Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In this study we investiga...
AlGaN-based deep-ultraviolet (DUV) LEDs could realize higher optical power output when adopting a p-AlGaN contact layer instead of a p-GaN contact layer. However, this new type DUV LEDs exhibit poor reliability. Thus, this study thoroughly investigat...
In this paper, the effects of laying angle on the stress distribution and stiffness degradation of glass epoxy laminates with symmetrical cracks are systematically studied by variational analysis and numerical simulation. Based on the principle of mi...
The effect of stress depolarization will cause actuation function degradation of a piezoelectric actuator, which can eventually trigger function failure of the piezoelectric smart structure system. In the present study, we experimentally demonstrate...
Background/Objectives: Forced degradation studies are critical for identifying potential degradation pathways of monoclonal antibodies (mAbs), particularly under thermal stress. Due to their structural complexity and sensitivity to elevated temperatu...
Ochratoxin A (OTA) is a naturally occurring mycotoxin mainly produced by certain species of Aspergillus and Penicillium and is a serious threat to human health and food safety. Previous studies showed that Brevundimonas naejangsanensis ML17 can compl...
The influence of service-induced degradation on residual life is very important for the safe service of turbine blades. In this study, a series of simulation experiments were conducted on a directionally solidified superalloy under (880–1020) &...
Stress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of...
Composite laminated structures have extensive applications in the field of bionic engineering. Proficient comprehension of the mechanical properties of these structures is instrumental in the advancement of bionic composite materials. The objective o...
In the accelerated degradation test (ADT) of motorized spindles, it is necessary to apply a variety of stresses to simulate real working conditions. However, the traditional accelerated test scheme optimization method does not consider the weight of...
Coastal marine soft clays subjected to long-term storm wave loading often exhibit inclined initial principal stress orientation (α0) and subsequent cyclic principal stress rotation (PSR). These stress states critically influence soil mechanical...
Performance decay of direct methanol fuel cells hinders technology competitiveness. The cathode electrochemical surface area loss is known to be a major reason for performance loss and it is mainly affected by cathode potential and dynamics, locally...
The step-stress accelerated degradation test (ADT) provides a feasible method for assessing the storage life of high-reliability, long-life products. However, this method results in a slower rate of performance degradation at the beginning of the tes...
The reliability information for novel products and specimens available for various tests is limited during the development stage. In many real cases, the results of general tests under use and the maximum stress levels for checking performance and de...
In this review article, we want to present an overview of oxidative stress in fungal cells in relation to signal transduction, interaction of fungi with plant hosts, and lignocellulose degradation. We will discuss external oxidative stress which may...
Due to the complex operating environment of LED lamp beads (hereinafter referred to as LED), the test method that only considers the action of multiple stresses alone ignores the mutual influence between stresses, making it difficult to accurately ob...
In this work, we investigated the degradation of the p-GaN gate stack induced by the forward gate voltage stress in normally off AlGaN/GaN high electron mobility transistors (HEMTs) with Schottky-type p-GaN gate. The gate stack degradations of p-GaN...
In this paper, a novel approach that combines technology computer-aided design (TCAD) simulation and machine learning (ML) techniques is demonstrated to assist the analysis of the performance degradation of GaN HEMTs under hot-electron stress. TCAD i...
III-nitride-based ultraviolet light emitting diode (UV LED) has numerous attractive applications in air and water purification, UV photolithography, and in situ activation of drugs through optical stimulus, solid state lighting, polymer curing, and l...
In this work, the degradation in luminous characteristics of red, green, and blue (RGB) micro-LEDs (10 µm × 10 µm) under electrical stress at 360 K has been investigated. After 280 h of aging, the AlGaInP-based red micro-LEDs exhibi...
Plastic film mulching is widely practiced in arid and semiarid farming systems, but the accumulation of plastic residues in soils can negatively affect soil properties. Therefore, efficient means of plastic film degradation are urgently needed to mit...
TRIM48 is a human-specific tripartite motif (TRIM) family protein with E3 ubiquitin ligase activity that plays a significant role in the oxidative stress response and tumor suppression. However, the mechanisms regulating TRIM48 expression remain unkn...
An isocratic reverse-phase high-performance liquid chromatography (RP-HPLC) method, coupled with photodiode array detection (PDA), was developed for the identification and characterization of stress degradation products and an unknown process-related...
With the wide application of motors in deep sea exploration, deep-sea motors require a higher power density and a longer lifetime. Motor lifetime mainly depends on the thermo-mechanical stress (TMS) load on its stator insulation. Unlike normal motors...
GaN-based high electron mobility transistors offer high carrier density combined with high electron mobility and often require operation at high frequencies, voltages, and temperatures. The device may be under high temperature and high voltage at the...
