Oxidative Stress in Cell Senescence
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 1
Special Issue Editor
Interests: stem cell biology; cell differentiation; cellular mechanisms; cell senescence; stress response; gene and protein expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress plays a pivotal role in regulating cellular aging and the functional decline of stem cells. Reactive oxygen species (ROS), produced as by-products of cellular metabolism, can damage DNA, proteins, and lipids, thereby triggering senescence—a state of irreversible cell cycle arrest. In stem cells, a tightly controlled redox balance is essential for preserving their self-renewal and differentiation capacities. Excessive oxidative stress disrupts this balance, leading to premature senescence and loss of regenerative potential. Moreover, the accumulation of senescent cells in tissues contributes to aging and age-related diseases through the senescence-associated secretory phenotype (SASP), which promotes chronic inflammation and alters tissue microenvironments. Understanding the interplay between oxidative stress, cellular senescence, and stem cell biology is crucial for developing therapeutic strategies aimed at enhancing tissue regeneration and counteracting degenerative disorders.
We invite you to submit original studies, reviews, and perspectives that explore the role of oxidative stress and cellular senescence in stem cell biology and regenerative medicine. Contributions that deepen our understanding of redox regulation, senescence-associated mechanisms, and their impacts on stem cell function and tissue regeneration are especially welcome.
We look forward to receiving your contribution.
Dr. Sara Cruciani
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- stem cells
- cell senescence
- regenerative medicine
- antioxidant strategies
- age-related diseases
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