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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Oxidative Stress in Male Infertility

edited by

Suresh C. Sikka

submission deadline 20 Mar 2026 | 5 articles | Viewed by 19161 | Submission Open

Keywords: male infertility; seminal reactive oxygen species; sperm; reactive nitrogen species; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants as Weapons to Maintain or Restore Oral Health

edited by

Célia Fortuna Rodrigues

and

José Carlos Andrade

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3972 | Submission Open

Keywords: polyphenols; biofilms; oral mucositis; gingivitis; caries; AMR

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phytochemical Profiling, Antioxidant Activity and Therapeutic Properties of Medicinal Plants

edited by

Lina Raudonė

submission deadline 20 Mar 2026 | 4 articles | Viewed by 3644 | Submission Open

Keywords: medicinal plants; phytochemicals; antioxidant activity; extraction optimization; functional foods and nutraceuticals; sustainability in phytotherapy

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Sleep Disorders

edited by

Agata Gabryelska

submission deadline 25 Mar 2026 | 1 articles | Viewed by 2461 | Submission Open

Keywords: sleep disorders; sleep apnea; insomnia; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Defense in Mitigating Abiotic Stresses in Plants: Mechanisms, Innovations, and Applications

edited by

Rong Zhou

submission deadline 25 Mar 2026 | 3 articles | Viewed by 2294 | Submission Open

Keywords: abiotic stress; antioxidant systems; reactive oxygen species; plant stress tolerance

(This special issue belongs to the Section ROS, RNS and RSS)

Reactive Oxygen Species (ROS): Key Components in Infection Control, Wound Healing, and Cancer Therapy

edited by Christian Scharf

submission deadline 28 Mar 2026 | 1 articles | Viewed by 1380 | Submission Open

Keywords: reactive oxygen species (ROS); oxidative stress; redox signaling; antioxidant defense; wound healing; biofilm eradication; infection control; cancer therapy; immune modulation; cold atmospheric plasma (CAP); plasma-activated media (PAM); translational redox medicine

(This special issue belongs to the Section ROS, RNS and RSS)

Blood Cells and Redox Homeostasis in Health and Disease, 2nd Edition

edited by

Angelo D'Alessandro

and

Alkmini T. Anastasiadi

submission deadline 30 Mar 2026 | 7 articles | Viewed by 12999 | Submission Open

Keywords: blood; redox status; antioxidants; oxidative stress; redox therapy; oxidative stress biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants and Their Oxidized Derivatives in Processed Food

edited by Concetta Condurso and Maria Merlino

submission deadline 30 Mar 2026 | 2 articles | Viewed by 9989 | Submission Open

Keywords: natural antioxidants; oxidized derivatives; bioavailability/bioaccessibility; antioxidant activity; processed food; thermal treatment; non-thermal treatment; innovative processing technologies; mild processing technologies; active packaging; shelf-life; nutritional benefits; health benefits; sensory quality

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Prevention of Atherosclerosis and of Low-Density Lipoprotein Oxidation: Role of Dietary Antioxidant Compounds and Altered Redox Pathways. A Commemorative Special Issue in Honour of Professor Stanley Omaye

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Mar 2026 | 6 articles | Viewed by 35713 | Submission Open

Keywords: LDL; oxidative stress; antioxidants; chronic; low-grade inflammation; vitamins; antioxidant enzymes; redox signalling

Oxidative Stress and Its Mitigation in Neurodegenerative Disorders

edited by

D. Allan Butterfield

submission deadline 31 Mar 2026 | 8 articles | Viewed by 16185 | Submission Open

Keywords: oxidative stress; neurodegenerative disorders; brain; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cardiovascular Diseases and Vascular Pathophysiology

edited by

Guillermo Zalba

submission deadline 31 Mar 2026 | 4 articles | Viewed by 9275 | Submission Open

Keywords: atherosclerosis; diabetes; heart failure; inflammation; myocardial infarction; NADPH oxidase; oxidative stress; reactive oxygen species; stroke

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Metabolic Disorders and Non-Communicable Diseases (NCDs): Molecular Pathways and Genetic Influence

edited by

Roberta Giordo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 7434 | Submission Open

