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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hormonal and Redox Regulation in Cancer, Metabolic Dysfunction, and Neurodegenerative Diseases

edited by

Moon Nyeo Park

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1442 | Submission Open

Keywords: hormonal regulation; redox signaling; antioxidant hormones; melatonin; oxidative stress; mitochondria; epigenetics; noncoding RNA; metabolic reprogramming; ferroptosis; inflammation; SIRT1/AMPK; Nrf2/Keap1; redox therapeutics; translational pharmacology; natural compounds

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Directed Lipid Oxygenation as an Antioxidant System

edited by Cecil Pace-Asciak

submission deadline 25 Jun 2026 | Viewed by 287 | Submission Open

Keywords: COX/LOX; phospholipases; mono; di and tri HPETES/HETES; ROS; antioxidants; second messengers; biological actions; pathology; therapeutics

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Jun 2026 | 10 articles | Viewed by 52565 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Janus Face of Oxidative Stress in Normal and Pathological Conditions

edited by

Marco Fiore

submission deadline 30 Jun 2026 | 13 articles | Viewed by 37622 | Submission Open

Keywords: ethanol; toxicity; abuse; addiction; binge drinking; oxidative stress; psychoactive drug; cancer; recreational drug; FASD

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Free Radicals, Antioxidants, and Oxidative Stress in Aging and Age-Related Diseases—2nd Edition

edited by

Abdelouahed Khalil

and

Tamas Fulop

submission deadline 30 Jun 2026 | 6 articles | Viewed by 31256 | Submission Open

Keywords: aging; oxidative stress; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Implication of Oxidative Stress in Promoting Cellular Senescence and Associated Pathologies—2nd Edition

edited by

Alexandra Barbouti

submission deadline 30 Jun 2026 | 9 articles | Viewed by 30385 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); cellular senescence; ageing; age-related pathologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

From Waste to Health: Upcycling Agrifood By-Products into Functional Antioxidant-Rich Ingredients and Products

edited by

Ítala Maria Gouveia Marx

and

Feliciano Priego-Capote

submission deadline 30 Jun 2026 | 6 articles | Viewed by 17867 | Submission Open

Keywords: antioxidant activity; oxidative stress; reactive oxygen species; polyphenols; bioactive compounds; functional ingredients; health-promoting formulations; agrifood waste; green extraction technologies; emerging analytical methods

Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment

edited by

Silvia M. Arribas

and

David Ramiro-Cortijo

submission deadline 30 Jun 2026 | 7 articles | Viewed by 16486 | Submission Open

Keywords: oxidative stress; pregnancy; germline damage; obstetric complications; fetal programming

Oxidative Stress in Cell Senescence

edited by

Sara Cruciani

submission deadline 30 Jun 2026 | 7 articles | Viewed by 16246 | Submission Open

Keywords: stem cells; cell senescence; regenerative medicine; antioxidant strategies; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress Induced by Micro(Nano)plastics

edited by

Lavinia Casati

Alessandro Villa

and

Marco Parolini

submission deadline 30 Jun 2026 | 3 articles | Viewed by 12828 | Submission Open

Keywords: micro(nano)plastics; oxidative stress; One Health; in vitro and in vivo models; organisms; cellular microenvironment

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Chronic Pain and Oxidative Stress

edited by

Olga Pol

submission deadline 30 Jun 2026 | 5 articles | Viewed by 12234 | Submission Open

Keywords: analgesia; antioxidants; chemotherapy; heme oxygenase 1; neuropathy; nociception; Nrf2 transcription factor; oxidative stress; pain

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants from Plant-Based By-Products: Mechanisms and Applications in Food Systems

edited by

María Jesús Petrón Testón

submission deadline 30 Jun 2026 | 7 articles | Viewed by 11882 | Submission Open

Keywords: natural antioxidants; plant-based by-products; phenolic compounds; food preservation; shelf life extension; sustainable food systems; extraction techniques

