Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subject Description
2.2. Baseline Diet and Lifestyle
2.3. Interventions
2.4. Blood Work
2.5. Ethics and Safety
3. Results
4. Discussion
4.1. The Lipid Energy Model Predicts Oreo Cookie Treatment Will Lower LDL Cholesterol
4.2. Evidence Is Lacking to Suggest Saturated Fat Is a Driver of the LMHR Phenotype
4.3. Increased Physical Activity in Week 6 of Statin Arm Increases LDL-C
4.4. Next Step: A Crossover Trial for LDL Cholesterol Lowering Approaches among LMHR
4.5. Additional Learnings and Limitations
4.5.1. Impact of Oreos on Ketosis
4.5.2. Next Step Study Considerations
4.6. Ethical Considerations of Self-Experimentation and the Citizen Scientist Movement
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Baseline | Oreo (12 Cookies) | Statin | |
---|---|---|---|
Calories | 2616 | 3350 | 2616 |
Total Fat (g) | 235 | 263 | 235 |
SAT (g) | 55 | 63 | 55 |
MUFA (g) | 154 | 170 | 154 |
PUFA (g) | 25 | 29 | 25 |
Protein (g) | 118 | 122 | 118 |
Carb, total (g) | 20 | 120 | 20 |
Fiber (g) | 9 | 11 | 9 |
Baseline | Oreo (12 Cookies) | Washout | Rosuvastatin, 20 mg | ||||||||
Day 0 | Day 7 | Day 16 | Week 0 | Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | ||
TC | 494 | 421 | 232 | 539 | 478 | 458 | 406 | 393 | 407 | 468 | |
LDL-C | 384 | 308 | 111 | 421 | 354 | 340 | 294 | 284 * | 295 | 346 | |
HDL-C | 99 | 102 | 113 | 107 | 116 | 107 | 102 | 102 | 102 | 112 | |
TG | 57 | 56 | 39 | 54 | 38 | 54 | 50 | 34 | 49 | 48 | |
LDL-C reduction, relative (absolute): −71% (−273 mg/dL) | LDL-C reduction *, relative (absolute): −32.5% (−137 mg/dL) |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Norwitz, N.G.; Cromwell, W.C. Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment. Metabolites 2024, 14, 73. https://doi.org/10.3390/metabo14010073
Norwitz NG, Cromwell WC. Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment. Metabolites. 2024; 14(1):73. https://doi.org/10.3390/metabo14010073
Chicago/Turabian StyleNorwitz, Nicholas G., and William C. Cromwell. 2024. "Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment" Metabolites 14, no. 1: 73. https://doi.org/10.3390/metabo14010073