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Open AccessFeature PaperArticle

Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline

1
Leibniz Institute of Photonic Technology, 07745 Jena, Germany
2
Institute of Physical Chemistry, Friedrich Schiller University, 07743 Jena, Germany
3
Abbe Center of Photonics, Friedrich Schiller University, 07745 Jena, Germany
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(8), 1866; https://doi.org/10.3390/molecules25081866
Received: 10 February 2020 / Revised: 7 April 2020 / Accepted: 8 April 2020 / Published: 17 April 2020
Stress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of tetracycline and the metabolite 4˗epianhydrotetracycline. These degradation processes were experimentally induced by changes in temperature, humidity, and irradiation with visible light over a time period of up to 23 days. The excitation wavelength λexc = 413 nm was proven to provide short acquisition times for the simultaneous Raman spectroscopic detection of the degradation of tetracycline and production of its impurity in small sample volumes. Small concentration changes could be detected (down to 1.4% for tetracycline and 0.3% for 4-epianhydrotetracycline), which shows the potential of resonance Raman spectroscopy for analyzing the decomposition of pharmaceutical products. View Full-Text
Keywords: resonance Raman spectroscopy; drug monitoring; active pharmaceutical ingredients; antibiotics; drug degradation; decomposition of pharmaceutical products; storage stress test resonance Raman spectroscopy; drug monitoring; active pharmaceutical ingredients; antibiotics; drug degradation; decomposition of pharmaceutical products; storage stress test
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MDPI and ACS Style

Domes, C.; Frosch, T.; Popp, J.; Frosch, T. Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline. Molecules 2020, 25, 1866.

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