79 Results Found

Silicified ostracods from the Tin Mountain Limestone provide new information regarding the Carboniferous paleontology of the Death Valley Region, California, USA. Acid maceration of marine limestones yielded the following ostracods: Acratia spp., Bai...

Many green technology innovations developed by academic institutions struggle to cross the “Valley of Death” (VoD), failing to achieve commercialization. Boundary-spanning green technology search (BGTS), as an inter-organizational mechani...

The Valley of Death is the gap between the completion of research and development (R&D) projects and their transition to innovation. A key aspect to explain it are mindsets, which are one of the most complex to explain due to the number of factor...

(1) Background: The survival and growth of startups in their early stages are negatively impacted by the lack of financial sustainability and scarce resources that entrepreneurs face during the first 5 years. This is known as the Valley of Death (VoD...

Scanlines constitute a robust method to better understand in 3D the fracture network variability in naturally fractured geothermal reservoirs. This study aims to characterize the spacing variability and the distribution of fracture patterns in a frac...

In the basement fractured reservoirs, geometric parameters of fractures constitute the main properties for modeling and prediction of reservoir behavior and then fluid flow. This study aims to propose geometric description and quantify the multiscale...

Reducing the environmental pressure along the products life cycle, increasing efficiency in the consumption of resources and use of renewable raw materials, and shifting the economic system toward a circular and a climate-neutral model represent the...

The Valley of Death confronts industrial biotechnology with a significant challenge to the commercialization of products. Fortunately, with the integration of computation, automation and artificial intelligence (AI) technology, the industrial biotech...

This study aims to advance the understanding of and address the valley of death that is significantly widening in the clean energy domain due to its financing challenges. We conduct a case study on three new investment vehicles in the US energy secto...

(1) Background: Rift Valley fever (RVF) outbreaks in domestic ruminants have severe socio-economic impacts. Climate-based continental predictions providing early warnings to regions at risk for RVF outbreaks are not of a high enough resolution for ru...

P2Et is the standardized extract of Caesalpinia spinosa (C. spinosa), which has shown the ability to reduce primary tumors and metastasis in animal models of cancer, by mechanisms involving the increase in intracellular Ca++, reticulum stress, induct...

Resource-based cities are suffering from resource scarcity and environmental deterioration. Spirit, vitality and prosperity are disappearing and cities have moved towards “the valley of death” in terms of urban development. This typically...

This article engages the concept of death as a revolutionary transformation within the contexts of mind uploading (MU) and Pierre Teilhard de Chardin’s theology of the Omega Point. The focus is not on the Omega Point itself as a conceptual endp...

Technology Readiness Levels (TRLs) are a widely used metric of technology maturity and risk for marine renewable energy (MRE) devices. To-date, a large number of device concepts have been proposed which have reached the early validation stages of dev...

Feral donkey removal from state land has raised concerns in terms of disease transmission between equine species. Disease outbreaks may occur as a result of the relocation of animals to new environments. Virus and bacteria DNA load and serum amyloid...

The clinical evaluation of lipid metabolism in equids is often limited to the measurement of total cholesterol and triglyceride concentrations. This provides a limited picture of metabolic state and general health, given the continuous exchange of li...

Disasters caused by climate change are continuing around the world. Densely populated urban areas have been pushed to the forefront of global climate change, and ecological security has gradually become the focus of global attention. Whether it is pr...

We characterized soil communities in the Mojave Desert across an elevation gradient. Our goal was to test the hypothesis that as soil quality improved with increasing elevation (due to increased productivity), the diversity of soil prokaryotes and ne...

The Brainport-Eindhoven region has developed into a leading location for deeptech entrepreneurship in Europe. Against all odds, it has transformed itself from a region that heavily depended on the multinational company Philips, into a diverse and fas...

In this paper, an integrative analysis is conducted for both sides of the border of Mexicali B.C. and Imperial Valley, regarding the official procedures and ways in which the collection, organization and disposal of data is carried out for the follow...

This paper explores women’s entrepreneurship in Kuwait in terms of sustainability, as defined by the United Nations (UN) [...]

Delivery of high-radiation doses to brain tumors via multiple arrays of synchrotron X-ray microbeams permits huge therapeutic advantages. Brain tumor (9LGS)-bearing and normal rats were irradiated using a conventional, homogeneous Broad Beam (BB), or...

The Hindukush and Himalaya regions of Pakistan are chronically prone to several geological hazards such as landslides. Studying landslides in these regions is crucial for risk assessment and disaster management, as well as for determining the effects...

Mortality increases during periods of elevated heat. Identification of vulnerable subgroups by demographics, causes of death, and geographic regions, including deaths occurring at home, is needed to inform public health prevention efforts. We calcula...

Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Côa Valley’s flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are trad...

The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurolog...