Keywords: metabolic disorders; non-communicable diseases (NCDs); reactive oxygen species (ROS); genetic influence; molecular pathways

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Inflammation and Oxidative Stress in Articular Cartilage

edited by

Carmelita G. Frondoza

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5030 | Submission Open

Keywords: cartilage; chondrocyte; joint inflammation; arthritis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Systems, Transcription Factors and Non-Coding RNAs

edited by

Raffaella Faraonio

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4606 | Submission Open

Keywords: antioxidant systems; oxidative stress; transcription factors; non-coding RNAs; stress response

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Activity of Grape and Grape By-Products

edited by

Cristiana Radulescu

and Radu Lucian Olteanu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4475 | Submission Open

Keywords: antioxidants; grapes and grape by-products; extracts; cosmetic formulations; chromatography; microencapsulation; phytochemical profile; microbiological assay

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress and Inflammation in Kidney Diseases

edited by

Andrea Angeletti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4053 | Submission Open

Keywords: chronic renal failure; clinical nephrology; renal physiology; glomerulonephritis; diabetic nephropathy; renal disease; oxidative stress; kidney transplantation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Recent Trends in Nanoantioxidants—2nd Edition

edited by

Maria Letizia Manca

and

Matteo Perra

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3628 | Submission Open

Keywords: nanocarriers; liposomes; nanocrystals; oxidative stress; inflammation; antioxidant; cosmeceuticals; nutraceuticals; ROS; liposomes; nanosystems

Role of Antioxidants and Oxidative Stress in Neurodegenerative Diseases

edited by

Barbara Sottero

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3622 | Submission Open

Keywords: neurodegenerative diseases; antioxidants; oxidative stress; Parkinson’ s disease; Alzheimer’ s disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Microalgae FoodOmics and FeedOmics: Antioxidant Enrichment, ROS Modulation, and Health-Boosting Applications

edited by

Clementina Sansone

and

Francesca Sansone

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2840 | Submission Open

Keywords: microalgae; bioactive compounds; antioxidants; antioxidant metabolism; antioxidant biosynthesis; omics; vitamins; probiotics; prebiotics; postbiotics; drug delivery; signal transduction; gut/brain axis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Dietary Antioxidants, Oxidative Stress, and Women’s Reproductive Health

edited by

Miran Čoklo

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2523 | Submission Open

Keywords: oxidative stress; women’ s reproductive health; dietary antioxidants; female fertility; reproductive outcomes; polycystic ovary syndrome (PCOS); endometriosis; preeclampsia; nutritional interventions; bioactive compounds; lifestyle modifications

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Impact of Antioxidant and Anti-Inflammatory Functions of HDL in Diseases—3rd Edition

edited by

Carlo Cervellati

and

Judit Marsillach

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1996 | Submission Open

Keywords: paraoxonases; oxidized LDL; high-density lipoproteins; metabolic diseases; apolipoproteins; cardiovascular disease; neurological disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Antioxidants in Carcinogenesis: A Multifaceted Approach—2nd Edition

edited by

Fábio Rodrigues Ferreira Seiva

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: oxidative stress; carcinogenesis; reactive oxygen species (ROS); antioxidants; cancer therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapies, Mitochondrial Function, and Transplantation Strategies: Mechanisms and Emerging Therapeutics

edited by

Junhwan Kim

and

P. Singh

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: oxidative stress; antioxidant therapies; mitochondrial function; mitochondrial dysfunction

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Capacity of Natural Products—3rd Edition

edited by

Younghwa Kim

submission deadline 31 Mar 2026 | 3 articles | Viewed by 1120 | Submission Open

Keywords: natural antioxidants; oxidative stress; phytochemicals; bioactive compounds; reactive oxygen species (ROS)

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Roles of Oxidative Stress in Human Pathophysiology

edited by

Alexandros Georgakilas

submission deadline 31 Mar 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: oxidative stress; reactive oxygen species; redox signaling; antioxidants; inflammation; biomarkers; human diseases; therapy; pathology; pathophysiology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Small Molecule Approaches to Modulating Oxidative Stress Responses

edited by

Hidekazu Hiroaki

submission deadline 31 Mar 2026 | Viewed by 940 | Submission Open

Keywords: natural products; nutraceuticals; antioxidants; polyphenols; flavonoids; barrier function; cellular senescence; inflammation; DNA damage; regeneration

