1,391 Results Found

The n-octanol–water partition coefficient (logP) is an important physicochemical parameter which describes the behavior of organic compounds. In this work, the apparent n-octanol/water partition coefficients (logD) of basic compounds were deter...

Borehole log is important data for urban geological 3D modeling. Most of the current borehole logs are stored in a papery form. The construction of a smart city puts forward requirements for the automatic and intelligent 3D modeling of urban geology....

Neural networks and deep learning have been successfully applied to tackle problems in drug discovery with increasing accuracy over time. There are still many challenges and opportunities to improve molecular property predictions with satisfactory ac...

Achieving the UN Sustainable Development Goals is impossible without sustainable oil and gas production, both in terms of ensuring equal access to cheap energy and preserving the environment, as well as caring for non-renewable fossil energy sources....

The purpose of this work was to demonstrate the use of the AQbD with the DOE approach to the methodical step-by-step development of a UHPLC method for the quantitative determination of the impurity profile of new CPL409116 substance (JAK/ROCK inhibit...

This study examined the behavior and penetration mechanisms of typical phenolic (benzoic) acids, which determine their observed penetration rates during membrane separation, focusing on the influence of electrostatic and hydrophobic solute/membrane i...

Resistivity logging is an important technique for identifying and estimating reservoirs. Oil-based mud (OBM) can improve drilling efficiency and decrease operation risks, and has been widely used in the well logging field. However, the non-conductive...

Biologically active compounds from the 1,3,4-thiadiazol-2-yl)-benzene-1,3-diols group described earlier have been studied. Various approaches were used to determine their lipophilicity and predict pharmacokinetic properties. The lipophilicity paramet...

The abundant satellite data have enabled the study of the dynamics of forest logging and its corresponding carbon balance with remote sensing. Change detection techniques with moderate-resolution imagery have been widely developed. Yet the signal pro...

Timber is the most important source of revenue in forestry and, therefore, is necessary to precisely estimate its volume. The share of timber volume produced by harvesters is annually growing in many European countries. Suitable settings of harvester...

The accurate measurement of logging residue volume is essential for efficient resource management and economic planning in the biomass supply chain. This study compares 3D laser scanning using a mobile ZEB-HORIZON™ scanner and conventional manu...

In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7–12) as well as fused pyrazolo[3',4':4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14–16) and 7,8,9,10-tetrahydropyrazolo[3',4':4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (...

Regioselective N-alkylation of 4-chloro-2-methoxy-7H-pyrrolo[2,3- d]pyrimidine (6) with ethyl 3-bromopropionate under liquid-liquid phase-transfer reactionconditions gave the ester 7a. Its saponification yielded the acid 7b. The logP values of a seri...

Traditional constant false alarm rate (CFAR) detectors only use the contrast information between ship targets and clutter, and they suffer probability of detection (PD) degradation in multiple target situations. This paper proposes a correlation-base...

The article describes an approach to expanding the methodology for applying hydraulic fracturing in oil fields by adding the possibilities of 3D modeling with color imaging of the pore structure of the productive intervals of wells. As an applied exa...

Harvesters produce one third of timber in Czechia. The aim of this study was to analyze the over- and under-bark volume estimates of Scots pine (Pinus sylvestris L.) timber produced by a mid-performance harvester. The data were collected between Marc...

A 3D seismic survey was done on a near surface karstic reservoir located at the hydrogeological experimental site (HES) of the University of Poitiers (France). The processing of the 3D data led to obtaining a 3D velocity block in depth. The velocity...

Sesterterpene MHO7 derived from mangrove fungus is a novel estrogen receptor degrader for the treatment of breast cancer. To explore its safety and pharmacokinetics in vivo, Log P/D values, stability in simulated gastric/intestinal (SGF/SIF), toxicit...

The purpose of this study was to determine corneal permeability and uptake in rabbit, porcine, and bovine corneas for twenty-five drugs using an N-in-1 (cassette) approach and relate these parameters to drug physicochemical properties and tissue thic...

Measuring the predictability and complexity of 2D data (image) series using entropy is an essential tool for evaluation of systems’ irregularity and complexity in remote sensing and geophysical mapping. However, the existing methods have some d...

Inhibitory activities of monocyclic nitroimidazoles against Mycobacterium tuberculosis (Mtb) deazaflavin-dependent nitroreductase (DDN) were modeled by using docking, pharmacophore alignment and comparative molecular similarity indices analysis (CoMS...

Free space optics (FSO)-based optical body area networks (OBANs) are receiving massive attention as an opportunity to address the limitations of their radio frequency (RF)-based counterparts. This boom in research interests is primarily due to multit...

The antimicrobial quantitative structure–activity relationship of plant flavonoids against Gram-positive bacteria was established in our previous works, and the cell membrane was confirmed as a major site of action. To investigate whether plant...