COVID-19 hit Italy in February 2020 after its outbreak in China at the beginning of January. Why was Italy first among the Western countries? What are the conditions that made Italy more vulnerable and the first target of this disease? What character...

Laser-induced breakdown spectroscopy (LIBS) is a form of optical emission spectroscopy that can be used for the rapid analysis of geological materials in the field under ambient environmental conditions. We describe here the innovative use of handhel...

Conventional cytotoxic chemotherapy involving DNA-interacting agents and indiscriminate cell death is no longer the future of cancer management. While chemotherapy is not likely to completely disappear from the armamentarium; the use of targeted ther...

Air pollution is one of the world’s leading environmental causes of death. The epidemiological relationship between outdoor air pollution and the onset of health diseases associated with death is now well established. Relevant toxicological pro...

In recent decades, natural disasters have increased drastically, with slope movements being the most damaging geological hazard, causing thousands of deaths and considerable economic losses. To reduce these losses, it is necessary to carry out cartog...

The land surface temperature (LST) in arid regions is a primary controller of many ecological processes. Consequently, we have developed a framework for detection of LST change on a regional scale using data sets covering all deserts of southern Cali...

Recent removal and relocation of feral donkeys from vast public lands to more concentrated holding pens, training facilities, and offsite adoption locations raises several health and welfare concerns. Very little is known regarding the common equid p...

The #CHEARIATIRA citizen science campaign was developed in February 2019 in Torino (western part of the Po Valley megacity region). The aim of the campaign was public engagement with measuring NO2 concentrations in an urban area that often exceeds ai...

Four large outbreaks of Rift Valley Fever (RVF) occurred in Mauritania in 1998, 2003, 2010 and 2012 which caused lots of animal and several human deaths. We investigated rainfall and vegetation conditions that might have impacted on RVF transmission...

Rift Valley fever (RVF) is a vector-borne viral disease of ruminants mainly, and man, characterized by abortions and neonatal deaths in animals and flu-like to more severe symptoms that can result in death in humans. The disease is endemic in Africa,...

Elephant endotheliotropic herpesviruses (EEHVs) are important causes of death in both captive and wild Asian elephants (Elephas maximus). Nothing is known about the prevalence of EEHVs in wild or domestic elephants in China. To determine if EEHVs are...

Berry cell death assessment can become one of the most objective parameters to assess important berry quality traits, such as aroma profiles that can be passed to the wine in the winemaking process. At the moment, the only practical tool to assess be...

Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes encephalitis. Previous work indicated that VEEV infection induced early growth response 1 (EGR1) expression, leading to cell death via the protein kinase R (PKR)-like endoplasmi...

Fracture connectivity within fractured granitic basement geothermal reservoirs is an important factor controlling their permeability. This study aims to improve the understanding of fluid–rock interaction processes at low to moderate regional s...

Early growth response 1 (EGR1) is an immediate early gene and transcription factor previously found to be significantly upregulated in human astrocytoma cells infected with Venezuelan equine encephalitis virus (VEEV). The loss of EGR1 resulted in dec...

Purpose: High doses of ionizing radiation in radiotherapy can elicit undesirable side effects to the skin. Proton minibeam radiotherapy (pMBRT) may circumvent such limitations due to tissue-sparing effects observed at the macro scale. Here, we mapped...

Monoplanar microbeam irradiation (MBI) and pencilbeam irradiation (PBI) are two new concepts of high dose rate radiotherapy, combined with spatial dose fractionation at the micrometre range. In a small animal model, we have explored the concept of in...

Previous hematologic and serum biochemistry reference interval (RI) values have been established for donkeys in various geographic regions, life-stages, or for specific donkey breeds. The last extensive investigation establishing RIs for adult donkey...

This study adopts the 5W2H management tool to investigate the opportunities and challenges of enzymatic biodiesel production from residual oils. The methodological approach enables a structured evaluation of technical, economic, environmental, and go...

The present work focuses on two recent flash floods in coastal Benguela (Angola), both triggered by moderate rainfall but which had disastrous consequences for local populations (namely 71 deaths in 2015 and 17 in 2019). The research involved a regio...

The academic study of Tibetan Buddhism has long emphasized the textual, philological, and monastic, and sometimes tended to ignore, dismiss, or undervalue the everyday practices and beliefs of ordinary people. In this article, I show that traditional...

Rift valley fever (RVF), caused by the RVF virus (RVFV), is a vector-borne zoonotic disease that primarily affects domestic ruminants. Abortion storms and neonatal deaths characterise the disease in animals. Humans develop flu-like symptoms, which ca...

At the European Union (EU) level, innovation matter is acknowledged as crucial for progress and sustainability. Related policy action is materialized through Horizon Europe, the 9th Framework Program (FP) for research and development (R&D). The p...

Taking an idea from a basic concept to a commercially available product is highly rewarding, but it can be a very long, complex, and difficult journey. Recognizing and understanding the stages of the process and using the right support to help you na...