2026 July - 129 articles
Glutamate excitotoxicity is a key contributor to the pathogenesis of glaucoma, a leading cause of irreversible blindness worldwide; however, the molecular events driving progressive retinal ganglion cell (RGC) loss and axonal degeneration remain inco...
Background: Vaccinium berries are rich in polyphenolic compounds with recognized health properties; however, studies integrating phytochemical characterization with functional cellular assays remain limited. This study comparatively evaluated wild (V...
China’s edible oil self-sufficiency rate is only about 30%, and approximately 100 million acres of saline-alkali land are potentially available for rapeseed cultivation. However, salt stress severely inhibits rapeseed growth and yield, making t...
Major depressive disorder (MDD) has been linked to oxidative stress, mitochondrial dysfunction, and impaired neuronal plasticity, but the reproducibility of related transcriptomic alterations across postmortem brain cohorts remains uncertain. We perf...
This study investigated the potential effects of Bellamya purificata polysaccharide (BPP) supplementation in feed on Cherax quadricarinatus, aiming to elucidate its impact on immune function and the underlying regulatory mechanisms. A 60-day feeding...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder of motor function, while at advanced stages it includes memory deficits and neuropsychiatric conditions. It is characterized primarily by the loss of dopaminergic neurons in t...
Classically, Hedgehog (Hh)/GLI signaling is recognized as a developmental pathway. Increasing evidence indicates that it also contributes to cellular metabolism and adaptation to stress. In this review, we examine the involvement of Hh/GLI signaling...
Macropinocytosis is an actin-driven endocytic process mediating nonspecific uptake of extracellular fluid through membrane ruffling. Neutrophil macropinocytosis has been reported only in limited descriptive studies, and its signaling mechanisms have...
NSAID-induced small intestinal injury is a clinically significant complication among chronic NSAID and aspirin users, yet effective treatment options remain limited. This systematic review evaluated natural products, functional foods, and probiotics...
Rice husk, a by-product of rice processing, is a natural source of phenolic compounds and cellulose. Although pressurized liquid extraction (PLE) is an efficient technique for recovering antioxidant compounds, its application to rice husk using water...
Curcumin is a major bioactive component present in turmeric, attributed with a bright yellow color; however, with low solubility and susceptibility to photooxidation, many of the purported health benefits are actually limited. We developed an encapsu...
Oxybaphus himalaicus Edgew. is a traditional Tibetan medicinal plant used to treat nephritis and edema; however, its active constituents and the molecular mechanisms underlying its renoprotective properties remain poorly elucidated. This study invest...
A novel class of resveratrol derivatives as dual PDE4 (Phosphodiesterase 4) inhibitors and free radical scavengers for the treatment of COPD (chronic obstructive pulmonary disease) was developed in this study. In vitro, the most promising compound WY...
Pectolinarigenin (PEC), a naturally occurring flavonoid, exhibits anti-inflammatory and antioxidant activities in various experimental models. However, its protective effects against lipopolysaccharide (LPS)-induced lung inflammation and the underlyi...
Polycystic ovary syndrome (PCOS), newly named as Polyendocrine Metabolic Ovarian Syndrome (PMOS) is the most common endocrinopathy affecting women of reproductive age, which often leads to infertility due to anovulation and poor oocyte quality. Poor...
Redox homeostasis is essential for intestinal and systemic health and is regulated by antioxidant defense systems and redox-sensitive signaling pathways such as the nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor ‘kapp...
Oxidative stress has emerged as an important component of the complex pathophysiology of inflammatory bowel disease (IBD), where increasing evidence suggests an interaction between redox imbalance, immune activation, epithelial dysfunction, and chron...
Lifespan is increasing throughout the world leading to a rise in non-communicable diseases in the global population that impacts over 800 million individuals with metabolic disorders, such as diabetes mellitus. Metabolic disease presents a significan...
Curcumin, a natural polyphenol with well-established antioxidant and anti-inflammatory properties, was evaluated for its protective effects against glyphosate (GLY)-induced mammary toxicity. Pregnant mice received GLY (50 or 250 mg/kg/day) with or wi...
To explore the physiological and metabolic response mechanism of Paecilomyces hepiali (P. hepiali) under varying temperatures, five temperature gradients were established in this study. Combined with in vitro antioxidant assays and untargeted and tar...
Reactive oxygen species (ROS)-regulated antioxidant defense is closely linked to non-small cell lung cancer (NSCLC) progression and therapy resistance. Wogonin (WGN), a flavonoid from Scutellaria baicalensis, has antitumor activity, but whether it is...
The present review examines markers of intrinsic antioxidant capacity in fish muscle, how these markers change after death, and the point to which their post mortem evolution is related to flesh quality and shelf life in farmed fish. Aquaculture para...
Background: Hypertension-associated kidney injury is driven by oxidative stress, inflammation, fibrosis, and gut-derived uremic toxins via the gut–kidney axis. Spent coffee grounds (SCG) represent a sustainable source of bioactive polyphenols w...
Background: Danshen–Gegen is a classic herb pair in traditional Chinese medicine, which has been used to treat cardiovascular and cerebrovascular diseases. Ischemic stroke (IS) is a prevalent cerebrovascular condition; ferroptosis is one of the...
The aim of the study was to assess the regional differences in Procambarus clarkii via analyzing amino acid and fatty acid profiles, minerals, antioxidant capacity, and metabolic profiles from ten major producing areas in China. The results showed th...