Peroxiredoxins

edited by

Dong-Seok Lee

submission deadline 31 Mar 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: peroxiredoxins; oxidative stress; neuron; neuroinflammation; stemness; cancer

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Antioxidants in Food Matrices: From Analytical Advances to Circular and Sustainable Applications

edited by

Sara Jaramillo-Carmona

and

Rafael Guillén Bejarano

submission deadline 31 Mar 2026 | 1 articles | Viewed by 847 | Submission Open

Keywords: food matrix; bioaccesibility; bioavailability; functionality; by-products; valorization; circular economy

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Redox-Based Targeting of Signaling Pathways as a Therapeutic Approach

edited by

Seung-rock Lee

and Dhiraj Kumar Sah

submission deadline 31 Mar 2026 | 1 articles | Viewed by 546 | Submission Open

Keywords: cellular signaling; redox-based; therapeutic intervention; human disease; longevity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Optimizing Physical Exercise: Post-Exercise Recovery, Oxidative and Nitrosative Stress, and the Role of Physical Activity in Healthy Aging and Neuroprotection

edited by

Celestyna Mila-Kierzenkowska

and

Marta Pawlowska

submission deadline 31 Mar 2026 | Viewed by 318 | Submission Open

Keywords: oxidative stress; exercise; nitrosative stress; post-exercise damage; post-exercise regeneration; aging; neuroprotection

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Therapeutic Potential of Natural Antioxidants in Respiratory Diseases and Airway Inflammation

edited by Yo-Han Han

submission deadline 31 Mar 2026 | Viewed by 264 | Submission Open

Keywords: natural product; acute/chronic lung injury; inflammation; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Redox Signaling in Kidney Diseases

edited by Xiaofeng Yang

submission deadline 31 Mar 2026 | Viewed by 251 | Submission Open

Keywords: oxidative stress; redox signaling; kidney diseases; antioxidant defense; inflammation; biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

NMR Spectroscopy for the Characterization of Foods: Applications in Antioxidant Research and Beyond

edited by

Giacomo Di Matteo

and

Federico Brigante

submission deadline 31 Mar 2026 | Viewed by 209 | Submission Open

Keywords: NMR spectroscopy; antioxidants; food science; bioactive compounds; oxidative stability; metabolomics; food processing; health promotion

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant and Antidiabetic Activities of Plant Matrices: Methods, Mechanisms, and Translational Relevance

edited by

Sabina Lachowicz-Wiśniewska

submission deadline 31 Mar 2026 | Viewed by 208 | Submission Open

Keywords: antioxidant assays; antidiabetic activity; α -glucosidase; α -amylase; DPP-IV; antiglycation/AGEs; tea (Camellia sinensis); wild plants; neglected and underutilized species (NUS); stachys; root and tuber crops; ultrasound; microwave; bioavailability; metabolomics; layer-by-layer; hydrogels; alginate; pectin; chitosan; zein; processing by-products

Antioxidant Defenses and Inflammation in Diabetic Retinopathy

edited by Devy Deliyanti

submission deadline 31 Mar 2026 | Viewed by 182 | Submission Open

Keywords: retinal injury; diabetic retinopathy; retinal inflammation; cell death; antioxidant; pro-oxidants; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Dietary, Environmental, and Lifestyle Modulators of Oxidative Stress in Health and Disease

edited by

Ines Drenjančević

and

Ivana Jukić

submission deadline 31 Mar 2026 | Viewed by 177 | Submission Open

Keywords: oxidative stress; nutrition; antioxidants; functional foods; dietary supplements; nutritional interventions; disease prevention; diet and health; environmental

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Biological Activities of Antioxidant Selenoproteins

edited by

Raquel Martin-Venegas

submission deadline 31 Mar 2026 | Viewed by 171 | Submission Open

Keywords: selenoproteins; selenium metabolism; microbial redox regulation; bacteria– host redox interactions; oxidative stress; antioxidant defence

