Targeting Oxidative Stress in Ischemia/Reperfusion Injury
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 26
Special Issue Editor
Interests: ischemia-reperfusion injury; oxidative stress; molecular biochemistry; cell biology; immunology; small molecule pharmacokinetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ischemia/reperfusion (I/R) injury is a critical pathological process that occurs across a broad spectrum of clinical scenarios, including myocardial infarction, stroke, organ transplantation, and major trauma. The sudden restoration of blood flow to ischemic tissues triggers an excessive generation of reactive oxygen species (ROS), initiating a complex cascade of redox-dependent signaling pathways. This oxidative burst plays a central role in causing cellular injury, inflammation, immune dysregulation, and ultimately, organ dysfunction.
This Special Issue aims to highlight recent advances in elucidating the role of oxidative stress in the pathophysiology of I/R injury. We welcome original research and reviews that explore novel redox-regulated molecular and cellular mechanisms, innovative antioxidant-based therapeutic strategies, and translational insights from both preclinical models and clinical investigations.
Topics of particular interest include, but are not limited to, the following:
- Post-transcriptional regulation of redox signaling, including RNA-binding proteins.
- Crosstalk between oxidative stress and immune responses in hepatic and systemic I/R injury.
- Mitochondrial dysfunction and redox imbalance during reperfusion.
- Development of targeted antioxidants or nanomedicine approaches for I/R injury.
- Biomarkers and diagnostic tools related to oxidative stress in I/R contexts.
Dr. Kenneth J. Dery
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ischemia/reperfusion injury
- reactive oxygen species
- redox-regulated molecular and cellular mechanism
- antioxidant-based therapeutic strategies
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