A key distinction between open and laparoscopic surgery is the use of CO2 insufflation to create pneumoperitoneum and establish the operative field. This study compared the effects of laparoscopic and open ovariectomy (OVE) on plasma cortisol, oxidat...
The topical application of ferulic acid (FA) is limited by its low solubility and high susceptibility to oxidation. To overcome these limitations, the multicomponent system Cicloferulic® (CF) was developed by mixing FA, hydroxypropyl β-cyclo...
Background: Age-related macular degeneration (AMD) is one of the most common causes of irreversible impairment of central vision in the elderly population. Although anti-VEGF therapy remains the standard treatment for neovascular AMD, nutritional fac...
Blueberry pomace is a polyphenol-rich by-product of fruit processing. A face-centered central composite design (FCCCD) optimized hydroethanolic extraction across time (20–60 min), temperature (20–60 °C) and ethanol (20–80%), eva...
Parkinson’s disease (PD) is a neurodegenerative disorder associated with gut dysbiosis and tryptophan metabolism disturbance, but the mechanisms of probiotic action are unclear. We orally administered Lactobacillus reuteri DSM 17938 live bacter...
Background: Endometriosis is a chronic inflammatory and estrogen-dependent disease in which oxidative stress, immune dysregulation, and lesion-supportive microenvironmental signaling contribute to lesion development. N-acetylcysteine (NAC), a glutath...
Hydrogen sulfide (H2S) is a vital gasotransmitter essential for maintaining redox homeostasis and modulating inflammatory responses. Herein, we examined a collection of Drosophila melanogaster knockout (KO) lines generated in our laboratory, lacking...
Purpose: We aim to elucidate the impact of endometriomas on oocyte developmental competence and identify genetic alterations that may influence ICSI success rates in women of different ages. Methods: In this retrospective study, two groups of patient...
Intracerebral hemorrhage (ICH) is a devastating stroke subtype in which secondary brain injury is driven by oxidative stress, iron overload, ferroptosis, neuroinflammation, blood–brain barrier disruption, and defective hematoma clearance. Nrf2...
Preeclampsia is a serious pregnancy complication characterised by maternal vascular dysfunction, placental dysfunction, and organ injury, with no effective treatment currently available. Kampo, a system of Japanese traditional medicine comprising sta...
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic strategy for cervical cancer. However, the mitochondrial factors governing ferroptosis sensitivity in this malignancy rem...
This review intends to provide an insight into the wide range of possibilities for vegetable oils to be used as solvents to extract natural ingredients for various applications with a special emphasis on antioxidants. The potential of using oils as f...
Glycyrrhiza glabra leaves (GGL) are an underutilized by-product of the licorice supply chain and a valuable source of bioactive flavanones. In this study, supercritical CO2 fluid extraction (SFE-CO2) was optimized for the selective recovery of leaf-e...
This study investigated the effects of high-lipid diets (HLD) with methionine (Met) supplementations on golden pompano (Trachinotus ovatus). T. ovatus (initial weight 82 ± 0.04 g) were fed with a normal lipid control diet (11.30% crude lipid a...
Dry eye disease (DED) is a multifactorial ocular surface disorder characterized by inflammation, oxidative stress, tear film instability, and secretory dysfunction. This study investigated the protective effects of Lute-gen®, a lutein and zeaxant...
Since lung cancer remains a leading cause of cancer-related mortality, effective adjunct strategies against this disease are needed. This study evaluated an extract prepared from organically cultivated Capsicum annuum treated with deep-seawater-deriv...
Medicinal plants are a rich source of biologically active compounds, including phenolic acids, flavonoids, ellagitannins and other secondary metabolites. However, the contribution of specific groups of phenolic compounds to antiproliferative activity...
Excessive ethanol consumption is a cause of gastric ulceration. This study aimed to identify the gastroprotective action of rufigallol, an anthraquinone, against ethanol-induced gastric ulcers and assess its antioxidant and anti-inflammatory properti...
The physiological implications of chronic oxidative stress motivate research on antioxidant activity: the cellular defence and repair mechanism for oxidative damage. Through evaluation of thermodynamic and kinetic quantities of hydroperoxyl (•OO...
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe, progressive liver disease lacking effective therapies. Disulfiram (DSF), an FDA-approved medication for alcohol dependence, exhibits diverse biological activities beyond its primary...
Selenium nanoparticles (SeNPs), which are nanoscale particles of elemental selenium (Se0), combine the biological activity of selenium with the distinctive properties inherent in nanomaterials, thereby making SeNPs a more promising candidate for adva...
Oxidative stress contributes to retinal neurovascular injury through inflammation, mitochondrial dysfunction, blood–retinal barrier (BRB) disruption, microcirculatory impairment, and regulated cell death. Hydroxysafflor yellow A (HSYA), a water...
The pathogenesis of cardiovascular diseases (CVDs) is intimately linked to cholesterol dysregulation. While high-density lipoprotein cholesterol (HDL-C) is classically considered cardioprotective, contemporary epidemiological evidence reveals a nonca...
Vitiligo is a multifactorial depigmentation disorder involving complex interactions among oxidative stress, immune dysregulation, inflammatory signaling, and programmed cell death pathways, which act as a central driver of melanocyte dysfunction and...
Ocean acidification poses a critical threat to marine invertebrate survival and diversification, yet the post-transcriptional regulatory mechanisms underlying acid stress responses remain poorly understood. Here, we employed Oxford Nanopore long-read...
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