Acute megakaryoblastic leukemia (AMKL) is a rare and heterogeneous subtype of acute myeloid leukemia (AML). We evaluated the immunophenotypic profile of 72 AMKL and 114 non-AMKL AML patients using the EuroFlow AML panel. Univariate and multivariate/m...
Flowcytometric analysis allows for detailed identification and characterization of large numbers of cells in blood, bone marrow, and other body fluids and tissue samples and therefore contributes to the diagnostics of hematological malignancies. Nove...
Background: Multiparameter flow cytometry is widely used in the diagnosis of acute leukemia, allowing for rapid identification of leukemic cells based on their immunophenotype. The EuroFlow Acute Leukemia Orientation Tube was designed as a standardiz...
Reference ranges of blood-circulating leukocyte populations by, e.g., age and sex, are required for monitoring immune-cell kinetics. Most previous reports in which flow cytometry has been used to define the reference ranges for leukocyte counts inclu...
Umbilical cord blood (UCB) is an alternative therapeutic resource for treating both hematological and non-hematological diseases, especially for pediatric patients. However, UCB transplantation faces challenges, including delayed engraftment, increas...
Objective interpretation of FC results may still be hampered by limited technical standardization. The EuroFlow consortium conducted a series of experiments to determine the impact of different variables on the relative distribution and the median fl...
Background: CD20 expression is a controversial issue regarding response prediction to anti-CD20 therapy in chronic lymphocytic leukemia (CLL). Methods: Median fluorescence intensities (MFIs) of standard fluorescence beads from the daily calibration o...
In order to meet the challenges in data evaluation and comparability between studies in multiple myeloma (MM) minimal residual disease (MRD) assessment, the goal of the current study was to provide a step-by-step evaluation of next-generation sequenc...
Early diagnosis of pediatric cancer is key for adequate patient management and improved outcome. Although multiparameter flow cytometry (MFC) has proven of great utility in the diagnosis and classification of hematologic malignancies, its application...
Minimal residual disease (MRD) status is now considered as one of the most relevant prognostic factors in multiple myeloma (MM) while MRD negativity became an important endpoint in clinical trials. Here, we report the results of the first study evalu...
Flow cytometry is a highly sensitive and specific approach for discriminating between normal and clonal plasma cells in multiple myeloma. Uniform response criteria after treatment have been established by the International Myeloma Working Group and t...
Detection of minimal residual disease (MRD) is a major independent prognostic marker in the clinical management of pediatric and adult B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL), and risk stratification nowadays heavily relies on MRD dia...
Background/Objectives: Relapse is the greatest obstacle in treating acute myeloid leukemia (AML), occurring in 40–50% of younger patients and most elderly patients. Current immunophenotyping panels for diagnosis and detection of measurable resi...
Background: Multiparametric Flow Cytometry (MFC) is an essential tool to study the involved cell lineages, the aberrant differentiation/maturation patterns and the expression of aberrant antigens in acute myeloid leukemia (AML). The characterization...
Multiple myeloma (MM) is one of the most common hematological malignancies and remains incurable. However, the survival of multiple myeloma patients has significantly increased due to the implementation of novel therapies along with autologous stem c...
Multiple myeloma (MM) is the second most common hematologic malignancy. It is still largely incurable, but treatment has changed greatly with proteasome inhibitors, immunomodulatory drugs, monoclonal and bispecific antibodies, autologous stem cell tr...
A comparative study was carried out incorporating a novel approach for thermal performance evaluations of commonly used parabolic trough collectors, namely the Euro, Sky, and Helio troughs. In the analysis, pressurized water and therminol-VP1 (eutect...
Italian harbours assume a decisive role in order to develop a Euro-Mediterranean web for maritime transportation. The geostrategic position of the Italian peninsula can be seen as a logistic platform at the centre of the maritime trades in the Medite...
In this work, the performance of on-board vehicle exhaust emission sensors is investigated and compared to reference laboratory and on-road instrumentation for two modern diesel light-duty commercial vehicles, type-approved as Euro 6d-TEMP-EVAP-ISC a...
This article examines why and how scholars could bridge intellectual traditions in research by developing the notion of “a bi/multi-cultural intellectual mind”. It begins with outlining the historical emergence of Western-centric dominanc...
The countries of Central and Eastern Europe, from the non-euro area, have completed the process of economic transition before joining the European Union. Achieving a certain level of economic development and membership in the European Union have gene...
Since the Euro-ІІІ standard was adopted, the main methods to inhibit NOx production in diesel engines are exhaust gas recirculation (EGR) and select catalyst reduction (SCR). On these methods SCR offers great fuel economy, so it has received wide att...
In this study, we use entropy-based measures to identify different types of trading behaviors. We detect the return-driven trading using the conditional block entropy that dynamically reflects the “self-causality” of market return flows....
This research studies the effect of climate change on the hydrological behavior of two semi-arid basins. For this purpose, the Soil and Water Assessment Tool (SWAT) model was used with the simulation of two future climate change scenarios, one Repres...
Evidence combining energy management and life cycle assessment of diesel-to-CNG substitution under real fleet operation remains limited. The energy and environmental assessments were jointly applied over a common functional unit—the transport o...
