,647 Views
17 Pages

Quality of Life and Executive Function Deficits in Inflammatory Arthritis: A Comparative Study of Rheumatoid and Psoriatic Arthritis

  • Cigdem Cekmece,
  • Begum Capa Tayyare,
  • Duygu Temiz Karadag,
  • Selime Ilgin Sade and ,
  • Ayse Cefle and
  • Nigar Dursun
  • + 1 author+ 0 author

7 August 2025

Background/Objective: Executive functions (EFs) are essential in the daily management of arthritis, as they influence treatment adherence, decision-making, and the ability to cope with disease-related challenges. The objective of this study was to co...

(This article belongs to the Special Issue Relationship Between Musculoskeletal Problems and Quality of Life)
  • Article
  • Open Access
1 Citations
2,927 Views
8 Pages

Study of the Interaction between Executive Function and Adaptive Behavior at School in Girls with Fragile X Syndrome

  • Lorena Joga-Elvira,
  • Jennifer Martinez-Olmo,
  • María-Luisa Joga,
  • Carlos Jacas and ,
  • Ana Roche-Martínez and
  • Carme Brun-Gasca
  • + 1 author+ 0 author

21 July 2021

The aim of this research is to analyze the relationship between executive functions and adaptive behavior in girls with Fragile X syndrome (FXS) in the school setting. This study is part of a larger investigation conducted at the Hospital Parc Tauli...

(This article belongs to the Special Issue Human Developmental Disability, Neurogenetics and Rare Diseases: From Basic Science to Genetic Counseling)
  • Article
  • Open Access
10 Citations
3,999 Views
15 Pages

Cognitive Functions after Carotid Artery Stenting—1-Year Follow-Up Study

  • Magdalena Piegza,
  • Izabela Jaworska,
  • Jacek Piegza,
  • Kamil Bujak and ,
  • Paweł Dębski,
  • Aleksandra Leksowska,
  • Piotr Gorczyca,
  • Mariusz Gąsior and
  • Robert Pudlo
  • + 4 authors+ 0 author

27 May 2022

Background: The revascularization of carotid arteries minimizes the risk of future cerebral stroke and usually improves cognitive functions. The aim of this study was to assess changes in cognitive function and verify the hypothesis assuming an impro...

(This article belongs to the Section Clinical Neurology)
  • Review
  • Open Access
1 Citations
2,655 Views
23 Pages

11 August 2025

Cognitive flexibility, the ability to adapt behavior to changing environmental demands, is a core deficit in schizophrenia (SZ), that predicts disease progression. This review synthesizes findings on the neural substates of cognitive flexibility by u...

(This article belongs to the Section Molecular Biology)
  • Article
  • Open Access
3 Citations
4,077 Views
14 Pages

Rey-Osterrieth Complex Figure (ROCF) is a neuropsychological assessment for the evaluation of visuospatial constructional ability and visual memory. Recent studies emphasize the involvement of executive functions in this test. Purpose. To examinate t...

  • Case Report
  • Open Access
2 Citations
2,825 Views
9 Pages

Executive Functions in a Patient with Low-Grade Glioma of the Central Nervous System: A Case Report

  • Manuel José Guerrero Gómez,
  • Ángela Jiménez Urrego,
  • Fernando Gonzáles and
  • Alejandro Botero Carvajal

18 April 2024

Central nervous system tumors produce adverse outcomes in daily life, although low-grade gliomas are rare in adults. In neurological clinics, the state of impairment of executive functions goes unnoticed in the examinations and interviews carried out...

  • Article
  • Open Access
4 Citations
3,950 Views
18 Pages

Cognitive Inflexibility Predicts Negative Symptoms Severity in Patients with First-Episode Psychosis: A 1-Year Follow-Up Study

  • Leonidas Mantonakis,
  • Pentagiotissa Stefanatou,
  • Antonis Tsionis,
  • George Konstantakopoulos and ,
  • Lida-Alkisti Xenaki,
  • Angeliki-Aikaterini Ntigrintaki,
  • Irene Ralli,
  • Stefanos Dimitrakopoulos,
  • Konstantinos Kollias and
  • Nikos C. Stefanis
  • + 5 authors+ 0 author

5 February 2024

Negative symptoms and cognitive deficits play a major role in psychosis and significantly influence the functional outcomes of patients, particularly those with a first episode of psychosis (FEP). However, limited research has explored the predictive...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
4 Citations
2,951 Views
13 Pages