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Harnessing Redox Status and Novel Molecular Signals and Targets Involved in Oxidative Stress to Afford Cardioprotection: From Experimental Insights to Clinical Applications

edited by

Tommaso Angelone

Carmine Rocca

and Anna De Bartolo

submission deadline 30 Jun 2026 | 4 articles | Viewed by 11252 | Submission Open

Keywords: oxidative stress; redox signaling; cardioprotection; antioxidants; heart disease; vascular dysfunction; molecular targets; therapeutic approaches

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Editorial Board Members’ Collection Series: Advances in Redox-Tools and Therapies in Cardiovascular Disease

edited by

Andreas Daiber

Albino Carrizzo

and

Moo-Yeol Lee

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10082 | Submission Open

Keywords: cardiovascular disease; oxidative stress; inflammation; reactive oxygen species; redox signalling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Heme Oxygenase in Health and Disease: New Insights and Future Directions

edited by

J. Catharina Duvigneau

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9742 | Submission Open

Keywords: enzyme activity; ferroptosis; carbon monoxide; oxidative stress; reactive oxygen and nitrogen species; heme proteins; heme degradation; heme responsive elements; heme regulation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Lipid Peroxidation and Cancer

edited by

Stefania Pizzimenti

and

Giuliana Muzio

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6634 | Submission Open

Keywords: lipid peroxidation; fatty acid metabolism; 4-hydroxynonenal (HNE); malondialdehyde (MDA); ferroptosis; carcinogenesis; cancer progression

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Recent Advances in Applications of Nanoantioxidants

edited by

Anna Calarco

and

Raffaele Conte

submission deadline 30 Jun 2026 | 1 articles | Viewed by 4512 | Submission Open

Keywords: nanoantioxidants; nanoscale engineering; medicine; cosmetics; functional foods; material characterization

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Bioactive Compounds: Antioxidant, Antibacterial, and Anti-Inflammatory Modulation—2nd Edition

edited by

Raquel Bridi

and

Christian Espinosa-Bustos

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3177 | Submission Open

Keywords: bioactive compounds; antioxidants; anti-inflammatory activity; antibacterial properties; reactive oxygen species; oxidative stress; phytochemicals

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant and Anticancer Activities of Food Ingredients and Natural Products

edited by

Constantinos Giaginis

and

Efthymios Poulios

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2167 | Submission Open

Keywords: oxidative stress; cancer; disease prevention or therapy; oxidative biomarkers; quality of life; apoptosis; cell cycle arrest; antioxidant enzymes; reactive oxygen species

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Sustainable Strategies for Natural Antioxidant Utilization

edited by

Vlasios Goulas

and Atalanti Christou

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1584 | Submission Open

Keywords: extraction; antioxidants; polyphenols; phytochemicals; green chemistry; sustainable process; natural products; drug discovery; formulation; natural product analysis

Artificial Intelligence and Other Bioinformatic Modern Technologies Approaches to the Study of Antioxidant Capacity in Food Production

edited by

Giuseppe Perretti

submission deadline 30 Jun 2026 | Viewed by 825 | Submission Open

Keywords: artificial intelligence; bioinformatics; food processing; food quality; antioxidant capacity; big data

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 30 Jun 2026 | 1 articles | Viewed by 824 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Statins as Antioxidants: Beyond Their Cholesterol Lowering Activity

edited by

Arianna Vignini

and Sonila Alia

submission deadline 30 Jun 2026 | Viewed by 600 | Submission Open

Keywords: statins; cholesterol; HMGCoA reductase; antioxidant; anti-inflammatory; dysmetabolic diseases

Advances in Mitochondrial Redox Biology—Second Edition

edited by

Masuko Ushio-Fukai

submission deadline 30 Jun 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: mitochondria; redox signaling; reactive oxygen species (ROS); mitochondrial dynamics; bioenergetics; mitochondria– nuclear communication; aging; cell metabolism

Antioxidants in Meat and Meat Products

edited by

Rubén Domínguez-Valencia

and

Mirian Pateiro

submission deadline 30 Jun 2026 | Viewed by 511 | Submission Open

Keywords: natural antioxidants; oxidative degradation; meat shelf-life; food quality; functional food; bioactive compounds; antioxidant active packaging