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 10 Apr 2026 | 7 articles | Viewed by 12458 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology of Glyoxalases and Advanced Glycation End Products in Health and Diseases

edited by

Cinzia Antognelli

Marilena Pariano

and

Vincenzo Nicola Talesa

submission deadline 10 Apr 2026 | 7 articles | Viewed by 10423 | Submission Open

Keywords: glyoxalases; methylglyoxal; advanced glycation end products; aging; diseases; antioxidants; apoptosis; cell proliferation; nutraceuticals; oxidative stress; inflammation; apoptosis; EMT; cell proliferation; signal transduction; biological mechanisms

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors

edited by Maria Clara Franco and

Luciana Hannibal

submission deadline 10 Apr 2026 | 1 articles | Viewed by 7558 | Submission Open

Keywords: tumor biology; reactive nitrogen species; redox signaling; oxidative stress; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants for Cosmetic Applications

edited by

Rita Cortesi

and

Maddalena Sguizzato

submission deadline 10 Apr 2026 | 3 articles | Viewed by 2995 | Submission Open

Keywords: cosmetic formulations; skin care; oxidative stress; photoprotection

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants and Metabolic Diseases, 2nd Edition

edited by

José Ángel Rufián-Henares

Fortuna Iannuzzo

Elisabetta Schiano

and

Maria Maisto

submission deadline 10 Apr 2026 | 2 articles | Viewed by 2012 | Submission Open

Keywords: metabolic syndrome; antioxidant compounds; diabetes; obesity; cardiovascular diseases; biological effects; food sources; medicinal plants; oxidative stress; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Synthetic Compounds: Antioxidant and Anti-Inflammatory Activities, Biomedical Properties and Formulations

edited by

Simone Carradori

and

Ilaria D'Agostino

submission deadline 20 Apr 2026 | 5 articles | Viewed by 10625 | Submission Open

Keywords: antioxidants; inflammation pathways; therapeutic activity; redox potential; synthesis; preclinical studies; macrophages; immunomodulation; packaging; formulations; topical application; polymers; nanotechnology; cytotoxicity; mechanism of action; food; drug design

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidant Mechanisms for Health and Diseases, 2nd Edition

edited by Yoshihisa Koyama

submission deadline 20 Apr 2026 | 4 articles | Viewed by 7680 | Submission Open

Keywords: antioxidant therapy; reactive oxygen species; oxidative stress; nano-antioxidant therapy; nutrigenomics; microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Targeting Oxidative Stress in Ischemia/Reperfusion Injury

edited by Kenneth J. Dery

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3149 | Submission Open

Keywords: ischemia/reperfusion injury; reactive oxygen species; redox-regulated molecular and cellular mechanism; antioxidant-based therapeutic strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress, Mitochondrial Dysfunction, and Inflammation in Autism

edited by

Abha Chauhan

submission deadline 20 Apr 2026 | Viewed by 411 | Submission Open

Keywords: autism; oxidative stress; mitochondria; inflammation; redox signaling; antioxidants; reactive oxygen species; immune response

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Natural Antioxidants on Neuroprotection

edited by

Mercedes Villacampa

José Carlos Menéndez

and

Ángel Cores

submission deadline 30 Apr 2026 | 6 articles | Viewed by 29471 | Submission Open

Keywords: drug design; polyphenols; oxidative stress; Nrf2 induction; neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Lysosomal Function in Health and Disease

edited by

Silvana M. Zanlungo

and Alejandra R. Álvarez

submission deadline 30 Apr 2026 | 4 articles | Viewed by 17154 | Submission Open

Keywords: lysosome; lysosomal dysfunction; lysosome homeostasis; autophagy; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Activities of Phytochemicals in Fruits and Vegetables

edited by

Wen Qin

submission deadline 30 Apr 2026 | 5 articles | Viewed by 9502 | Submission Open

Keywords: ROS and oxidative stress; green and efficient extraction technology of phytochemicals; antioxidant activity of phytochemicals in fruits and vegetables; polyphenols and polysaccharides in fruits and vegetables; phytochemicals and inflammation

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress from Environmental Exposures

edited by

Giulia Squillacioti

Valeria Bellisario

and

Federica Ghelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5926 | Submission Open

Keywords: environmental exposures; human health; air pollution; lifestyle; oxidative stress; particulate matter; environmental stressors

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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