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Antioxidants, Volume 15, Issue 1

2026 January - 149 articles

Cover Story: N-Benzylthiocarbamate (NBTC) analogs, synthesized as potential Cu2+-chelating tyrosinase (TYR) inhibitors, demonstrated strong Cu2+-chelating activity. In B16F10 cells, all analogs outperformed kojic acid (KA) in inhibiting melanin production; however, none inhibited mushroom TYR (mTYR) activity more effectively than KA. Their melanin-inhibitory effects were attributed to inhibition of cellular TYR (cTYR). The differing TYR inhibitory activities of the analogs toward mTYR and B16F10 TYR are likely due to structural differences between because mTYR and mammalian TYR. Analogs 1 was highly effective in reducing browning in potato juice, while Analog 3 showed strong depigmenting activity in zebrafish larvae. Overall, the differential TYR inhibitory activity of NBTC analogs appears to result from their high sensitivity to interactions with TYRs of different origins. View this paper
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Articles (149)

  • Article
  • Open Access
313 Views
25 Pages

Targeting Skin Aging Hallmarks In Vitro: Antioxidant, Anti-Inflammatory, and Anti-Senescence Effects of Phenolic-Rich Extracts from Cistus L. Species

  • Mário Pedro Marques,
  • Euclides Landim,
  • Carla Varela,
  • Ricardo M. F. da Costa,
  • Joana Marques,
  • Luís A. E. Batista de Carvalho,
  • Ana Silva,
  • Maria Teresa Cruz,
  • Rebeca André and
  • Célia Cabral
  • + 4 authors

22 January 2026

Plant-based extracts are rich sources of phenolic compounds, which may act as skin antiaging mediators. Herein, Cistus albidus L. (Ca), Cistus ladanifer L. subsp. ladanifer (Cl) and Cistus salviifolius L. (Cs) were selected to test whether their phyt...

  • Article
  • Open Access
213 Views
17 Pages

22 January 2026

Short-term hypothermic storage at 4 °C represents a promising non-freezing alternative for transporting bovine embryos and synchronizing assisted reproductive procedures. However, chilling induces oxidative stress, mitochondrial dysfunction, and...

  • Article
  • Open Access
168 Views
28 Pages

Integrative Transcriptomic and Network Analysis of Hemocyte Volume Plasticity and Redox Regulation Under Osmotic Stress in Penaeus monodon

  • Sheng Huang,
  • Falin Zhou,
  • Qibin Yang,
  • Song Jiang,
  • Jilin Chen,
  • Jie Xiong,
  • Erchao Li and
  • Yundong Li

22 January 2026

Osmotic stress affects ion transport and cell hydration, potentially disrupting redox homeostasis through altered proteostasis and mitochondrial metabolism. However, how immune hemocytes coordinate volume regulation with these stress-linked processes...

  • Article
  • Open Access
176 Views
22 Pages

Olive Leaf Extract Added to Losartan Treatment Improved Klotho/Wnt/β-Catenin Signaling in Hypertensive Rats with Focal Segmental Glomerulosclerosis

  • Danijela Karanović,
  • Nevena Mihailović-Stanojević,
  • Milan Ivanov,
  • Una-Jovana Vujačić,
  • Jelica Grujić-Milanović,
  • Maja Životić,
  • Dragana Dekanski,
  • Djurdjica Jovović and
  • Zoran Miloradović

22 January 2026

The downregulation of Klotho in renal injury predicts the progression of chronic kidney disease (CKD). Klotho acts as an antagonist of the Wnt/β-catenin pathway, which is involved in the pathogenesis of proteinuria, glomerulosclerosis and tubulo...

  • Article
  • Open Access
154 Views
22 Pages

Metal-Chelating Macroalgal Extract as a Marine Antioxidant for Stabilizing DHA Nanoemulsions

  • Sakhi Ghelichi,
  • Behdad Shokrollahi Yancheshmeh,
  • Mona Hajfathalian,
  • Seyed Hossein Helalat,
  • Arpan Shrestha,
  • Saroj Katwal and
  • Charlotte Jacobsen

22 January 2026

Docosahexaenoic acid (DHA), an omega-3 fatty acid essential for human health, is highly prone to oxidation in nanoemulsions due to their large interfacial area and presence of transition metal ions. This study investigated macroalgal chelators for st...

  • Review
  • Open Access
251 Views
21 Pages

OPA1 as a Cancer Target: Molecular Mechanisms, Structural Insights, and Strategies for Drug Development

  • Antonio Curcio,
  • Ludovica Ganino,
  • Ilenia Valentino,
  • Massimo Gentile,
  • Stefano Alcaro,
  • Roberta Rocca,
  • Anna Artese and
  • Nicola Amodio

22 January 2026

Mitochondria are highly dynamic organelles that integrate metabolic regulation, signal transduction, and programmed cell death with their canonical role in adenosine triphosphate (ATP) production. Their ability to undergo continuous remodeling throug...

  • Article
  • Open Access
174 Views
19 Pages

Phytochemical Composition, Antioxidant and Anti-Inflammatory Activities, and Protective Effect Against LPS-Induced Liver Injury in Mice of Gerbera delavayi Franch

  • Hongmei Yin,
  • Yinrong Zhao,
  • Rouxian Hu,
  • Jing Yang,
  • Yuanhang Chen,
  • Huaqiao Tang,
  • Xiaoyan Li,
  • Gang Ye,
  • Fei Shi and
  • Ling Zhao
  • + 1 author

22 January 2026

The main objective of this study was to preliminarily analyze the major flavonoid and phenolic acid components of the ethanolic extract of Gerbera delavayi Franch (E-GDF), and to evaluate its anti-inflammatory and antioxidant properties in lipopolysa...

  • Review
  • Open Access
249 Views
20 Pages

The Mechanism of Oxidative Stress in Pulmonary Fibrosis and Research Progress

  • Duo Xu,
  • Qian Wang,
  • Meng Lyu,
  • Chunyu Huang,
  • Xianglin Yuan,
  • Xinyi Chen and
  • Yongbiao Huang

22 January 2026

Pulmonary fibrosis (PF) is a group of chronic progressive lung diseases characterized by irreversible remodeling of lung tissue structure, abnormal proliferation of fibroblasts, and excessive deposition of extracellular matrix (ECM), among which idio...

  • Article
  • Open Access
181 Views
20 Pages

22 January 2026

Tea production in Europe represents an emerging segment of the specialty tea market, but a structured comparative analysis remains unexplored. This study employs a standardized approach to systematically characterize hot brews from black and green te...

  • Article
  • Open Access
232 Views
18 Pages

Baicalin Alleviates Chronic Restraint Stress-Induced Depression-like Behavior by Suppressing ROS/H2O2 Generation via a BDNF-Associated Mechanism in Mice

  • Yu-Ning Teng,
  • Tien-Wei Hsu,
  • Wei-Hao Peng,
  • Cheng-Chun Wu,
  • Tian-Huei Chu,
  • Yung-Kuo Lee,
  • Ming Tatt Lee and
  • Yu-Cheng Ho

21 January 2026

Major depressive disorder (MDD) is a leading cause of global morbidity and mortality. Although pharmacological treatments are widely used, their effects are often limited, and nearly half of patients show resistance to current antidepressants, includ...

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Antioxidants - ISSN 2076-3921