Molecular Pathogenesis and Targeted Therapies of Hematological Malignancies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 415
Editor
Special Issue Information
Dear Colleagues,
The landscape of hematological malignancies—including leukemia, lymphoma, and multiple myeloma—is undergoing a profound transformation in both pediatric and adult populations. While traditional treatment regimens continue to be refined, a new era of precision oncology has arrived, wherein progress is driven by a deeper understanding of the genetic, epigenetic, and microenvironmental mechanisms that underlie disease initiation, progression, and therapeutic resistance.
This Special Issue invites the submission of original research articles and comprehensive reviews that explore the molecular basis of hematological malignancies and innovative targeted therapeutic strategies. We welcome studies across a broad spectrum, including but not limited to the research areas listed below:
- Molecular characterization of disease subtypes and biomarkers;
- Mechanisms of drug resistance and strategies to overcome them;
- Preclinical and clinical development of novel targeted agents;
- Cellular immunotherapies such as CAR-T, CAR-NK, and TCR-engineered T cells;
- Integrative multi-omics, functional genomics, and epigenetic approaches;
- Applications of artificial intelligence and machine learning in risk stratification, drug response prediction, and minimal residual disease (MRD) monitoring;
- Translational studies bridging basic discovery with clinical practice.
By collating diverse molecular and therapeutic perspectives, this collection aims to highlight how personalized medicine is reshaping outcomes for patients with hematological malignancies. We encourage submissions that advance fundamental knowledge, validate clinical predictors, or introduce novel therapeutic concepts—whether they focus on a single molecule, a signaling pathway, or a computational model. All studies that rigorously address molecular pathogenesis or targeted treatment will be considered for inclusion.
Dr. Can Küçük, Assoc. Prof.
Guest Editor
Manuscript Submission Information
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Keywords
- hematological malignancies
- precision oncology
- molecular mechanisms
- therapeutic resistance
- targeted therapy
- cellular immunotherapies
- multi-omics
- artificial intelligence
- translational medicine
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