Ras is the most frequently mutated oncogene and recent drug development efforts have spurred significant new research interest. Here we review progress toward understanding how Ras functions in nanoscale, proteo-lipid signaling complexes on the plasm...
RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pa...
Signals conveyed through the RAS-ERK pathway constitute a pivotal regulatory element in cancer-related cellular processes. Recently, RAS dimerization has been proposed as a key step in the relay of RAS signals, critically contributing to RAF activati...
The development of K-Ras independence may explain the failure of targeted therapy for pancreatic cancer (PC). In this paper, active N as well as K-Ras was shown in all human cell lines tested. In a cell line dependent on mutant K-Ras, it was shown th...
Aberrant activity of oncogenic rat sarcoma virus (RAS) protein promotes tumor growth and progression. RAS-driven cancers comprise more than 30% of all human cancers and are refractory to frontline treatment strategies. Since direct targeting of RAS h...
In this paper, we propose a new protocol called LoRaCog to introduce the concept of Cognitive Radio (CR) in the LoRa network. LoRaCog will enable access to a wider spectrum than that of LoRaWAN by using the unutilized spectrum and thus has better eff...
Among the low power wide area network communication protocols for large scale Internet of Things, LoRaWAN is considered one of the most promising, owing to its flexibility and energy-saving capabilities. For these reasons, during recent years, the sc...
The management of metastatic colorectal cancer in patients harboring RAS mutations primarily involves chemotherapy, often combined with bevacizumab, as a standard first-line treatment. However, emerging evidence suggests that tumors in a subset of th...
The RAS family of oncogenes (HRAS, NRAS, and KRAS) are among the most frequently mutated protein families in cancers. RAS-mutated tumors were originally thought to proliferate independently of upstream signaling inputs, but we now know that non-mutat...
The interference of human activities in water bodies has contributed to a deterioration in water quality. With the advancement of the Internet of Things (IoT), aided by transmission technologies such as LoRa (Long Range), low-cost solutions have emer...
Proto-oncogenes in the RAS superfamily play dual roles in maintaining cellular homeostasis, such as regulating growth signals and contributing to cancer development through proliferation and deregulation. Activating proto-oncogenes in vitro transform...
Coverage limitation due to signal attenuation is one of the main challenges facing single-hop LoRaWAN when deployed in IoT applications that require low power consumption and operate over a wide area network. The challenge can be figured out using th...
The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases) are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic activities of RAS have been shown to be difficult. Alternatively, RAS funct...
Systemic lupus erythematosus (SLE) is characterized by an imbalance between proinflammatory and anti-inflammatory mediators. Single-nucleotide polymorphisms (SNPs) in genes coding IL10RA, IL10RB, and IL22RA could affect their expression or function a...
The central protein in the oncogenic circuitry is the Ras GTPase that has been under intense scrutiny for the last four decades. From its discovery as a viral oncogene and its non-oncogenic contribution to crucial cellular functioning, an elaborate g...
Large language models (LLMs), consisting of billions and trillions of parameters, have demonstrated exceptional ability in natural language understanding (NLU) and natural language generation (NLG) tasks. Increases in their numbers of parameters and...
Radium isotopes have traditionally been used as tracers of surface and underground fresh waters in land–ocean interactions. The concentration of these isotopes is most effective on sorbents containing mixed oxides of manganese. During the 116 R...
Background: Preoperative recurrence risk stratification for colorectal liver metastases (CRLM) undergoing hepatectomy is essential when designing a treatment strategy. We developed a Beppu classification system consisting of three risk groups and fou...
Recent advancements in low-rank adaptation (LoRA) have shown its effectiveness in fine-tuning diffusion models for generating images tailored to new downstream tasks. Research on integrating multiple LoRA modules to accommodate new tasks has also gai...
LoRaWAN is a flagship Low-Power Wide Area Network (LPWAN) technology that has highly attracted much attention from the community in recent years. Many LoRaWAN end-devices, such as sensors or actuators, are expected not to be powered by the electricit...
For decades RAS mutations represented a chimera for drug developers, as all efforts put into attempting to pharmacologically inhibit them failed. Finally, in recent years, the advent of the KRAS G12C inhibitors sotorasib and adagrasib pushed the deve...
Since the optic nerve is one of the most myelinated tracts in the central nervous system (CNS), many myelin diseases affect the visual system. In this sense, our laboratory has recently reported that the GTPases R-Ras1 and R-Ras2 are essential for ol...
Energy efficiency is the key requirement to maximize sensor node lifetime. Sensor nodes are typically powered by a battery source that has finite lifetime. Most Internet of Thing (IoT) applications require sensor nodes to operate reliably for an exte...
Approximately 30% of all human cancers are driven by mutations in RAS genes, KRAS, HRAS, and NRAS, resulting in the constitutive activation of RAS proteins and stimulation of MAPK/AKT signaling. Non-mutant, i.e., wild-type (WT) RAS can also become ac...
RAS genes encode signaling proteins, which, in mammalian cells, act as molecular switches regulating critical cellular processes as proliferation, growth, differentiation, survival, motility, and metabolism in response to specific stimuli. Deregulati...