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress in Neurodevelopmental Disorders

edited by

Marco Fiore

submission deadline 30 Jun 2026 | Viewed by 338 | Submission Open

Keywords: brain development; neurodevelopmental disorders; reactive oxygen species; attention deficit/hyperactivity disorder; fetal alcohol spectrum disorders; autism spectrum disorder; intellectual disability; neuroinflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Oxidative Stress in Chronic Pain and Inflammation

edited by

Lucia Carmela Passacatini

and

Saverio Nucera

submission deadline 30 Jun 2026 | Viewed by 284 | Submission Open

Keywords: chronic pain; oxidative stress; antioxidant; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Dialysis-Induced Oxidative Stress, MicroRNAs and Organ Damage: From Bench to Bedside

edited by

Yuri Battaglia

submission deadline 30 Jun 2026 | Viewed by 249 | Submission Open

Keywords: dialysis; hemodialysis; hemodiafiltration; oxidative stress; microRNAs; non-coding RNAs; organ damage; cardiovascular disease; inflammation; biomarkers; end-stage kidney disease; redox imbalance

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Chronic and End-Stage Kidney Disease: Defining Biological and Clinical Plausibility

edited by

Stefanos Roumeliotis

and

Vassilios Liakopoulos

submission deadline 30 Jun 2026 | Viewed by 227 | Submission Open

Keywords: CKD; ESKD; cardiovascular disease; catalase; chronic kidney disease; end stage kidney disease; N-acetylcysteine; superoxide dismutase; vascular calcification; vitamin C; vitamin E

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Agri-Food Wastes as Natural Source of Bioactive Antioxidants: Fourth Edition

edited by

Silvana Hrelia

Cristina Angeloni

and

Maria Cristina Barbalace

submission deadline 10 Jul 2026 | 11 articles | Viewed by 21067 | Submission Open

Keywords: agri-food by-products; agri-food waste; nutraceuticals; functional foods; cosmeceutical products; sustainable practices; bioactive compounds; health effects

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Heme Proteins and Signaling in Redox Biology

edited by

Brandon Reeder

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: heme proteins; redox biology; globin; oxygen binding and sensing proteins

(This special issue belongs to the Section ROS, RNS and RSS)

Hydrophilic and Lipophilic Antioxidants in Foods and Food Processing

edited by

Volker Böhm

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2676 | Submission Open

Keywords: antioxidant activity; antioxidant capacity; antioxidant mechanisms; carotenoids; polyphenols; vitamin C; vitamin E; impact of food processing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants

edited by

Magdalena Jeszka-Skowron

Agnieszka Zgoła-Grześkowiak

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 20 Jul 2026 | 10 articles | Viewed by 30857 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

The Interaction Between Gut Microbiota and Host Oxidative Stress

edited by

Jie Yin

submission deadline 20 Jul 2026 | 4 articles | Viewed by 12373 | Submission Open

Keywords: oxidative stress; antioxidants; gut microbiome; immunity

Antioxidants and Multifunction Photoprotection—2nd Edition

edited by

André Rolim Baby

and

Catarina Rosado

submission deadline 20 Jul 2026 | 1 articles | Viewed by 8808 | Submission Open

Keywords: natural and synthetic antioxidants; sunscreens; multifunctional products; safety and efficacy establishment; product technologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Glutathione and Health: From Development to Disease

edited by

Ying Chen

and Vasilis K. Vasiliou

submission deadline 20 Jul 2026 | 3 articles | Viewed by 8576 | Submission Open

Keywords: glutathione; antioxidants; antioxidant enzymes; oxidative stress; redox biology; molecular biology; cellular biology; biochemistry; development; disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress Induced by Air Pollution, 3rd Edition

edited by

Yasuhiro Yoshida

submission deadline 20 Jul 2026 | 3 articles | Viewed by 3543 | Submission Open

Keywords: particulate matter; air pollution; oxidative stress; reactive oxygen species; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Lipid Peroxidation, Vegetable Oil Oxidation, and the Role of Plant Extracts in Enhancing Oxidative Stability

edited by

Daniele Sanna

and

Angela Fadda

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1904 | Submission Open

Keywords: oil oxidative stability; natural antioxidants; lipid peroxidation; surfactants; encapsulation

