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Clinical Progress in Cardiovascular Surgery
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Clinical Progress in Cardiovascular Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 15 November 2026 | Viewed by 1012

Editor

Dr. Georgios P. Georghiou

E-Mail Website
Guest Editor
School of Medicine, European University Cyprus, P.O. Box 22006, 1516 Nicosia, Cyprus
Interests: cardiac surgery; vascular surgery; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease remains the leading cause of mortality and a major global public health burden worldwide, necessitating sustained and targeted innovation across cardiothoracic surgical practice, clinical research, and integrated multidisciplinary cardiovascular care. In recent years, minimally invasive surgical techniques, hybrid coronary and valvular interventions, state-of-the-art aortic surgery, evolving mechanical circulatory support systems, and the emerging field of cardio-oncology have collectively reshaped clinical decision-making pathways, refining treatment algorithms and significantly enhancing patient survival and long-term functional outcomes.

This Special Issue is dedicated to showcasing cutting-edge, state-of-the-art clinical progress in cardiovascular surgery, with a strong interdisciplinary focus on bridging cardiovascular surgery, clinical cardiology, perioperative medicine, and patient outcomes research. Specific attention will be given to surgical strategies, the prevention and management of arrhythmias and postoperative atrial fibrillation, the role of echocardiology in perioperative surgical patient care, and policy-driven cardiovascular care pathways that align with the core strategic priorities of the European Society of Cardiology (ESC).

We invite high-quality original research, review articles, and clinical studies that address prevailing clinical challenges, optimize patient selection, improve perioperative management, and advance long-term cardiovascular outcomes.

Dr. Georgios P. Georghiou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular surgery
  • CABG
  • valvular surgery
  • aortic surgery
  • postoperative atrial fibrillation
  • cardio-oncology
  • minimally invasive cardiac surgery
  • mechanical circulatory support
  • outcomes research
  • ESC-aligned cardiovascular care

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Published Papers (2 papers)

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Research

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14 pages, 7708 KB  
Article
Incidence and Predictors of Acute Kidney Injury Following Tricuspid Valve Surgery: The Prognostic Value of Right Ventricular Length–Force Relationship
by Sercan Tak, Özant Helvacı, Erkan İriz, Hikmet Selçuk Gedik, Mustafa Hakan Zor, Abdullah Özer, Başak Koçak, Yonca Durkan, Taha Enes Çetin and Gürsel Levent Oktar
J. Clin. Med. 2026, 15(13), 5155; https://doi.org/10.3390/jcm15135155 - 2 Jul 2026
Viewed by 287
Abstract
Background/Objectives: Tricuspid valve surgery carries a high risk of postoperative acute kidney injury (AKI) due to pre-existing right ventricular dysfunction and congestive end-organ remodeling. We aimed to evaluate the incidence and predictors of postoperative AKI, with particular focus on the prognostic value [...] Read more.
Background/Objectives: Tricuspid valve surgery carries a high risk of postoperative acute kidney injury (AKI) due to pre-existing right ventricular dysfunction and congestive end-organ remodeling. We aimed to evaluate the incidence and predictors of postoperative AKI, with particular focus on the prognostic value of the TAPSE/sPAP index. Methods: This retrospective, single-center study evaluated adult patients who underwent tricuspid valve surgery (isolated/concomitant) between 2010 and 2025. The primary outcome was postoperative AKI of any stage, defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Predictors were identified using a pre-specified multivariable logistic regression model including baseline estimated glomerular filtration rate (eGFR), cardiopulmonary bypass time, and EuroSCORE II; TAPSE/sPAP associations with severe renal outcomes were assessed univariably and presented as exploratory. Results: Of 80 patients, postoperative AKI occurred in 32 (40.0%), with 16 (20.0%) requiring renal replacement therapy. The pre-specified multivariable model discriminated any-stage AKI (AUC 0.86, 95% CI 0.77–0.94). Lower baseline eGFR (adjusted OR 1.82 per 10 mL/min/1.73 m2 decrease, p < 0.001) and higher EuroSCORE II (adjusted OR 1.53 per point, p = 0.03) were independent predictors. The TAPSE/sPAP index was not associated with any-stage AKI (p = 0.42), but lower values predicted advanced renal outcomes, including KDIGO stage ≥ 2 AKI (OR 2.11, p = 0.03) and the requirement for renal replacement therapy (OR 2.71, p = 0.01). Outcomes did not differ between isolated (n =14) and combined procedures (n = 66; AKI 35.7% vs. 40.9%, p = 0.77). Conclusions: Lower preoperative eGFR and higher EuroSCORE II independently predict any-stage postoperative AKI. In univariable analysis, the TAPSE/sPAP index identified the subgroup with severe renal outcomes; this exploratory finding requires prospective validation. Whether perioperative renal protection depends on addressing right-sided filling pressures rather than augmenting forward flow alone requires prospective testing. Full article
(This article belongs to the Special Issue Clinical Progress in Cardiovascular Surgery)
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Review

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16 pages, 1302 KB  
Review
Cancer as a Hidden Catalyst: Rethinking Postoperative Atrial Fibrillation After Cardiac Surgery
by Sotiris Kyriakou, Marios Markantonis, Panos Georghiou, Filippos Triposkiadis, Amalia Georgiou, Konstantinos Lampropoulos, Argyris Kyriakou, Nikolas Iosif and Georgios P. Georghiou
J. Clin. Med. 2026, 15(12), 4456; https://doi.org/10.3390/jcm15124456 - 9 Jun 2026
Viewed by 441
Abstract
Postoperative atrial fibrillation (POAF) is the most frequent post-cardiac surgical arrhythmia and is associated with haemodynamic instability, longer hospital stays, higher healthcare utilisation, stroke and adverse long-term outcomes. Conventional models of POAF focus on advancing age, pre-existing atrial substrate, increasing operative complexity, inflammatory [...] Read more.
Postoperative atrial fibrillation (POAF) is the most frequent post-cardiac surgical arrhythmia and is associated with haemodynamic instability, longer hospital stays, higher healthcare utilisation, stroke and adverse long-term outcomes. Conventional models of POAF focus on advancing age, pre-existing atrial substrate, increasing operative complexity, inflammatory responses related to cardiopulmonary bypass, disturbances in autonomic balance, and acute metabolic insults during the perioperative period. Although these explanations are important, they may be incomplete. Malignancy and the cancer-associated systemic environment involve biological processes potentially relevant to postoperative atrial vulnerability, such as chronic inflammation, oxidative stress, impaired vascular function, hypercoagulability, altered immune response, frailty, and treatment-related myocardial, pericardial, or conduction-system injury. This review assesses whether malignancy should be regarded as an underrecognised modifier of susceptibility rather than as a coincidental comorbidity. Most available data are extrapolated from cardio-oncology and thoracic oncology studies or general studies related to atrial fibrillation (AF) rather than studies focused on cardiac surgery. While malignancy cannot be dismissed as irrelevant to the generation of POAF, it also does not permit causal inference. Future studies should move beyond binary cancer status and incorporate cancer activity, treatment exposures, biomarker profiles, and atrial substrate measures to determine whether malignancy improves perioperative POAF risk stratification. Full article
(This article belongs to the Special Issue Clinical Progress in Cardiovascular Surgery)
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