The stress-induced leakage current (SILC) degradation of partially depleted silicon in insulator (PDSOI) devices under constant voltage stress (CVS) was studied. Firstly, the behaviors of threshold voltage degradation and SILC degradation of H-gate P...
Chloroplasts are extraordinary organelles for photosynthesis and nutrient storage in plants. During leaf senescence or under stress conditions, damaged chloroplasts are degraded and provide nutrients for developing organs. Autophagy is a high-through...
This paper aims to improve the accuracy of reliability estimates and the failure time prediction for products exhibiting nonlinear degradation behavior under constant-stress accelerated degradation test (CSADT). To achieve this, a novel degradation m...
A novel, stability-indicating UHPLC method was developed for the quantitative determination of Abacavir sulfate, its related substances, and forced degra-dation impurities in bulk drugs. The chromatographic separation was achieved on a Waters Acquity...
This study aimed to comprehensively understand the performance and degradation of both p- and n-channel vertical double diffused MOS (VDMOS) transistors under bias temperature stress. Conducted experimental investigations involved various stress cond...
A rapid, reversed-phase liquid chromatographic method was developed for the quantitative determination of Atorvastatin calcium, its related substances (12 impurities), and degradation impurities in bulk drugs. The chromatographic separation was achie...
Despite the wide application of organic light-emitting diodes (OLEDs), the performance of OLED devices is sometimes limited by their reliabilities. In this paper, we report the transient degradation behaviors of fluorescent blue OLEDs, where both the...
The chip is the core component of the integrated circuit. Degradation and failure of chip solder joints can directly lead to function loss of the integrated circuit. In order to establish the degradation model of chip solder joints under coupled stre...
The integration of photovoltaic (PV) systems into power grids has surged due to the global shift towards renewable energy, but this rapid adoption presents challenges like voltage regulation and inverter degradation. High PV penetration can lead to o...
In the field of reliability analysis, the constant-stress accelerated degradation test is one of the most commonly used methods to evaluate a product’s reliability as degradation data are provided. In this paper, a constant-stress accelerated d...
The E3 ubiquitin ligase, von Hippel–Lindau (VHL), regulates protein expression by polyubiquitination. Although the protein VHL (pVHL) was reported to be involved in the heart function, the underlying mechanism is unclear. Here, we show that pVHL was...
Lithium-ion batteries power numerous systems from consumer electronics to electric vehicles, and thus undergo qualification testing for degradation assessment prior to deployment. Qualification testing involves repeated charge–discharge operation of...
The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress. The UPR signaling netwo...
Selective autolysosomal degradation of damaged mitochondria, also called mitophagy, is an indispensable process for maintaining integrity and homeostasis of mitochondria. One well-established mechanism mediating selective removal of mitochondria unde...
Research on compostable bioplastics has recently obtained performances comparable to traditional plastics, like water vapor permeability, sealability, and UV transmission. Therefore, it is crucial to create new tools that help the developers of new p...
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteopor...
The conversion from existing electrical networks into an all-renewable and environmentally friendly electrification scenario is insufficient to produce and distribute energy efficiently. Electrochemical devices’ premature degradation as a whole cause...
Oxidative stress induces DNA damage which can be repaired by DNA repair proteins, such as Ku70/80. Excess reactive oxygen species (ROS) stimulate the activation of caspase-3, which degrades Ku 70/80. Cells with decreased Ku protein levels undergo apo...
Nostoc flagelliforme is a kind of terrestrial edible cyanobacteria with important ecological and economic value which has developed special mechanisms to adapt to drought conditions. However, the specific mechanism of lipidome changes in drought tole...
In this paper, the reliability of InP/InGaAs DHBTs under high reverse base–collector bias stress is analyzed by experiments and simulation. The DC characteristics and S parameters of the devices under different stress times were measured, and t...
Accurate optimal design for the test plan with limited prior information is impossible since the optimal design method of a three-stress accelerated degradation test plan for a motorized spindle is based on the determination of model parameters. In o...
Stroke is the fifth leading cause of death annually in the United States. Ischemic stroke occurs when a blood vessel supplying the brain is occluded. The hippocampus is particularly susceptible to AMPA receptor-mediated delayed neuronal death as a re...
Barley germination under ultraviolet B (UV-B) illumination stress induces effective accumulation of phenolic compounds in the barley. Spermidine can enhance the biosynthesis of phenolic compounds and alleviate the oxidative damage caused by UV-B. To...
This study investigated the role of oxidative stress in the mitochondrial apoptotic pathways and structural protein degradation of fish during postmortem storage by measuring oxidative stress levels, mitochondrial antioxidant enzyme activity, mitocho...
Zearalenone (ZEN) is one of the most common mycotoxin contaminants in food. For food safety, an efficient and environmental-friendly approach to ZEN degradation is significant. In this study, an Aspergillus niger strain, FS10, was stimulated with 1.0...
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