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Most Cited

  • Review
  • Open Access
296 Citations
17,875 Views
37 Pages

Plant Secondary Metabolites: The Weapons for Biotic Stress Management

  • Jameel M. Al-Khayri,
  • Ramakrishnan Rashmi,
  • Varsha Toppo,
  • Pranjali Bajrang Chole,
  • Akshatha Banadka,
  • Wudali Narasimha Sudheer,
  • Praveen Nagella,
  • Wael Fathi Shehata,
  • Muneera Qassim Al-Mssallem and
  • Fatima Mohammed Alessa
  • + 2 authors

The rise in global temperature also favors the multiplication of pests and pathogens, which calls into question global food security. Plants have developed special coping mechanisms since they are sessile and lack an immune system. These mechanisms u...

  • Review
  • Open Access
163 Citations
10,303 Views
24 Pages

Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

  • Yongxia Zhao,
  • Xiaochun Ye,
  • Zhifeng Xiong,
  • Awais Ihsan,
  • Irma Ares,
  • Marta Martínez,
  • Bernardo Lopez-Torres,
  • María-Rosa Martínez-Larrañaga,
  • Arturo Anadón and
  • Xu Wang
  • + 1 author

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations...

  • Review
  • Open Access
128 Citations
13,434 Views
23 Pages

Secondary metabolites are gaining an increasing importance in various industries, such as pharmaceuticals, dyes, and food, as is the need for reliable and efficient methods of procuring these compounds. To develop sustainable and cost-effective appro...

  • Review
  • Open Access
112 Citations
13,661 Views
47 Pages

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

  • Lucas Fornari Laurindo,
  • Ana Rita de Oliveira dos Santos,
  • Antonelly Cassio Alves de Carvalho,
  • Marcelo Dib Bechara,
  • Elen Landgraf Guiguer,
  • Ricardo de Alvares Goulart,
  • Renata Vargas Sinatora,
  • Adriano Cressoni Araújo and
  • Sandra Maria Barbalho

7 January 2023

Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative colitis (UC) and Crohn’s disease (CD). IBD can be associated w...

  • Review
  • Open Access
101 Citations
25,331 Views
16 Pages

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

  • Lúcio Ricardo Leite Diniz,
  • Leonardo Luiz Calado,
  • Allana Brunna Sucupira Duarte and
  • Damião Pergentino de Sousa

14 February 2023

An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a...

  • Review
  • Open Access
98 Citations
19,690 Views
18 Pages

20 November 2023

Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, and cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing and the ho...

  • Feature Paper
  • Review
  • Open Access
81 Citations
7,485 Views
40 Pages

Role of Oxidative Stress in Ocular Diseases: A Balancing Act

  • Daisy Y. Shu,
  • Suman Chaudhary,
  • Kin-Sang Cho,
  • Anton Lennikov,
  • William P. Miller,
  • David C. Thorn,
  • Menglu Yang and
  • Tina B. McKay

27 January 2023

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any disruption of this balance leads to oxidative stress, which is a key pathogenic...

  • Review
  • Open Access
79 Citations
14,543 Views
61 Pages

Due to the continued emergence of resistance and a lack of new and promising antibiotics, bacterial infection has become a major public threat. High-throughput screening (HTS) allows rapid screening of a large collection of molecules for bioactivity...

  • Review
  • Open Access
77 Citations
9,366 Views
26 Pages

Flavonoid Production: Current Trends in Plant Metabolic Engineering and De Novo Microbial Production

  • Hasnat Tariq,
  • Saaim Asif,
  • Anisa Andleeb,
  • Christophe Hano and
  • Bilal Haider Abbasi

13 January 2023

Flavonoids are secondary metabolites that represent a heterogeneous family of plant polyphenolic compounds. Recent research has determined that the health benefits of fruits and vegetables, as well as the therapeutic potential of medicinal plants, ar...

  • Feature Paper
  • Review
  • Open Access
69 Citations
11,812 Views
36 Pages

Biosynthetic Pathways of Hormones in Plants

  • Andrzej Bajguz and
  • Alicja Piotrowska-Niczyporuk

Phytohormones exhibit a wide range of chemical structures, though they primarily originate from three key metabolic precursors: amino acids, isoprenoids, and lipids. Specific amino acids, such as tryptophan, methionine, phenylalanine, and arginine, c...

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Metabolites - ISSN 2218-1989