RAS mutations involving codon 61 are rare in metastatic colorectal cancer (mCRC), accounting for only 1–4%, but they have recently been identified with high frequency in the circulating tumor DNA (ctDNA) of patients with secondary resistance to...
In the last two decades, abnormal Ras (rat sarcoma protein)–ERK (extracellular signal-regulated kinase) signalling in the brain has been involved in a variety of neuropsychiatric disorders, including drug addiction, certain forms of intellectual disa...
Background and objectives: Cancer represents the miscommunication between and within the body cells. The mutations of the oncogenes encoding the MAPK pathways play an important role in the development of tumoral diseases. The mutations of KRAS and BR...
Industrial Internet of Things (IIoT) systems are increasingly deployed in heavy industrial facilities to support real-time monitoring, automation, and safety-critical operations. Long-range low-power communication technologies such as LoRaWAN are wid...
Research into, and the usage of, Low-Power Wide-Area Networks (LPWANs) has increased significantly to support the ever-expanding requirements set by IoT applications. Specifically, the usage of Long-Range Wide-Area Networks (LoRaWANs) has increased,...
Recently, Semtech has released a Long Range (LoRa) chipset which operates at the globally available
Porcine cumulus–oocyte complexes (COCs) undergo dynamic morphological and molecular changes during maturation; however, cell type- and stage-dependent transcript patterns of Ras-related factors in cumulus cells and oocytes remain unclear. This...
Four Ras guanine nucleotide-releasing proteins (RasGRP1 through 4) belong to the family of guanine nucleotide exchange factors (GEFs). RasGRPs catalyze the release of GDP from small GTPases Ras and Rap and facilitate their transition from an inactive...
The digital revolution has changed the way we implement and use connected devices and systems by offering Internet communication capabilities to simple objects around us. The growth of information technologies, together with the concept of the Intern...
Background/Objectives: Fully robotic pancreatic resections using the Hugo™ RAS platform have not yet been described in the literature. Methods: A 72-year-old male with a cystic lesion in the pancreatic tail underwent a fully robotic distal panc...
Internet of Things (IoT) applications are rapidly adopting low-power wide-area network (LPWAN) technology due to its ability to provide broad coverage for a range of battery-powered devices. LoRaWAN has become the most widely used LPWAN solution due...
In our modern world, many Internet of Things (IoT) technologies are being researched and developed. IoT devices are currently being used in many fields. IoT devices use Wi-Fi and Bluetooth, however, communication distance is short and battery consump...
Ras and Raf-kinase interact through the Ras-binding (RBD) and cysteine-rich domains (CRD) of Raf to signal through the mitogen-activated protein kinase pathway, yet the molecular mechanism leading to Raf activation has remained elusive. We present th...
Low-power wide-area network (LPWAN) technologies play a pivotal role in IoT applications, owing to their capability to meet the key IoT requirements (e.g., long range, low cost, small data volumes, massive device number, and low energy consumption)....
The large development of Internet of Things technologies is increasing the use of smart-devices to solve and support several real-life issues. In many cases, the aim is to move toward systems that, even if significant demands are not required in term...
In maritime settings, effective communication between vessels and land infrastructure is crucial, but existing technologies often prove impractical for energy-sensitive IoT applications, like deploying sensors at sea. In this study, we explore the vi...
Recent data suggest that K-Ras4B (hereafter K-Ras) can drive cancer cell stemness via calmodulin (CaM)-dependent, non-canonical Wnt-signalling. Here we examined whether another Ca2+-binding protein, the CaM-related centrin1, binds to K-Ras and could...
Parameter-efficient fine-tuning (PEFT) methods like Low-Rank Adaptation (LoRA) are widely used to adapt large pre-trained models under limited resources, yet they often underperform full fine-tuning in low-resource automatic speech recognition (ASR)....
Carbon Capture and Storage (CCS) technology presents a practical solution for reducing industrial carbon dioxide (CO2) emissions through underground anthropogenic CO2 storage in depleted hydrocarbon reservoirs. The long-term storage efficiency faces...
The fundamental properties of long-range (LoRa) performance have been revealed by previous research, but advanced issues remain unresolved. This paper tackles three technical challenges that are confronted when establishing a LoRa network on a smart...
In this paper, we propose a novel MAC protocol, called DG-LoRa, for improving scalability in low power wide area networks. DG-LoRa is backward compatible with legacy LoRaWAN and adds new features, such as group acknowledgment transmissions in the tim...
Long-Range Frequency Hopping Spread Spectrum (LR-FHSS) is the newest modulation in LoRaWAN, designed to overcome the scalability and coverage limits of conventional LoRa. This study provides a real-world evaluation of LR-FHSS performance, benchmarkin...
When LoRaWAN networks are deployed in complex environments with buildings, jungles, and other obstacles, the communication range of LoRa signals experiences a notable reduction, primarily due to multipath propagation, fading, and interference. With t...
Automated visual inspection of photovoltaic (PV) cells is an important component of solar-module quality assurance. However, adapting modern pre-trained vision backbones to PV defect classification remains challenging because full fine-tuning require...
LoRaWAN is one of the low power wide area network (LPWAN) technologies that have received significant attention by the research community in the recent years. It offers low-power, low-data rate communication over a wide range of covered area. In the...
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