We address the mechanisms underlying low-frequency zonal flow generation in a turbulent system through the parametric decay of collisionless trapped particle modes and its feedback on the stabilization of the system. This model is in connection with...
Next to building insulation, heat pumps driven by electrical compressors (eHPs) or by gas engines (geHPs) can be used to reduce primary energy demand for heating. They come with different investment requirements, operating costs and emissions caused....
In this study, we evaluate the potential of blue roofs (BRs) to mitigate future increases in rainfall intensity projected by climate models. Using hourly EURO-CORDEX regional climate model data and a scaling-based methodology, we derived rainfall dep...
The floods in 2002 and 2013, as well as the recent flood of 2021, caused billions Euros worth of property damage in Germany. The aim of the project Innovative Vulnerability and Risk Assessment of Urban Areas against Flood Events (INNOVARU) involved t...
Harvesting residual thermal energy from exhaust gases with thermoelectric generators is one of the paths that are currently being explored to achieve more sustainable and environmentally friendly means of transport. In some cases, thermoelectric gene...
Background/Objectives: Tricuspid valve surgery carries a high risk of postoperative acute kidney injury (AKI) due to pre-existing right ventricular dysfunction and congestive end-organ remodeling. We aimed to evaluate the incidence and predictors of...
Allogeneic hematopoietic stem cell transplantation (HSCT) represents the best therapeutic option for many patients with acute myeloid leukemia (AML). However, relapse remains the main cause of mortality after transplantation. The detection of measura...
Accurate measurement of streamflow is fundamental for water resources management, ecological conservation, flash flood early warning, and climate change impact studies. This study presents a proof of concept on the usage of Internet of Things (IoT) f...
Coastal lagoons at the global scale occupy an area equivalent to 13% of continental coastlines and play a crucial role in multiple biogeochemical processes and their productivity. In these ecosystems, management choices are often suboptimal, partly d...
This study investigates the impact of climate change on the Mudurnu Stream Basin in northwest Türkiye by analyzing climate parameters in the Mediterranean region. Historical data from EC-Earth2, HadGEM2-ES, and MPI-ESM-MR GCMs from the CMIP5 Eur...
Climate change is one of the most critical factors impacting hydrological dynamic systems. This study investigated how climate change influences the hydrological dynamics within the Siliana watershed in northwestern Tunisia, employing the Soil and Wa...
This aim of this work is to study the relationship between foreign direct investment (FDI) and trade. FDI is a driving force for economic growth for host countries. The positive effects of FDI are seen in many aspects of the economy. However, the imp...
Real-driving emissions (RDE) testing with portable emissions measurement systems (PEMS) during the type approval and in-service conformity of light-duty vehicles was recently introduced in the European Union legislation. In this paper, three PEMS wer...
Plug-in hybrid electric vehicles (PHEVs) are a promising technology for reducing the tailpipe emissions of CO2 as well as air pollutants, especially in urban environments. However, several studies raise questions over their after-treatment exhaust ef...
Bias-correction methods are commonly applied to climate model data in hydrological climate impact studies. This is due to the often large deviations between simulated and observed climate variables. These biases may cause unrealistic simulation resul...
Climate change affects the hydrological cycle of river basins and strongly impacts water resource availability. The mechanistic hydrological model PROMET was driven with an ensemble of EURO-CORDEX regional climate model projections under the emission...
This paper analyses Foreign Direct Investment (FDI) investment in Ireland and Iceland from other European countries during two periods, i.e., the pre-financial crisis period of 2000–2007 and the financial crisis period of 2008–2010. The a...
In October 2015, two intense rainfall events hit the central and southern regions of Italy and triggered a combination of different and widespread effects, including floods, landslides, and soil erosion. These outcomes devastated about 68 municipalit...
Non-exhaust emissions (NEEs), particularly brake wear particles (BWPs), have become a dominant source of traffic-related particulate matter (PM), accounting for approximately 77% of PM10 and 60% of PM2.5 emissions. Accurate quantification of these em...
On 19 September 2021, a strombolian volcanic eruption began on the island of La Palma in the Canary Islands. This event resulted in the destruction of 73 km of roads, urban infrastructure, numerous houses, and agricultural crops, affecting approximat...
The Versilia plain, a well-known and populated tourist area in northwestern Tuscany, is historically subject to floods. The last hydrogeological disaster of 1996 resulted in 13 deaths and in loss worth hundreds of millions of euros. A valid managemen...
Aim: To evaluate and describe lymphocyte populations’ and B cell subsets’ frequencies in patients presenting with Predominantly antibody deficiencies (PAD) and diagnosed with bronchiectasis or recurrent pneumonia seen in Cali (Colombian S...
This paper presents a lightweight hyper-network architecture for cross-scale multi-task object classification, addressing the critical challenge of gradient interference in joint learning scenarios. We propose a HyperConv module integrated into a sli...
This article is devoted to the problem of developing a kinetic model of a complex chemical reaction using a parallel optimization method. The design of the kinetic model consists of finding the kinetic parameters of the reaction, which cannot be calc...
Laboratory-based certification cycles systematically underestimate real-world fuel consumption and CO2 emissions. On-board diagnostics (OBD-II) telemetry offers a low-cost alternative, yet most published approaches rely on mass air flow (MAF) sensors...
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