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition

edited by

Washington Luiz Esteves Magalhães

and Tielidy Lima

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1842 | Submission Open

Keywords: antioxidant biomaterials; tissue regeneration; biocompatibility; controlled release; premature aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation in Algae

edited by

Kim Gwang Hoon

submission deadline 20 Jul 2026 | Viewed by 298 | Submission Open

Keywords: algae; reactive oxygen species; redox regulation; stress responses; NADPH oxidases; antioxidants; redox-sensitive transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

The Role of Oxidative Stress in Age-Related and Degenerative Eye Diseases

edited by

Ting Zhang

submission deadline 30 Jul 2026 | 6 articles | Viewed by 7730 | Submission Open

Keywords: oxidative stress; age-related macular degeneration; retinal degeneration; reactive oxygen species; redox signaling; mitochondrial dysfunction; antioxidant therapy; artificial intelligence; multi-omics; biomarkers; vision science

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Jul 2026 | 4 articles | Viewed by 22722 | Submission Open

Keywords: obesity; cardiovascular diseases; chronic disease; dietary prevention; antioxidants intake; gut microbiome; natural and synthetic antioxidants; antioxidant enzyme systems; antioxidant extraction

Green Extraction of Antioxidant from Natural Source

edited by

Jolanta Flieger

submission deadline 31 Jul 2026 | 8 articles | Viewed by 19736 | Submission Open

Keywords: green extraction techniques ; supercritical fluid extraction ; ionic liquid (IL)-based extraction; microwave-assisted extraction; antioxidants; plants; cosmetic formulation

Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment

edited by

Marcello Chieppa

and

Angelo Santino

submission deadline 31 Jul 2026 | 7 articles | Viewed by 18130 | Submission Open

Keywords: IBD; antioxidant; gut barrier; inflammation; natural compounds; microbiome; colon cancer; adjuvant; nutritional bioactive products; polyphenols

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Exploring New Frontiers in Oxidative Stress and Antioxidant Research: From Model Organisms to Human Disease

edited by

Marcello Ziosi

and

Gaetano Santulli

submission deadline 31 Jul 2026 | 6 articles | Viewed by 15842 | Submission Open

Keywords: oxidative stress; antioxidant therapeutics; cell death and survival pathways; cellular signaling networks; gene regulation and expression

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Compounds and Health Benefits of Mediterranean Functional Food

edited by

Stefania D'Angelo

submission deadline 31 Jul 2026 | 6 articles | Viewed by 14839 | Submission Open

Keywords: antioxidants; anti-inflammatory; anti-obesity; functional food; human health; Mediterranean diet; nutraceuticals; nutrition; oxidative stress; phytochemicals; polyphenols

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Plant Materials and Their Antioxidant Potential, 3rd Edition

edited by

Elisabeta Irina Geana

and

Ovidiu Tita

submission deadline 31 Jul 2026 | 6 articles | Viewed by 6156 | Submission Open

Keywords: antiseptic; antioxidant; volatile oil; compounds; fruits and vegetables; medicinal plants; agri-food industry; food ingredients; functional foods; nutraceuticals; food supplements; pharmaceutical products; antioxidant activity; oxidative stress; aging; anti-inflammatory activity; sustainable recovery; circular bioeconomy

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

edited by

Jolanta Flieger

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5030 | Submission Open

Keywords: bioactive antioxidants; therapeutic potential; synthetic strategies; structural characterization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Olive Antioxidants: Extraction, Biological Activity and Practical Applications—3rd Edition

edited by

Juan Fernández-Bolaños

and

Alejandra Bermudez-Oria

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4553 | Submission Open

Keywords: antioxidant effect; olive oil; olive by-products; olive leaves; polyphenols; carotenoids; polysaccharide– polyphenol complexes; vitamin E; health; Mediterranean diet

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Natural Antioxidants in Counteracting Mycotoxin and Heavy Metal Toxicity

edited by

Shusheng Tang

and Xingyao Pei

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4450 | Submission Open

Keywords: natural antioxidants; mycotoxins; heavy metal; detoxification

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