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Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine

by 1,2,†, 2,†, 1,3, 4 and 1,2,*
1
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24523, Korea
2
Institute of New Frontier Research, College of Medicine, Hallym University, Chuncheon 24523, Korea
3
Department of Psychology, College of Social Sciences, Hallym University, Chuncheon 24523, Korea
4
Department of Anesthesiology and Pain Medicine, College of Medicine, Kangwon National University, Chuncheon 24523, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Stefan Evers
J. Clin. Med. 2021, 10(13), 2779; https://doi.org/10.3390/jcm10132779
Received: 23 May 2021 / Revised: 16 June 2021 / Accepted: 21 June 2021 / Published: 24 June 2021
(This article belongs to the Section Clinical Neurology)
Neuroimaging and neuropsychological investigations have indicated that migraineurs exhibit frontal lobe-related cognitive impairment. We investigated whether orbitofrontal and dorsolateral functioning differed between individuals with episodic migraine (EM) and chronic migraine (CM), focusing on orbitofrontal dysfunction because it is implicated in migraine chronification and medication overuse headache (MOH) in migraineurs. This cross-sectional study recruited women with CM with/without MOH (CM + MOH, CM − MOH), EM, and control participants who were matched in terms of age and education. We conducted neuropsychological assessments of frontal lobe function via the Trail Making Test (TMT) A and B, the Wisconsin Card Sorting Test (WCST), and the Iowa Gambling Task (IGT). We enrolled 36 CM (19 CM + MOH, 17 CM − MOH), 30 EM, and 30 control participants. The CM patients performed significantly (p < 0.01) worse on the TMT A and B than the EM patients and the control participants. The WCST also revealed significant differences, with poorer performance in the CM patients versus the EM patients and the control participants. However, the net scores on the IGT did not significantly differ among the three groups. Our findings suggest that the CM patients exhibited frontal lobe dysfunction, and, particularly, dorsolateral dysfunction. However, we found no differences in frontal lobe function according to the presence or absence of MOH. View Full-Text
Keywords: chronic migraine; episodic migraine; medication overuse headache; frontal lobe function chronic migraine; episodic migraine; medication overuse headache; frontal lobe function
MDPI and ACS Style

Lee, S.-H.; Lee, Y.; Song, M.; Lee, J.J.; Sohn, J.-H. Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine. J. Clin. Med. 2021, 10, 2779. https://doi.org/10.3390/jcm10132779

AMA Style

Lee S-H, Lee Y, Song M, Lee JJ, Sohn J-H. Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine. Journal of Clinical Medicine. 2021; 10(13):2779. https://doi.org/10.3390/jcm10132779

Chicago/Turabian Style

Lee, Sang-Hwa, Yeonkyeong Lee, Minji Song, Jae Jun Lee, and Jong-Hee Sohn. 2021. "Differences in Frontal Lobe Dysfunction in Patients with Episodic and Chronic Migraine" Journal of Clinical Medicine 10, no. 13: 2779. https://doi.org/10.3390/jcm10132779

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