Depression and Cognitive Dysfunction in Patients with Chronic Hepatitis C: Correlation with Viral Replication in the Peripheral Blood Mononuclear Cells and Cytokines in Serum

  • Marek Radkowski,
  • Tomasz Kryczka,
  • Bogna Szymańska-Kotwica,
  • Hanna Berak and ,
  • Andrzej Horban,
  • Tomasz Pawłowski,
  • Karol Perlejewski and
  • Tomasz Laskus
  • + 3 authors+ 0 author

19 October 2023

Chronic hepatitis C virus (HCV) infection is commonly associated with depression and cognitive dysfunction, the cause of which could be related to the HCV neuroinvasion and/or state of chronic inflammation. Viral sequences and proteins were previousl...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
12 Citations
4,706 Views
16 Pages

Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study

  • Mikel Etxandi,
  • Isabel Baenas,
  • Bernat Mora-Maltas,
  • Roser Granero and ,
  • Fernando Fernández-Aranda,
  • Sulay Tovar,
  • Neus Solé-Morata,
  • Ignacio Lucas,
  • Sabela Casado and
  • Susana Jiménez-Murcia
  • + 12 authors+ 7 authors

29 November 2022

Gambling disorder (GD) is a modestly prevalent and severe condition for which neurobiology is not yet fully understood. Although alterations in signals involved in energy homeostasis have been studied in substance use disorders, they have yet to be e...

(This article belongs to the Special Issue Eating Disorders and Addictive Behaviors: Implications for Human Health)
  • Article
  • Open Access
24 Citations
12,252 Views
19 Pages

CogBeacon: A Multi-Modal Dataset and Data-Collection Platform for Modeling Cognitive Fatigue

  • Michalis Papakostas,
  • Akilesh Rajavenkatanarayanan and
  • Fillia Makedon

In this work, we present CogBeacon, a multi-modal dataset designed to target the effects of cognitive fatigue in human performance. The dataset consists of 76 sessions collected from 19 male and female users performing different versions of a cogniti...

  • Article
  • Open Access
1,144 Views
12 Pages

Norma Latina Neuropsychological Evaluation in Individuals with Multiple Sclerosis and Its Relationship with Disability

  • Adriana Aguayo-Arelis,
  • Brenda Viridiana Rabago-Barajas,
  • Alina Mariela Cárdenas Gómez,
  • Jesús Emmanuel Arana Yepez and ,
  • Ana Miriam Saldaña-Cruz and
  • Alberto Fragoso-Ruiz
  • + 1 author+ 0 author

21 November 2025

Background: Multiple Sclerosis (MS) is an inflammatory, autoimmune and neurodegenerative disease of the central nervous system that leads to the progressive loss of motor and sensory functions. Cognitive dysfunction is a common symptom that significa...

(This article belongs to the Section Systems Neuroscience)
  • Article
  • Open Access
12 Citations
3,906 Views
13 Pages

The Characteristics of Cognitive Impairment in ALS Patients Depend on the Lateralization of Motor Damage

  • Umberto Manera,
  • Laura Peotta,
  • Barbara Iazzolino,
  • Antonio Canosa and ,
  • Rosario Vasta,
  • Francesca Palumbo,
  • Maria Claudia Torrieri,
  • Luca Solero,
  • Margherita Daviddi and
  • Marco Cavallo
  • + 9 authors+ 4 authors

19 September 2020

(1) Background: Cognitive features of patients with amyotrophic lateral sclerosis (ALS) have never been specifically analyzed according to the lateralization of motor impairment. In the present study we investigated the cognitive performances of ALS...

  • Article
  • Open Access
4 Citations
5,935 Views
36 Pages

11 March 2014

We treat the non-equilibrium evolution of an open one-particle statistical system, subject to a potential and to an external “heat bath” (hb) with negligible dissipation. For the classical equilibrium Boltzmann distribution, Wc,eq, a non-equilibrium...

(This article belongs to the Special Issue Advances in Methods and Foundations of Non-Equilibrium Thermodynamics)
  • Review
  • Open Access

Over the last 20 years major advances in mathematics and computing opened up remarkable opportunities for studying the function, biochemistry and microstructure of the human brain. Magnetic resonance imaging (MRI) in neuroscience describes the functi...