Performing tasks with a robot hand often requires a complete knowledge of the manipulated object, including its properties (shape, rigidity, surface texture) and its location in the environment, in order to ensure safe and efficient manipulation. Whi...

The integration of various geophysical methodologies is considered a fundamental tool for accurately reconstructing the extent and shape of a groundwater body and for estimating the physical parameters that characterize it. This is often essential fo...

The Clearwater River, located in western Washington, USA, is a free-flowing river with high precipitation rates impacted by spatially extensive logging throughout the 1900s. Declining salmon productivity within the watershed has been linked to the ef...

Camptothecin (CPT) is a potent anticancer drug, and its putative oral administration is envisioned although difficult due to physiological barriers that must be overcome. A comprehensive biophysical analysis of CPT interaction with biointerface model...

The combination of ultrasound and microbubbles (USMB) has been applied to enhance drug permeability across tissue barriers. Most studies focused on only one physicochemical aspect (i.e., molecular weight of the delivered molecule). Using an in vitro...

To improve solid precipitation monitoring in the hydrology and meteorology field, 1-min precipitation data observed by the PARticle SIze VELocity (PARSIVEL) disdrometer in Nanjing, eastern China, from February 2014 to February 2019 for all days with...

The melanin-concentrating hormone (MCH) system is a new target for the treatment of human disorders. Since the knowledge of the MCH system's involvement in a variety of pathologies (obesity, diabetes, and deregulation of metabolic feedback mechanism)...

Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable 18F-folates for clinical P...

Background and Objectives: The tumor-node-metastasis (TNM) classification system is the standard for staging gastric cancer and predicting survival. However, its accuracy can be compromised by insufficient lymph node (LN) dissection during surgery or...

Profiling the blood–brain barrier (BBB) permeability of bioactive molecules during early drug development is critical for optimizing their pharmacokinetic profile. The in vivo ability of a compound to cross the BBB is measured by the log BB par...

Existing methods for estimating formation boundaries from well-log data only analyze the formation along the wellbore, failing to capture changes in the 3D formation structure around it. This paper presents a method for real-time 3D formation boundar...

Despite its undeniable advantages, the operation of a CT scanner also carries risks to human health. The CT scanner is a source of ionizing radiation, which also affects people in its surroundings. The aim of this paper is to quantify the radiation e...

One of the most challenging goals in modern pharmaceutical research is to develop models that can predict drugs’ behavior, particularly permeability in human tissues. Since the permeability is closely related to the molecular properties, numero...

The quantification of the solid wood content in a wood stack has been an object of investigation since the 18th century. Particularly, the log parameters exert a considerable influence on the volume of the stack, such as (1) the log midpoint diameter...

The challenge of fracture segmentation remains a significant obstacle in imaging logging interpretation within the current oil and gas exploration and development field. However, existing image segmentation algorithms still encounter issues related t...

The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications. The hydrophilicity of the tetrazine has c...

Antimicrobial resistance (AMR) poses a serious threat to human health, and new antimicrobial agents are desperately needed. Plant flavonoids are increasingly being paid attention to for their antibacterial activities, for the enhancing of the antibac...

All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyloi...

What is the effect of focusing auditory attention on an upcoming signal tone? Weak signal tones, 40 ms in duration, were presented in 50 dB continuous white noise and were either uncued or cued 82 ms beforehand by a 12 dB SL cue tone of the same freq...

This paper presents various aspects of the use of chromatography to determine the biological activity of substances. On the one hand, the use of chromatography to determine the lipophilicity of a substance, a property that affects all LADME steps in...

Simple physico-chemical properties, like logD, solubility, or melting point, can reveal a great deal about how a compound under development might later behave. These data are typically measured for most compounds in drug discovery projects in a mediu...

Antifungal resistance of human fungal pathogens represents an increasing challenge in modern medicine. Short antimicrobial peptides (AMP) display a promising class of antifungals with a different mode of action, but lack target specificity and metabo...

Linked Data (LD) principles, when applied to Open Government Data (OGD), aim to make government data accessible and interconnected, unlocking its full potential and facilitating widespread reuse. As a modular and scalable solution to fragmented gover...

Objective: The aim of this study was to develop quantitative structure–pharmacokinetics relationship (QSPKR) models for a group of xanthine derivatives with proven pharmacological activity and to investigate its applicability for the prediction...

The Côte d’Ivoire Basin is one of the most important oil production areas in Africa; and it is also the focus of global oil and gas exploration, but the degree of oil exploration and development in this basin are still in the early stages...

Combining two peptides addressing two different receptors to a heterobivalent peptidic ligand (HBPL) is thought to enable an improved tumor-targeting sensitivity and thus tumor visualization, compared to monovalent peptide ligands. In the case of mel...

The development of organelle-specific fluorescent probes has been impeded by the absence of a comprehensive understanding of the relationship between the physicochemical properties of fluorescent probes and their selectivity towards specific organell...